Incidental Mutation 'IGL01809:Dynlt1a'
ID155783
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dynlt1a
Ensembl Gene ENSMUSG00000092074
Gene Namedynein light chain Tctex-type 1A
Synonyms
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.537) question?
Stock #IGL01809
Quality Score
Status
Chromosome17
Chromosomal Location6306340-6317500 bp(-) (GRCm38)
Type of Mutationunclassified (2558 bp from exon)
DNA Base Change (assembly) G to A at 6310872 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000156382 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088940] [ENSMUST00000169415] [ENSMUST00000232383] [ENSMUST00000232499]
Predicted Effect probably null
Transcript: ENSMUST00000088940
SMART Domains Protein: ENSMUSP00000086333
Gene: ENSMUSG00000038141

DomainStartEndE-ValueType
transmembrane domain 17 36 N/A INTRINSIC
Pfam:MIG-14_Wnt-bd 127 422 1e-100 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000169415
SMART Domains Protein: ENSMUSP00000127990
Gene: ENSMUSG00000092074

DomainStartEndE-ValueType
Pfam:Tctex-1 16 112 5.4e-36 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181052
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228334
Predicted Effect probably null
Transcript: ENSMUST00000232383
Predicted Effect probably benign
Transcript: ENSMUST00000232499
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232591
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A T 11: 9,290,339 N734I probably damaging Het
Abi1 T C 2: 22,946,717 I371V probably benign Het
Atp8b3 A G 10: 80,520,011 F1289S probably benign Het
Brca2 T A 5: 150,531,061 probably null Het
C8a A T 4: 104,845,942 I306N probably benign Het
Crybg3 G T 16: 59,524,853 probably benign Het
Disp2 T A 2: 118,787,264 probably benign Het
Dtl A G 1: 191,548,303 F373S probably damaging Het
Dyrk1a G A 16: 94,659,617 R44H probably benign Het
Fam114a2 C T 11: 57,513,635 probably null Het
Fsip2 A G 2: 82,978,347 E1670G possibly damaging Het
Gbp10 A T 5: 105,217,359 N594K probably benign Het
Gpam T A 19: 55,075,625 K679* probably null Het
Gtf2i A T 5: 134,249,950 V524E probably damaging Het
Itpr2 T A 6: 146,227,581 E2011D probably damaging Het
Jag1 C A 2: 137,115,484 G103W probably damaging Het
Klkb1 A T 8: 45,276,053 V378E probably benign Het
Lyst T A 13: 13,637,803 S933R probably damaging Het
Man2b2 T C 5: 36,814,516 S619G probably benign Het
Mex3b T C 7: 82,869,712 S412P probably benign Het
Mtf2 A G 5: 108,087,325 I36V probably benign Het
Nckipsd T C 9: 108,817,554 Y652H probably damaging Het
Olfr1136 T C 2: 87,693,745 I46V possibly damaging Het
Olfr870 A G 9: 20,171,295 I92T probably damaging Het
Olfr968 A T 9: 39,772,694 Y35* probably null Het
Olfr994 A G 2: 85,430,154 L225P probably damaging Het
Phykpl T C 11: 51,599,524 F411L probably benign Het
Rbm8a T A 3: 96,631,537 F101I probably damaging Het
Rbp3 G T 14: 33,955,300 G402W probably damaging Het
Recql4 G A 15: 76,708,870 R254* probably null Het
Rsph14 G A 10: 74,957,786 probably benign Het
Stau2 A T 1: 16,440,315 probably null Het
Tmprss11c G A 5: 86,237,662 S304L possibly damaging Het
Vipr1 T G 9: 121,661,440 M184R possibly damaging Het
Zfp106 G A 2: 120,533,671 R752C probably damaging Het
Other mutations in Dynlt1a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00428:Dynlt1a APN 17 6311787 missense possibly damaging 0.50
R0266:Dynlt1a UTSW 17 6317395 missense probably benign 0.00
R4258:Dynlt1a UTSW 17 6310909 missense probably benign 0.03
R6525:Dynlt1a UTSW 17 6311739 missense probably benign 0.10
Posted On2014-02-04