Incidental Mutation 'R1311:Zmym6'
ID 157927
Institutional Source Beutler Lab
Gene Symbol Zmym6
Ensembl Gene ENSMUSG00000042408
Gene Name zinc finger, MYM-type 6
Synonyms 9330177P20Rik, Zfp258, D4Wsu24e
MMRRC Submission 039377-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1311 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 126971176-127018165 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 127017151 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 977 (L977F)
Ref Sequence ENSEMBL: ENSMUSP00000045366 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046751] [ENSMUST00000094712] [ENSMUST00000094713] [ENSMUST00000106097]
AlphaFold Q8BS54
Predicted Effect probably damaging
Transcript: ENSMUST00000046751
AA Change: L977F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000045366
Gene: ENSMUSG00000042408
AA Change: L977F

DomainStartEndE-ValueType
Blast:TRASH 77 113 1e-12 BLAST
TRASH 123 163 1.18e-1 SMART
TRASH 197 231 5.47e3 SMART
TRASH 241 277 4.01e1 SMART
TRASH 349 385 2.46e1 SMART
TRASH 391 426 3.32e2 SMART
TRASH 434 472 2.91e-1 SMART
TRASH 478 513 9.99e0 SMART
low complexity region 602 612 N/A INTRINSIC
low complexity region 642 656 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000094712
SMART Domains Protein: ENSMUSP00000092302
Gene: ENSMUSG00000070737

DomainStartEndE-ValueType
Pfam:DoxX 5 103 9e-9 PFAM
Pfam:DoxX_2 7 124 4.8e-15 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000094713
AA Change: L885F

PolyPhen 2 Score 0.679 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000092303
Gene: ENSMUSG00000042408
AA Change: L885F

DomainStartEndE-ValueType
Blast:TRASH 77 113 1e-12 BLAST
TRASH 123 163 1.18e-1 SMART
TRASH 197 231 5.47e3 SMART
TRASH 262 293 6.03e2 SMART
TRASH 299 334 3.32e2 SMART
TRASH 342 380 2.91e-1 SMART
TRASH 386 421 9.99e0 SMART
low complexity region 510 520 N/A INTRINSIC
low complexity region 550 564 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000106097
SMART Domains Protein: ENSMUSP00000101703
Gene: ENSMUSG00000070737

DomainStartEndE-ValueType
Pfam:DoxX_2 27 111 8.1e-12 PFAM
Meta Mutation Damage Score 0.2294 question?
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.7%
  • 10x: 94.1%
  • 20x: 86.2%
Validation Efficiency 98% (42/43)
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acvr1c T C 2: 58,170,261 (GRCm39) Q449R probably benign Het
Cap1 A G 4: 122,759,007 (GRCm39) Y195H possibly damaging Het
Casp8ap2 T A 4: 32,648,111 (GRCm39) N1939K probably damaging Het
Cd209c T A 8: 3,995,908 (GRCm39) M1L probably benign Het
Ckb TCCACCACCA TCCACCA 12: 111,636,079 (GRCm39) probably benign Het
Col13a1 A G 10: 61,699,789 (GRCm39) probably benign Het
Dennd4a T C 9: 64,817,286 (GRCm39) V1640A probably benign Het
Eml6 T C 11: 29,781,088 (GRCm39) probably benign Het
Fat3 G A 9: 15,932,706 (GRCm39) T1409I probably damaging Het
Gm4884 G C 7: 40,692,539 (GRCm39) E169D possibly damaging Het
Gm5709 T C 3: 59,526,100 (GRCm39) noncoding transcript Het
Htr2b C A 1: 86,038,346 (GRCm39) A87S probably damaging Het
Kansl2 G T 15: 98,426,797 (GRCm39) H275N possibly damaging Het
Megf6 G A 4: 154,348,239 (GRCm39) probably null Het
Mtpn A G 6: 35,489,185 (GRCm39) I113T possibly damaging Het
Myh6 G T 14: 55,183,822 (GRCm39) A1704E probably damaging Het
Notum C T 11: 120,546,575 (GRCm39) probably benign Het
Nxpe2 T C 9: 48,237,914 (GRCm39) T114A probably damaging Het
Olfml1 T C 7: 107,167,103 (GRCm39) probably null Het
Or14c41 T A 7: 86,235,161 (GRCm39) V226D probably damaging Het
Ptpn5 A T 7: 46,728,980 (GRCm39) probably benign Het
Rapgef2 A G 3: 78,990,854 (GRCm39) F985L probably benign Het
Slc7a7 A T 14: 54,610,487 (GRCm39) Y386* probably null Het
Snph G T 2: 151,439,122 (GRCm39) P36Q probably damaging Het
St18 T C 1: 6,915,868 (GRCm39) C838R probably damaging Het
Sucla2 C T 14: 73,798,074 (GRCm39) probably benign Het
Supt7l T C 5: 31,677,605 (GRCm39) Y187C probably damaging Het
Sycp2l A T 13: 41,288,661 (GRCm39) K241* probably null Het
Tenm2 G T 11: 35,959,421 (GRCm39) probably benign Het
Tfap4 A G 16: 4,377,290 (GRCm39) probably null Het
Tmem132e T C 11: 82,335,122 (GRCm39) Y643H probably damaging Het
Tmem200c A T 17: 69,147,758 (GRCm39) S114C probably damaging Het
Ush2a T C 1: 188,679,342 (GRCm39) I4850T possibly damaging Het
Other mutations in Zmym6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00430:Zmym6 APN 4 126,995,742 (GRCm39) nonsense probably null
IGL00486:Zmym6 APN 4 127,017,978 (GRCm39) utr 5 prime probably benign
IGL01017:Zmym6 APN 4 126,982,152 (GRCm39) missense probably benign 0.00
IGL01385:Zmym6 APN 4 127,017,899 (GRCm39) missense probably benign 0.02
IGL01577:Zmym6 APN 4 126,999,223 (GRCm39) missense probably damaging 1.00
IGL01654:Zmym6 APN 4 127,017,519 (GRCm39) missense probably damaging 1.00
IGL01736:Zmym6 APN 4 127,002,437 (GRCm39) missense probably damaging 1.00
IGL01824:Zmym6 APN 4 127,002,499 (GRCm39) missense probably damaging 0.99
IGL01916:Zmym6 APN 4 127,017,549 (GRCm39) missense probably damaging 0.98
IGL01985:Zmym6 APN 4 126,994,541 (GRCm39) missense probably damaging 1.00
IGL02056:Zmym6 APN 4 126,997,207 (GRCm39) missense probably damaging 1.00
IGL02477:Zmym6 APN 4 126,972,295 (GRCm39) nonsense probably null
IGL02754:Zmym6 APN 4 127,003,764 (GRCm39) splice site probably benign
IGL03344:Zmym6 APN 4 127,014,314 (GRCm39) missense probably damaging 1.00
IGL03412:Zmym6 APN 4 126,986,731 (GRCm39) missense probably damaging 1.00
R0335:Zmym6 UTSW 4 127,016,601 (GRCm39) missense probably damaging 1.00
R0448:Zmym6 UTSW 4 127,002,487 (GRCm39) missense probably benign 0.01
R0463:Zmym6 UTSW 4 127,016,565 (GRCm39) missense probably damaging 0.98
R0538:Zmym6 UTSW 4 127,017,162 (GRCm39) missense probably benign 0.21
R0789:Zmym6 UTSW 4 127,016,615 (GRCm39) missense possibly damaging 0.52
R0798:Zmym6 UTSW 4 126,997,316 (GRCm39) missense probably benign 0.00
R1351:Zmym6 UTSW 4 127,016,798 (GRCm39) missense probably benign 0.00
R1429:Zmym6 UTSW 4 127,017,672 (GRCm39) missense probably damaging 1.00
R1636:Zmym6 UTSW 4 127,017,560 (GRCm39) missense probably damaging 0.99
R1666:Zmym6 UTSW 4 127,016,652 (GRCm39) missense probably damaging 0.98
R1919:Zmym6 UTSW 4 126,997,207 (GRCm39) missense probably damaging 1.00
R2058:Zmym6 UTSW 4 126,982,208 (GRCm39) nonsense probably null
R3957:Zmym6 UTSW 4 127,017,089 (GRCm39) missense possibly damaging 0.68
R3978:Zmym6 UTSW 4 127,017,348 (GRCm39) missense possibly damaging 0.71
R4417:Zmym6 UTSW 4 126,986,781 (GRCm39) missense probably damaging 1.00
R4801:Zmym6 UTSW 4 127,017,009 (GRCm39) missense probably benign 0.19
R4802:Zmym6 UTSW 4 127,017,009 (GRCm39) missense probably benign 0.19
R5052:Zmym6 UTSW 4 127,017,767 (GRCm39) missense possibly damaging 0.92
R5105:Zmym6 UTSW 4 127,017,551 (GRCm39) missense probably benign 0.33
R5217:Zmym6 UTSW 4 126,999,167 (GRCm39) missense possibly damaging 0.76
R5682:Zmym6 UTSW 4 126,998,200 (GRCm39) missense probably damaging 1.00
R5841:Zmym6 UTSW 4 126,994,463 (GRCm39) missense possibly damaging 0.71
R5991:Zmym6 UTSW 4 127,002,266 (GRCm39) splice site probably null
R6478:Zmym6 UTSW 4 127,017,176 (GRCm39) missense possibly damaging 0.86
R7014:Zmym6 UTSW 4 127,017,337 (GRCm39) nonsense probably null
R7287:Zmym6 UTSW 4 127,016,775 (GRCm39) missense possibly damaging 0.50
R7290:Zmym6 UTSW 4 127,017,294 (GRCm39) missense possibly damaging 0.73
R7371:Zmym6 UTSW 4 126,998,106 (GRCm39) missense probably damaging 1.00
R7967:Zmym6 UTSW 4 127,016,453 (GRCm39) missense probably benign 0.03
R8237:Zmym6 UTSW 4 127,016,544 (GRCm39) missense probably damaging 0.99
R8306:Zmym6 UTSW 4 127,016,355 (GRCm39) missense probably damaging 1.00
R8312:Zmym6 UTSW 4 127,017,627 (GRCm39) missense probably damaging 1.00
R9090:Zmym6 UTSW 4 127,017,854 (GRCm39) missense probably damaging 0.99
R9216:Zmym6 UTSW 4 127,002,500 (GRCm39) missense probably benign 0.00
R9271:Zmym6 UTSW 4 127,017,854 (GRCm39) missense probably damaging 0.99
R9695:Zmym6 UTSW 4 127,016,340 (GRCm39) missense probably benign
X0025:Zmym6 UTSW 4 127,016,143 (GRCm39) missense possibly damaging 0.60
X0067:Zmym6 UTSW 4 126,998,107 (GRCm39) missense probably damaging 1.00
Z1177:Zmym6 UTSW 4 127,017,590 (GRCm39) missense not run
Predicted Primers
Posted On 2014-02-18