Incidental Mutation 'IGL01807:Or5ac15'
ID 155698
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5ac15
Ensembl Gene ENSMUSG00000063020
Gene Name olfactory receptor family 5 subfamily AC member 15
Synonyms MOR182-13, MOR182-7P, GA_x54KRFPKG5P-55348161-55347241, Olfr194
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # IGL01807
Quality Score
Status
Chromosome 16
Chromosomal Location 58939511-58940431 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 58939936 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 166 (T166A)
Ref Sequence ENSEMBL: ENSMUSP00000149379 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072608] [ENSMUST00000213228] [ENSMUST00000216519]
AlphaFold L7N1Y8
Predicted Effect probably benign
Transcript: ENSMUST00000072608
AA Change: T166A

PolyPhen 2 Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000072407
Gene: ENSMUSG00000063020
AA Change: T166A

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 1.7e-47 PFAM
Pfam:7tm_1 40 289 1.9e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213228
AA Change: T166A

PolyPhen 2 Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000216519
AA Change: T166A

PolyPhen 2 Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc9 G T 6: 142,551,640 (GRCm39) L1223M probably damaging Het
Ano7 A G 1: 93,330,418 (GRCm39) E814G possibly damaging Het
Atf1 T C 15: 100,149,945 (GRCm39) probably benign Het
Bco2 T C 9: 50,457,158 (GRCm39) probably benign Het
Birc6 A G 17: 74,938,032 (GRCm39) I2625V probably benign Het
Bub1 A G 2: 127,654,897 (GRCm39) S545P probably benign Het
Cacna1i T A 15: 80,258,348 (GRCm39) I1173N probably damaging Het
Ccdc175 T C 12: 72,206,616 (GRCm39) E210G probably benign Het
Ccl2 G A 11: 81,926,513 (GRCm39) G9D possibly damaging Het
Chmp2b T A 16: 65,337,091 (GRCm39) T189S probably benign Het
Col4a1 A T 8: 11,297,056 (GRCm39) probably benign Het
Ecm1 A G 3: 95,643,891 (GRCm39) S236P probably damaging Het
Epha8 A G 4: 136,658,993 (GRCm39) V887A probably benign Het
Fam227a T C 15: 79,533,856 (GRCm39) M36V probably benign Het
Fbxo15 T A 18: 84,999,506 (GRCm39) probably benign Het
Mtmr4 A G 11: 87,494,976 (GRCm39) I423V possibly damaging Het
Ngly1 C T 14: 16,290,873 (GRCm38) L452F probably benign Het
Or52u1 T A 7: 104,237,091 (GRCm39) W27R probably damaging Het
Pak2 T C 16: 31,856,097 (GRCm39) K247E probably damaging Het
Pola2 A G 19: 6,003,187 (GRCm39) probably benign Het
Ppp1r9a C T 6: 5,158,248 (GRCm39) Q1219* probably null Het
Rasgrf1 T C 9: 89,873,566 (GRCm39) I625T probably damaging Het
Rpap1 T C 2: 119,613,189 (GRCm39) T120A possibly damaging Het
Scin T C 12: 40,134,288 (GRCm39) Y252C probably damaging Het
Slc5a9 A T 4: 111,734,737 (GRCm39) *686R probably null Het
Smc1b T A 15: 84,980,946 (GRCm39) D774V probably damaging Het
Uba6 C T 5: 86,270,270 (GRCm39) R838Q probably damaging Het
Ulk4 A G 9: 121,084,251 (GRCm39) S105P probably damaging Het
Vwa3a G A 7: 120,374,729 (GRCm39) probably null Het
Xirp2 A G 2: 67,345,375 (GRCm39) T2539A probably benign Het
Zfpm2 T C 15: 40,616,452 (GRCm39) probably null Het
Other mutations in Or5ac15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02098:Or5ac15 APN 16 58,940,433 (GRCm39) utr 5 prime probably benign
IGL02276:Or5ac15 APN 16 58,940,378 (GRCm39) missense probably benign 0.01
IGL03122:Or5ac15 APN 16 58,939,801 (GRCm39) missense probably benign 0.00
R0781:Or5ac15 UTSW 16 58,940,187 (GRCm39) missense probably damaging 0.97
R1162:Or5ac15 UTSW 16 58,939,735 (GRCm39) missense probably damaging 0.99
R1526:Or5ac15 UTSW 16 58,940,293 (GRCm39) missense probably damaging 1.00
R1654:Or5ac15 UTSW 16 58,940,052 (GRCm39) missense possibly damaging 0.50
R4379:Or5ac15 UTSW 16 58,940,027 (GRCm39) missense probably benign 0.22
R4380:Or5ac15 UTSW 16 58,940,027 (GRCm39) missense probably benign 0.22
R5768:Or5ac15 UTSW 16 58,940,335 (GRCm39) small deletion probably benign
R5771:Or5ac15 UTSW 16 58,940,335 (GRCm39) small deletion probably benign
R5942:Or5ac15 UTSW 16 58,940,039 (GRCm39) nonsense probably null
R6131:Or5ac15 UTSW 16 58,940,256 (GRCm39) missense probably damaging 1.00
R6539:Or5ac15 UTSW 16 58,940,114 (GRCm39) missense probably damaging 0.99
R6621:Or5ac15 UTSW 16 58,940,287 (GRCm39) missense probably benign 0.19
R7642:Or5ac15 UTSW 16 58,940,011 (GRCm39) missense possibly damaging 0.94
R8308:Or5ac15 UTSW 16 58,939,899 (GRCm39) missense probably damaging 1.00
R8863:Or5ac15 UTSW 16 58,939,712 (GRCm39) nonsense probably null
RF009:Or5ac15 UTSW 16 58,940,274 (GRCm39) missense probably damaging 0.99
Z1177:Or5ac15 UTSW 16 58,939,735 (GRCm39) nonsense probably null
Posted On 2014-02-04