Incidental Mutation 'R1371:Or2y1'
ID 157326
Institutional Source Beutler Lab
Gene Symbol Or2y1
Ensembl Gene ENSMUSG00000059729
Gene Name olfactory receptor family 2 subfamily Y member 1
Synonyms Olfr1385, Olfr1549-ps1, MOR256-42P, MOR256-42P, GA_x6K02T2QP88-5941817-5940888, MOR256-41P
MMRRC Submission 039435-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.117) question?
Stock # R1371 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 49385362-49386291 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 49385650 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 97 (C97S)
Ref Sequence ENSEMBL: ENSMUSP00000150035 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071807] [ENSMUST00000214948]
AlphaFold Q7TQT1
Predicted Effect probably damaging
Transcript: ENSMUST00000071807
AA Change: C97S

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000071710
Gene: ENSMUSG00000059729
AA Change: C97S

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 2.1e-46 PFAM
Pfam:7TM_GPCR_Srsx 35 214 9.5e-6 PFAM
Pfam:7tm_1 41 289 2.8e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214948
AA Change: C97S

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216450
Meta Mutation Damage Score 0.8279 question?
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.7%
  • 10x: 94.7%
  • 20x: 89.0%
Validation Efficiency 100% (55/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b T A 11: 109,844,379 (GRCm39) D884V probably damaging Het
Acvr2a C T 2: 48,789,628 (GRCm39) T457M probably damaging Het
Akr1b10 C T 6: 34,369,394 (GRCm39) T208I probably benign Het
Aldh16a1 G T 7: 44,796,674 (GRCm39) T275K possibly damaging Het
Alkbh2 C T 5: 114,262,287 (GRCm39) E148K probably damaging Het
Asgr1 T G 11: 69,946,923 (GRCm39) C56W probably benign Het
Atp11b T C 3: 35,860,918 (GRCm39) I335T probably damaging Het
BC061237 A G 14: 44,741,762 (GRCm39) probably benign Het
Bdh1 G T 16: 31,275,720 (GRCm39) K280N probably benign Het
Bmp1 C T 14: 70,729,906 (GRCm39) C466Y probably damaging Het
Ccdc181 A G 1: 164,108,172 (GRCm39) E285G probably benign Het
Ces1f C T 8: 94,006,277 (GRCm39) G18R probably damaging Het
Cfap43 T A 19: 47,824,045 (GRCm39) I109L possibly damaging Het
Cma2 T C 14: 56,210,283 (GRCm39) L56S probably damaging Het
Edc4 A G 8: 106,617,382 (GRCm39) probably benign Het
F3 T C 3: 121,526,159 (GRCm39) C241R probably damaging Het
Fhdc1 T A 3: 84,352,310 (GRCm39) S972C probably damaging Het
Heatr1 T G 13: 12,432,513 (GRCm39) I1086R possibly damaging Het
Hsh2d A T 8: 72,950,738 (GRCm39) probably benign Het
Ice1 T C 13: 70,744,340 (GRCm39) Y2081C probably damaging Het
Il1rl1 A G 1: 40,481,873 (GRCm39) N194D probably damaging Het
Ip6k1 G A 9: 107,923,022 (GRCm39) V385M probably damaging Het
Lig1 G A 7: 13,022,611 (GRCm39) R147Q probably damaging Het
Lrp1b C T 2: 40,537,165 (GRCm39) V41I probably damaging Het
Macroh2a2 A T 10: 61,585,112 (GRCm39) D177E possibly damaging Het
Mst1r T A 9: 107,794,424 (GRCm39) V1201E probably damaging Het
Myof T C 19: 37,892,116 (GRCm39) probably benign Het
Nbas G T 12: 13,532,379 (GRCm39) probably benign Het
Ndst1 A G 18: 60,840,719 (GRCm39) I321T possibly damaging Het
Nek10 G A 14: 14,850,983 (GRCm38) G343R probably damaging Het
Or2a7 A T 6: 43,151,234 (GRCm39) T105S probably benign Het
Or4d2b A T 11: 87,780,122 (GRCm39) I200N probably damaging Het
Pde4d T C 13: 109,253,595 (GRCm39) S141P probably benign Het
Pigm A T 1: 172,204,381 (GRCm39) Q39L probably damaging Het
Prl7a2 T A 13: 27,846,750 (GRCm39) I88F probably benign Het
Prss16 T A 13: 22,192,856 (GRCm39) probably benign Het
Psmc4 G A 7: 27,742,222 (GRCm39) probably benign Het
Ptger3 T A 3: 157,273,365 (GRCm39) C237* probably null Het
Recql G A 6: 142,318,601 (GRCm39) T214M probably damaging Het
Rfx7 T A 9: 72,526,857 (GRCm39) V1349D probably damaging Het
Ros1 A G 10: 51,964,041 (GRCm39) S1740P probably damaging Het
Rrm2b A T 15: 37,947,053 (GRCm39) S83T probably benign Het
Sall4 A G 2: 168,598,394 (GRCm39) Y149H probably benign Het
Smad1 A G 8: 80,076,207 (GRCm39) probably benign Het
Snrnp70 T C 7: 45,030,129 (GRCm39) probably benign Het
Spef2 C A 15: 9,725,194 (GRCm39) probably benign Het
Sptlc1 T C 13: 53,505,660 (GRCm39) T253A probably benign Het
Zbbx T C 3: 74,959,784 (GRCm39) Y595C possibly damaging Het
Zfp382 T C 7: 29,833,114 (GRCm39) V255A probably benign Het
Other mutations in Or2y1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01722:Or2y1 APN 11 49,385,793 (GRCm39) missense probably damaging 0.99
IGL02098:Or2y1 APN 11 49,386,224 (GRCm39) missense probably damaging 1.00
IGL03206:Or2y1 APN 11 49,385,536 (GRCm39) missense probably benign 0.05
IGL03402:Or2y1 APN 11 49,385,873 (GRCm39) missense probably benign
R0412:Or2y1 UTSW 11 49,385,594 (GRCm39) missense probably damaging 1.00
R1263:Or2y1 UTSW 11 49,385,848 (GRCm39) missense probably benign
R1488:Or2y1 UTSW 11 49,385,945 (GRCm39) missense probably benign 0.07
R1835:Or2y1 UTSW 11 49,385,497 (GRCm39) missense probably damaging 1.00
R1923:Or2y1 UTSW 11 49,386,131 (GRCm39) missense probably damaging 0.97
R2290:Or2y1 UTSW 11 49,385,857 (GRCm39) missense probably benign
R3738:Or2y1 UTSW 11 49,386,287 (GRCm39) missense possibly damaging 0.56
R3739:Or2y1 UTSW 11 49,386,287 (GRCm39) missense possibly damaging 0.56
R4034:Or2y1 UTSW 11 49,386,287 (GRCm39) missense possibly damaging 0.56
R4193:Or2y1 UTSW 11 49,386,134 (GRCm39) missense probably damaging 1.00
R4406:Or2y1 UTSW 11 49,385,744 (GRCm39) missense probably benign 0.01
R5239:Or2y1 UTSW 11 49,385,555 (GRCm39) missense possibly damaging 0.93
R6713:Or2y1 UTSW 11 49,385,784 (GRCm39) missense probably damaging 1.00
R6861:Or2y1 UTSW 11 49,385,632 (GRCm39) missense probably benign 0.00
R7916:Or2y1 UTSW 11 49,385,543 (GRCm39) missense probably benign
R8712:Or2y1 UTSW 11 49,385,671 (GRCm39) missense probably benign
R9509:Or2y1 UTSW 11 49,385,476 (GRCm39) missense probably benign
R9624:Or2y1 UTSW 11 49,385,834 (GRCm39) missense possibly damaging 0.94
R9793:Or2y1 UTSW 11 49,385,882 (GRCm39) missense probably damaging 1.00
R9795:Or2y1 UTSW 11 49,385,882 (GRCm39) missense probably damaging 1.00
Z1176:Or2y1 UTSW 11 49,385,894 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CATCATCGCTCTCTCCCAAATGGAC -3'
(R):5'- GCCAACTTGAGGAAGACAGGCATC -3'

Sequencing Primer
(F):5'- ATGGACCTTCGACTGCAC -3'
(R):5'- TTCAGTCGATGTCCACAGAG -3'
Posted On 2014-02-18