Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00158:Nat8f4'

1568

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Nat8f4

Ensembl Gene

ENSMUSG00000068299

Gene Name

N-acetyltransferase 8 (GCN5-related) family member 4

Synonyms

1700019G17Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.078) question?

Stock #

IGL00158

Quality Score

Status

Chromosome

Chromosomal Location

85876033-85881866 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 85877969 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Serine at position 185 (A185S)

Ref Sequence

ENSEMBL: ENSMUSP00000093430 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095757] [ENSMUST00000159755]

AlphaFold

G5E8L3

Predicted Effect

probably benign
Transcript: ENSMUST00000095757
AA Change: A185S

PolyPhen 2 Score 0.048 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000093430
Gene: ENSMUSG00000068299
AA Change: A185S

Domain	Start	End	E-Value	Type
transmembrane domain	33	55	N/A	INTRINSIC
Pfam:Acetyltransf_10	75	192	2.5e-11	PFAM
Pfam:Acetyltransf_8	83	200	2.1e-11	PFAM
Pfam:Acetyltransf_7	104	194	3.3e-14	PFAM
Pfam:Acetyltransf_1	111	193	6.3e-17	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000159755

SMART Domains

Protein: ENSMUSP00000124071
Gene: ENSMUSG00000068299

Domain	Start	End	E-Value	Type
transmembrane domain	33	55	N/A	INTRINSIC
transmembrane domain	60	82	N/A	INTRINSIC
low complexity region	117	130	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abhd3	T	A	18: 10,647,869 (GRCm39)	D300V	possibly damaging	Het
Agap1	A	G	1: 89,591,518 (GRCm39)		probably benign	Het
Best3	A	G	10: 116,840,446 (GRCm39)		probably benign	Het
Cfap43	T	G	19: 47,818,914 (GRCm39)	I125L	probably benign	Het
Cntn1	A	G	15: 92,148,758 (GRCm39)	E335G	possibly damaging	Het
Csmd3	A	T	15: 48,150,891 (GRCm39)	S396T	possibly damaging	Het
Cxxc5	T	G	18: 35,993,745 (GRCm39)	*318G	probably null	Het
Dpep3	T	C	8: 106,705,779 (GRCm39)	T49A	probably benign	Het
Elf1	T	A	14: 79,817,789 (GRCm39)	M436K	possibly damaging	Het
Ephx2	T	G	14: 66,330,286 (GRCm39)	I310L	probably benign	Het
Fancm	A	G	12: 65,122,510 (GRCm39)	T11A	possibly damaging	Het
Ganab	G	T	19: 8,879,959 (GRCm39)	A73S	probably benign	Het
Glp1r	T	G	17: 31,120,891 (GRCm39)	L14R	possibly damaging	Het
Kif14	G	A	1: 136,396,756 (GRCm39)	S354N	probably benign	Het
Krtap9-1	C	T	11: 99,764,680 (GRCm39)	P139S	unknown	Het
L2hgdh	T	C	12: 69,748,208 (GRCm39)	D306G	possibly damaging	Het
Liat1	T	C	11: 75,894,192 (GRCm39)	S190P	probably benign	Het
Lrriq4	A	G	3: 30,705,104 (GRCm39)		probably null	Het
Mbd3	T	G	10: 80,229,717 (GRCm39)		probably benign	Het
Men1	G	A	19: 6,387,237 (GRCm39)		probably null	Het
Mug1	T	C	6: 121,842,768 (GRCm39)	S585P	probably damaging	Het
Nlrc5	C	T	8: 95,228,839 (GRCm39)		probably benign	Het
Or8b12	T	A	9: 37,657,685 (GRCm39)	I85N	possibly damaging	Het
Or8g23	T	A	9: 38,971,159 (GRCm39)	M268L	probably benign	Het
Peg3	T	A	7: 6,713,273 (GRCm39)	I650F	probably benign	Het
Prom1	A	T	5: 44,213,279 (GRCm39)	N142K	probably damaging	Het
Qser1	T	A	2: 104,596,401 (GRCm39)	D1537V	probably damaging	Het
Rbm44	T	A	1: 91,084,831 (GRCm39)	D684E	probably benign	Het
Rnf19a	A	C	15: 36,265,948 (GRCm39)	S50A	probably damaging	Het
Rnf31	A	G	14: 55,829,776 (GRCm39)		probably null	Het
Rspry1	A	G	8: 95,349,614 (GRCm39)	M1V	probably null	Het
Rspry1	A	T	8: 95,349,608 (GRCm39)		probably benign	Het
Sap130	C	A	18: 31,831,819 (GRCm39)	P769T	probably benign	Het
Slc22a16	T	A	10: 40,471,278 (GRCm39)	M483K	probably damaging	Het
Slc27a1	T	C	8: 72,037,416 (GRCm39)		probably null	Het
Slc35a5	A	T	16: 44,972,971 (GRCm39)	C65*	probably null	Het
Sox4	C	A	13: 29,136,956 (GRCm39)	G17W	probably damaging	Het
Ubqlnl	T	C	7: 103,798,372 (GRCm39)	E375G	probably benign	Het
Uggt2	G	A	14: 119,286,688 (GRCm39)	T692I	possibly damaging	Het
Vmn1r211	A	T	13: 23,036,272 (GRCm39)	C132S	probably benign	Het
Vmn2r61	A	T	7: 41,950,175 (GRCm39)	N865I	possibly damaging	Het
Vmn2r73	A	T	7: 85,506,795 (GRCm39)	M839K		Het
Xrn2	T	A	2: 146,878,670 (GRCm39)	S455R	probably benign	Het
Zan	T	A	5: 137,452,519 (GRCm39)	T1521S	unknown	Het
Zfp326	A	G	5: 106,054,911 (GRCm39)	M361V	possibly damaging	Het
Zfp472	A	G	17: 33,196,498 (GRCm39)	Y191C	possibly damaging	Het

Other mutations in Nat8f4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03072:Nat8f4	APN	6	85,877,836 (GRCm39)	intron	probably benign
R1341:Nat8f4	UTSW	6	85,878,406 (GRCm39)	missense	probably damaging	0.96
R1725:Nat8f4	UTSW	6	85,878,080 (GRCm39)	nonsense	probably null
R1923:Nat8f4	UTSW	6	85,878,497 (GRCm39)	missense	probably damaging	1.00
R2258:Nat8f4	UTSW	6	85,878,207 (GRCm39)	missense	possibly damaging	0.84
R3975:Nat8f4	UTSW	6	85,878,052 (GRCm39)	missense	possibly damaging	0.62
R4697:Nat8f4	UTSW	6	85,878,368 (GRCm39)	missense	probably benign	0.01
R4784:Nat8f4	UTSW	6	85,878,481 (GRCm39)	missense	probably benign	0.03
R4924:Nat8f4	UTSW	6	85,878,401 (GRCm39)	missense	probably benign	0.03
R4991:Nat8f4	UTSW	6	85,878,122 (GRCm39)	missense	probably benign	0.30
R6074:Nat8f4	UTSW	6	85,878,169 (GRCm39)	missense	probably damaging	0.98
R7058:Nat8f4	UTSW	6	85,878,271 (GRCm39)	missense	possibly damaging	0.73
R7790:Nat8f4	UTSW	6	85,877,873 (GRCm39)	missense	probably benign	0.00
R8079:Nat8f4	UTSW	6	85,877,976 (GRCm39)	missense	probably benign	0.25
R9782:Nat8f4	UTSW	6	85,878,052 (GRCm39)	missense	probably damaging	1.00

Posted On

2011-07-12