Incidental Mutation 'R0040:Zfp68'
ID15643
Institutional Source Beutler Lab
Gene Symbol Zfp68
Ensembl Gene ENSMUSG00000058291
Gene Namezinc finger protein 68
SynonymsZfp68, Zfp70, KRAZ2, KRAB3
MMRRC Submission 038334-MU
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.791) question?
Stock #R0040 (G1)
Quality Score
Status Validated
Chromosome5
Chromosomal Location138603652-138619761 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 138607779 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Isoleucine at position 94 (T94I)
Ref Sequence ENSEMBL: ENSMUSP00000106530 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063262] [ENSMUST00000085852] [ENSMUST00000110905] [ENSMUST00000129832]
Predicted Effect probably benign
Transcript: ENSMUST00000063262
AA Change: T94I

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000069615
Gene: ENSMUSG00000058291
AA Change: T94I

DomainStartEndE-ValueType
KRAB 10 70 1.11e-30 SMART
ZnF_C2H2 317 339 1.58e-3 SMART
ZnF_C2H2 345 367 3.16e-3 SMART
ZnF_C2H2 373 395 5.5e-3 SMART
ZnF_C2H2 401 423 2.27e-4 SMART
ZnF_C2H2 429 451 3.44e-4 SMART
ZnF_C2H2 457 479 3.07e-1 SMART
ZnF_C2H2 485 507 2.09e-3 SMART
ZnF_C2H2 513 535 3.29e-1 SMART
ZnF_C2H2 541 563 2.99e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000085852
AA Change: T56I

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000083013
Gene: ENSMUSG00000058291
AA Change: T56I

DomainStartEndE-ValueType
KRAB 1 32 6e-1 SMART
ZnF_C2H2 279 301 1.58e-3 SMART
ZnF_C2H2 307 329 3.16e-3 SMART
ZnF_C2H2 335 357 5.5e-3 SMART
ZnF_C2H2 363 385 2.27e-4 SMART
ZnF_C2H2 391 413 3.44e-4 SMART
ZnF_C2H2 419 441 3.07e-1 SMART
ZnF_C2H2 447 469 2.09e-3 SMART
ZnF_C2H2 475 497 3.29e-1 SMART
ZnF_C2H2 503 525 2.99e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000110905
AA Change: T94I

PolyPhen 2 Score 0.237 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000106530
Gene: ENSMUSG00000058291
AA Change: T94I

DomainStartEndE-ValueType
KRAB 10 70 1.11e-30 SMART
ZnF_C2H2 317 339 1.58e-3 SMART
ZnF_C2H2 345 367 3.16e-3 SMART
ZnF_C2H2 373 395 5.5e-3 SMART
ZnF_C2H2 401 423 2.27e-4 SMART
ZnF_C2H2 429 451 3.44e-4 SMART
ZnF_C2H2 457 479 3.07e-1 SMART
ZnF_C2H2 485 507 2.09e-3 SMART
ZnF_C2H2 513 535 3.29e-1 SMART
ZnF_C2H2 541 563 2.99e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000119137
Predicted Effect probably benign
Transcript: ENSMUST00000129832
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175175
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197654
Meta Mutation Damage Score 0.1476 question?
Coding Region Coverage
  • 1x: 84.2%
  • 3x: 77.3%
  • 10x: 61.4%
  • 20x: 43.8%
Validation Efficiency 96% (74/77)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m T G 6: 121,645,206 L356R possibly damaging Het
Antxr2 G A 5: 97,938,425 T441I possibly damaging Het
Apcs A G 1: 172,894,456 Y108H probably benign Het
Arpp21 T C 9: 112,147,409 probably benign Het
Atcay C T 10: 81,210,519 probably null Het
Bahcc1 A G 11: 120,268,370 D141G probably damaging Het
Cacng5 A T 11: 107,884,510 L11Q probably damaging Het
Ccdc73 T C 2: 104,992,084 S793P probably damaging Het
Ceacam10 A G 7: 24,778,264 Y68C probably damaging Het
Csmd3 G A 15: 47,633,816 P3062S probably damaging Het
Dctn4 A G 18: 60,544,042 N145D possibly damaging Het
Dusp12 A G 1: 170,880,657 Y164H probably damaging Het
Fat1 A G 8: 45,026,404 D2829G probably damaging Het
Fbxl13 T C 5: 21,486,373 T671A probably damaging Het
Fndc3b T A 3: 27,556,117 probably null Het
Gprc6a T A 10: 51,614,984 K819* probably null Het
Gucy2g T A 19: 55,217,302 T709S possibly damaging Het
Gxylt1 A T 15: 93,254,555 probably benign Het
Idh2 A G 7: 80,097,822 S317P probably damaging Het
Ifi30 T C 8: 70,763,776 probably null Het
Ifna16 G A 4: 88,676,630 A76V probably benign Het
Itpr2 C T 6: 146,345,140 E1127K probably damaging Het
Kank4 A G 4: 98,779,220 V330A probably benign Het
Kri1 T C 9: 21,281,105 Y131C probably damaging Het
Krt71 T A 15: 101,738,433 H280L possibly damaging Het
Lox A T 18: 52,520,826 H399Q possibly damaging Het
Mapt A G 11: 104,305,398 M446V probably damaging Het
Mpp7 A T 18: 7,403,180 probably benign Het
Mycbp2 A G 14: 103,224,272 V1447A probably benign Het
Myl3 A C 9: 110,767,929 D119A probably damaging Het
Myo1b A T 1: 51,781,989 I451N probably damaging Het
Nubp1 A G 16: 10,421,117 T199A probably damaging Het
Olfml2b A G 1: 170,668,751 H317R probably benign Het
Pard3b A T 1: 62,637,820 Y1170F probably damaging Het
Pear1 T C 3: 87,754,358 D536G probably damaging Het
Pira6 A G 7: 4,281,483 noncoding transcript Het
Pkhd1l1 T A 15: 44,573,625 Y3460N probably damaging Het
Plxna2 G T 1: 194,643,896 R46L probably benign Het
Rnf168 T A 16: 32,278,173 probably null Het
Rpl14 C G 9: 120,572,101 F3L possibly damaging Het
Scara5 C T 14: 65,762,717 probably benign Het
Sh3rf1 T A 8: 61,329,252 Y143N possibly damaging Het
Slc4a8 T A 15: 100,789,846 I288N probably damaging Het
Synpr G A 14: 13,563,024 A86T probably damaging Het
Ttc38 C A 15: 85,841,489 F184L probably damaging Het
Wdpcp A G 11: 21,711,638 I303M probably damaging Het
Zc3h12d G A 10: 7,867,914 A483T probably benign Het
Zfp106 C A 2: 120,531,613 K1008N probably damaging Het
Zfp867 C T 11: 59,463,865 A213T possibly damaging Het
Zkscan3 A T 13: 21,394,920 probably null Het
Other mutations in Zfp68
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02167:Zfp68 APN 5 138606367 missense probably benign 0.00
R0040:Zfp68 UTSW 5 138607779 missense probably benign 0.24
R0152:Zfp68 UTSW 5 138606613 missense probably damaging 1.00
R0390:Zfp68 UTSW 5 138607225 missense probably benign 0.14
R1490:Zfp68 UTSW 5 138606829 missense probably benign 0.16
R4688:Zfp68 UTSW 5 138616481 nonsense probably null
R4992:Zfp68 UTSW 5 138607337 missense possibly damaging 0.50
R5072:Zfp68 UTSW 5 138606317 missense probably benign 0.01
R7076:Zfp68 UTSW 5 138606939 missense possibly damaging 0.49
R7117:Zfp68 UTSW 5 138606318 missense probably benign 0.01
Posted On2012-12-21