Mutagenetix > Incidental Mutation

Incidental Mutation 'R1356:Gm21718'

156332

Institutional Source

Beutler Lab

Gene Symbol

Gm21718

Ensembl Gene

ENSMUSG00000094991

Gene Name

predicted gene, 21718

Synonyms

MMRRC Submission

039421-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.129) question?

Stock #

R1356 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

51548954-51555225 bp(+) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

A to G at 51554104 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000179170

SMART Domains

Protein: ENSMUSP00000137290
Gene: ENSMUSG00000094991

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:LBP_BPI_CETP	47	171	5.6e-14	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000186974

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000228121

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000228344

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.2%
20x: 92.7%

Validation Efficiency

100% (34/34)

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	A	G	1: 71,342,112 (GRCm39)		probably benign	Het
Adam18	A	G	8: 25,158,611 (GRCm39)		probably benign	Het
Cd274	C	A	19: 29,350,970 (GRCm39)	T22K	possibly damaging	Het
Cfap45	G	A	1: 172,355,430 (GRCm39)	R26Q	possibly damaging	Het
Dvl3	AGCGGCGGCGGCGG	AGCGGCGGCGG	16: 20,343,055 (GRCm39)		probably benign	Het
E2f8	A	G	7: 48,530,018 (GRCm39)		probably benign	Het
Ercc4	A	G	16: 12,943,146 (GRCm39)	H255R	probably damaging	Het
Fam227b	C	T	2: 125,960,928 (GRCm39)	D234N	probably damaging	Het
Foxp1	A	T	6: 98,993,637 (GRCm39)		probably benign	Het
Fsip2	T	A	2: 82,820,089 (GRCm39)	V5274D	probably benign	Het
Gpr85	G	A	6: 13,836,146 (GRCm39)	P253S	probably benign	Het
Grm7	A	T	6: 111,335,985 (GRCm39)	I799F	probably damaging	Het
Inpp1	A	G	1: 52,836,215 (GRCm39)	F84L	possibly damaging	Het
Kprp	T	A	3: 92,732,909 (GRCm39)	E47V	probably damaging	Het
Krt9	CTGC	CTGCNNNNNNNNNNNNNNNNNNNNNTGC	11: 100,079,640 (GRCm39)		probably benign	Het
Lama3	G	A	18: 12,633,634 (GRCm39)		probably benign	Het
Lurap1l	C	G	4: 80,829,767 (GRCm39)	A59G	probably benign	Het
Macc1	A	T	12: 119,410,290 (GRCm39)	T353S	probably benign	Het
Mctp2	A	G	7: 71,814,471 (GRCm39)		probably benign	Het
Mdn1	T	C	4: 32,700,334 (GRCm39)		probably benign	Het
Mpeg1	T	A	19: 12,438,689 (GRCm39)	V49D	probably damaging	Het
Nos2	C	T	11: 78,843,629 (GRCm39)	P859S	probably benign	Het
Or8g18	G	C	9: 39,149,547 (GRCm39)	P58A	probably benign	Het
Parn	A	T	16: 13,468,538 (GRCm39)	Y214*	probably null	Het
Pibf1	A	G	14: 99,374,632 (GRCm39)	E357G	possibly damaging	Het
Prex2	C	T	1: 11,150,316 (GRCm39)	Q163*	probably null	Het
Prune2	T	A	19: 17,189,681 (GRCm39)	S294T	probably benign	Het
Slc46a1	A	G	11: 78,361,550 (GRCm39)	N399D	probably benign	Het
Sstr2	T	C	11: 113,515,720 (GRCm39)	F213S	probably damaging	Het
Tnxb	A	G	17: 34,914,446 (GRCm39)	E1967G	possibly damaging	Het
Vmn2r59	A	G	7: 41,661,218 (GRCm39)	*866Q	probably null	Het

Other mutations in Gm21718

Allele	Source	Chr	Coord	Type	Predicted Effect
R1172:Gm21718	UTSW	14	51,553,348 (GRCm39)	unclassified	noncoding transcript
R2163:Gm21718	UTSW	14	51,555,223 (GRCm39)	exon	noncoding transcript
R4924:Gm21718	UTSW	14	51,550,292 (GRCm39)	unclassified	noncoding transcript
R4947:Gm21718	UTSW	14	51,553,416 (GRCm39)	unclassified	noncoding transcript

Predicted Primers

PCR Primer
(F):5'- CTGAGTGTAGTGATGACACAGGGC -3'
(R):5'- TGAATGTCACACATGCTGGGCAAG -3'

Sequencing Primer
(F):5'- TGATGACACAGGGCAAGGTTG -3'
(R):5'- aaaatagtgtggtaagtgattggg -3'

Posted On

2014-02-11