Incidental Mutation 'R1312:Vmn1r167'
| ID |
157964 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r167
|
| Ensembl Gene |
ENSMUSG00000090715 |
| Gene Name |
vomeronasal 1 receptor 167 |
| Synonyms |
Gm6279 |
| MMRRC Submission |
039378-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.054)
|
| Stock # |
R1312 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
23204067-23205014 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 23204548 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Serine
at position 156
(F156S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153774
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164527]
[ENSMUST00000227713]
|
| AlphaFold |
G3UW71 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164527
AA Change: F156S
PolyPhen 2
Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000129193
Gene: ENSMUSG00000090715
AA Change: F156S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
19 |
307 |
1.5e-13 |
PFAM |
|
Pfam:7tm_1
|
41 |
299 |
3.8e-6 |
PFAM |
|
Pfam:V1R
|
52 |
306 |
2.1e-18 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227713
AA Change: F156S
PolyPhen 2
Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 98.8%
- 3x: 97.7%
- 10x: 94.0%
- 20x: 85.7%
|
| Validation Efficiency |
98% (41/42) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 35 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4921539E11Rik |
A |
T |
4: 103,127,994 (GRCm39) |
F44I |
probably damaging |
Het |
| Acot10 |
A |
G |
15: 20,666,585 (GRCm39) |
V52A |
probably benign |
Het |
| Arhgap32 |
T |
C |
9: 32,166,608 (GRCm39) |
V415A |
probably benign |
Het |
| Cacna2d3 |
T |
C |
14: 28,767,625 (GRCm39) |
D750G |
probably benign |
Het |
| Cdh15 |
G |
A |
8: 123,588,188 (GRCm39) |
|
probably benign |
Het |
| Edem2 |
T |
G |
2: 155,544,505 (GRCm39) |
D415A |
probably damaging |
Het |
| Eml6 |
A |
G |
11: 29,781,219 (GRCm39) |
|
probably benign |
Het |
| Ercc5 |
T |
C |
1: 44,203,179 (GRCm39) |
F272S |
probably damaging |
Het |
| Fcamr |
C |
T |
1: 130,739,224 (GRCm39) |
R175C |
probably damaging |
Het |
| Frem3 |
G |
A |
8: 81,341,951 (GRCm39) |
V1415I |
probably benign |
Het |
| Fry |
T |
C |
5: 150,326,897 (GRCm39) |
|
probably benign |
Het |
| Gm14443 |
A |
T |
2: 175,013,383 (GRCm39) |
|
probably benign |
Het |
| Ift70a2 |
A |
T |
2: 75,806,676 (GRCm39) |
V612D |
probably benign |
Het |
| Insrr |
A |
G |
3: 87,707,797 (GRCm39) |
T80A |
probably damaging |
Het |
| Itih2 |
T |
A |
2: 10,102,735 (GRCm39) |
T800S |
probably benign |
Het |
| Lgals9 |
G |
A |
11: 78,867,443 (GRCm39) |
Q42* |
probably null |
Het |
| Lrrk2 |
A |
G |
15: 91,584,098 (GRCm39) |
N286S |
probably damaging |
Het |
| Mefv |
A |
G |
16: 3,526,398 (GRCm39) |
|
probably benign |
Het |
| Mkx |
T |
A |
18: 6,937,192 (GRCm39) |
D284V |
probably benign |
Het |
| Mtrex |
A |
C |
13: 113,019,785 (GRCm39) |
L775* |
probably null |
Het |
| Or11g27 |
T |
A |
14: 50,771,652 (GRCm39) |
I261K |
probably benign |
Het |
| Pde1b |
T |
G |
15: 103,434,700 (GRCm39) |
S339A |
possibly damaging |
Het |
| Plch2 |
C |
T |
4: 155,074,256 (GRCm39) |
V765M |
probably damaging |
Het |
| Ppp4r3b |
A |
T |
11: 29,123,358 (GRCm39) |
Q18L |
probably benign |
Het |
| Psme4 |
T |
A |
11: 30,757,687 (GRCm39) |
|
probably null |
Het |
| Pwp1 |
G |
A |
10: 85,715,173 (GRCm39) |
D220N |
probably damaging |
Het |
| Rel |
G |
A |
11: 23,707,010 (GRCm39) |
T64I |
probably damaging |
Het |
| Rho |
C |
G |
6: 115,912,566 (GRCm39) |
N160K |
probably damaging |
Het |
| Sntb2 |
A |
G |
8: 107,728,209 (GRCm39) |
T386A |
probably damaging |
Het |
| Styxl2 |
A |
T |
1: 165,926,860 (GRCm39) |
N917K |
possibly damaging |
Het |
| Sucla2 |
C |
T |
14: 73,798,074 (GRCm39) |
|
probably benign |
Het |
| Vcp |
T |
C |
4: 42,988,728 (GRCm39) |
T249A |
possibly damaging |
Het |
| Vrk2 |
G |
A |
11: 26,485,522 (GRCm39) |
|
probably benign |
Het |
| Zfp407 |
C |
T |
18: 84,577,898 (GRCm39) |
A1072T |
probably benign |
Het |
| Zfp638 |
A |
G |
6: 83,906,023 (GRCm39) |
N63D |
probably damaging |
Het |
|
| Other mutations in Vmn1r167 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02137:Vmn1r167
|
APN |
7 |
23,204,864 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02261:Vmn1r167
|
APN |
7 |
23,204,261 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL02963:Vmn1r167
|
APN |
7 |
23,204,975 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R0054:Vmn1r167
|
UTSW |
7 |
23,204,334 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R0555:Vmn1r167
|
UTSW |
7 |
23,204,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0766:Vmn1r167
|
UTSW |
7 |
23,204,548 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1464:Vmn1r167
|
UTSW |
7 |
23,204,681 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R1464:Vmn1r167
|
UTSW |
7 |
23,204,681 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R1532:Vmn1r167
|
UTSW |
7 |
23,204,204 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1937:Vmn1r167
|
UTSW |
7 |
23,204,452 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2162:Vmn1r167
|
UTSW |
7 |
23,204,224 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4639:Vmn1r167
|
UTSW |
7 |
23,205,011 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4661:Vmn1r167
|
UTSW |
7 |
23,204,117 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4845:Vmn1r167
|
UTSW |
7 |
23,204,158 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4868:Vmn1r167
|
UTSW |
7 |
23,204,161 (GRCm39) |
missense |
probably benign |
|
|
R4993:Vmn1r167
|
UTSW |
7 |
23,204,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5693:Vmn1r167
|
UTSW |
7 |
23,204,646 (GRCm39) |
nonsense |
probably null |
|
|
R6622:Vmn1r167
|
UTSW |
7 |
23,205,014 (GRCm39) |
start codon destroyed |
probably null |
|
|
R7800:Vmn1r167
|
UTSW |
7 |
23,204,069 (GRCm39) |
makesense |
probably null |
|
|
R8297:Vmn1r167
|
UTSW |
7 |
23,204,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8365:Vmn1r167
|
UTSW |
7 |
23,204,200 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8411:Vmn1r167
|
UTSW |
7 |
23,204,981 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9667:Vmn1r167
|
UTSW |
7 |
23,204,990 (GRCm39) |
missense |
probably benign |
0.06 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGAGACACTGCTCCAGATGATGATG -3'
(R):5'- AGCCAACTTAGCTGTGGGCAATAC -3'
Sequencing Primer
(F):5'- GATGATGCTGATGAACACTCC -3'
(R):5'- CTGTGGGCAATACCTTGATTC -3'
|
| Posted On |
2014-02-18 |
Incidental Mutation