Incidental Mutation 'R1301:Paqr7'
ID 158357
Institutional Source Beutler Lab
Gene Symbol Paqr7
Ensembl Gene ENSMUSG00000037348
Gene Name progestin and adipoQ receptor family member VII
Synonyms mPR, 2310021M12Rik, PGLP, Mpra
MMRRC Submission 039367-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1301 (G1)
Quality Score 86
Status Validated
Chromosome 4
Chromosomal Location 134224315-134237548 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 134235124 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 327 (L327P)
Ref Sequence ENSEMBL: ENSMUSP00000125932 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081525] [ENSMUST00000095074] [ENSMUST00000105866] [ENSMUST00000125330] [ENSMUST00000134506] [ENSMUST00000136171]
AlphaFold Q80ZE4
Predicted Effect probably damaging
Transcript: ENSMUST00000081525
AA Change: L327P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000080240
Gene: ENSMUSG00000037348
AA Change: L327P

DomainStartEndE-ValueType
Pfam:HlyIII 65 289 7.1e-52 PFAM
transmembrane domain 314 336 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000095074
AA Change: L327P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000125932
Gene: ENSMUSG00000037348
AA Change: L327P

DomainStartEndE-ValueType
Pfam:HlyIII 65 289 2.4e-45 PFAM
transmembrane domain 314 336 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000105866
SMART Domains Protein: ENSMUSP00000101492
Gene: ENSMUSG00000078521

DomainStartEndE-ValueType
Pfam:AIB 26 335 1.5e-134 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000125330
SMART Domains Protein: ENSMUSP00000116485
Gene: ENSMUSG00000037348

DomainStartEndE-ValueType
Pfam:HlyIII 65 147 3.4e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000134506
SMART Domains Protein: ENSMUSP00000120959
Gene: ENSMUSG00000037348

DomainStartEndE-ValueType
Pfam:HlyIII 65 127 4.6e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000136171
SMART Domains Protein: ENSMUSP00000122936
Gene: ENSMUSG00000037348

DomainStartEndE-ValueType
Pfam:HlyIII 65 237 1.5e-28 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155449
Meta Mutation Damage Score 0.3823 question?
Coding Region Coverage
  • 1x: 98.7%
  • 3x: 97.5%
  • 10x: 93.3%
  • 20x: 82.6%
Validation Efficiency 96% (67/70)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4fm2 T A 4: 144,291,635 (GRCm39) I24L probably benign Het
Ano1 A G 7: 144,187,426 (GRCm39) W447R possibly damaging Het
Blm T A 7: 80,105,165 (GRCm39) K103* probably null Het
Camta2 A G 11: 70,567,230 (GRCm39) I675T probably benign Het
Catsperz G A 19: 6,902,450 (GRCm39) R15C probably damaging Het
Chd1l T C 3: 97,510,964 (GRCm39) probably benign Het
Corin C A 5: 72,462,276 (GRCm39) E844D possibly damaging Het
Cyb5rl T G 4: 106,938,104 (GRCm39) M127R probably damaging Het
Dcdc2a A T 13: 25,286,569 (GRCm39) N164I possibly damaging Het
Dnah6 A G 6: 73,185,528 (GRCm39) probably null Het
Emilin2 T C 17: 71,562,960 (GRCm39) probably benign Het
Epb41l2 T A 10: 25,319,800 (GRCm39) V211D probably damaging Het
Fbxo47 C T 11: 97,759,427 (GRCm39) M166I probably benign Het
Golm1 T C 13: 59,786,187 (GRCm39) D335G probably damaging Het
Gpn1 T A 5: 31,660,773 (GRCm39) M188K probably damaging Het
Gpr84 T A 15: 103,217,646 (GRCm39) S144C probably damaging Het
Grm8 G T 6: 27,981,200 (GRCm39) Q237K possibly damaging Het
Gsdmd C A 15: 75,738,908 (GRCm39) probably null Het
Hmgcr G A 13: 96,795,528 (GRCm39) T347I probably damaging Het
Hsd17b7 T A 1: 169,788,774 (GRCm39) probably benign Het
Hsd3b9 G A 3: 98,354,182 (GRCm39) Q106* probably null Het
Klhl7 T G 5: 24,364,489 (GRCm39) W508G probably damaging Het
Lrp2 C A 2: 69,258,948 (GRCm39) D4581Y probably damaging Het
Lrrc7 T C 3: 157,840,968 (GRCm39) N1357D probably benign Het
Macf1 T C 4: 123,380,451 (GRCm39) probably benign Het
Mroh7 T C 4: 106,577,692 (GRCm39) T329A probably damaging Het
Mroh9 C T 1: 162,871,552 (GRCm39) probably null Het
Mta2 A G 19: 8,926,550 (GRCm39) probably benign Het
Myo3a A T 2: 22,271,906 (GRCm39) probably benign Het
Nrip2 A G 6: 128,384,352 (GRCm39) D153G probably benign Het
Nup133 T C 8: 124,644,156 (GRCm39) probably benign Het
Nup210 C T 6: 91,019,329 (GRCm39) V259M possibly damaging Het
Or10ak14 C T 4: 118,610,816 (GRCm39) M308I probably benign Het
Or5b112 A T 19: 13,319,211 (GRCm39) I30F probably benign Het
Or9i14 A T 19: 13,792,726 (GRCm39) V76D probably damaging Het
Otog C T 7: 45,939,113 (GRCm39) R2048C probably damaging Het
Pacc1 T C 1: 191,080,632 (GRCm39) V284A probably damaging Het
Parl A G 16: 20,105,676 (GRCm39) S249P probably damaging Het
Phc1 A G 6: 122,302,833 (GRCm39) I230T probably benign Het
Pitpnm1 T G 19: 4,160,831 (GRCm39) probably null Het
Plpp1 A G 13: 112,971,477 (GRCm39) Y48C probably damaging Het
Pxdc1 A G 13: 34,812,870 (GRCm39) F194L probably benign Het
Rp1 A T 1: 4,416,159 (GRCm39) V1651D possibly damaging Het
Serpinb1c T A 13: 33,080,943 (GRCm39) R47* probably null Het
Sis T C 3: 72,853,915 (GRCm39) T521A possibly damaging Het
Slc16a9 A G 10: 70,118,308 (GRCm39) D209G probably benign Het
Slc26a4 A T 12: 31,575,567 (GRCm39) C706* probably null Het
Slc37a2 A G 9: 37,148,177 (GRCm39) V325A probably benign Het
Speg T A 1: 75,378,145 (GRCm39) D784E probably damaging Het
Sycp1 T C 3: 102,827,938 (GRCm39) I270V probably benign Het
Tatdn2 T A 6: 113,681,076 (GRCm39) F309I probably damaging Het
Tmem67 T C 4: 12,089,400 (GRCm39) probably benign Het
Trpm1 T A 7: 63,852,801 (GRCm39) probably null Het
Wrn T C 8: 33,782,714 (GRCm39) R496G probably damaging Het
Zfhx2 A G 14: 55,300,854 (GRCm39) V2299A probably benign Het
Zfp819 T A 7: 43,266,524 (GRCm39) S260T possibly damaging Het
Other mutations in Paqr7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00824:Paqr7 APN 4 134,234,278 (GRCm39) missense probably damaging 1.00
IGL02418:Paqr7 APN 4 134,234,284 (GRCm39) missense probably damaging 1.00
R1763:Paqr7 UTSW 4 134,234,409 (GRCm39) missense probably benign 0.10
R1781:Paqr7 UTSW 4 134,234,592 (GRCm39) splice site probably null
R1852:Paqr7 UTSW 4 134,234,980 (GRCm39) missense probably benign 0.23
R4843:Paqr7 UTSW 4 134,234,278 (GRCm39) missense probably damaging 1.00
R5931:Paqr7 UTSW 4 134,235,031 (GRCm39) missense probably damaging 0.99
R6426:Paqr7 UTSW 4 134,234,278 (GRCm39) missense probably damaging 1.00
R7337:Paqr7 UTSW 4 134,234,431 (GRCm39) missense probably benign 0.01
R8103:Paqr7 UTSW 4 134,234,821 (GRCm39) missense probably benign 0.00
R9299:Paqr7 UTSW 4 134,234,311 (GRCm39) missense probably benign
R9380:Paqr7 UTSW 4 134,234,350 (GRCm39) missense probably damaging 1.00
R9470:Paqr7 UTSW 4 134,234,914 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TGTTGCACCGCATCATAGTGTCTC -3'
(R):5'- CCTGCCAGATAGAACCAGCTTTACC -3'

Sequencing Primer
(F):5'- TCCACGGTTATGCCTGAGAG -3'
(R):5'- AGTCCAGGCTTTTGTCCCTA -3'
Posted On 2014-02-18