Incidental Mutation 'R1332:Bid'
ID 156737
Institutional Source Beutler Lab
Gene Symbol Bid
Ensembl Gene ENSMUSG00000004446
Gene Name BH3 interacting domain death agonist
Synonyms 2700049M22Rik
MMRRC Submission 039397-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R1332 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 120870080-120894074 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 120874216 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 110 (A110T)
Ref Sequence ENSEMBL: ENSMUSP00000125731 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004560] [ENSMUST00000009256] [ENSMUST00000145948] [ENSMUST00000160684]
AlphaFold P70444
Predicted Effect possibly damaging
Transcript: ENSMUST00000004560
AA Change: A110T

PolyPhen 2 Score 0.821 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000004560
Gene: ENSMUSG00000004446
AA Change: A110T

DomainStartEndE-ValueType
Pfam:BID 3 192 2.8e-94 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000009256
SMART Domains Protein: ENSMUSP00000009256
Gene: ENSMUSG00000009112

DomainStartEndE-ValueType
low complexity region 51 67 N/A INTRINSIC
BCL 106 197 4.19e0 SMART
transmembrane domain 409 431 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000145948
SMART Domains Protein: ENSMUSP00000117529
Gene: ENSMUSG00000004446

DomainStartEndE-ValueType
Pfam:BID 1 52 1.7e-16 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000160684
AA Change: A110T

PolyPhen 2 Score 0.821 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000125731
Gene: ENSMUSG00000004446
AA Change: A110T

DomainStartEndE-ValueType
Pfam:BID 1 195 3.8e-93 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161594
Meta Mutation Damage Score 0.6330 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.1%
  • 20x: 93.0%
Validation Efficiency 100% (35/35)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mutants survive with little or no liver damage after injection with antibody against Fas, whereas mice normally die from hepatocellular apoptosis and hemorragic necrosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933415A04Rik T TNNNNNNNNNNNNNNNNNN 11: 43,478,256 (GRCm39) probably benign Het
Abhd14b A T 9: 106,329,195 (GRCm39) I42F probably damaging Het
Apbb1 A T 7: 105,214,750 (GRCm39) I498N possibly damaging Het
Asah2 A G 19: 32,022,341 (GRCm39) I231T probably damaging Het
Caskin2 C T 11: 115,694,171 (GRCm39) probably benign Het
Ccdc141 T C 2: 76,844,784 (GRCm39) T1428A probably damaging Het
Cd22 A C 7: 30,569,912 (GRCm39) W477G possibly damaging Het
Cox16 T C 12: 81,519,064 (GRCm39) D89G probably damaging Het
Dnah17 A G 11: 117,934,041 (GRCm39) I3511T possibly damaging Het
Dpy19l4 A T 4: 11,276,901 (GRCm39) Y333N probably damaging Het
Eya2 T C 2: 165,529,528 (GRCm39) probably benign Het
Fras1 A G 5: 96,855,167 (GRCm39) D1892G probably benign Het
Hlf G T 11: 90,231,679 (GRCm39) S265* probably null Het
Immt T C 6: 71,823,256 (GRCm39) probably benign Het
Lair1 T C 7: 4,013,595 (GRCm39) E36G possibly damaging Het
Lrfn5 T C 12: 61,904,314 (GRCm39) probably benign Het
Nos1ap T C 1: 170,177,001 (GRCm39) N134S probably damaging Het
Ogfod1 T C 8: 94,784,727 (GRCm39) C344R probably damaging Het
Or6c212 A G 10: 129,559,116 (GRCm39) L99S probably damaging Het
Pkhd1l1 G A 15: 44,368,943 (GRCm39) V863I probably damaging Het
Pmfbp1 T G 8: 110,256,898 (GRCm39) I534S probably damaging Het
Prex2 A G 1: 11,274,315 (GRCm39) D1329G probably damaging Het
Rasal2 T C 1: 157,003,391 (GRCm39) T423A probably benign Het
Rif1 T A 2: 51,968,326 (GRCm39) W170R probably benign Het
Scarb2 C T 5: 92,599,205 (GRCm39) probably null Het
Stard9 C A 2: 120,504,117 (GRCm39) S221R probably damaging Het
Tlr3 A C 8: 45,851,774 (GRCm39) N374K probably damaging Het
Uck1 T C 2: 32,149,666 (GRCm39) D71G probably damaging Het
Vcan C T 13: 89,841,174 (GRCm39) E497K probably damaging Het
Vmn2r86 G A 10: 130,282,739 (GRCm39) L626F probably damaging Het
Vmn2r89 A G 14: 51,692,559 (GRCm39) T121A probably benign Het
Wdr64 T C 1: 175,622,706 (GRCm39) S828P possibly damaging Het
Zfp334 A T 2: 165,222,776 (GRCm39) H422Q probably damaging Het
Other mutations in Bid
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1331:Bid UTSW 6 120,874,216 (GRCm39) missense possibly damaging 0.82
R1333:Bid UTSW 6 120,874,216 (GRCm39) missense possibly damaging 0.82
R1335:Bid UTSW 6 120,874,216 (GRCm39) missense possibly damaging 0.82
R1760:Bid UTSW 6 120,877,209 (GRCm39) missense possibly damaging 0.65
R1930:Bid UTSW 6 120,874,216 (GRCm39) missense possibly damaging 0.82
R1932:Bid UTSW 6 120,874,216 (GRCm39) missense possibly damaging 0.82
R2152:Bid UTSW 6 120,877,215 (GRCm39) missense probably damaging 1.00
R4937:Bid UTSW 6 120,872,707 (GRCm39) missense probably benign 0.31
R7546:Bid UTSW 6 120,877,112 (GRCm39) splice site probably null
R8272:Bid UTSW 6 120,877,176 (GRCm39) missense probably damaging 1.00
R8303:Bid UTSW 6 120,877,200 (GRCm39) missense probably benign 0.00
Z1177:Bid UTSW 6 120,877,219 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGCAGTCAAGGACAGGGTTTACTTC -3'
(R):5'- CCGCAGCAGCAAGCATATAATCTGG -3'

Sequencing Primer
(F):5'- CCTGGGAAAGACTGGTTCGAC -3'
(R):5'- TCATGGTCCTCACTAGGGCAG -3'
Posted On 2014-02-11