Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01808:Gpr171'

155744

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr171

Ensembl Gene

ENSMUSG00000050075

Gene Name

G protein-coupled receptor 171

Synonyms

H963, F730001G15Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

IGL01808

Quality Score

Status

Chromosome

Chromosomal Location

59003869-59009242 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 59005572 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Proline to Serine at position 68 (P68S)

Ref Sequence

ENSEMBL: ENSMUSP00000082115 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000029393] [ENSMUST00000040325] [ENSMUST00000040846] [ENSMUST00000085040] [ENSMUST00000164225] [ENSMUST00000199659]

AlphaFold

Q8BG55

Predicted Effect

probably benign
Transcript: ENSMUST00000029393

SMART Domains

Protein: ENSMUSP00000029393
Gene: ENSMUSG00000056476

Domain	Start	End	E-Value	Type
Med12	101	172	1.54e-17	SMART
low complexity region	227	235	N/A	INTRINSIC
low complexity region	280	289	N/A	INTRINSIC
Pfam:Med12-LCEWAV	293	737	1.6e-200	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000040325

SMART Domains

Protein: ENSMUSP00000042269
Gene: ENSMUSG00000056476

Domain	Start	End	E-Value	Type
Med12	101	161	1.71e-24	SMART
low complexity region	216	224	N/A	INTRINSIC
low complexity region	269	278	N/A	INTRINSIC
Pfam:Med12-LCEWAV	282	730	2.6e-207	PFAM
low complexity region	744	758	N/A	INTRINSIC
low complexity region	853	872	N/A	INTRINSIC
low complexity region	1455	1466	N/A	INTRINSIC
low complexity region	1728	1742	N/A	INTRINSIC
low complexity region	1769	1783	N/A	INTRINSIC
Pfam:Med12-PQL	1803	2029	2.3e-14	PFAM
low complexity region	2055	2076	N/A	INTRINSIC
low complexity region	2083	2101	N/A	INTRINSIC
low complexity region	2116	2136	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000040846

SMART Domains

Protein: ENSMUSP00000041859
Gene: ENSMUSG00000056476

Domain	Start	End	E-Value	Type
Med12	101	172	1.54e-17	SMART
low complexity region	227	235	N/A	INTRINSIC
low complexity region	280	289	N/A	INTRINSIC
Pfam:Med12-LCEWAV	293	728	9e-201	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000085040
AA Change: P68S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000082115
Gene: ENSMUSG00000050075
AA Change: P68S

Domain	Start	End	E-Value	Type
Pfam:7tm_1	31	285	4e-26	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000164225

SMART Domains

Protein: ENSMUSP00000127038
Gene: ENSMUSG00000056476

Domain	Start	End	E-Value	Type
Med12	101	161	1.71e-24	SMART
low complexity region	216	224	N/A	INTRINSIC
low complexity region	269	278	N/A	INTRINSIC
Pfam:Med12-LCEWAV	283	765	5e-187	PFAM
low complexity region	779	793	N/A	INTRINSIC
low complexity region	888	907	N/A	INTRINSIC
low complexity region	1490	1501	N/A	INTRINSIC
low complexity region	1763	1777	N/A	INTRINSIC
low complexity region	1804	1818	N/A	INTRINSIC
Pfam:Med12-PQL	1840	2063	9.7e-66	PFAM
low complexity region	2090	2111	N/A	INTRINSIC
low complexity region	2118	2136	N/A	INTRINSIC
low complexity region	2151	2171	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000199659

SMART Domains

Protein: ENSMUSP00000142903
Gene: ENSMUSG00000056476

Domain	Start	End	E-Value	Type
Med12	101	161	1.71e-24	SMART
low complexity region	216	224	N/A	INTRINSIC
low complexity region	269	278	N/A	INTRINSIC
Pfam:Med12-LCEWAV	282	765	5.5e-209	PFAM
low complexity region	779	793	N/A	INTRINSIC
low complexity region	888	907	N/A	INTRINSIC
low complexity region	1490	1501	N/A	INTRINSIC
low complexity region	1761	1775	N/A	INTRINSIC
low complexity region	1802	1816	N/A	INTRINSIC
Pfam:Med12-PQL	1836	2062	1.7e-15	PFAM
low complexity region	2088	2130	N/A	INTRINSIC
low complexity region	2144	2164	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 24 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ager	A	T	17: 34,818,431 (GRCm39)	Q266L	probably damaging	Het
Amz1	A	G	5: 140,727,034 (GRCm39)		probably benign	Het
Ebf2	C	T	14: 67,651,932 (GRCm39)	A488V	probably benign	Het
Gm5885	A	T	6: 133,508,181 (GRCm39)		noncoding transcript	Het
Gnas	T	C	2: 174,140,490 (GRCm39)	S220P	probably damaging	Het
H2ax	T	C	9: 44,246,246 (GRCm39)	I63T	possibly damaging	Het
H2-M9	A	T	17: 36,952,711 (GRCm39)		probably null	Het
Igsf9	T	C	1: 172,312,370 (GRCm39)	V27A	probably benign	Het
Kcnh6	G	T	11: 105,914,753 (GRCm39)		probably benign	Het
Mapkbp1	A	G	2: 119,853,650 (GRCm39)		probably null	Het
Mllt6	C	A	11: 97,563,310 (GRCm39)	H298N	possibly damaging	Het
Mtmr3	A	G	11: 4,447,404 (GRCm39)	I352T	probably damaging	Het
Mtrr	T	C	13: 68,714,212 (GRCm39)	D509G	probably benign	Het
Ncan	C	T	8: 70,560,090 (GRCm39)		probably null	Het
Or51aa2	T	A	7: 103,187,781 (GRCm39)	Y220F	probably damaging	Het
Pcdhb4	T	C	18: 37,442,067 (GRCm39)	V459A	probably damaging	Het
Phrf1	C	A	7: 140,840,879 (GRCm39)	P1274Q	probably damaging	Het
Slc4a2	T	C	5: 24,645,205 (GRCm39)	L1125P	probably damaging	Het
Synpo	T	C	18: 60,735,280 (GRCm39)	I650V	probably benign	Het
Tsc1	G	A	2: 28,552,519 (GRCm39)	R86H	probably damaging	Het
Ugt2a3	A	G	5: 87,473,414 (GRCm39)	V501A	probably benign	Het
Vmn1r203	T	C	13: 22,708,717 (GRCm39)	I166T	probably benign	Het
Vps13a	A	G	19: 16,687,650 (GRCm39)	C933R	probably damaging	Het
Zfp142	A	T	1: 74,615,184 (GRCm39)	F342Y	probably damaging	Het

Other mutations in Gpr171

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02635:Gpr171	APN	3	59,005,017 (GRCm39)	missense	probably benign	0.04
IGL02858:Gpr171	APN	3	59,005,288 (GRCm39)	missense	probably benign	0.26
R1491:Gpr171	UTSW	3	59,005,016 (GRCm39)	missense	probably benign	0.01
R1539:Gpr171	UTSW	3	59,005,142 (GRCm39)	missense	possibly damaging	0.50
R1819:Gpr171	UTSW	3	59,005,341 (GRCm39)	missense	probably benign	0.02
R2255:Gpr171	UTSW	3	59,005,628 (GRCm39)	missense	probably benign	0.01
R3721:Gpr171	UTSW	3	59,005,091 (GRCm39)	missense	possibly damaging	0.95
R3856:Gpr171	UTSW	3	59,005,506 (GRCm39)	missense	probably damaging	0.96
R4259:Gpr171	UTSW	3	59,004,948 (GRCm39)	missense	probably damaging	1.00
R4749:Gpr171	UTSW	3	59,004,887 (GRCm39)	missense	probably benign	0.11
R4816:Gpr171	UTSW	3	59,005,517 (GRCm39)	missense	probably damaging	1.00
R4972:Gpr171	UTSW	3	59,005,386 (GRCm39)	missense	probably damaging	1.00
R6363:Gpr171	UTSW	3	59,005,313 (GRCm39)	missense	possibly damaging	0.91
R6414:Gpr171	UTSW	3	59,005,544 (GRCm39)	missense	probably damaging	0.97
R7076:Gpr171	UTSW	3	59,005,577 (GRCm39)	missense	probably damaging	0.98
R7290:Gpr171	UTSW	3	59,005,147 (GRCm39)	missense	probably benign	0.00
R7404:Gpr171	UTSW	3	59,005,622 (GRCm39)	missense	probably damaging	0.99
R7447:Gpr171	UTSW	3	59,005,860 (GRCm39)	critical splice acceptor site	probably null
R7721:Gpr171	UTSW	3	59,005,320 (GRCm39)	missense	probably benign	0.40
R8120:Gpr171	UTSW	3	59,005,406 (GRCm39)	missense	probably damaging	0.96
R8548:Gpr171	UTSW	3	59,005,400 (GRCm39)	missense	probably damaging	1.00
R8897:Gpr171	UTSW	3	59,005,116 (GRCm39)	missense	probably benign
R9126:Gpr171	UTSW	3	59,005,488 (GRCm39)	missense	probably damaging	1.00
R9339:Gpr171	UTSW	3	59,005,362 (GRCm39)	missense	probably damaging	1.00
R9411:Gpr171	UTSW	3	59,005,311 (GRCm39)	nonsense	probably null
R9418:Gpr171	UTSW	3	59,004,999 (GRCm39)	missense	possibly damaging	0.82

Posted On

2014-02-04