Mutagenetix > Incidental Mutation

Incidental Mutation 'R0041:Zfp1001'

15712

Institutional Source

Beutler Lab

Gene Symbol

Zfp1001

Ensembl Gene

ENSMUSG00000095315

Gene Name

zinc finger protein 1001

Synonyms

Gm10130

MMRRC Submission

038335-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.114) question?

Stock #

R0041 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

150153370-150168933 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 150165745 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 42 (I42V)

Ref Sequence

ENSEMBL: ENSMUSP00000117028 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000051153] [ENSMUST00000133235]

AlphaFold

A0A571BEN2

Predicted Effect

probably benign
Transcript: ENSMUST00000051153

SMART Domains

Protein: ENSMUSP00000055454
Gene: ENSMUSG00000063364

Domain	Start	End	E-Value	Type
KRAB	22	84	4.09e-20	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000124945

Predicted Effect

possibly damaging
Transcript: ENSMUST00000133235
AA Change: I42V

PolyPhen 2 Score 0.778 (Sensitivity: 0.85; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000117028
Gene: ENSMUSG00000095315
AA Change: I42V

Domain	Start	End	E-Value	Type
KRAB	3	66	4.56e-18	SMART

Meta Mutation Damage Score

0.1988

Coding Region Coverage

1x: 77.6%
3x: 65.6%
10x: 37.8%
20x: 19.1%

Validation Efficiency

90% (47/52)

Allele List at MGI

Other mutations in this stock

Total: 24 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgra3	A	G	5: 50,117,901 (GRCm39)	Y1216H	probably benign	Het
Avpi1	C	A	19: 42,112,223 (GRCm39)	E112*	probably null	Het
Braf	C	T	6: 39,617,413 (GRCm39)	A534T	probably damaging	Het
Cntnap5c	C	A	17: 58,183,464 (GRCm39)	Q57K	probably benign	Het
Dlk1	G	C	12: 109,421,439 (GRCm39)	G50A	probably damaging	Het
Dtna	C	T	18: 23,779,932 (GRCm39)		probably benign	Het
Fancm	T	A	12: 65,153,217 (GRCm39)	C1224*	probably null	Het
Gigyf2	A	C	1: 87,306,698 (GRCm39)	R129S	probably damaging	Het
Kcnk2	G	T	1: 189,027,888 (GRCm39)	N122K	probably benign	Het
Lrrc7	G	A	3: 157,869,897 (GRCm39)		probably benign	Het
Msto1	A	G	3: 88,817,542 (GRCm39)	S464P	probably damaging	Het
Myh1	A	C	11: 67,099,904 (GRCm39)	N605H	possibly damaging	Het
Olfml1	A	T	7: 107,189,393 (GRCm39)	I153L	possibly damaging	Het
Plekhg1	T	A	10: 3,914,074 (GRCm39)	N1265K	probably benign	Het
Prss59	A	T	6: 40,903,042 (GRCm39)	L110*	probably null	Het
Rlf	T	A	4: 121,007,126 (GRCm39)	H618L	probably damaging	Het
Rock1	T	C	18: 10,140,240 (GRCm39)	D117G	probably damaging	Het
Serpinb6d	A	G	13: 33,851,615 (GRCm39)	D124G	probably damaging	Het
Slco1a1	A	G	6: 141,864,185 (GRCm39)		probably benign	Het
Swap70	A	G	7: 109,878,562 (GRCm39)	K511E	probably benign	Het
Synb	T	C	14: 69,747,926 (GRCm39)	T193A	probably damaging	Het
Syt11	A	G	3: 88,655,210 (GRCm39)	Y364H	probably damaging	Het
Vcan	T	A	13: 89,810,104 (GRCm39)	H3229L	probably damaging	Het
Wdr64	G	A	1: 175,554,037 (GRCm39)	W189*	probably null	Het

Other mutations in Zfp1001

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02096:Zfp1001	APN	2	150,165,634 (GRCm39)	missense	probably damaging	1.00
R0109:Zfp1001	UTSW	2	150,165,761 (GRCm39)	splice site	probably benign
R5402:Zfp1001	UTSW	2	150,204,886 (GRCm39)	missense	probably benign	0.03
R5582:Zfp1001	UTSW	2	150,204,972 (GRCm39)	unclassified	probably benign
R6910:Zfp1001	UTSW	2	150,165,987 (GRCm39)	missense	probably benign	0.03
R8499:Zfp1001	UTSW	2	150,204,907 (GRCm39)	missense	probably benign	0.00
R9055:Zfp1001	UTSW	2	150,165,753 (GRCm39)	splice site	probably benign

Posted On

2012-12-21