Incidental Mutation 'R0028:Zfp202'
| ID |
15582 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp202
|
| Ensembl Gene |
ENSMUSG00000025602 |
| Gene Name |
zinc finger protein 202 |
| Synonyms |
C130037E22Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0028 (G1)
|
| Quality Score |
|
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
40103612-40124900 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 40123048 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Glutamine
at position 603
(H603Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000026693
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000026693]
[ENSMUST00000168691]
[ENSMUST00000168832]
|
| AlphaFold |
Q8C879 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000026693
AA Change: H603Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000026693
Gene: ENSMUSG00000025602
AA Change: H603Q
| Domain | Start | End | E-Value | Type |
|---|
|
SCAN
|
42 |
154 |
1.19e-75 |
SMART |
|
KRAB
|
237 |
297 |
1.7e-17 |
SMART |
|
ZnF_C2H2
|
391 |
413 |
9.44e-2 |
SMART |
|
ZnF_C2H2
|
419 |
441 |
6.42e-4 |
SMART |
|
ZnF_C2H2
|
473 |
495 |
3.44e-4 |
SMART |
|
ZnF_C2H2
|
501 |
523 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
529 |
551 |
1.64e-1 |
SMART |
|
ZnF_C2H2
|
557 |
579 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
585 |
607 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
613 |
635 |
3.39e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168691
|
| SMART Domains |
Protein: ENSMUSP00000130163
Gene: ENSMUSG00000025602
| Domain | Start | End | E-Value | Type |
|---|
|
SCAN
|
42 |
132 |
1.03e-56 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168832
|
| SMART Domains |
Protein: ENSMUSP00000132131
Gene: ENSMUSG00000025602
| Domain | Start | End | E-Value | Type |
|---|
|
SCAN
|
42 |
154 |
1.19e-75 |
SMART |
|
KRAB
|
237 |
277 |
5.32e-2 |
SMART |
|
| Meta Mutation Damage Score |
0.7146 |
| Coding Region Coverage |
- 1x: 80.7%
- 3x: 72.7%
- 10x: 50.3%
- 20x: 30.1%
|
| Validation Efficiency |
96% (74/77) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 30 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca3 |
T |
C |
17: 24,596,698 (GRCm39) |
F384L |
probably benign |
Het |
| AC159748.1 |
T |
C |
10: 5,542,006 (GRCm38) |
|
silent |
Het |
| Adamts12 |
C |
T |
15: 11,215,710 (GRCm39) |
R244C |
probably damaging |
Het |
| Bms1 |
T |
C |
6: 118,393,480 (GRCm39) |
I131V |
probably benign |
Het |
| Ccdc107 |
A |
G |
4: 43,495,549 (GRCm39) |
T151A |
probably benign |
Het |
| Col1a2 |
G |
A |
6: 4,518,822 (GRCm39) |
|
probably benign |
Het |
| Col4a4 |
A |
G |
1: 82,465,231 (GRCm39) |
|
probably null |
Het |
| Creb1 |
A |
G |
1: 64,609,307 (GRCm39) |
D126G |
probably damaging |
Het |
| Ddb1 |
T |
A |
19: 10,596,610 (GRCm39) |
V443E |
probably damaging |
Het |
| Dnmt3a |
T |
A |
12: 3,950,337 (GRCm39) |
S634T |
probably damaging |
Het |
| Fras1 |
A |
C |
5: 96,825,175 (GRCm39) |
N1455T |
probably benign |
Het |
| Fyb1 |
A |
G |
15: 6,674,395 (GRCm39) |
|
probably benign |
Het |
| Gpr141 |
C |
T |
13: 19,936,599 (GRCm39) |
V59M |
probably damaging |
Het |
| Ikbke |
T |
C |
1: 131,199,921 (GRCm39) |
I222V |
possibly damaging |
Het |
| Macf1 |
A |
T |
4: 123,275,895 (GRCm39) |
H6222Q |
probably damaging |
Het |
| Mapk8ip3 |
C |
T |
17: 25,123,871 (GRCm39) |
|
probably benign |
Het |
| Phactr1 |
A |
T |
13: 43,210,655 (GRCm39) |
D74V |
probably damaging |
Het |
| Prickle2 |
T |
C |
6: 92,399,323 (GRCm39) |
I185V |
probably benign |
Het |
| Rnasel |
A |
T |
1: 153,630,465 (GRCm39) |
D327V |
probably benign |
Het |
| Slc25a13 |
T |
C |
6: 6,181,047 (GRCm39) |
N46D |
probably benign |
Het |
| Slc28a2 |
T |
A |
2: 122,282,083 (GRCm39) |
F261L |
probably damaging |
Het |
| Slc6a15 |
A |
T |
10: 103,252,541 (GRCm39) |
Y568F |
probably benign |
Het |
| Slc7a1 |
A |
G |
5: 148,272,321 (GRCm39) |
V452A |
probably benign |
Het |
| Tectb |
T |
C |
19: 55,183,109 (GRCm39) |
I330T |
probably benign |
Het |
| Tmem92 |
C |
T |
11: 94,669,778 (GRCm39) |
V118I |
possibly damaging |
Het |
| Tmf1 |
T |
C |
6: 97,135,059 (GRCm39) |
E985G |
probably damaging |
Het |
| Traf5 |
T |
A |
1: 191,758,421 (GRCm39) |
|
probably benign |
Het |
| Trip11 |
T |
C |
12: 101,851,016 (GRCm39) |
E731G |
probably damaging |
Het |
| Unc5a |
A |
G |
13: 55,151,726 (GRCm39) |
S50G |
possibly damaging |
Het |
| Wrnip1 |
T |
C |
13: 33,004,280 (GRCm39) |
L517P |
probably damaging |
Het |
|
| Other mutations in Zfp202 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00662:Zfp202
|
APN |
9 |
40,122,339 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01862:Zfp202
|
APN |
9 |
40,123,124 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL03069:Zfp202
|
APN |
9 |
40,122,695 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0158:Zfp202
|
UTSW |
9 |
40,120,212 (GRCm39) |
nonsense |
probably null |
|
|
R0278:Zfp202
|
UTSW |
9 |
40,119,778 (GRCm39) |
missense |
probably benign |
0.15 |
|
R1132:Zfp202
|
UTSW |
9 |
40,122,318 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1404:Zfp202
|
UTSW |
9 |
40,122,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1404:Zfp202
|
UTSW |
9 |
40,122,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1764:Zfp202
|
UTSW |
9 |
40,121,762 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1928:Zfp202
|
UTSW |
9 |
40,121,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2929:Zfp202
|
UTSW |
9 |
40,122,984 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3153:Zfp202
|
UTSW |
9 |
40,119,734 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3948:Zfp202
|
UTSW |
9 |
40,119,721 (GRCm39) |
missense |
probably benign |
0.43 |
|
R4190:Zfp202
|
UTSW |
9 |
40,122,633 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4273:Zfp202
|
UTSW |
9 |
40,118,790 (GRCm39) |
nonsense |
probably null |
|
|
R6181:Zfp202
|
UTSW |
9 |
40,118,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6182:Zfp202
|
UTSW |
9 |
40,118,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6816:Zfp202
|
UTSW |
9 |
40,123,109 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6835:Zfp202
|
UTSW |
9 |
40,121,531 (GRCm39) |
splice site |
probably null |
|
|
R7382:Zfp202
|
UTSW |
9 |
40,122,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7493:Zfp202
|
UTSW |
9 |
40,118,640 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R7542:Zfp202
|
UTSW |
9 |
40,122,443 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7689:Zfp202
|
UTSW |
9 |
40,121,829 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7832:Zfp202
|
UTSW |
9 |
40,121,758 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8084:Zfp202
|
UTSW |
9 |
40,122,538 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8349:Zfp202
|
UTSW |
9 |
40,118,976 (GRCm39) |
nonsense |
probably null |
|
|
R8449:Zfp202
|
UTSW |
9 |
40,118,976 (GRCm39) |
nonsense |
probably null |
|
|
R8879:Zfp202
|
UTSW |
9 |
40,123,053 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9135:Zfp202
|
UTSW |
9 |
40,120,237 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9411:Zfp202
|
UTSW |
9 |
40,118,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9785:Zfp202
|
UTSW |
9 |
40,120,233 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0012:Zfp202
|
UTSW |
9 |
40,122,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2012-12-21 |
Incidental Mutation