Incidental Mutation 'IGL01809:Olfr968'
ID155751
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr968
Ensembl Gene ENSMUSG00000095903
Gene Nameolfactory receptor 968
SynonymsGA_x6K02T2PVTD-33470347-33469403, MOR171-15
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.134) question?
Stock #IGL01809
Quality Score
Status
Chromosome9
Chromosomal Location39768776-39783253 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 39772694 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 35 (Y35*)
Ref Sequence ENSEMBL: ENSMUSP00000148969 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075928] [ENSMUST00000216458]
Predicted Effect probably null
Transcript: ENSMUST00000075928
AA Change: Y35*
SMART Domains Protein: ENSMUSP00000096472
Gene: ENSMUSG00000095903
AA Change: Y35*

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1e-51 PFAM
Pfam:7tm_1 41 290 2e-22 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000216458
AA Change: Y35*
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A T 11: 9,290,339 N734I probably damaging Het
Abi1 T C 2: 22,946,717 I371V probably benign Het
Atp8b3 A G 10: 80,520,011 F1289S probably benign Het
Brca2 T A 5: 150,531,061 probably null Het
C8a A T 4: 104,845,942 I306N probably benign Het
Crybg3 G T 16: 59,524,853 probably benign Het
Disp2 T A 2: 118,787,264 probably benign Het
Dtl A G 1: 191,548,303 F373S probably damaging Het
Dynlt1a G A 17: 6,310,872 probably null Het
Dyrk1a G A 16: 94,659,617 R44H probably benign Het
Fam114a2 C T 11: 57,513,635 probably null Het
Fsip2 A G 2: 82,978,347 E1670G possibly damaging Het
Gbp10 A T 5: 105,217,359 N594K probably benign Het
Gpam T A 19: 55,075,625 K679* probably null Het
Gtf2i A T 5: 134,249,950 V524E probably damaging Het
Itpr2 T A 6: 146,227,581 E2011D probably damaging Het
Jag1 C A 2: 137,115,484 G103W probably damaging Het
Klkb1 A T 8: 45,276,053 V378E probably benign Het
Lyst T A 13: 13,637,803 S933R probably damaging Het
Man2b2 T C 5: 36,814,516 S619G probably benign Het
Mex3b T C 7: 82,869,712 S412P probably benign Het
Mtf2 A G 5: 108,087,325 I36V probably benign Het
Nckipsd T C 9: 108,817,554 Y652H probably damaging Het
Olfr1136 T C 2: 87,693,745 I46V possibly damaging Het
Olfr870 A G 9: 20,171,295 I92T probably damaging Het
Olfr994 A G 2: 85,430,154 L225P probably damaging Het
Phykpl T C 11: 51,599,524 F411L probably benign Het
Rbm8a T A 3: 96,631,537 F101I probably damaging Het
Rbp3 G T 14: 33,955,300 G402W probably damaging Het
Recql4 G A 15: 76,708,870 R254* probably null Het
Rsph14 G A 10: 74,957,786 probably benign Het
Stau2 A T 1: 16,440,315 probably null Het
Tmprss11c G A 5: 86,237,662 S304L possibly damaging Het
Vipr1 T G 9: 121,661,440 M184R possibly damaging Het
Zfp106 G A 2: 120,533,671 R752C probably damaging Het
Other mutations in Olfr968
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00743:Olfr968 APN 9 39772111 missense possibly damaging 0.78
IGL01109:Olfr968 APN 9 39771997 missense probably benign 0.06
IGL02517:Olfr968 APN 9 39772504 missense probably damaging 0.98
IGL02708:Olfr968 APN 9 39771918 missense probably damaging 1.00
IGL03061:Olfr968 APN 9 39772162 missense probably benign 0.41
K3955:Olfr968 UTSW 9 39772173 missense probably benign 0.00
R1786:Olfr968 UTSW 9 39772495 missense probably benign 0.00
R1897:Olfr968 UTSW 9 39772065 missense probably damaging 0.99
R2424:Olfr968 UTSW 9 39772297 missense probably benign 0.39
R3016:Olfr968 UTSW 9 39772683 missense probably benign 0.41
R3862:Olfr968 UTSW 9 39772624 missense probably benign 0.39
R5987:Olfr968 UTSW 9 39772540 missense probably benign 0.00
R5995:Olfr968 UTSW 9 39772692 missense probably benign 0.03
R6184:Olfr968 UTSW 9 39772620 missense probably damaging 1.00
R6297:Olfr968 UTSW 9 39772226 missense possibly damaging 0.45
X0028:Olfr968 UTSW 9 39772794 missense probably benign
Posted On2014-02-04