Incidental Mutation 'R0042:Ccnb2'
ID 15576
Institutional Source Beutler Lab
Gene Symbol Ccnb2
Ensembl Gene ENSMUSG00000032218
Gene Name cyclin B2
Synonyms CycB2
MMRRC Submission 038336-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.574) question?
Stock # R0042 (G1)
Quality Score
Status Validated
Chromosome 9
Chromosomal Location 70314974-70328829 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 70326335 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 34 (V34A)
Ref Sequence ENSEMBL: ENSMUSP00000034742 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034742]
AlphaFold P30276
Predicted Effect probably benign
Transcript: ENSMUST00000034742
AA Change: V34A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000034742
Gene: ENSMUSG00000032218
AA Change: V34A

DomainStartEndE-ValueType
CYCLIN 171 255 8.58e-28 SMART
Cyclin_C 264 382 9.83e-34 SMART
CYCLIN 268 349 2.73e-21 SMART
Meta Mutation Damage Score 0.0634 question?
Coding Region Coverage
  • 1x: 81.9%
  • 3x: 73.7%
  • 10x: 53.7%
  • 20x: 34.5%
Validation Efficiency 94% (58/62)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutation of this gene results in reduced body weight and reduced litter size. Homozygous pups are underrepresented in litters from a heterozygous intercross. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca1 C T 4: 53,059,245 (GRCm39) probably benign Het
Adgrf3 A G 5: 30,402,426 (GRCm39) L534P probably damaging Het
Ank2 T C 3: 126,730,280 (GRCm39) D3568G probably damaging Het
Atr T A 9: 95,809,409 (GRCm39) probably benign Het
Dmxl1 C A 18: 49,997,102 (GRCm39) T466K probably benign Het
Eya1 T C 1: 14,254,713 (GRCm39) D373G probably damaging Het
Fam120a A G 13: 49,087,490 (GRCm39) V290A probably damaging Het
Gpr179 C T 11: 97,225,757 (GRCm39) V2133I probably benign Het
Grb10 G T 11: 11,886,798 (GRCm39) H435Q probably damaging Het
Gzmm T C 10: 79,530,399 (GRCm39) I190T probably benign Het
H2-Q3 A G 17: 35,578,823 (GRCm39) noncoding transcript Het
Hspb7 A G 4: 141,151,245 (GRCm39) E129G probably damaging Het
Il17ra T C 6: 120,449,086 (GRCm39) probably benign Het
Itgb3 A G 11: 104,557,966 (GRCm39) T787A possibly damaging Het
Krt4 T G 15: 101,831,187 (GRCm39) probably benign Het
Lgsn C T 1: 31,229,534 (GRCm39) T85I probably benign Het
Metap1 C T 3: 138,177,918 (GRCm39) V217I probably benign Het
Mib2 A T 4: 155,743,897 (GRCm39) C48* probably null Het
Mroh4 T A 15: 74,482,154 (GRCm39) I768F probably damaging Het
Npas3 T A 12: 54,095,624 (GRCm39) D361E probably damaging Het
P4hb G A 11: 120,459,092 (GRCm39) R134C probably damaging Het
Prr35 C A 17: 26,166,956 (GRCm39) E194* probably null Het
Rbl1 A G 2: 157,017,624 (GRCm39) probably benign Het
Rdh10 T A 1: 16,178,260 (GRCm39) probably benign Het
Spata31 A T 13: 65,070,377 (GRCm39) I842L probably benign Het
Stk32b A C 5: 37,874,092 (GRCm39) D13E probably benign Het
Svep1 T C 4: 58,123,192 (GRCm39) D708G possibly damaging Het
Taar6 T C 10: 23,861,021 (GRCm39) D175G probably benign Het
Tmod4 T C 3: 95,037,099 (GRCm39) D164G possibly damaging Het
Ttc23l A C 15: 10,551,627 (GRCm39) L33W probably damaging Het
Ttc39d T C 17: 80,523,379 (GRCm39) Y13H probably benign Het
Utp18 G T 11: 93,766,684 (GRCm39) T309K probably damaging Het
Vps11 G T 9: 44,267,588 (GRCm39) Y341* probably null Het
Vsig8 T C 1: 172,387,925 (GRCm39) V5A possibly damaging Het
Other mutations in Ccnb2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00481:Ccnb2 APN 9 70,326,189 (GRCm39) missense probably damaging 0.96
IGL01474:Ccnb2 APN 9 70,326,305 (GRCm39) missense probably benign
IGL03097:Ccnb2 APN 9 70,316,678 (GRCm39) splice site probably benign
IGL03298:Ccnb2 APN 9 70,326,156 (GRCm39) missense probably benign
R0042:Ccnb2 UTSW 9 70,326,335 (GRCm39) missense probably benign
R1585:Ccnb2 UTSW 9 70,317,559 (GRCm39) splice site probably null
R1756:Ccnb2 UTSW 9 70,318,070 (GRCm39) missense probably benign 0.41
R2046:Ccnb2 UTSW 9 70,316,629 (GRCm39) missense probably benign 0.11
R6045:Ccnb2 UTSW 9 70,326,375 (GRCm39) missense probably benign
R7202:Ccnb2 UTSW 9 70,318,128 (GRCm39) missense probably damaging 1.00
R7623:Ccnb2 UTSW 9 70,326,170 (GRCm39) missense probably benign
R8515:Ccnb2 UTSW 9 70,320,382 (GRCm39) critical splice donor site probably null
R9072:Ccnb2 UTSW 9 70,318,095 (GRCm39) missense possibly damaging 0.65
R9073:Ccnb2 UTSW 9 70,318,095 (GRCm39) missense possibly damaging 0.65
R9235:Ccnb2 UTSW 9 70,318,163 (GRCm39) missense probably damaging 0.98
Posted On 2012-12-21