|Institutional Source||Beutler Lab|
|Gene Name||prostaglandin D receptor|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R1368 (G1)|
|Chromosomal Location||44851235-44859375 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to A at 44853342 bp|
|Amino Acid Change||Isoleucine to Phenylalanine at position 320 (I320F)|
|Ref Sequence||ENSEMBL: ENSMUSP00000093653 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000095959]|
|Predicted Effect||probably damaging
AA Change: I320F
PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
AA Change: I320F
|Meta Mutation Damage Score||0.22|
|Coding Region Coverage||
|Validation Efficiency||98% (55/56)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
PHENOTYPE: Mice homozygous for disruptions in this gene display a reduced inflammatory response to airborn allergens and reduced susceptibility to passive cutaneous anaphylaxis induced by IgE antigen challenge due to impaired mast cell degranulation. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ptgdr||
(F):5'- TTTTCCAAGCACGGCTCTTTGAATG -3'
(R):5'- CTGAGAATGCAGAACAGCCCTGAG -3'
(F):5'- AATGTGTGCTGTATTTTCAGCTTATC -3'
(R):5'- TCAGCCATAGGGTGAGAATTCC -3'