Incidental Mutation 'R1328:Or9i14'
ID 157295
Institutional Source Beutler Lab
Gene Symbol Or9i14
Ensembl Gene ENSMUSG00000045395
Gene Name olfactory receptor family 9 subfamily I member 14
Synonyms GA_x6K02T2RE5P-4147744-4146800, Olfr1499, MOR211-2
MMRRC Submission 039394-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.280) question?
Stock # R1328 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 13792008-13792952 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 13792900 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 18 (T18I)
Ref Sequence ENSEMBL: ENSMUSP00000150330 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055672] [ENSMUST00000216659]
AlphaFold Q8VG65
Predicted Effect probably benign
Transcript: ENSMUST00000055672
AA Change: T18I

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000059747
Gene: ENSMUSG00000045395
AA Change: T18I

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 2.6e-44 PFAM
Pfam:7tm_1 41 290 1.5e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216659
AA Change: T18I

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 95.2%
  • 20x: 89.9%
Validation Efficiency 100% (37/37)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp4 C T 7: 43,906,516 (GRCm39) probably null Het
Bcap29 T C 12: 31,680,807 (GRCm39) I60V probably benign Het
Ccdc71 T A 9: 108,340,148 (GRCm39) probably benign Het
Ccnb1ip1 A T 14: 51,027,382 (GRCm39) V240E probably benign Het
Copa C T 1: 171,949,258 (GRCm39) probably benign Het
Dmxl2 G T 9: 54,303,533 (GRCm39) Q2314K probably benign Het
Fam181b T C 7: 92,729,437 (GRCm39) I70T probably damaging Het
Fbxl14 T C 6: 119,457,347 (GRCm39) L176P possibly damaging Het
Fip1l1 T A 5: 74,706,796 (GRCm39) F144L possibly damaging Het
Flnc T C 6: 29,438,612 (GRCm39) W169R probably damaging Het
H2-M3 T C 17: 37,581,925 (GRCm39) V127A possibly damaging Het
Il23r T A 6: 67,468,802 (GRCm39) probably benign Het
Krt18 C T 15: 101,939,169 (GRCm39) A251V probably benign Het
Mast1 A G 8: 85,644,617 (GRCm39) probably benign Het
Or6c202 A G 10: 128,996,293 (GRCm39) S187P possibly damaging Het
Pkhd1l1 T C 15: 44,361,392 (GRCm39) Y481H probably benign Het
Polr3e C T 7: 120,533,046 (GRCm39) probably benign Het
Pou4f2 G A 8: 79,162,759 (GRCm39) A92V probably benign Het
Pramel5 A G 4: 143,998,058 (GRCm39) L395P probably damaging Het
Prmt9 T C 8: 78,299,283 (GRCm39) I659T possibly damaging Het
Rin2 C T 2: 145,702,366 (GRCm39) T354I probably benign Het
Rrp36 T A 17: 46,983,705 (GRCm39) K36* probably null Het
Sag G A 1: 87,738,016 (GRCm39) probably benign Het
Setd7 T C 3: 51,450,240 (GRCm39) Y62C possibly damaging Het
Smr2 AT ATT 5: 88,256,683 (GRCm39) probably null Het
Sox13 T C 1: 133,311,555 (GRCm39) D559G probably damaging Het
Srd5a1 T A 13: 69,723,310 (GRCm39) Y236F probably damaging Het
Stxbp2 A T 8: 3,692,657 (GRCm39) I570F possibly damaging Het
Tbc1d31 T C 15: 57,805,859 (GRCm39) probably benign Het
Trim33 A G 3: 103,260,913 (GRCm39) T1064A possibly damaging Het
Vmn1r8 T C 6: 57,013,278 (GRCm39) S110P possibly damaging Het
Vmn2r118 C A 17: 55,915,620 (GRCm39) M443I probably benign Het
Other mutations in Or9i14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01534:Or9i14 APN 19 13,792,666 (GRCm39) missense probably benign 0.09
IGL01844:Or9i14 APN 19 13,792,180 (GRCm39) missense possibly damaging 0.95
IGL03102:Or9i14 APN 19 13,792,735 (GRCm39) missense probably damaging 1.00
IGL03352:Or9i14 APN 19 13,792,292 (GRCm39) missense probably damaging 1.00
R0218:Or9i14 UTSW 19 13,792,342 (GRCm39) missense probably benign 0.19
R0490:Or9i14 UTSW 19 13,792,219 (GRCm39) missense probably damaging 1.00
R0682:Or9i14 UTSW 19 13,792,501 (GRCm39) missense possibly damaging 0.94
R1301:Or9i14 UTSW 19 13,792,726 (GRCm39) missense probably damaging 1.00
R2100:Or9i14 UTSW 19 13,792,600 (GRCm39) missense possibly damaging 0.95
R3701:Or9i14 UTSW 19 13,792,712 (GRCm39) missense probably benign 0.03
R4563:Or9i14 UTSW 19 13,792,646 (GRCm39) missense probably benign 0.01
R4709:Or9i14 UTSW 19 13,792,814 (GRCm39) missense possibly damaging 0.94
R5231:Or9i14 UTSW 19 13,792,711 (GRCm39) missense probably damaging 0.99
R5301:Or9i14 UTSW 19 13,792,933 (GRCm39) missense probably damaging 0.99
R5343:Or9i14 UTSW 19 13,792,324 (GRCm39) missense probably damaging 1.00
R6268:Or9i14 UTSW 19 13,792,671 (GRCm39) nonsense probably null
R6442:Or9i14 UTSW 19 13,792,992 (GRCm39) start gained probably benign
R7132:Or9i14 UTSW 19 13,792,786 (GRCm39) missense probably benign 0.09
R7764:Or9i14 UTSW 19 13,792,111 (GRCm39) missense probably benign 0.01
R7943:Or9i14 UTSW 19 13,792,600 (GRCm39) missense probably damaging 0.99
R8703:Or9i14 UTSW 19 13,792,105 (GRCm39) missense probably damaging 1.00
R8736:Or9i14 UTSW 19 13,792,358 (GRCm39) missense probably benign 0.05
R9069:Or9i14 UTSW 19 13,792,735 (GRCm39) missense probably damaging 1.00
R9177:Or9i14 UTSW 19 13,792,388 (GRCm39) missense probably damaging 1.00
R9258:Or9i14 UTSW 19 13,792,099 (GRCm39) nonsense probably null
R9268:Or9i14 UTSW 19 13,792,388 (GRCm39) missense probably damaging 1.00
Z1088:Or9i14 UTSW 19 13,792,912 (GRCm39) missense probably damaging 1.00
Z1177:Or9i14 UTSW 19 13,792,408 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTGTAGCAGGCATCCAACACAGAG -3'
(R):5'- TGCAAGCACAAAAGTGGCATCTTC -3'

Sequencing Primer
(F):5'- TCCAACACAGAGAGATGACTCAG -3'
(R):5'- TTCCCCAAACCTGAGGATTATC -3'
Posted On 2014-02-18