Incidental Mutation 'R1354:Oas3'
ID 156239
Institutional Source Beutler Lab
Gene Symbol Oas3
Ensembl Gene ENSMUSG00000032661
Gene Name 2'-5' oligoadenylate synthetase 3
Synonyms Oasl10, 2'-5' oligoadenylate synthetase-like 10
MMRRC Submission 039419-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R1354 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 120891163-120915726 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 120908065 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Leucine at position 292 (V292L)
Ref Sequence ENSEMBL: ENSMUSP00000035588 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044833]
AlphaFold Q8VI93
Predicted Effect possibly damaging
Transcript: ENSMUST00000044833
AA Change: V292L

PolyPhen 2 Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000035588
Gene: ENSMUSG00000032661
AA Change: V292L

DomainStartEndE-ValueType
Pfam:OAS1_C 159 341 6.3e-83 PFAM
Pfam:OAS1_C 610 795 3.1e-78 PFAM
Pfam:NTP_transf_2 831 920 4.5e-11 PFAM
Pfam:OAS1_C 954 1136 9e-85 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000166703
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.9%
  • 20x: 92.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atoh1 A G 6: 64,706,341 (GRCm39) E12G possibly damaging Het
Ccdc183 T C 2: 25,502,151 (GRCm39) N241S probably benign Het
Cmya5 G A 13: 93,228,566 (GRCm39) T2174I possibly damaging Het
Edem1 A G 6: 108,831,277 (GRCm39) I579M possibly damaging Het
Gimap9 A T 6: 48,654,982 (GRCm39) M190L probably benign Het
Glod4 A T 11: 76,128,654 (GRCm39) probably null Het
Ighv8-6 A T 12: 115,129,700 (GRCm39) S19T probably damaging Het
Lef1 C T 3: 130,988,317 (GRCm39) P267S probably damaging Het
Megf11 A G 9: 64,560,459 (GRCm39) E335G probably benign Het
Muc5ac A G 7: 141,361,114 (GRCm39) N1475S probably damaging Het
Ndst2 C A 14: 20,775,043 (GRCm39) R749L possibly damaging Het
Phactr1 A T 13: 43,210,807 (GRCm39) I210F possibly damaging Het
Plppr5 G A 3: 117,369,496 (GRCm39) R51H possibly damaging Het
Ppp1r12b G A 1: 134,763,721 (GRCm39) T771M probably benign Het
Rasgrf2 G A 13: 92,165,174 (GRCm39) P331S probably damaging Het
Rtl6 C T 15: 84,440,728 (GRCm39) V223M probably damaging Het
Tbc1d9 A C 8: 83,995,610 (GRCm39) probably null Het
Tgm3 T C 2: 129,883,818 (GRCm39) I492T probably benign Het
Trdv1 T A 14: 54,119,375 (GRCm39) probably benign Het
Wdr45b A T 11: 121,226,256 (GRCm39) I191N probably damaging Het
Other mutations in Oas3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00547:Oas3 APN 5 120,915,507 (GRCm39) splice site probably benign
IGL01095:Oas3 APN 5 120,910,954 (GRCm39) missense probably damaging 1.00
IGL01835:Oas3 APN 5 120,904,193 (GRCm39) nonsense probably null
IGL02006:Oas3 APN 5 120,907,300 (GRCm39) missense probably benign 0.00
IGL02811:Oas3 APN 5 120,902,387 (GRCm39) missense unknown
IGL03194:Oas3 APN 5 120,897,018 (GRCm39) missense probably damaging 1.00
R0066:Oas3 UTSW 5 120,896,940 (GRCm39) missense probably damaging 1.00
R0195:Oas3 UTSW 5 120,894,210 (GRCm39) missense probably damaging 1.00
R0196:Oas3 UTSW 5 120,894,210 (GRCm39) missense probably damaging 1.00
R0197:Oas3 UTSW 5 120,894,210 (GRCm39) missense probably damaging 1.00
R0445:Oas3 UTSW 5 120,894,210 (GRCm39) missense probably damaging 1.00
R0523:Oas3 UTSW 5 120,904,209 (GRCm39) missense unknown
R0592:Oas3 UTSW 5 120,909,214 (GRCm39) missense probably damaging 1.00
R0946:Oas3 UTSW 5 120,907,128 (GRCm39) missense unknown
R1642:Oas3 UTSW 5 120,915,639 (GRCm39) missense possibly damaging 0.90
R1681:Oas3 UTSW 5 120,907,973 (GRCm39) missense probably benign 0.22
R1844:Oas3 UTSW 5 120,898,045 (GRCm39) missense probably damaging 0.99
R1981:Oas3 UTSW 5 120,899,900 (GRCm39) splice site probably benign
R2443:Oas3 UTSW 5 120,915,553 (GRCm39) missense probably benign 0.35
R2902:Oas3 UTSW 5 120,896,982 (GRCm39) missense probably damaging 1.00
R3034:Oas3 UTSW 5 120,909,121 (GRCm39) missense probably damaging 1.00
R4565:Oas3 UTSW 5 120,909,104 (GRCm39) missense probably damaging 1.00
R4692:Oas3 UTSW 5 120,907,420 (GRCm39) missense probably benign 0.03
R4723:Oas3 UTSW 5 120,904,321 (GRCm39) missense unknown
R4812:Oas3 UTSW 5 120,899,212 (GRCm39) unclassified probably benign
R5288:Oas3 UTSW 5 120,895,055 (GRCm39) missense probably damaging 1.00
R5343:Oas3 UTSW 5 120,894,303 (GRCm39) missense possibly damaging 0.70
R5494:Oas3 UTSW 5 120,899,709 (GRCm39) missense unknown
R5688:Oas3 UTSW 5 120,896,867 (GRCm39) missense probably benign 0.31
R5894:Oas3 UTSW 5 120,895,019 (GRCm39) missense probably damaging 1.00
R5921:Oas3 UTSW 5 120,908,046 (GRCm39) missense probably damaging 1.00
R6037:Oas3 UTSW 5 120,907,384 (GRCm39) missense probably benign 0.41
R6037:Oas3 UTSW 5 120,907,384 (GRCm39) missense probably benign 0.41
R6066:Oas3 UTSW 5 120,910,989 (GRCm39) missense probably damaging 0.97
R6104:Oas3 UTSW 5 120,899,758 (GRCm39) missense unknown
R6134:Oas3 UTSW 5 120,907,113 (GRCm39) missense unknown
R6255:Oas3 UTSW 5 120,909,295 (GRCm39) missense probably benign 0.04
R6257:Oas3 UTSW 5 120,899,200 (GRCm39) unclassified probably benign
R6776:Oas3 UTSW 5 120,896,939 (GRCm39) missense probably damaging 1.00
R8022:Oas3 UTSW 5 120,895,031 (GRCm39) missense possibly damaging 0.91
R8137:Oas3 UTSW 5 120,915,565 (GRCm39) missense probably benign 0.07
R8967:Oas3 UTSW 5 120,896,907 (GRCm39) missense probably damaging 0.99
R9124:Oas3 UTSW 5 120,912,170 (GRCm39) missense probably damaging 1.00
R9287:Oas3 UTSW 5 120,892,754 (GRCm39) missense probably damaging 1.00
R9661:Oas3 UTSW 5 120,904,230 (GRCm39) missense unknown
R9745:Oas3 UTSW 5 120,899,284 (GRCm39) missense unknown
RF006:Oas3 UTSW 5 120,912,165 (GRCm39) missense probably damaging 1.00
X0024:Oas3 UTSW 5 120,899,793 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- GCCTTATCAGCCAGAGCAGAAAGTG -3'
(R):5'- GGCTCCAGCAAAGTGGGTGATAC -3'

Sequencing Primer
(F):5'- TTCTAGGTGGACAGACATATCCAG -3'
(R):5'- AGTGGGTGATACCATCATTATGC -3'
Posted On 2014-02-11