Incidental Mutation 'R1367:Prl3b1'
ID 156087
Institutional Source Beutler Lab
Gene Symbol Prl3b1
Ensembl Gene ENSMUSG00000038891
Gene Name prolactin family 3, subfamily b, member 1
Synonyms mplII, PL, Pl-2, mPL-II, Pl2, prolactin-like, Csh2
MMRRC Submission 039432-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R1367 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 27426413-27433666 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 27427848 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 53 (A53T)
Ref Sequence ENSEMBL: ENSMUSP00000047680 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035273] [ENSMUST00000225089]
AlphaFold P09586
Predicted Effect probably benign
Transcript: ENSMUST00000035273
AA Change: A53T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000047680
Gene: ENSMUSG00000038891
AA Change: A53T

DomainStartEndE-ValueType
Pfam:Hormone_1 18 222 1e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000225089
AA Change: A53T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.6%
  • 10x: 94.2%
  • 20x: 86.6%
Validation Efficiency 98% (48/49)
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc1 T C 16: 14,261,250 (GRCm39) V676A probably damaging Het
Acvr1b T C 15: 101,091,819 (GRCm39) L33P possibly damaging Het
Adamts12 T G 15: 11,256,980 (GRCm39) probably benign Het
Ank1 T A 8: 23,601,819 (GRCm39) probably benign Het
Arhgef10 T A 8: 14,990,225 (GRCm39) D233E probably damaging Het
Cd209e T C 8: 3,899,084 (GRCm39) *209W probably null Het
Cebpz A G 17: 79,230,742 (GRCm39) V825A probably benign Het
Cep170 A G 1: 176,563,290 (GRCm39) F1575L probably damaging Het
Exoc2 A T 13: 31,066,256 (GRCm39) Y473* probably null Het
F3 A G 3: 121,523,023 (GRCm39) T78A probably damaging Het
Fanca G A 8: 124,031,020 (GRCm39) probably benign Het
Gga2 G A 7: 121,598,138 (GRCm39) R319* probably null Het
Gid8 A G 2: 180,355,025 (GRCm39) I10M probably benign Het
Glrb A G 3: 80,769,311 (GRCm39) W139R probably damaging Het
H2-M1 A G 17: 36,982,059 (GRCm39) S181P probably benign Het
Hectd3 G T 4: 116,854,367 (GRCm39) V310L probably null Het
Insyn1 G T 9: 58,406,263 (GRCm39) D58Y probably damaging Het
Kif17 C A 4: 138,005,305 (GRCm39) S290* probably null Het
Kif26b A G 1: 178,744,028 (GRCm39) N1375D probably damaging Het
Lgr4 C G 2: 109,821,480 (GRCm39) P121A probably damaging Het
Ly75 A G 2: 60,124,102 (GRCm39) probably null Het
Mfsd13a C T 19: 46,354,943 (GRCm39) T40I probably benign Het
Nek3 T C 8: 22,650,377 (GRCm39) probably benign Het
Nin A T 12: 70,090,703 (GRCm39) L904Q probably damaging Het
Nlrp14 A G 7: 106,782,018 (GRCm39) D405G probably benign Het
Nuak1 C T 10: 84,228,192 (GRCm39) probably benign Het
Or5h23 T A 16: 58,906,706 (GRCm39) I47F probably benign Het
Plcg2 T A 8: 118,341,977 (GRCm39) W1113R probably damaging Het
Pms2 G A 5: 143,862,731 (GRCm39) V613M probably damaging Het
Pxk T G 14: 8,150,915 (GRCm38) probably null Het
Rasl10b G A 11: 83,308,665 (GRCm39) probably null Het
Rbm28 A T 6: 29,137,639 (GRCm39) I438N probably damaging Het
Rictor T C 15: 6,820,119 (GRCm39) probably benign Het
Slc41a1 A G 1: 131,771,746 (GRCm39) T387A probably benign Het
Slc44a2 T C 9: 21,254,322 (GRCm39) V228A probably benign Het
Slpi A G 2: 164,196,787 (GRCm39) probably benign Het
Tkfc A G 19: 10,570,838 (GRCm39) S481P probably benign Het
Tll2 G A 19: 41,108,667 (GRCm39) R328C probably damaging Het
Tns3 T C 11: 8,398,704 (GRCm39) H1216R probably benign Het
Ugt2b38 A T 5: 87,571,973 (GRCm39) S20T probably benign Het
Usp48 T A 4: 137,366,606 (GRCm39) D921E possibly damaging Het
Usp48 T A 4: 137,371,774 (GRCm39) S967T probably damaging Het
Vmn2r115 ATCTTCT ATCT 17: 23,578,962 (GRCm39) probably benign Het
Zdhhc23 A G 16: 43,794,513 (GRCm39) S54P probably benign Het
Other mutations in Prl3b1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02385:Prl3b1 APN 13 27,433,366 (GRCm39) missense possibly damaging 0.51
IGL02669:Prl3b1 APN 13 27,429,795 (GRCm39) missense probably benign 0.24
IGL03035:Prl3b1 APN 13 27,433,516 (GRCm39) unclassified probably benign
IGL03077:Prl3b1 APN 13 27,429,759 (GRCm39) missense probably benign 0.00
Gabby UTSW 13 27,431,928 (GRCm39) missense probably damaging 1.00
peaches UTSW 13 27,426,473 (GRCm39) start codon destroyed probably null 1.00
Pits UTSW 13 27,431,957 (GRCm39) critical splice donor site probably null
R2014_Prl3b1_632 UTSW 13 27,431,948 (GRCm39) missense probably benign 0.00
R0716:Prl3b1 UTSW 13 27,427,779 (GRCm39) missense probably benign 0.02
R0758:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R0773:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R0774:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R0775:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1364:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1366:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1368:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1530:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1884:Prl3b1 UTSW 13 27,431,886 (GRCm39) missense possibly damaging 0.95
R1990:Prl3b1 UTSW 13 27,429,775 (GRCm39) missense possibly damaging 0.94
R1991:Prl3b1 UTSW 13 27,431,895 (GRCm39) missense possibly damaging 0.60
R2014:Prl3b1 UTSW 13 27,431,948 (GRCm39) missense probably benign 0.00
R2885:Prl3b1 UTSW 13 27,433,505 (GRCm39) missense probably damaging 1.00
R4259:Prl3b1 UTSW 13 27,427,889 (GRCm39) splice site probably null
R4580:Prl3b1 UTSW 13 27,433,450 (GRCm39) missense possibly damaging 0.93
R4913:Prl3b1 UTSW 13 27,433,460 (GRCm39) missense probably damaging 0.99
R5897:Prl3b1 UTSW 13 27,429,858 (GRCm39) missense probably benign 0.08
R6235:Prl3b1 UTSW 13 27,431,928 (GRCm39) missense probably damaging 1.00
R6366:Prl3b1 UTSW 13 27,427,875 (GRCm39) missense probably benign 0.00
R6597:Prl3b1 UTSW 13 27,431,957 (GRCm39) critical splice donor site probably null
R7179:Prl3b1 UTSW 13 27,427,827 (GRCm39) missense probably benign 0.05
R7312:Prl3b1 UTSW 13 27,426,473 (GRCm39) start codon destroyed probably null 1.00
X0026:Prl3b1 UTSW 13 27,431,906 (GRCm39) missense probably benign 0.21
Z1177:Prl3b1 UTSW 13 27,427,742 (GRCm39) missense probably benign 0.23
Predicted Primers PCR Primer
(F):5'- GGACAGACAGTATAGCCTCTACAGTGT -3'
(R):5'- AGGGTTTGATGATTGCTCCATTGGAA -3'

Sequencing Primer
(F):5'- CAGTATAGCCTCTACAGTGTCATTTG -3'
(R):5'- ggaggaggtgagaggtgg -3'
Posted On 2014-02-11