Incidental Mutation 'IGL01808:H2-M9'
ID155747
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol H2-M9
Ensembl Gene ENSMUSG00000067201
Gene Namehistocompatibility 2, M region locus 9
SynonymsM9
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.049) question?
Stock #IGL01808
Quality Score
Status
Chromosome17
Chromosomal Location36639285-36642666 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to T at 36641819 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000084411 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087165] [ENSMUST00000087167]
Predicted Effect probably null
Transcript: ENSMUST00000087165
SMART Domains Protein: ENSMUSP00000084409
Gene: ENSMUSG00000067201

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:MHC_I 25 203 2.4e-45 PFAM
transmembrane domain 216 238 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000087167
SMART Domains Protein: ENSMUSP00000084411
Gene: ENSMUSG00000067201

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:MHC_I 25 203 5.3e-44 PFAM
IGc1 222 293 5.73e-22 SMART
transmembrane domain 308 330 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ager A T 17: 34,599,457 Q266L probably damaging Het
Amz1 A G 5: 140,741,279 probably benign Het
Ebf2 C T 14: 67,414,483 A488V probably benign Het
Gm5885 A T 6: 133,531,218 noncoding transcript Het
Gnas T C 2: 174,298,697 S220P probably damaging Het
Gpr171 G A 3: 59,098,151 P68S probably damaging Het
H2afx T C 9: 44,334,949 I63T possibly damaging Het
Igsf9 T C 1: 172,484,803 V27A probably benign Het
Kcnh6 G T 11: 106,023,927 probably benign Het
Mapkbp1 A G 2: 120,023,169 probably null Het
Mllt6 C A 11: 97,672,484 H298N possibly damaging Het
Mtmr3 A G 11: 4,497,404 I352T probably damaging Het
Mtrr T C 13: 68,566,093 D509G probably benign Het
Ncan C T 8: 70,107,440 probably null Het
Olfr612 T A 7: 103,538,574 Y220F probably damaging Het
Pcdhb4 T C 18: 37,309,014 V459A probably damaging Het
Phrf1 C A 7: 141,260,966 P1274Q probably damaging Het
Slc4a2 T C 5: 24,440,207 L1125P probably damaging Het
Synpo T C 18: 60,602,208 I650V probably benign Het
Tsc1 G A 2: 28,662,507 R86H probably damaging Het
Ugt2a3 A G 5: 87,325,555 V501A probably benign Het
Vmn1r203 T C 13: 22,524,547 I166T probably benign Het
Vps13a A G 19: 16,710,286 C933R probably damaging Het
Zfp142 A T 1: 74,576,025 F342Y probably damaging Het
Other mutations in H2-M9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02133:H2-M9 APN 17 36641737 missense possibly damaging 0.95
IGL02323:H2-M9 APN 17 36640741 missense probably damaging 1.00
IGL02957:H2-M9 APN 17 36642157 missense probably benign 0.00
IGL03127:H2-M9 APN 17 36640822 missense possibly damaging 0.48
R0025:H2-M9 UTSW 17 36641755 missense probably damaging 1.00
R0026:H2-M9 UTSW 17 36641527 splice site probably benign
R0926:H2-M9 UTSW 17 36641773 missense probably damaging 0.98
R1171:H2-M9 UTSW 17 36641653 missense probably benign 0.14
R1264:H2-M9 UTSW 17 36642592 missense probably benign
R1995:H2-M9 UTSW 17 36641786 missense probably damaging 1.00
R4622:H2-M9 UTSW 17 36641824 splice site probably null
R4737:H2-M9 UTSW 17 36640739 nonsense probably null
R4808:H2-M9 UTSW 17 36640792 missense probably damaging 0.99
R5176:H2-M9 UTSW 17 36641631 missense probably damaging 0.98
R6756:H2-M9 UTSW 17 36642335 missense probably damaging 1.00
R6785:H2-M9 UTSW 17 36642233 missense probably damaging 0.99
X0018:H2-M9 UTSW 17 36641722 missense probably benign 0.01
Posted On2014-02-04