Incidental Mutation 'R1294:Vmn1r25'
| ID |
158016 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r25
|
| Ensembl Gene |
ENSMUSG00000115668 |
| Gene Name |
vomeronasal 1 receptor 25 |
| Synonyms |
V1rc8 |
| MMRRC Submission |
039360-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.107)
|
| Stock # |
R1294 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
57955379-57956287 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 57955464 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 275
(I275T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154074
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000176572]
[ENSMUST00000228585]
|
| AlphaFold |
H3BLP0 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000176572
AA Change: I275T
PolyPhen 2
Score 0.554 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000135860
Gene: ENSMUSG00000115668
AA Change: I275T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
29 |
293 |
5.4e-52 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000228585
AA Change: I275T
PolyPhen 2
Score 0.554 (Sensitivity: 0.88; Specificity: 0.91)
|
| Meta Mutation Damage Score |
0.1795 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.5%
- 20x: 93.4%
|
| Validation Efficiency |
97% (33/34) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 29 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| C2cd2 |
A |
G |
16: 97,723,469 (GRCm39) |
L16P |
probably damaging |
Het |
| Cfap57 |
A |
T |
4: 118,463,731 (GRCm39) |
|
probably null |
Het |
| Cnn2 |
A |
G |
10: 79,829,359 (GRCm39) |
D163G |
probably damaging |
Het |
| Csmd1 |
T |
C |
8: 16,748,052 (GRCm39) |
D233G |
probably damaging |
Het |
| Csta2 |
T |
A |
16: 36,077,618 (GRCm39) |
D58E |
probably damaging |
Het |
| Dhh |
T |
C |
15: 98,792,264 (GRCm39) |
Q248R |
probably benign |
Het |
| Elavl2 |
G |
A |
4: 91,199,826 (GRCm39) |
A19V |
probably benign |
Het |
| Fxr1 |
T |
A |
3: 34,101,201 (GRCm39) |
M169K |
probably benign |
Het |
| Ghr |
A |
G |
15: 3,418,128 (GRCm39) |
|
probably null |
Het |
| Gm5334 |
T |
C |
7: 68,268,862 (GRCm39) |
S94P |
probably damaging |
Het |
| Klk1b3 |
C |
A |
7: 43,849,720 (GRCm39) |
S35Y |
probably damaging |
Het |
| Lama5 |
T |
C |
2: 179,832,714 (GRCm39) |
N1646S |
probably benign |
Het |
| Lap3 |
T |
C |
5: 45,655,863 (GRCm39) |
V156A |
probably benign |
Het |
| Pcbp3 |
A |
G |
10: 76,599,155 (GRCm39) |
I327T |
probably damaging |
Het |
| Plaat5 |
A |
G |
19: 7,592,015 (GRCm39) |
|
probably benign |
Het |
| Polr1a |
A |
T |
6: 71,889,886 (GRCm39) |
N35I |
probably damaging |
Het |
| Rab3c |
T |
C |
13: 110,397,099 (GRCm39) |
T56A |
possibly damaging |
Het |
| Rapsn |
A |
T |
2: 90,867,120 (GRCm39) |
K141* |
probably null |
Het |
| Rxrg |
G |
T |
1: 167,441,470 (GRCm39) |
A83S |
probably benign |
Het |
| Serpinc1 |
T |
C |
1: 160,817,211 (GRCm39) |
S102P |
probably damaging |
Het |
| Setd2 |
A |
G |
9: 110,378,575 (GRCm39) |
N797D |
probably benign |
Het |
| Skic2 |
T |
C |
17: 35,060,040 (GRCm39) |
|
probably null |
Het |
| Slc24a1 |
A |
T |
9: 64,843,295 (GRCm39) |
V619E |
unknown |
Het |
| Slc25a20 |
A |
G |
9: 108,554,838 (GRCm39) |
M128V |
probably benign |
Het |
| Spam1 |
A |
G |
6: 24,796,906 (GRCm39) |
I286V |
probably benign |
Het |
| Tbc1d22a |
T |
A |
15: 86,381,027 (GRCm39) |
F479Y |
probably damaging |
Het |
| Tdrd1 |
A |
G |
19: 56,837,208 (GRCm39) |
|
probably null |
Het |
| Trim58 |
T |
A |
11: 58,533,953 (GRCm39) |
I169N |
probably benign |
Het |
| Zfp27 |
T |
A |
7: 29,595,737 (GRCm39) |
Y76F |
possibly damaging |
Het |
|
| Other mutations in Vmn1r25 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01867:Vmn1r25
|
APN |
6 |
57,956,196 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0299:Vmn1r25
|
UTSW |
6 |
57,955,494 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0401:Vmn1r25
|
UTSW |
6 |
57,955,696 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0499:Vmn1r25
|
UTSW |
6 |
57,955,494 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1562:Vmn1r25
|
UTSW |
6 |
57,955,786 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1661:Vmn1r25
|
UTSW |
6 |
57,955,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1665:Vmn1r25
|
UTSW |
6 |
57,955,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1879:Vmn1r25
|
UTSW |
6 |
57,955,912 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2221:Vmn1r25
|
UTSW |
6 |
57,956,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2223:Vmn1r25
|
UTSW |
6 |
57,956,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2374:Vmn1r25
|
UTSW |
6 |
57,955,543 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4073:Vmn1r25
|
UTSW |
6 |
57,955,572 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4398:Vmn1r25
|
UTSW |
6 |
57,955,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4590:Vmn1r25
|
UTSW |
6 |
57,955,480 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4779:Vmn1r25
|
UTSW |
6 |
57,956,011 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5397:Vmn1r25
|
UTSW |
6 |
57,956,060 (GRCm39) |
nonsense |
probably null |
|
|
R6113:Vmn1r25
|
UTSW |
6 |
57,955,557 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6858:Vmn1r25
|
UTSW |
6 |
57,955,996 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7407:Vmn1r25
|
UTSW |
6 |
57,956,044 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R7748:Vmn1r25
|
UTSW |
6 |
57,955,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8001:Vmn1r25
|
UTSW |
6 |
57,956,065 (GRCm39) |
nonsense |
probably null |
|
|
R8472:Vmn1r25
|
UTSW |
6 |
57,955,531 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9235:Vmn1r25
|
UTSW |
6 |
57,955,488 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9651:Vmn1r25
|
UTSW |
6 |
57,956,306 (GRCm39) |
unclassified |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGAAGAATCTCACTTTGCCCCTTGAC -3'
(R):5'- AGCATCTTCATAGCATCAGGCACC -3'
Sequencing Primer
(F):5'- tcatcagacacaccagaagag -3'
(R):5'- CATCAGGCACCTGAGAGTG -3'
|
| Posted On |
2014-02-18 |
Incidental Mutation