Incidental Mutation 'R1368:Vmn1r19'
ID 155874
Institutional Source Beutler Lab
Gene Symbol Vmn1r19
Ensembl Gene ENSMUSG00000115799
Gene Name vomeronasal 1 receptor 19
Synonyms V1rc27
MMRRC Submission 039433-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.094) question?
Stock # R1368 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 57381449-57382375 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 57381656 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 70 (F70L)
Ref Sequence ENSEMBL: ENSMUSP00000087264 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089830]
AlphaFold Q8R2C7
Predicted Effect probably benign
Transcript: ENSMUST00000089830
AA Change: F70L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000087264
Gene: ENSMUSG00000115799
AA Change: F70L

DomainStartEndE-ValueType
Pfam:V1R 28 293 6.6e-58 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 95.1%
Validation Efficiency 98% (55/56)
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A G 11: 9,241,836 (GRCm39) D1233G probably benign Het
Abcc8 G A 7: 45,772,284 (GRCm39) R832W probably damaging Het
Atp10b A G 11: 43,092,981 (GRCm39) T439A probably damaging Het
Brd10 C A 19: 29,693,796 (GRCm39) S1966I probably damaging Het
C130073F10Rik T A 4: 101,747,953 (GRCm39) N74Y possibly damaging Het
Cct8 G A 16: 87,288,200 (GRCm39) S124L probably damaging Het
Cdh9 T A 15: 16,848,568 (GRCm39) probably benign Het
Cep290 C T 10: 100,330,828 (GRCm39) probably benign Het
Chrng T A 1: 87,133,575 (GRCm39) L10H probably damaging Het
Cnn3 T C 3: 121,250,786 (GRCm39) L189S probably benign Het
Cog4 A G 8: 111,585,157 (GRCm39) probably benign Het
Cxcl12 A G 6: 117,153,111 (GRCm39) probably benign Het
Eif2b2 G A 12: 85,270,230 (GRCm39) A257T probably damaging Het
Entrep2 A T 7: 64,469,625 (GRCm39) V41E probably damaging Het
Fanca G A 8: 124,031,020 (GRCm39) probably benign Het
Fcgbpl1 A G 7: 27,858,903 (GRCm39) Q2341R possibly damaging Het
Fktn G A 4: 53,734,880 (GRCm39) G173R probably damaging Het
Gabbr2 T C 4: 46,674,464 (GRCm39) N841S probably benign Het
Gm5622 T A 14: 51,899,647 (GRCm39) V167E possibly damaging Het
Gnaq T C 19: 16,355,651 (GRCm39) V289A probably benign Het
Gpatch2l T G 12: 86,307,439 (GRCm39) D272E possibly damaging Het
Gzmg G A 14: 56,395,263 (GRCm39) T74I probably benign Het
Ikzf2 G A 1: 69,578,474 (GRCm39) A271V possibly damaging Het
Lig4 T C 8: 10,021,176 (GRCm39) D868G possibly damaging Het
Mfsd6 T C 1: 52,747,764 (GRCm39) E367G possibly damaging Het
Mpz T C 1: 170,987,533 (GRCm39) L223P probably damaging Het
Muc17 T C 5: 137,175,674 (GRCm39) probably benign Het
Or2f1b C A 6: 42,739,613 (GRCm39) T209K possibly damaging Het
Pdcd2 G T 17: 15,746,846 (GRCm39) N104K probably damaging Het
Pigg G T 5: 108,465,154 (GRCm39) G129V probably damaging Het
Ppp3cc T C 14: 70,483,311 (GRCm39) Y254C probably damaging Het
Prl3b1 G A 13: 27,427,848 (GRCm39) A53T probably benign Het
Psg23 A G 7: 18,348,645 (GRCm39) V54A probably benign Het
Psmd3 A G 11: 98,573,746 (GRCm39) D64G probably damaging Het
Psmg2 CTTCAGTT CTTCAGTTCAGTT 18: 67,779,095 (GRCm39) probably null Het
Ptgdr T A 14: 45,090,799 (GRCm39) I320F probably damaging Het
Rad50 T A 11: 53,574,072 (GRCm39) K722* probably null Het
Rasl10b G A 11: 83,308,665 (GRCm39) probably null Het
Rgs9 G A 11: 109,138,977 (GRCm39) S255L probably benign Het
Ror1 C T 4: 100,298,334 (GRCm39) P569L possibly damaging Het
Rsad2 T C 12: 26,497,147 (GRCm39) probably null Het
Scn8a A G 15: 100,933,422 (GRCm39) D1501G probably damaging Het
Sema3c A G 5: 17,883,330 (GRCm39) T313A possibly damaging Het
Serpinc1 T A 1: 160,821,094 (GRCm39) F59L probably damaging Het
Sike1 A G 3: 102,903,500 (GRCm39) D63G possibly damaging Het
Slc25a11 T A 11: 70,536,352 (GRCm39) probably null Het
Slc32a1 A G 2: 158,453,240 (GRCm39) M27V probably benign Het
Smc5 A G 19: 23,187,807 (GRCm39) V1003A probably damaging Het
Tll2 G A 19: 41,108,667 (GRCm39) R328C probably damaging Het
Topaz1 A G 9: 122,577,315 (GRCm39) E75G possibly damaging Het
Tspan3 A T 9: 56,054,783 (GRCm39) V48E probably benign Het
Ugt1a6b T C 1: 88,035,358 (GRCm39) I232T probably benign Het
Unc79 A G 12: 103,122,772 (GRCm39) K2290E probably damaging Het
Other mutations in Vmn1r19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00948:Vmn1r19 APN 6 57,382,247 (GRCm39) missense probably benign 0.03
IGL01287:Vmn1r19 APN 6 57,382,179 (GRCm39) missense probably damaging 1.00
IGL01516:Vmn1r19 APN 6 57,381,857 (GRCm39) missense probably benign 0.03
IGL01895:Vmn1r19 APN 6 57,382,245 (GRCm39) missense probably benign 0.02
IGL02676:Vmn1r19 APN 6 57,382,025 (GRCm39) missense possibly damaging 0.94
IGL03040:Vmn1r19 APN 6 57,382,347 (GRCm39) missense unknown
IGL03087:Vmn1r19 APN 6 57,381,476 (GRCm39) missense probably benign 0.01
PIT4802001:Vmn1r19 UTSW 6 57,382,037 (GRCm39) missense probably damaging 1.00
R0319:Vmn1r19 UTSW 6 57,381,600 (GRCm39) missense possibly damaging 0.93
R1997:Vmn1r19 UTSW 6 57,382,033 (GRCm39) missense probably damaging 1.00
R2920:Vmn1r19 UTSW 6 57,381,909 (GRCm39) missense probably benign 0.03
R3857:Vmn1r19 UTSW 6 57,382,098 (GRCm39) missense possibly damaging 0.68
R4090:Vmn1r19 UTSW 6 57,381,720 (GRCm39) missense probably damaging 1.00
R4547:Vmn1r19 UTSW 6 57,381,774 (GRCm39) missense possibly damaging 0.56
R4823:Vmn1r19 UTSW 6 57,382,219 (GRCm39) nonsense probably null
R4951:Vmn1r19 UTSW 6 57,381,927 (GRCm39) missense probably benign 0.36
R5077:Vmn1r19 UTSW 6 57,382,026 (GRCm39) missense probably benign 0.00
R5459:Vmn1r19 UTSW 6 57,381,475 (GRCm39) nonsense probably null
R5625:Vmn1r19 UTSW 6 57,382,281 (GRCm39) missense probably damaging 1.00
R5690:Vmn1r19 UTSW 6 57,381,780 (GRCm39) missense probably benign 0.10
R5761:Vmn1r19 UTSW 6 57,382,338 (GRCm39) missense unknown
R6124:Vmn1r19 UTSW 6 57,381,602 (GRCm39) missense probably benign 0.02
R6373:Vmn1r19 UTSW 6 57,382,317 (GRCm39) missense unknown
R6476:Vmn1r19 UTSW 6 57,381,578 (GRCm39) missense probably damaging 0.99
R6938:Vmn1r19 UTSW 6 57,381,992 (GRCm39) missense possibly damaging 0.94
R7027:Vmn1r19 UTSW 6 57,381,475 (GRCm39) nonsense probably null
R7359:Vmn1r19 UTSW 6 57,382,080 (GRCm39) missense probably damaging 0.99
R7568:Vmn1r19 UTSW 6 57,381,813 (GRCm39) missense possibly damaging 0.69
R7893:Vmn1r19 UTSW 6 57,381,664 (GRCm39) missense probably damaging 1.00
R8481:Vmn1r19 UTSW 6 57,381,932 (GRCm39) missense probably damaging 0.99
R8487:Vmn1r19 UTSW 6 57,382,166 (GRCm39) missense probably benign 0.03
R8812:Vmn1r19 UTSW 6 57,381,436 (GRCm39) start gained probably benign
R8907:Vmn1r19 UTSW 6 57,381,991 (GRCm39) missense probably benign
R8976:Vmn1r19 UTSW 6 57,381,719 (GRCm39) missense probably benign 0.01
R9277:Vmn1r19 UTSW 6 57,382,322 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- GCTGGACTTGGACTCCTACCAAATATG -3'
(R):5'- AGTGACCTTCATCTGGCGGTTTTC -3'

Sequencing Primer
(F):5'- TAAGCCCATGGACCTGATCT -3'
(R):5'- GCGGTTTTCACTCACATTGG -3'
Posted On 2014-02-11