Incidental Mutation 'R1445:Megf8'
| ID |
158782 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Megf8
|
| Ensembl Gene |
ENSMUSG00000045039 |
| Gene Name |
multiple EGF-like-domains 8 |
| Synonyms |
m687Ddg, b2b1702Clo, Egfl4, b2b288Clo |
| MMRRC Submission |
039500-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.947)
|
| Stock # |
R1445 (G1)
|
| Quality Score |
138 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
25016589-25065342 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 25042081 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 1300
(S1300P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000122192
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000128119]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000128119
AA Change: S1300P
PolyPhen 2
Score 0.967 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000122192
Gene: ENSMUSG00000045039
AA Change: S1300P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
27 |
N/A |
INTRINSIC |
|
CUB
|
33 |
140 |
1.24e-15 |
SMART |
|
EGF
|
141 |
170 |
4.26e0 |
SMART |
|
EGF
|
173 |
203 |
2.43e1 |
SMART |
|
Pfam:Kelch_4
|
227 |
277 |
1.3e-11 |
PFAM |
|
Pfam:Kelch_3
|
240 |
287 |
1.6e-7 |
PFAM |
|
low complexity region
|
320 |
341 |
N/A |
INTRINSIC |
|
low complexity region
|
517 |
531 |
N/A |
INTRINSIC |
|
low complexity region
|
728 |
738 |
N/A |
INTRINSIC |
|
PSI
|
847 |
899 |
1.37e0 |
SMART |
|
low complexity region
|
932 |
938 |
N/A |
INTRINSIC |
|
PSI
|
949 |
991 |
2.11e-2 |
SMART |
|
PSI
|
1005 |
1073 |
7.82e-1 |
SMART |
|
EGF_CA
|
1074 |
1115 |
2.62e-9 |
SMART |
|
EGF
|
1117 |
1160 |
5.4e-2 |
SMART |
|
EGF_like
|
1163 |
1208 |
4e-1 |
SMART |
|
EGF_Lam
|
1211 |
1259 |
1.03e-7 |
SMART |
|
Blast:CUB
|
1263 |
1401 |
1e-30 |
BLAST |
|
EGF_like
|
1406 |
1445 |
3.29e1 |
SMART |
|
Pfam:Kelch_4
|
1509 |
1564 |
6.5e-12 |
PFAM |
|
Pfam:Kelch_3
|
1520 |
1574 |
1.2e-10 |
PFAM |
|
PSI
|
1868 |
1923 |
2.75e-1 |
SMART |
|
PSI
|
2004 |
2062 |
1.6e0 |
SMART |
|
PSI
|
2064 |
2121 |
1.68e-5 |
SMART |
|
EGF
|
2125 |
2164 |
1.08e-1 |
SMART |
|
EGF
|
2166 |
2194 |
4.26e0 |
SMART |
|
EGF
|
2204 |
2244 |
2.2e1 |
SMART |
|
EGF_like
|
2248 |
2321 |
6.37e-1 |
SMART |
|
low complexity region
|
2493 |
2504 |
N/A |
INTRINSIC |
|
low complexity region
|
2530 |
2541 |
N/A |
INTRINSIC |
|
transmembrane domain
|
2592 |
2614 |
N/A |
INTRINSIC |
|
low complexity region
|
2649 |
2668 |
N/A |
INTRINSIC |
|
low complexity region
|
2674 |
2702 |
N/A |
INTRINSIC |
|
low complexity region
|
2759 |
2774 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000153077
|
| Meta Mutation Damage Score |
0.2362 |
| Coding Region Coverage |
- 1x: 98.8%
- 3x: 97.7%
- 10x: 93.9%
- 20x: 84.0%
|
| Validation Efficiency |
96% (101/105) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a single-pass type I membrane protein of unknown function that contains several EGF-like domains, Kelch repeats, and PSI domains. Defects in this gene are a cause of Carpenter syndrome 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
PHENOTYPE: Mice homozygous for an ENU mutation exhibit varying degrees of heterotaxia and congenital heart defects. Mice homozygous for another ENU-induced mutation exhibit abnormal development and patterning of the peripheral nervous system. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 94 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700061I17Rik |
G |
T |
3: 116,861,385 (GRCm39) |
|
noncoding transcript |
Het |
| 2300003K06Rik |
G |
T |
11: 99,728,793 (GRCm39) |
Q17K |
probably benign |
Het |
| Abca16 |
T |
C |
7: 120,119,256 (GRCm39) |
V999A |
probably benign |
Het |
| Actn3 |
C |
T |
19: 4,915,483 (GRCm39) |
|
probably benign |
Het |
| Agap2 |
T |
A |
10: 126,926,981 (GRCm39) |
|
probably benign |
Het |
| Ago3 |
C |
A |
4: 126,265,580 (GRCm39) |
R278L |
probably benign |
Het |
| Aldh1a2 |
T |
C |
9: 71,192,492 (GRCm39) |
V449A |
possibly damaging |
Het |
| Alkbh2 |
C |
T |
5: 114,262,287 (GRCm39) |
E148K |
probably damaging |
Het |
| Aplnr |
A |
G |
2: 84,967,353 (GRCm39) |
Y126C |
probably damaging |
Het |
| Apob |
T |
C |
12: 8,066,084 (GRCm39) |
I4351T |
possibly damaging |
Het |
| Ash1l |
T |
C |
3: 88,914,659 (GRCm39) |
L1763P |
probably benign |
Het |
| Aspn |
T |
C |
13: 49,710,849 (GRCm39) |
S165P |
possibly damaging |
Het |
| Atg13 |
A |
T |
2: 91,510,335 (GRCm39) |
V349E |
probably damaging |
Het |
| Atp1b2 |
T |
A |
11: 69,493,309 (GRCm39) |
|
probably null |
Het |
| B3glct |
A |
T |
5: 149,677,604 (GRCm39) |
D411V |
probably damaging |
Het |
| Bcar3 |
A |
T |
3: 122,316,840 (GRCm39) |
I255F |
probably damaging |
Het |
| Cacna1b |
G |
A |
2: 24,608,148 (GRCm39) |
|
probably benign |
Het |
| Cep164 |
T |
G |
9: 45,690,198 (GRCm39) |
E675A |
possibly damaging |
Het |
| Chd1l |
C |
T |
3: 97,490,047 (GRCm39) |
E503K |
probably benign |
Het |
| Chst8 |
C |
A |
7: 34,447,593 (GRCm39) |
M8I |
possibly damaging |
Het |
| Clec4n |
A |
G |
6: 123,212,475 (GRCm39) |
E67G |
probably benign |
Het |
| Cobll1 |
A |
T |
2: 64,929,480 (GRCm39) |
D653E |
probably damaging |
Het |
| Col9a1 |
T |
C |
1: 24,276,579 (GRCm39) |
|
probably null |
Het |
| Crip2 |
T |
C |
12: 113,107,124 (GRCm39) |
L30P |
probably damaging |
Het |
| Ctbp1 |
C |
T |
5: 33,418,407 (GRCm39) |
V22I |
probably benign |
Het |
| Cwc22 |
T |
C |
2: 77,747,521 (GRCm39) |
|
probably benign |
Het |
| Cyp4a32 |
C |
A |
4: 115,460,147 (GRCm39) |
Y119* |
probably null |
Het |
| Dido1 |
G |
T |
2: 180,313,263 (GRCm39) |
A463E |
possibly damaging |
Het |
| Dnah7a |
G |
A |
1: 53,567,956 (GRCm39) |
P1880L |
probably benign |
Het |
| Dock2 |
T |
A |
11: 34,189,705 (GRCm39) |
T1489S |
probably benign |
Het |
| Dsp |
A |
G |
13: 38,375,907 (GRCm39) |
T1231A |
probably damaging |
Het |
| Eif2ak1 |
G |
T |
5: 143,810,717 (GRCm39) |
|
probably benign |
Het |
| Entrep1 |
G |
A |
19: 23,998,998 (GRCm39) |
T140M |
probably damaging |
Het |
| Epc1 |
A |
T |
18: 6,452,360 (GRCm39) |
M233K |
probably damaging |
Het |
| Gigyf2 |
A |
G |
1: 87,371,360 (GRCm39) |
|
probably benign |
Het |
| Greb1 |
T |
G |
12: 16,757,852 (GRCm39) |
H58P |
probably damaging |
Het |
| Gtpbp1 |
T |
C |
15: 79,597,649 (GRCm39) |
I348T |
possibly damaging |
Het |
| Hck |
A |
T |
2: 152,970,192 (GRCm39) |
N64Y |
probably benign |
Het |
| Herc2 |
T |
C |
7: 55,818,744 (GRCm39) |
S2812P |
probably damaging |
Het |
| Inpp4b |
T |
A |
8: 82,679,463 (GRCm39) |
|
probably null |
Het |
| Kcnq5 |
A |
C |
1: 21,475,248 (GRCm39) |
S473A |
probably benign |
Het |
| Lrat |
T |
G |
3: 82,810,676 (GRCm39) |
D115A |
probably damaging |
Het |
| Lyst |
A |
G |
13: 13,814,639 (GRCm39) |
I1131M |
possibly damaging |
Het |
| Man2a2 |
T |
C |
7: 80,018,310 (GRCm39) |
D160G |
probably benign |
Het |
| Marf1 |
C |
T |
16: 13,933,688 (GRCm39) |
D1567N |
probably benign |
Het |
| Mars1 |
T |
C |
10: 127,133,857 (GRCm39) |
D680G |
possibly damaging |
Het |
| Mat1a |
T |
C |
14: 40,843,797 (GRCm39) |
S339P |
probably damaging |
Het |
| Mga |
T |
C |
2: 119,733,179 (GRCm39) |
L9S |
probably damaging |
Het |
| Mllt6 |
T |
C |
11: 97,563,277 (GRCm39) |
|
probably benign |
Het |
| Mrpl37 |
A |
G |
4: 106,921,692 (GRCm39) |
L179P |
probably benign |
Het |
| Mtnr1a |
G |
T |
8: 45,540,782 (GRCm39) |
V248L |
probably benign |
Het |
| Mylk |
T |
C |
16: 34,635,835 (GRCm39) |
S19P |
possibly damaging |
Het |
| Or11g1 |
A |
G |
14: 50,651,858 (GRCm39) |
T286A |
probably damaging |
Het |
| Pacc1 |
A |
G |
1: 191,080,559 (GRCm39) |
|
probably benign |
Het |
| Parp8 |
A |
T |
13: 117,161,886 (GRCm39) |
|
probably null |
Het |
| Pcnx2 |
T |
C |
8: 126,479,023 (GRCm39) |
D2075G |
probably damaging |
Het |
| Pigo |
A |
T |
4: 43,021,460 (GRCm39) |
I494K |
probably benign |
Het |
| Pkd1l1 |
A |
T |
11: 8,820,313 (GRCm39) |
D1217E |
probably benign |
Het |
| Pkhd1l1 |
T |
C |
15: 44,369,040 (GRCm39) |
V895A |
probably benign |
Het |
| Plcb4 |
A |
T |
2: 135,842,109 (GRCm39) |
H1031L |
possibly damaging |
Het |
| Plxnb1 |
A |
G |
9: 108,937,989 (GRCm39) |
K1245R |
probably null |
Het |
| Pold1 |
C |
T |
7: 44,192,181 (GRCm39) |
|
probably benign |
Het |
| Ptprq |
T |
C |
10: 107,498,423 (GRCm39) |
I885V |
probably damaging |
Het |
| Ptprz1 |
A |
G |
6: 23,050,473 (GRCm39) |
D1398G |
probably damaging |
Het |
| Pygm |
G |
A |
19: 6,439,917 (GRCm39) |
A364T |
probably benign |
Het |
| Rbl1 |
T |
C |
2: 157,035,018 (GRCm39) |
N354S |
probably benign |
Het |
| Scgb2b19 |
C |
T |
7: 32,979,037 (GRCm39) |
|
probably null |
Het |
| Slc26a8 |
C |
T |
17: 28,867,187 (GRCm39) |
V545M |
possibly damaging |
Het |
| Slc27a1 |
T |
A |
8: 72,036,757 (GRCm39) |
|
probably null |
Het |
| Smpd1 |
A |
G |
7: 105,205,881 (GRCm39) |
D416G |
possibly damaging |
Het |
| Sorbs3 |
A |
G |
14: 70,431,095 (GRCm39) |
V284A |
probably benign |
Het |
| Stfa2l1 |
T |
C |
16: 35,982,154 (GRCm39) |
V75A |
probably damaging |
Het |
| Syndig1 |
A |
G |
2: 149,772,841 (GRCm39) |
D166G |
probably damaging |
Het |
| Tcp10a |
G |
A |
17: 7,593,406 (GRCm39) |
|
probably null |
Het |
| Themis2 |
T |
A |
4: 132,510,212 (GRCm39) |
I663F |
possibly damaging |
Het |
| Thrap3 |
T |
C |
4: 126,070,129 (GRCm39) |
Q586R |
probably damaging |
Het |
| Tinag |
C |
A |
9: 76,952,798 (GRCm39) |
C62F |
probably damaging |
Het |
| Tmod1 |
T |
C |
4: 46,090,884 (GRCm39) |
Y146H |
probably damaging |
Het |
| Tmprss4 |
T |
A |
9: 45,095,683 (GRCm39) |
I54F |
possibly damaging |
Het |
| Tnks |
A |
C |
8: 35,301,757 (GRCm39) |
|
probably benign |
Het |
| Trim43a |
GATTTATTTATTTATTTATTTATTTATTTATTTATTTATT |
GATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATT |
9: 88,465,042 (GRCm39) |
|
probably benign |
Het |
| Trpc6 |
A |
G |
9: 8,680,538 (GRCm39) |
E844G |
probably benign |
Het |
| Ubtd2 |
C |
T |
11: 32,466,125 (GRCm39) |
R115W |
probably damaging |
Het |
| Ubxn6 |
T |
C |
17: 56,376,042 (GRCm39) |
D373G |
probably benign |
Het |
| Upf1 |
T |
A |
8: 70,794,174 (GRCm39) |
Q244L |
probably benign |
Het |
| Usp33 |
A |
G |
3: 152,074,271 (GRCm39) |
I372M |
probably damaging |
Het |
| Usp34 |
A |
G |
11: 23,301,629 (GRCm39) |
E351G |
probably damaging |
Het |
| Utrn |
A |
G |
10: 12,554,318 (GRCm39) |
|
probably benign |
Het |
| Vmn1r78 |
A |
G |
7: 11,886,508 (GRCm39) |
K40E |
possibly damaging |
Het |
| Vmn2r7 |
T |
A |
3: 64,632,223 (GRCm39) |
M80L |
probably benign |
Het |
| Vps13a |
G |
T |
19: 16,678,602 (GRCm39) |
Y1126* |
probably null |
Het |
| Wfdc11 |
T |
C |
2: 164,506,366 (GRCm39) |
N60S |
probably benign |
Het |
| Wnk2 |
C |
T |
13: 49,224,586 (GRCm39) |
D992N |
probably damaging |
Het |
| Zpbp2 |
C |
A |
11: 98,444,670 (GRCm39) |
T66K |
probably damaging |
Het |
|
| Other mutations in Megf8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00639:Megf8
|
APN |
7 |
25,043,109 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL00696:Megf8
|
APN |
7 |
25,041,817 (GRCm39) |
missense |
probably benign |
|
|
IGL01021:Megf8
|
APN |
7 |
25,037,799 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL01290:Megf8
|
APN |
7 |
25,049,083 (GRCm39) |
nonsense |
probably null |
|
|
IGL01392:Megf8
|
APN |
7 |
25,063,174 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01410:Megf8
|
APN |
7 |
25,059,296 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01634:Megf8
|
APN |
7 |
25,058,206 (GRCm39) |
splice site |
probably benign |
|
|
IGL01648:Megf8
|
APN |
7 |
25,026,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01930:Megf8
|
APN |
7 |
25,034,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01954:Megf8
|
APN |
7 |
25,048,439 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02150:Megf8
|
APN |
7 |
25,045,842 (GRCm39) |
splice site |
probably null |
|
|
IGL02192:Megf8
|
APN |
7 |
25,053,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02250:Megf8
|
APN |
7 |
25,042,000 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02301:Megf8
|
APN |
7 |
25,037,325 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02317:Megf8
|
APN |
7 |
25,063,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02324:Megf8
|
APN |
7 |
25,039,873 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02503:Megf8
|
APN |
7 |
25,062,988 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL02583:Megf8
|
APN |
7 |
25,055,218 (GRCm39) |
missense |
probably benign |
|
|
IGL02636:Megf8
|
APN |
7 |
25,057,857 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02704:Megf8
|
APN |
7 |
25,059,207 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02898:Megf8
|
APN |
7 |
25,045,933 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL03082:Megf8
|
APN |
7 |
25,029,661 (GRCm39) |
missense |
probably benign |
|
|
IGL03182:Megf8
|
APN |
7 |
25,046,773 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
megatherium
|
UTSW |
7 |
25,041,850 (GRCm39) |
critical splice donor site |
probably null |
|
|
PIT4810001:Megf8
|
UTSW |
7 |
25,041,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0076:Megf8
|
UTSW |
7 |
25,053,383 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0217:Megf8
|
UTSW |
7 |
25,063,504 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0514:Megf8
|
UTSW |
7 |
25,063,728 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0561:Megf8
|
UTSW |
7 |
25,028,257 (GRCm39) |
missense |
probably benign |
0.21 |
|
R0563:Megf8
|
UTSW |
7 |
25,041,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0601:Megf8
|
UTSW |
7 |
25,027,965 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0879:Megf8
|
UTSW |
7 |
25,037,896 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R1323:Megf8
|
UTSW |
7 |
25,059,527 (GRCm39) |
splice site |
probably null |
|
|
R1323:Megf8
|
UTSW |
7 |
25,059,527 (GRCm39) |
splice site |
probably null |
|
|
R1430:Megf8
|
UTSW |
7 |
25,063,768 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1533:Megf8
|
UTSW |
7 |
25,034,280 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1606:Megf8
|
UTSW |
7 |
25,058,120 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1635:Megf8
|
UTSW |
7 |
25,046,172 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1654:Megf8
|
UTSW |
7 |
25,037,911 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R1661:Megf8
|
UTSW |
7 |
25,063,272 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1880:Megf8
|
UTSW |
7 |
25,034,285 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1962:Megf8
|
UTSW |
7 |
25,062,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2077:Megf8
|
UTSW |
7 |
25,053,163 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2127:Megf8
|
UTSW |
7 |
25,064,007 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2129:Megf8
|
UTSW |
7 |
25,030,140 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2199:Megf8
|
UTSW |
7 |
25,039,039 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R2201:Megf8
|
UTSW |
7 |
25,040,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2205:Megf8
|
UTSW |
7 |
25,041,173 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2207:Megf8
|
UTSW |
7 |
25,049,222 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2361:Megf8
|
UTSW |
7 |
25,048,379 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2680:Megf8
|
UTSW |
7 |
25,016,981 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3084:Megf8
|
UTSW |
7 |
25,048,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3085:Megf8
|
UTSW |
7 |
25,048,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3086:Megf8
|
UTSW |
7 |
25,048,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3433:Megf8
|
UTSW |
7 |
25,059,549 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3939:Megf8
|
UTSW |
7 |
25,058,627 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4022:Megf8
|
UTSW |
7 |
25,037,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4214:Megf8
|
UTSW |
7 |
25,054,793 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4357:Megf8
|
UTSW |
7 |
25,055,174 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4521:Megf8
|
UTSW |
7 |
25,042,126 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4620:Megf8
|
UTSW |
7 |
25,054,523 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4700:Megf8
|
UTSW |
7 |
25,062,940 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4916:Megf8
|
UTSW |
7 |
25,039,089 (GRCm39) |
missense |
probably benign |
0.24 |
|
R4940:Megf8
|
UTSW |
7 |
25,060,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5048:Megf8
|
UTSW |
7 |
25,030,517 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5258:Megf8
|
UTSW |
7 |
25,047,751 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5271:Megf8
|
UTSW |
7 |
25,041,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5390:Megf8
|
UTSW |
7 |
25,039,714 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5391:Megf8
|
UTSW |
7 |
25,039,714 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5708:Megf8
|
UTSW |
7 |
25,034,022 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5752:Megf8
|
UTSW |
7 |
25,054,539 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5930:Megf8
|
UTSW |
7 |
25,025,866 (GRCm39) |
nonsense |
probably null |
|
|
R6037:Megf8
|
UTSW |
7 |
25,063,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6037:Megf8
|
UTSW |
7 |
25,063,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6153:Megf8
|
UTSW |
7 |
25,046,796 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6210:Megf8
|
UTSW |
7 |
25,043,145 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6457:Megf8
|
UTSW |
7 |
25,049,120 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6659:Megf8
|
UTSW |
7 |
25,058,159 (GRCm39) |
missense |
probably benign |
0.38 |
|
R6867:Megf8
|
UTSW |
7 |
25,030,460 (GRCm39) |
missense |
probably benign |
0.42 |
|
R6896:Megf8
|
UTSW |
7 |
25,029,357 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6899:Megf8
|
UTSW |
7 |
25,060,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6905:Megf8
|
UTSW |
7 |
25,037,357 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7099:Megf8
|
UTSW |
7 |
25,045,945 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7172:Megf8
|
UTSW |
7 |
25,043,092 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7378:Megf8
|
UTSW |
7 |
25,048,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7427:Megf8
|
UTSW |
7 |
25,037,796 (GRCm39) |
missense |
probably benign |
0.44 |
|
R7492:Megf8
|
UTSW |
7 |
25,053,273 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7699:Megf8
|
UTSW |
7 |
25,029,353 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7700:Megf8
|
UTSW |
7 |
25,029,353 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7756:Megf8
|
UTSW |
7 |
25,041,850 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7758:Megf8
|
UTSW |
7 |
25,041,850 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7786:Megf8
|
UTSW |
7 |
25,017,120 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7797:Megf8
|
UTSW |
7 |
25,034,022 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7881:Megf8
|
UTSW |
7 |
25,040,060 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R8165:Megf8
|
UTSW |
7 |
25,053,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8258:Megf8
|
UTSW |
7 |
25,057,848 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8259:Megf8
|
UTSW |
7 |
25,057,848 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8328:Megf8
|
UTSW |
7 |
25,046,917 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8362:Megf8
|
UTSW |
7 |
25,039,943 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8680:Megf8
|
UTSW |
7 |
25,059,166 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9080:Megf8
|
UTSW |
7 |
25,041,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9297:Megf8
|
UTSW |
7 |
25,030,511 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9314:Megf8
|
UTSW |
7 |
25,029,297 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9378:Megf8
|
UTSW |
7 |
25,039,840 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9530:Megf8
|
UTSW |
7 |
25,030,124 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9557:Megf8
|
UTSW |
7 |
25,058,511 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9592:Megf8
|
UTSW |
7 |
25,028,228 (GRCm39) |
missense |
probably benign |
0.29 |
|
R9612:Megf8
|
UTSW |
7 |
25,054,488 (GRCm39) |
missense |
probably benign |
0.40 |
|
R9629:Megf8
|
UTSW |
7 |
25,043,194 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R9643:Megf8
|
UTSW |
7 |
25,046,907 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9666:Megf8
|
UTSW |
7 |
25,030,166 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R9745:Megf8
|
UTSW |
7 |
25,058,133 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
Z1088:Megf8
|
UTSW |
7 |
25,039,094 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
Z1177:Megf8
|
UTSW |
7 |
25,046,794 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Megf8
|
UTSW |
7 |
25,045,587 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTGCTCTCCAGGATACTATGGGGAC -3'
(R):5'- AAGGGCTGGATGACCTGACCAATG -3'
Sequencing Primer
(F):5'- TAAAGAACATGTGGGGCTTGTC -3'
(R):5'- GATGACCTGACCAATGGTTTTAG -3'
|
| Posted On |
2014-03-14 |
Incidental Mutation