Incidental Mutation 'R1373:Vmn1r11'
ID 157401
Institutional Source Beutler Lab
Gene Symbol Vmn1r11
Ensembl Gene ENSMUSG00000115236
Gene Name vomeronasal 1 receptor 11
Synonyms V1rc3
MMRRC Submission 039437-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.104) question?
Stock # R1373 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 57114338-57115237 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 57114963 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 209 (C209Y)
Ref Sequence ENSEMBL: ENSMUSP00000154588 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071304] [ENSMUST00000176954] [ENSMUST00000226968] [ENSMUST00000228235]
AlphaFold Q3SXA2
Predicted Effect probably benign
Transcript: ENSMUST00000071304
AA Change: C209Y

PolyPhen 2 Score 0.232 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000071272
Gene: ENSMUSG00000115236
AA Change: C209Y

DomainStartEndE-ValueType
Pfam:V1R 28 293 4.5e-56 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000176954
AA Change: C209Y

PolyPhen 2 Score 0.232 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000135192
Gene: ENSMUSG00000093635
AA Change: C209Y

DomainStartEndE-ValueType
Pfam:V1R 28 293 9.7e-59 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226968
AA Change: C209Y

PolyPhen 2 Score 0.232 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000228235
AA Change: C172Y

PolyPhen 2 Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 95.2%
Validation Efficiency 94% (34/36)
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamdec1 G A 14: 68,808,400 (GRCm39) R317C probably damaging Het
Adgrl1 T C 8: 84,664,392 (GRCm39) V1261A probably benign Het
Btla G A 16: 45,044,783 (GRCm39) G23D probably benign Het
Card19 T C 13: 49,357,440 (GRCm39) D110G probably damaging Het
Cbx7 C T 15: 79,803,074 (GRCm39) G160R probably damaging Het
Ccng2 C T 5: 93,418,914 (GRCm39) probably benign Het
Col4a3 G A 1: 82,667,808 (GRCm39) probably benign Het
Colgalt2 A G 1: 152,348,912 (GRCm39) T186A probably damaging Het
Cps1 A G 1: 67,268,583 (GRCm39) N1437S possibly damaging Het
Dcaf1 A G 9: 106,735,079 (GRCm39) I676V probably benign Het
Dnah5 T A 15: 28,314,064 (GRCm39) probably benign Het
Dock1 T C 7: 134,768,904 (GRCm39) S1758P probably benign Het
Furin C T 7: 80,041,932 (GRCm39) probably benign Het
Ice2 G A 9: 69,314,401 (GRCm39) R50H probably benign Het
Ifi207 T A 1: 173,557,913 (GRCm39) D275V unknown Het
Nrxn2 C T 19: 6,522,331 (GRCm39) T190M probably damaging Het
Odad4 T C 11: 100,436,658 (GRCm39) F11S probably damaging Het
Or14j8 T C 17: 38,263,251 (GRCm39) I221M probably damaging Het
Or2ag17 C T 7: 106,389,963 (GRCm39) V82I probably benign Het
Pcnx3 A G 19: 5,715,544 (GRCm39) L1494P probably damaging Het
Pitrm1 G T 13: 6,620,736 (GRCm39) M739I probably benign Het
Rbm15 G T 3: 107,239,946 (GRCm39) R151S possibly damaging Het
Sfr1 C G 19: 47,723,355 (GRCm39) D286E possibly damaging Het
Slx4 A G 16: 3,803,374 (GRCm39) S1147P probably benign Het
Sry C G Y: 2,662,864 (GRCm39) Q265H unknown Het
Tgfbr3 T C 5: 107,362,809 (GRCm39) I68V probably benign Het
Tpmt A C 13: 47,180,734 (GRCm39) probably null Het
Trpm5 A G 7: 142,640,579 (GRCm39) probably benign Het
Txlnb A G 10: 17,714,695 (GRCm39) T376A probably damaging Het
Usp25 T C 16: 76,859,273 (GRCm39) probably benign Het
Vps13c A T 9: 67,834,793 (GRCm39) K1707N probably damaging Het
Other mutations in Vmn1r11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02134:Vmn1r11 APN 6 57,115,022 (GRCm39) missense possibly damaging 0.66
IGL02141:Vmn1r11 APN 6 57,114,364 (GRCm39) nonsense probably null
IGL03147:Vmn1r11 UTSW 6 57,114,650 (GRCm39) missense probably damaging 0.98
R0908:Vmn1r11 UTSW 6 57,115,049 (GRCm39) missense probably damaging 1.00
R1185:Vmn1r11 UTSW 6 57,114,492 (GRCm39) missense possibly damaging 0.89
R1185:Vmn1r11 UTSW 6 57,114,492 (GRCm39) missense possibly damaging 0.89
R1185:Vmn1r11 UTSW 6 57,114,492 (GRCm39) missense possibly damaging 0.89
R1347:Vmn1r11 UTSW 6 57,114,963 (GRCm39) missense probably benign 0.23
R1347:Vmn1r11 UTSW 6 57,114,963 (GRCm39) missense probably benign 0.23
R1348:Vmn1r11 UTSW 6 57,114,963 (GRCm39) missense probably benign 0.23
R1349:Vmn1r11 UTSW 6 57,114,963 (GRCm39) missense probably benign 0.23
R1497:Vmn1r11 UTSW 6 57,114,394 (GRCm39) missense probably damaging 1.00
R2147:Vmn1r11 UTSW 6 57,114,583 (GRCm39) missense probably benign 0.29
R2367:Vmn1r11 UTSW 6 57,114,416 (GRCm39) missense probably benign 0.00
R3087:Vmn1r11 UTSW 6 57,114,691 (GRCm39) missense possibly damaging 0.94
R4445:Vmn1r11 UTSW 6 57,114,515 (GRCm39) missense probably benign 0.31
R4667:Vmn1r11 UTSW 6 57,114,483 (GRCm39) missense probably damaging 1.00
R4769:Vmn1r11 UTSW 6 57,114,597 (GRCm39) missense probably damaging 1.00
R5513:Vmn1r11 UTSW 6 57,114,617 (GRCm39) missense probably damaging 0.97
R5841:Vmn1r11 UTSW 6 57,114,787 (GRCm39) missense probably damaging 1.00
R6089:Vmn1r11 UTSW 6 57,114,645 (GRCm39) missense possibly damaging 0.95
R7155:Vmn1r11 UTSW 6 57,115,147 (GRCm39) missense probably benign 0.07
R7359:Vmn1r11 UTSW 6 57,115,184 (GRCm39) missense probably damaging 1.00
R8846:Vmn1r11 UTSW 6 57,114,807 (GRCm39) missense probably benign 0.19
R9222:Vmn1r11 UTSW 6 57,114,992 (GRCm39) missense possibly damaging 0.94
R9300:Vmn1r11 UTSW 6 57,114,872 (GRCm39) missense probably benign 0.00
R9517:Vmn1r11 UTSW 6 57,114,555 (GRCm39) missense possibly damaging 0.88
Predicted Primers PCR Primer
(F):5'- CCCAATACCTCGCTGTTGGCAAA -3'
(R):5'- GTCAGGATGACTGGGTCATACATCCAT -3'

Sequencing Primer
(F):5'- GTGCTTATACCAATGTGAGTGAGAC -3'
(R):5'- TGGGTCATACATCCATAACAGG -3'
Posted On 2014-02-18