Incidental Mutation 'R1296:Gpr61'
ID 158108
Institutional Source Beutler Lab
Gene Symbol Gpr61
Ensembl Gene ENSMUSG00000046793
Gene Name G protein-coupled receptor 61
Synonyms
MMRRC Submission 039362-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1296 (G1)
Quality Score 211
Status Validated
Chromosome 3
Chromosomal Location 108055660-108062218 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 108057797 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 288 (V288A)
Ref Sequence ENSEMBL: ENSMUSP00000111988 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000000001] [ENSMUST00000062028] [ENSMUST00000116284]
AlphaFold Q8C010
Predicted Effect probably benign
Transcript: ENSMUST00000000001
SMART Domains Protein: ENSMUSP00000000001
Gene: ENSMUSG00000000001

DomainStartEndE-ValueType
G_alpha 13 353 4.43e-218 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000062028
AA Change: V288A

PolyPhen 2 Score 0.126 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000055557
Gene: ENSMUSG00000046793
AA Change: V288A

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
Pfam:7tm_1 59 341 1.7e-36 PFAM
low complexity region 394 406 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000116284
AA Change: V288A

PolyPhen 2 Score 0.776 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000111988
Gene: ENSMUSG00000046793
AA Change: V288A

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
Pfam:7tm_1 59 341 4.2e-41 PFAM
low complexity region 394 406 N/A INTRINSIC
Meta Mutation Damage Score 0.2079 question?
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.7%
  • 10x: 94.5%
  • 20x: 87.1%
Validation Efficiency 100% (72/72)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The protein encoded by this gene is most closely related to biogenic amine receptors. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam29 G A 8: 56,324,754 (GRCm39) Q567* probably null Het
Apol11a T C 15: 77,395,219 (GRCm39) probably benign Het
Arhgap29 A G 3: 121,786,044 (GRCm39) H275R probably benign Het
Arhgef17 C A 7: 100,530,476 (GRCm39) E428* probably null Het
Atm A T 9: 53,367,830 (GRCm39) V2431E probably damaging Het
Atn1 G T 6: 124,724,750 (GRCm39) P161Q unknown Het
Atp13a2 T C 4: 140,721,113 (GRCm39) S99P probably damaging Het
Atp8a1 A T 5: 67,780,049 (GRCm39) probably benign Het
Cdk18 T C 1: 132,047,698 (GRCm39) probably benign Het
Cep85 A G 4: 133,894,711 (GRCm39) W32R probably damaging Het
Cntn4 G T 6: 106,486,363 (GRCm39) G264C probably damaging Het
Col6a4 A G 9: 105,940,052 (GRCm39) S1293P possibly damaging Het
Col6a6 T C 9: 105,658,290 (GRCm39) K641E probably damaging Het
Dmd A T X: 82,922,126 (GRCm39) K1465N probably damaging Het
Dus2 T C 8: 106,779,675 (GRCm39) V403A possibly damaging Het
Frs2 C T 10: 116,916,979 (GRCm39) C5Y probably benign Het
Gm5174 A G 10: 86,492,866 (GRCm39) noncoding transcript Het
Grik3 G A 4: 125,598,357 (GRCm39) probably benign Het
Haao T A 17: 84,146,267 (GRCm39) Q69L probably benign Het
Ints6 T C 14: 62,942,352 (GRCm39) probably benign Het
Ints8 T C 4: 11,221,204 (GRCm39) I724V possibly damaging Het
Lrrk2 G A 15: 91,613,123 (GRCm39) C749Y probably damaging Het
Map4k1 A G 7: 28,697,877 (GRCm39) D471G possibly damaging Het
Mbtd1 A G 11: 93,801,185 (GRCm39) Y122C probably damaging Het
Mif-ps9 T A 19: 56,743,766 (GRCm39) noncoding transcript Het
Mrfap1 A G 5: 36,953,817 (GRCm39) S41P possibly damaging Het
Mrm2 T C 5: 140,314,308 (GRCm39) T176A probably benign Het
Mslnl T C 17: 25,962,214 (GRCm39) L204P probably damaging Het
Muc6 T C 7: 141,238,144 (GRCm39) E112G probably benign Het
Nfyb A G 10: 82,586,665 (GRCm39) probably benign Het
Nlgn3 T C X: 100,352,522 (GRCm39) probably benign Het
Nr3c1 G A 18: 39,620,051 (GRCm39) Q79* probably null Het
Nxpe4 C G 9: 48,307,793 (GRCm39) T299R probably benign Het
Otud4 C A 8: 80,400,603 (GRCm39) H1105N unknown Het
Pcnx2 A G 8: 126,500,572 (GRCm39) L1506P probably damaging Het
Prl2c5 T A 13: 13,364,009 (GRCm39) H88Q probably damaging Het
Psmb2 A G 4: 126,580,825 (GRCm39) Y73C probably damaging Het
Rbl1 A T 2: 157,011,891 (GRCm39) V688D probably benign Het
Rhox2g C A X: 36,824,865 (GRCm39) probably benign Het
Rmnd5a G A 6: 71,375,439 (GRCm39) L80F probably benign Het
Ryr2 T C 13: 11,702,765 (GRCm39) probably benign Het
Sele T A 1: 163,878,379 (GRCm39) S239R probably damaging Het
Siglecf A T 7: 43,005,344 (GRCm39) R435* probably null Het
Slc23a1 C T 18: 35,755,676 (GRCm39) V407M possibly damaging Het
Slc6a14 G A X: 21,587,807 (GRCm39) V122I probably benign Het
Spdl1 T A 11: 34,704,434 (GRCm39) E466D unknown Het
Stau2 A G 1: 16,510,596 (GRCm39) F121L probably benign Het
Stxbp1 A T 2: 32,684,648 (GRCm39) S594T probably benign Het
Sufu G A 19: 46,443,159 (GRCm39) probably benign Het
Tap2 G T 17: 34,430,889 (GRCm39) V330L probably benign Het
Tbc1d1 T C 5: 64,421,775 (GRCm39) L389P probably damaging Het
Tbx2 A G 11: 85,725,592 (GRCm39) E181G probably damaging Het
Tlcd4 A G 3: 121,000,940 (GRCm39) V231A probably benign Het
Tmprss9 G T 10: 80,726,279 (GRCm39) A510S probably benign Het
Tnxb G A 17: 34,890,551 (GRCm39) C298Y probably damaging Het
Tril G T 6: 53,795,012 (GRCm39) R737S probably damaging Het
Ugt2a3 A T 5: 87,475,005 (GRCm39) L413Q probably damaging Het
Vcan A G 13: 89,805,675 (GRCm39) I2335T probably damaging Het
Vmn2r28 T C 7: 5,484,544 (GRCm39) N552S possibly damaging Het
Zc3h7a C T 16: 10,978,890 (GRCm39) R95H probably damaging Het
Zfp598 A G 17: 24,898,623 (GRCm39) N474S probably benign Het
Zng1 A T 19: 24,920,039 (GRCm39) probably benign Het
Zpld1 T C 16: 55,068,697 (GRCm39) D138G probably damaging Het
Other mutations in Gpr61
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00505:Gpr61 APN 3 108,058,514 (GRCm39) missense probably damaging 1.00
IGL02354:Gpr61 APN 3 108,057,534 (GRCm39) missense probably damaging 1.00
IGL02878:Gpr61 APN 3 108,057,344 (GRCm39) missense probably damaging 0.97
R1061:Gpr61 UTSW 3 108,057,623 (GRCm39) missense probably damaging 1.00
R1295:Gpr61 UTSW 3 108,057,797 (GRCm39) missense possibly damaging 0.78
R1329:Gpr61 UTSW 3 108,057,830 (GRCm39) missense probably benign 0.16
R1718:Gpr61 UTSW 3 108,057,696 (GRCm39) missense possibly damaging 0.81
R1840:Gpr61 UTSW 3 108,057,797 (GRCm39) missense possibly damaging 0.78
R2139:Gpr61 UTSW 3 108,058,077 (GRCm39) missense probably damaging 1.00
R5016:Gpr61 UTSW 3 108,057,983 (GRCm39) missense possibly damaging 0.63
R7042:Gpr61 UTSW 3 108,058,647 (GRCm39) missense possibly damaging 0.93
R7689:Gpr61 UTSW 3 108,057,966 (GRCm39) missense probably damaging 1.00
R8058:Gpr61 UTSW 3 108,058,211 (GRCm39) missense probably damaging 1.00
R8118:Gpr61 UTSW 3 108,057,888 (GRCm39) missense probably damaging 1.00
R8931:Gpr61 UTSW 3 108,057,470 (GRCm39) missense probably benign
R9063:Gpr61 UTSW 3 108,057,555 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- AACTGTTTGCTAAGCTCGCCCC -3'
(R):5'- AATGGAGCCATAGTGCCTACTGCC -3'

Sequencing Primer
(F):5'- GATCTGACGGTTGAGACATCC -3'
(R):5'- ATCCTGATCTTTGTGGTCTACTG -3'
Posted On 2014-02-18