Incidental Mutation 'R1370:Or5ac16'
ID 155974
Institutional Source Beutler Lab
Gene Symbol Or5ac16
Ensembl Gene ENSMUSG00000052537
Gene Name olfactory receptor family 5 subfamily AC member 16
Synonyms MOR182-8, GA_x54KRFPKG5P-55416332-55415412, Olfr198
MMRRC Submission 039434-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R1370 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 59021867-59022787 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 59022043 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 249 (S249P)
Ref Sequence ENSEMBL: ENSMUSP00000146813 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064452] [ENSMUST00000208244]
AlphaFold Q7TS40
Predicted Effect probably damaging
Transcript: ENSMUST00000064452
AA Change: S249P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000065535
Gene: ENSMUSG00000052537
AA Change: S249P

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 4.9e-45 PFAM
Pfam:7tm_1 41 290 4.2e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000208244
AA Change: S249P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 98.7%
  • 3x: 97.5%
  • 10x: 93.6%
  • 20x: 84.8%
Validation Efficiency 99% (80/81)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb10 C T 8: 124,688,791 (GRCm39) G495D probably damaging Het
Adgra3 T C 5: 50,118,129 (GRCm39) I1140V possibly damaging Het
Adrb3 A T 8: 27,717,798 (GRCm39) probably null Het
Afap1 A G 5: 36,092,944 (GRCm39) D16G unknown Het
AI593442 T C 9: 52,589,308 (GRCm39) K90E probably damaging Het
Aicda A T 6: 122,538,144 (GRCm39) N101Y probably benign Het
Alx1 A G 10: 102,864,353 (GRCm39) S39P possibly damaging Het
Ankrd52 A G 10: 128,224,565 (GRCm39) D781G possibly damaging Het
Arhgef5 T A 6: 43,260,846 (GRCm39) F1424I probably damaging Het
Atp10b G A 11: 43,042,482 (GRCm39) W14* probably null Het
Bin1 A G 18: 32,562,756 (GRCm39) I416V probably benign Het
Bptf A T 11: 106,937,920 (GRCm39) S2724T probably damaging Het
Brf1 A T 12: 112,924,728 (GRCm39) probably null Het
Ccdc39 T C 3: 33,880,629 (GRCm39) K446R probably damaging Het
Cd226 T A 18: 89,265,147 (GRCm39) S29T probably benign Het
Cdan1 A G 2: 120,549,620 (GRCm39) probably null Het
Chaf1a A T 17: 56,371,032 (GRCm39) H639L probably benign Het
Chd1 G A 17: 17,607,742 (GRCm39) G430D probably benign Het
Ciao3 A G 17: 25,995,962 (GRCm39) E62G probably benign Het
Clca3a2 T C 3: 144,519,624 (GRCm39) probably benign Het
Clptm1 A G 7: 19,367,797 (GRCm39) V605A possibly damaging Het
Cmpk2 A G 12: 26,521,451 (GRCm39) D241G probably damaging Het
Cryzl1 A G 16: 91,489,546 (GRCm39) V266A possibly damaging Het
Cyp2c68 A G 19: 39,729,400 (GRCm39) L29P probably damaging Het
Dennd3 A C 15: 73,412,703 (GRCm39) probably benign Het
Dennd4c T A 4: 86,729,747 (GRCm39) I783N probably damaging Het
Dock10 A G 1: 80,518,060 (GRCm39) S1305P probably damaging Het
Eml6 T G 11: 29,783,085 (GRCm39) S599R probably benign Het
Gbp8 C T 5: 105,164,442 (GRCm39) A394T possibly damaging Het
H1f10 A G 6: 87,958,133 (GRCm39) I69T probably damaging Het
Herc2 T A 7: 55,818,621 (GRCm39) C2771S probably benign Het
Ism1 A T 2: 139,573,994 (GRCm39) I115F possibly damaging Het
Itga10 C T 3: 96,559,054 (GRCm39) probably benign Het
Itgb8 C T 12: 119,134,738 (GRCm39) G443E probably benign Het
Kalrn T A 16: 33,795,954 (GRCm39) I1274F possibly damaging Het
Klk1b11 A G 7: 43,426,331 (GRCm39) I22V probably benign Het
Krt6b T C 15: 101,585,987 (GRCm39) D362G probably damaging Het
Lce1e A G 3: 92,615,150 (GRCm39) S66P unknown Het
Letm1 A T 5: 33,936,026 (GRCm39) probably null Het
Lrrcc1 G T 3: 14,613,174 (GRCm39) V299L probably benign Het
Mettl5 A T 2: 69,711,764 (GRCm39) probably null Het
Mrpl12 A G 11: 120,376,127 (GRCm39) S46G probably benign Het
Ndrg3 T C 2: 156,780,570 (GRCm39) E198G probably damaging Het
Pcdh20 A G 14: 88,705,737 (GRCm39) I521T probably benign Het
Pdzph1 T C 17: 59,281,082 (GRCm39) D400G possibly damaging Het
Per2 A T 1: 91,373,279 (GRCm39) S170T possibly damaging Het
Pramel25 T A 4: 143,521,874 (GRCm39) L497I possibly damaging Het
Pros1 A G 16: 62,739,921 (GRCm39) K457E probably benign Het
Rer1 T A 4: 155,160,081 (GRCm39) M156L probably benign Het
Rerg A T 6: 137,034,799 (GRCm39) probably benign Het
Sel1l3 G T 5: 53,357,559 (GRCm39) H144Q possibly damaging Het
Septin2 G T 1: 93,426,828 (GRCm39) V146L probably damaging Het
Setd1b C T 5: 123,298,748 (GRCm39) probably benign Het
Sh3bp4 A T 1: 89,071,494 (GRCm39) Y114F probably benign Het
Slc44a5 C A 3: 153,948,796 (GRCm39) T188K probably benign Het
Slco6d1 A C 1: 98,350,819 (GRCm39) I100L probably benign Het
Slfn4 G T 11: 83,079,632 (GRCm39) D441Y probably damaging Het
Smg1 T C 7: 117,758,975 (GRCm39) probably benign Het
Snrpb2 A G 2: 142,907,086 (GRCm39) probably benign Het
Sspo T A 6: 48,425,560 (GRCm39) S60R probably benign Het
Stard9 T C 2: 120,527,958 (GRCm39) V1405A probably benign Het
Syt1 A G 10: 108,526,783 (GRCm39) L42P probably damaging Het
Tarbp1 T C 8: 127,175,069 (GRCm39) D789G probably benign Het
Tbcel A T 9: 42,361,358 (GRCm39) D63E probably damaging Het
Tdrd3 A T 14: 87,695,490 (GRCm39) probably benign Het
Tiam1 A T 16: 89,695,109 (GRCm39) I116N probably benign Het
Tsc22d1 A G 14: 76,675,104 (GRCm39) probably benign Het
Tsga10 G T 1: 37,874,534 (GRCm39) T117K probably damaging Het
Ttc3 A G 16: 94,219,496 (GRCm39) S492G possibly damaging Het
Ttn G T 2: 76,677,495 (GRCm39) probably benign Het
Wasf3 T C 5: 146,407,018 (GRCm39) probably benign Het
Zbtb37 C T 1: 160,859,592 (GRCm39) E238K probably benign Het
Zfp354c A G 11: 50,706,667 (GRCm39) I136T probably benign Het
Zfp384 G A 6: 125,013,416 (GRCm39) A479T probably benign Het
Zfp646 T A 7: 127,479,036 (GRCm39) N404K probably damaging Het
Other mutations in Or5ac16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01395:Or5ac16 APN 16 59,022,460 (GRCm39) missense possibly damaging 0.94
IGL03053:Or5ac16 APN 16 59,022,610 (GRCm39) missense probably damaging 1.00
IGL03168:Or5ac16 APN 16 59,022,610 (GRCm39) missense probably damaging 1.00
R1355:Or5ac16 UTSW 16 59,022,043 (GRCm39) missense probably damaging 1.00
R1510:Or5ac16 UTSW 16 59,022,546 (GRCm39) missense probably damaging 0.99
R1777:Or5ac16 UTSW 16 59,022,379 (GRCm39) missense probably benign 0.35
R1962:Or5ac16 UTSW 16 59,022,271 (GRCm39) missense possibly damaging 0.88
R1964:Or5ac16 UTSW 16 59,022,271 (GRCm39) missense possibly damaging 0.88
R5409:Or5ac16 UTSW 16 59,021,920 (GRCm39) missense probably damaging 1.00
R5642:Or5ac16 UTSW 16 59,022,369 (GRCm39) missense probably damaging 1.00
R5704:Or5ac16 UTSW 16 59,022,369 (GRCm39) missense probably damaging 1.00
R6323:Or5ac16 UTSW 16 59,022,645 (GRCm39) missense probably damaging 1.00
R6829:Or5ac16 UTSW 16 59,021,898 (GRCm39) missense probably damaging 1.00
R7315:Or5ac16 UTSW 16 59,022,496 (GRCm39) missense probably benign 0.00
R7738:Or5ac16 UTSW 16 59,022,318 (GRCm39) missense probably benign 0.00
R8540:Or5ac16 UTSW 16 59,022,323 (GRCm39) missense possibly damaging 0.56
R8815:Or5ac16 UTSW 16 59,022,264 (GRCm39) missense possibly damaging 0.78
R8844:Or5ac16 UTSW 16 59,021,929 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACGAGATGCTCACTGCCTTCAAC -3'
(R):5'- TGCACTGATCCTACAATGAACGTCC -3'

Sequencing Primer
(F):5'- CATGAGCTACTGGTGACCTG -3'
(R):5'- GATCCTACAATGAACGTCCTTCTG -3'
Posted On 2014-02-11