Incidental Mutation 'P0041:Olfr351'
ID15733
Institutional Source Beutler Lab
Gene Symbol Olfr351
Ensembl Gene ENSMUSG00000075383
Gene Nameolfactory receptor 351
SynonymsMOR127-2, GA_x6K02T2NLDC-33554926-33553994
MMRRC Submission 038289-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.085) question?
Stock #P0041 (G1)
Quality Score
Status Validated
Chromosome2
Chromosomal Location36857539-36862660 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 36859461 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Glutamic Acid at position 296 (K296E)
Ref Sequence ENSEMBL: ENSMUSP00000150346 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100150] [ENSMUST00000213676] [ENSMUST00000215137]
Predicted Effect probably damaging
Transcript: ENSMUST00000100150
AA Change: K296E

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000097727
Gene: ENSMUSG00000075383
AA Change: K296E

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 2.7e-56 PFAM
Pfam:7tm_1 39 288 5.3e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213676
AA Change: K296E

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000215137
AA Change: K296E

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Meta Mutation Damage Score 0.198 question?
Coding Region Coverage
  • 1x: 86.7%
  • 3x: 79.7%
  • 10x: 43.1%
  • 20x: 3.5%
Validation Efficiency 96% (69/72)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap1 A G 2: 91,669,393 E291G probably benign Het
Atg5 A C 10: 44,289,942 E63A probably benign Het
Clec4b2 A G 6: 123,181,294 T40A possibly damaging Het
Colgalt1 A G 8: 71,622,790 M447V probably benign Het
Enpep T C 3: 129,332,198 D95G possibly damaging Het
Epha3 C A 16: 63,612,868 E170D probably damaging Het
Gm9900 A T 11: 58,329,583 Y63* probably null Het
Gtf2i C T 5: 134,244,888 probably benign Het
Klhl1 T A 14: 96,280,211 N343I probably damaging Het
Large2 A G 2: 92,367,254 probably benign Het
Mobp G A 9: 120,168,017 probably benign Het
Nek10 A T 14: 14,861,603 H553L probably benign Het
Nploc4 A T 11: 120,418,331 D148E probably damaging Het
Ppp1r3a A G 6: 14,719,697 I406T probably benign Het
Slc9c1 T A 16: 45,550,161 M255K possibly damaging Het
Synrg C T 11: 83,982,311 probably benign Het
Trak2 A G 1: 58,909,964 V559A probably damaging Het
Trpm3 A G 19: 22,897,686 D552G probably benign Het
Wdr63 G A 3: 146,081,242 S346F possibly damaging Het
Other mutations in Olfr351
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01962:Olfr351 APN 2 36859775 missense probably benign 0.04
IGL02481:Olfr351 APN 2 36859818 missense probably damaging 0.96
IGL02673:Olfr351 APN 2 36860176 missense probably benign 0.25
IGL02754:Olfr351 APN 2 36860220 missense probably damaging 1.00
R1392:Olfr351 UTSW 2 36860175 missense probably damaging 1.00
R1392:Olfr351 UTSW 2 36860175 missense probably damaging 1.00
R2271:Olfr351 UTSW 2 36859625 missense probably damaging 1.00
R2274:Olfr351 UTSW 2 36860101 missense probably damaging 0.99
R3053:Olfr351 UTSW 2 36859947 missense probably benign 0.06
R4712:Olfr351 UTSW 2 36860369 splice site probably null
R5001:Olfr351 UTSW 2 36860070 missense probably benign 0.00
R5364:Olfr351 UTSW 2 36859994 missense probably damaging 1.00
R5502:Olfr351 UTSW 2 36860270 missense probably damaging 0.98
R6048:Olfr351 UTSW 2 36859841 missense probably benign 0.00
R6401:Olfr351 UTSW 2 36860165 nonsense probably null
R7353:Olfr351 UTSW 2 36859668 nonsense probably null
Posted On2012-12-21