Incidental Mutation 'R1351:Gpr162'
ID 156651
Institutional Source Beutler Lab
Gene Symbol Gpr162
Ensembl Gene ENSMUSG00000038390
Gene Name G protein-coupled receptor 162
Synonyms Grca, A-2
MMRRC Submission 039416-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.114) question?
Stock # R1351 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 124835407-124840900 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 124838161 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 163 (Y163C)
Ref Sequence ENSEMBL: ENSMUSP00000145267 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023958] [ENSMUST00000024044] [ENSMUST00000046893] [ENSMUST00000135127] [ENSMUST00000204667]
AlphaFold Q3UN16
Predicted Effect probably benign
Transcript: ENSMUST00000023958
SMART Domains Protein: ENSMUSP00000023958
Gene: ENSMUSG00000023191

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
low complexity region 58 76 N/A INTRINSIC
low complexity region 127 142 N/A INTRINSIC
low complexity region 222 242 N/A INTRINSIC
low complexity region 256 277 N/A INTRINSIC
P4Hc 460 670 8.51e-49 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000024044
SMART Domains Protein: ENSMUSP00000024044
Gene: ENSMUSG00000023274

DomainStartEndE-ValueType
low complexity region 6 21 N/A INTRINSIC
IGv 37 114 7.02e-8 SMART
IG 131 206 3.63e-1 SMART
IG 212 317 3.36e0 SMART
transmembrane domain 394 416 N/A INTRINSIC
Pfam:Tcell_CD4_C 425 452 2.2e-18 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000046893
AA Change: Y163C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000038536
Gene: ENSMUSG00000038390
AA Change: Y163C

DomainStartEndE-ValueType
Pfam:7tm_1 30 337 1.1e-19 PFAM
low complexity region 348 362 N/A INTRINSIC
low complexity region 462 477 N/A INTRINSIC
low complexity region 482 504 N/A INTRINSIC
low complexity region 513 540 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000135127
SMART Domains Protein: ENSMUSP00000116338
Gene: ENSMUSG00000023191

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
low complexity region 58 76 N/A INTRINSIC
low complexity region 127 142 N/A INTRINSIC
low complexity region 222 242 N/A INTRINSIC
low complexity region 256 277 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204161
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204253
Predicted Effect probably damaging
Transcript: ENSMUST00000204667
AA Change: Y163C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000145267
Gene: ENSMUSG00000038390
AA Change: Y163C

DomainStartEndE-ValueType
Pfam:7tm_1 30 337 1.1e-19 PFAM
low complexity region 348 362 N/A INTRINSIC
low complexity region 462 477 N/A INTRINSIC
low complexity region 482 504 N/A INTRINSIC
low complexity region 513 540 N/A INTRINSIC
Meta Mutation Damage Score 0.1437 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 95.0%
Validation Efficiency 100% (51/51)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was identified upon genomic analysis of a gene-dense region at human chromosome 12p13. It appears to be mainly expressed in the brain; however, its function is not known. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgef26 A G 3: 62,288,262 (GRCm39) E444G probably damaging Het
Astl G A 2: 127,189,105 (GRCm39) V144M possibly damaging Het
AW146154 A T 7: 41,129,878 (GRCm39) C413S probably damaging Het
Bicdl2 G A 17: 23,886,519 (GRCm39) probably benign Het
Cacna1h G T 17: 25,610,925 (GRCm39) S624R probably benign Het
Car9 G T 4: 43,512,439 (GRCm39) probably null Het
Cep126 C T 9: 8,100,087 (GRCm39) E816K probably damaging Het
Cyp2j13 T C 4: 95,945,155 (GRCm39) K291R probably benign Het
Defb26 A T 2: 152,349,737 (GRCm39) M181K unknown Het
Dicer1 G A 12: 104,695,401 (GRCm39) R177C probably damaging Het
Eif4g2 A G 7: 110,673,287 (GRCm39) Y831H probably damaging Het
Ermap C T 4: 119,038,558 (GRCm39) probably null Het
Fcamr C T 1: 130,740,757 (GRCm39) T392I possibly damaging Het
Fgf3 T C 7: 144,394,517 (GRCm39) probably benign Het
Gprc5d T C 6: 135,093,230 (GRCm39) R226G possibly damaging Het
Hapln3 A C 7: 78,771,708 (GRCm39) S60R probably damaging Het
Hif1a T C 12: 73,987,235 (GRCm39) S443P probably benign Het
Irf2bpl A G 12: 86,929,398 (GRCm39) M425T probably benign Het
Lrrc39 G T 3: 116,359,469 (GRCm39) A5S possibly damaging Het
Mbtps1 A G 8: 120,244,901 (GRCm39) L850S possibly damaging Het
Mios T A 6: 8,228,120 (GRCm39) M679K possibly damaging Het
Mocos T C 18: 24,793,107 (GRCm39) F68S probably damaging Het
Nuf2 T C 1: 169,338,118 (GRCm39) probably benign Het
Or51k1 A G 7: 103,661,523 (GRCm39) Y129H possibly damaging Het
Orc1 T A 4: 108,452,564 (GRCm39) D146E probably benign Het
Pcdhb22 T C 18: 37,651,627 (GRCm39) F32L probably benign Het
Pde4d G T 13: 110,087,809 (GRCm39) E562D possibly damaging Het
Pgk2 T C 17: 40,518,691 (GRCm39) K246E probably damaging Het
Plekhh2 A T 17: 84,884,574 (GRCm39) probably benign Het
Pou3f2 A T 4: 22,487,162 (GRCm39) C324S probably damaging Het
Prkdc C T 16: 15,485,564 (GRCm39) L464F possibly damaging Het
Prrc2a T C 17: 35,376,863 (GRCm39) H749R possibly damaging Het
Rad18 T C 6: 112,597,863 (GRCm39) N218S possibly damaging Het
Rbm11 T C 16: 75,393,531 (GRCm39) Y76H possibly damaging Het
Rif1 T G 2: 52,001,567 (GRCm39) Y1674D possibly damaging Het
Rrp1b A G 17: 32,275,611 (GRCm39) H386R possibly damaging Het
Sacs T C 14: 61,440,210 (GRCm39) V752A probably benign Het
Sema3c A G 5: 17,883,334 (GRCm39) D314G possibly damaging Het
Spata2l G A 8: 123,960,072 (GRCm39) R406C probably damaging Het
Tacc2 C T 7: 130,264,733 (GRCm39) probably benign Het
Tent4b C A 8: 88,927,002 (GRCm39) Y137* probably null Het
Trpc4 A G 3: 54,102,423 (GRCm39) E107G probably damaging Het
Vmn2r70 A G 7: 85,214,262 (GRCm39) S297P probably damaging Het
Xdh A G 17: 74,230,073 (GRCm39) I286T probably benign Het
Zfp608 T C 18: 55,031,463 (GRCm39) T826A probably benign Het
Zfp646 T A 7: 127,482,683 (GRCm39) V1620E probably benign Het
Zfyve28 T G 5: 34,389,549 (GRCm39) D217A probably damaging Het
Zmym6 G A 4: 127,016,798 (GRCm39) G768R probably benign Het
Other mutations in Gpr162
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01134:Gpr162 APN 6 124,835,820 (GRCm39) splice site probably null
IGL01879:Gpr162 APN 6 124,838,204 (GRCm39) missense probably damaging 1.00
IGL01901:Gpr162 APN 6 124,838,370 (GRCm39) missense possibly damaging 0.95
IGL01930:Gpr162 APN 6 124,838,575 (GRCm39) missense possibly damaging 0.82
IGL02334:Gpr162 APN 6 124,838,123 (GRCm39) missense probably damaging 1.00
R1036:Gpr162 UTSW 6 124,837,823 (GRCm39) missense probably damaging 0.99
R1322:Gpr162 UTSW 6 124,835,864 (GRCm39) missense probably damaging 0.96
R1549:Gpr162 UTSW 6 124,837,051 (GRCm39) missense probably damaging 1.00
R1933:Gpr162 UTSW 6 124,838,410 (GRCm39) missense probably damaging 0.98
R4214:Gpr162 UTSW 6 124,837,031 (GRCm39) missense probably damaging 1.00
R4367:Gpr162 UTSW 6 124,838,658 (GRCm39) start gained probably benign
R4628:Gpr162 UTSW 6 124,838,405 (GRCm39) missense probably benign 0.03
R5290:Gpr162 UTSW 6 124,838,232 (GRCm39) missense probably benign 0.17
R5354:Gpr162 UTSW 6 124,836,600 (GRCm39) missense probably benign 0.06
R5404:Gpr162 UTSW 6 124,838,606 (GRCm39) missense possibly damaging 0.73
R5465:Gpr162 UTSW 6 124,838,134 (GRCm39) missense probably damaging 1.00
R5520:Gpr162 UTSW 6 124,837,876 (GRCm39) missense probably damaging 1.00
R5566:Gpr162 UTSW 6 124,837,901 (GRCm39) nonsense probably null
R6184:Gpr162 UTSW 6 124,838,204 (GRCm39) missense probably damaging 1.00
R6450:Gpr162 UTSW 6 124,838,152 (GRCm39) missense possibly damaging 0.84
R6685:Gpr162 UTSW 6 124,838,494 (GRCm39) missense probably damaging 1.00
R6807:Gpr162 UTSW 6 124,838,164 (GRCm39) missense probably damaging 0.97
R6972:Gpr162 UTSW 6 124,838,272 (GRCm39) missense probably damaging 0.99
R6982:Gpr162 UTSW 6 124,837,919 (GRCm39) missense probably damaging 1.00
R7543:Gpr162 UTSW 6 124,838,355 (GRCm39) nonsense probably null
R7650:Gpr162 UTSW 6 124,838,806 (GRCm39) start gained probably benign
R8974:Gpr162 UTSW 6 124,837,876 (GRCm39) missense probably damaging 1.00
R9096:Gpr162 UTSW 6 124,836,570 (GRCm39) missense probably benign 0.11
R9097:Gpr162 UTSW 6 124,836,570 (GRCm39) missense probably benign 0.11
R9233:Gpr162 UTSW 6 124,836,014 (GRCm39) missense possibly damaging 0.68
R9356:Gpr162 UTSW 6 124,838,297 (GRCm39) missense possibly damaging 0.71
R9389:Gpr162 UTSW 6 124,838,357 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCGAGTATCCTCCACCACAATGGC -3'
(R):5'- CTATGACTGGAACGAGAGCATCTGC -3'

Sequencing Primer
(F):5'- TGGCTGGCACCTCAAAAG -3'
(R):5'- CGAGAGCATCTGCAAGGTC -3'
Posted On 2014-02-11