Incidental Mutation 'R0038:Oog4'
| ID |
15661 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Oog4
|
| Ensembl Gene |
ENSMUSG00000047799 |
| Gene Name |
oogenesin 4 |
| Synonyms |
|
| MMRRC Submission |
038332-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.089)
|
| Stock # |
R0038 (G1)
|
| Quality Score |
|
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
143163734-143176894 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 143165514 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 211
(D211G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000073325
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000061277]
[ENSMUST00000073641]
|
| AlphaFold |
Q4G0C7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000061277
AA Change: D139G
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
| SMART Domains |
Protein: ENSMUSP00000052217
Gene: ENSMUSG00000047799
AA Change: D139G
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1a4ya_
|
195 |
357 |
6e-7 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000073641
AA Change: D211G
PolyPhen 2
Score 0.197 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000073325
Gene: ENSMUSG00000047799
AA Change: D211G
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1a4ya_
|
267 |
429 |
3e-7 |
SMART |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 83.6%
- 3x: 76.1%
- 10x: 58.6%
- 20x: 40.4%
|
| Validation Efficiency |
91% (67/74) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 30 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Agfg1 |
T |
C |
1: 82,863,823 (GRCm39) |
|
probably benign |
Het |
| Ahnak2 |
T |
C |
12: 112,740,896 (GRCm39) |
T253A |
probably benign |
Het |
| Ankrd28 |
A |
T |
14: 31,429,992 (GRCm39) |
M892K |
probably damaging |
Het |
| Arhgef25 |
T |
C |
10: 127,022,734 (GRCm39) |
|
probably benign |
Het |
| Cldn8 |
A |
G |
16: 88,359,922 (GRCm39) |
M1T |
probably null |
Het |
| Clec11a |
A |
G |
7: 43,955,906 (GRCm39) |
|
probably benign |
Het |
| Ddx39a |
T |
C |
8: 84,449,127 (GRCm39) |
L305P |
probably damaging |
Het |
| Depdc5 |
A |
G |
5: 33,026,197 (GRCm39) |
E60G |
probably benign |
Het |
| Etl4 |
A |
T |
2: 20,748,385 (GRCm39) |
H39L |
probably damaging |
Het |
| Gramd1b |
G |
A |
9: 40,228,822 (GRCm39) |
T252M |
probably damaging |
Het |
| Hcrtr2 |
A |
T |
9: 76,166,963 (GRCm39) |
S125T |
probably benign |
Het |
| Htr2a |
T |
G |
14: 74,943,687 (GRCm39) |
S422R |
probably benign |
Het |
| Kirrel3 |
T |
A |
9: 34,823,066 (GRCm39) |
|
probably null |
Het |
| Krtap9-5 |
G |
A |
11: 99,839,428 (GRCm39) |
C43Y |
possibly damaging |
Het |
| Lama2 |
T |
C |
10: 26,862,793 (GRCm39) |
D2990G |
probably benign |
Het |
| Ncor1 |
A |
G |
11: 62,283,377 (GRCm39) |
F437L |
probably damaging |
Het |
| Nlrp1b |
A |
G |
11: 71,062,997 (GRCm39) |
S685P |
possibly damaging |
Het |
| Pcdh15 |
A |
T |
10: 74,479,272 (GRCm39) |
E723V |
possibly damaging |
Het |
| Pgm3 |
A |
T |
9: 86,446,726 (GRCm39) |
|
probably benign |
Het |
| Pnpla5 |
A |
G |
15: 84,006,714 (GRCm39) |
Y90H |
probably damaging |
Het |
| Polr1b |
C |
T |
2: 128,957,588 (GRCm39) |
R548* |
probably null |
Het |
| Rnf168 |
T |
C |
16: 32,117,813 (GRCm39) |
V458A |
probably benign |
Het |
| Rnf32 |
T |
C |
5: 29,410,652 (GRCm39) |
|
probably benign |
Het |
| Sclt1 |
T |
C |
3: 41,583,943 (GRCm39) |
|
probably benign |
Het |
| Serpina12 |
A |
G |
12: 104,004,216 (GRCm39) |
F139L |
probably damaging |
Het |
| Stag3 |
T |
A |
5: 138,299,298 (GRCm39) |
|
probably null |
Het |
| Stard5 |
T |
C |
7: 83,285,951 (GRCm39) |
|
probably benign |
Het |
| Suclg1 |
A |
G |
6: 73,237,486 (GRCm39) |
E77G |
probably benign |
Het |
| Ush2a |
G |
T |
1: 188,358,809 (GRCm39) |
G2112C |
probably benign |
Het |
| Zfp644 |
T |
G |
5: 106,782,909 (GRCm39) |
E1155A |
probably benign |
Het |
|
| Other mutations in Oog4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01580:Oog4
|
APN |
4 |
143,165,682 (GRCm39) |
missense |
probably benign |
0.27 |
|
IGL02207:Oog4
|
APN |
4 |
143,165,510 (GRCm39) |
missense |
probably benign |
0.20 |
|
R0038:Oog4
|
UTSW |
4 |
143,165,514 (GRCm39) |
missense |
probably benign |
0.20 |
|
R0326:Oog4
|
UTSW |
4 |
143,165,773 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0372:Oog4
|
UTSW |
4 |
143,164,259 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1056:Oog4
|
UTSW |
4 |
143,164,581 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R1598:Oog4
|
UTSW |
4 |
143,164,571 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1712:Oog4
|
UTSW |
4 |
143,166,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4028:Oog4
|
UTSW |
4 |
143,166,770 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4029:Oog4
|
UTSW |
4 |
143,166,770 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4030:Oog4
|
UTSW |
4 |
143,166,770 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4705:Oog4
|
UTSW |
4 |
143,165,445 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5260:Oog4
|
UTSW |
4 |
143,164,424 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5945:Oog4
|
UTSW |
4 |
143,164,293 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6499:Oog4
|
UTSW |
4 |
143,164,548 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6614:Oog4
|
UTSW |
4 |
143,164,445 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R6852:Oog4
|
UTSW |
4 |
143,165,679 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7371:Oog4
|
UTSW |
4 |
143,165,346 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7375:Oog4
|
UTSW |
4 |
143,165,544 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7501:Oog4
|
UTSW |
4 |
143,164,022 (GRCm39) |
frame shift |
probably null |
|
|
R7564:Oog4
|
UTSW |
4 |
143,164,022 (GRCm39) |
frame shift |
probably null |
|
|
R7678:Oog4
|
UTSW |
4 |
143,164,022 (GRCm39) |
frame shift |
probably null |
|
|
R7688:Oog4
|
UTSW |
4 |
143,164,022 (GRCm39) |
frame shift |
probably null |
|
|
R7689:Oog4
|
UTSW |
4 |
143,164,022 (GRCm39) |
frame shift |
probably null |
|
|
R8219:Oog4
|
UTSW |
4 |
143,166,508 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8274:Oog4
|
UTSW |
4 |
143,166,459 (GRCm39) |
splice site |
probably benign |
|
|
R8352:Oog4
|
UTSW |
4 |
143,164,047 (GRCm39) |
missense |
probably benign |
0.22 |
|
R8452:Oog4
|
UTSW |
4 |
143,164,047 (GRCm39) |
missense |
probably benign |
0.22 |
|
Z1177:Oog4
|
UTSW |
4 |
143,164,145 (GRCm39) |
missense |
probably benign |
0.06 |
|
Z1177:Oog4
|
UTSW |
4 |
143,164,144 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
| Posted On |
2012-12-21 |
Incidental Mutation