Incidental Mutation 'R1449:Wnk1'
ID 159123
Institutional Source Beutler Lab
Gene Symbol Wnk1
Ensembl Gene ENSMUSG00000045962
Gene Name WNK lysine deficient protein kinase 1
Synonyms Prkwnk1, 6430573H23Rik, EG406236, Hsn2
MMRRC Submission 039504-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1449 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 119900930-120015633 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 119929779 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 1246 (V1246A)
Ref Sequence ENSEMBL: ENSMUSP00000086017 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060043] [ENSMUST00000088644] [ENSMUST00000088646] [ENSMUST00000160686] [ENSMUST00000203030] [ENSMUST00000177761]
AlphaFold P83741
Predicted Effect probably benign
Transcript: ENSMUST00000060043
AA Change: V988A

PolyPhen 2 Score 0.390 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000063001
Gene: ENSMUSG00000045962
AA Change: V988A

DomainStartEndE-ValueType
low complexity region 101 115 N/A INTRINSIC
low complexity region 127 141 N/A INTRINSIC
low complexity region 171 193 N/A INTRINSIC
Pfam:Pkinase_Tyr 221 477 1.5e-44 PFAM
Pfam:Pkinase 221 479 4.4e-58 PFAM
Pfam:OSR1_C 500 537 2e-22 PFAM
coiled coil region 563 597 N/A INTRINSIC
low complexity region 734 746 N/A INTRINSIC
low complexity region 865 876 N/A INTRINSIC
low complexity region 1018 1028 N/A INTRINSIC
low complexity region 1042 1058 N/A INTRINSIC
internal_repeat_1 1136 1178 2.15e-5 PROSPERO
low complexity region 1289 1305 N/A INTRINSIC
low complexity region 1345 1357 N/A INTRINSIC
low complexity region 1379 1396 N/A INTRINSIC
low complexity region 1398 1428 N/A INTRINSIC
low complexity region 1429 1454 N/A INTRINSIC
low complexity region 1496 1515 N/A INTRINSIC
low complexity region 1542 1556 N/A INTRINSIC
low complexity region 1586 1609 N/A INTRINSIC
low complexity region 1670 1691 N/A INTRINSIC
low complexity region 1698 1712 N/A INTRINSIC
low complexity region 1738 1764 N/A INTRINSIC
low complexity region 1882 1900 N/A INTRINSIC
coiled coil region 2065 2092 N/A INTRINSIC
low complexity region 2103 2114 N/A INTRINSIC
low complexity region 2116 2140 N/A INTRINSIC
low complexity region 2208 2232 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000088644
AA Change: V1246A

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000086017
Gene: ENSMUSG00000045962
AA Change: V1246A

DomainStartEndE-ValueType
low complexity region 101 115 N/A INTRINSIC
low complexity region 127 141 N/A INTRINSIC
low complexity region 171 193 N/A INTRINSIC
Pfam:Pkinase_Tyr 221 477 5.5e-44 PFAM
Pfam:Pkinase 221 479 4.3e-56 PFAM
Pfam:OSR1_C 500 537 1.9e-22 PFAM
coiled coil region 563 597 N/A INTRINSIC
low complexity region 742 753 N/A INTRINSIC
low complexity region 919 935 N/A INTRINSIC
low complexity region 1050 1063 N/A INTRINSIC
low complexity region 1067 1076 N/A INTRINSIC
low complexity region 1146 1158 N/A INTRINSIC
low complexity region 1276 1286 N/A INTRINSIC
low complexity region 1300 1316 N/A INTRINSIC
internal_repeat_1 1394 1436 2.19e-5 PROSPERO
low complexity region 1547 1563 N/A INTRINSIC
low complexity region 1603 1615 N/A INTRINSIC
low complexity region 1637 1654 N/A INTRINSIC
low complexity region 1656 1686 N/A INTRINSIC
low complexity region 1687 1712 N/A INTRINSIC
low complexity region 1754 1773 N/A INTRINSIC
low complexity region 1800 1814 N/A INTRINSIC
low complexity region 1844 1867 N/A INTRINSIC
low complexity region 1928 1949 N/A INTRINSIC
low complexity region 1956 1970 N/A INTRINSIC
low complexity region 1996 2022 N/A INTRINSIC
low complexity region 2140 2158 N/A INTRINSIC
coiled coil region 2323 2350 N/A INTRINSIC
low complexity region 2361 2372 N/A INTRINSIC
low complexity region 2374 2398 N/A INTRINSIC
low complexity region 2466 2490 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000088646
AA Change: V834A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000086019
Gene: ENSMUSG00000045962
AA Change: V834A

DomainStartEndE-ValueType
low complexity region 101 115 N/A INTRINSIC
low complexity region 127 141 N/A INTRINSIC
low complexity region 171 193 N/A INTRINSIC
Pfam:Pkinase_Tyr 221 477 1.3e-44 PFAM
Pfam:Pkinase 221 479 4e-58 PFAM
Pfam:OSR1_C 500 537 1.8e-22 PFAM
coiled coil region 563 597 N/A INTRINSIC
low complexity region 734 746 N/A INTRINSIC
low complexity region 864 874 N/A INTRINSIC
low complexity region 888 904 N/A INTRINSIC
internal_repeat_1 982 1024 7.56e-6 PROSPERO
low complexity region 1135 1151 N/A INTRINSIC
low complexity region 1191 1203 N/A INTRINSIC
low complexity region 1225 1242 N/A INTRINSIC
low complexity region 1244 1274 N/A INTRINSIC
low complexity region 1275 1300 N/A INTRINSIC
low complexity region 1342 1361 N/A INTRINSIC
low complexity region 1388 1402 N/A INTRINSIC
low complexity region 1432 1455 N/A INTRINSIC
low complexity region 1516 1537 N/A INTRINSIC
low complexity region 1544 1558 N/A INTRINSIC
low complexity region 1584 1610 N/A INTRINSIC
low complexity region 1700 1718 N/A INTRINSIC
coiled coil region 1883 1910 N/A INTRINSIC
low complexity region 1921 1932 N/A INTRINSIC
low complexity region 1934 1958 N/A INTRINSIC
low complexity region 2026 2050 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159397
Predicted Effect unknown
Transcript: ENSMUST00000159785
AA Change: V128A
SMART Domains Protein: ENSMUSP00000124905
Gene: ENSMUSG00000045962
AA Change: V128A

DomainStartEndE-ValueType
low complexity region 159 169 N/A INTRINSIC
low complexity region 183 199 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000160686
SMART Domains Protein: ENSMUSP00000137334
Gene: ENSMUSG00000045962

DomainStartEndE-ValueType
low complexity region 102 115 N/A INTRINSIC
low complexity region 119 128 N/A INTRINSIC
low complexity region 198 210 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000203030
SMART Domains Protein: ENSMUSP00000145304
Gene: ENSMUSG00000045962

DomainStartEndE-ValueType
low complexity region 101 115 N/A INTRINSIC
low complexity region 127 141 N/A INTRINSIC
low complexity region 171 193 N/A INTRINSIC
Pfam:Pkinase_Tyr 221 477 4.1e-44 PFAM
Pfam:Pkinase 221 479 3.2e-56 PFAM
Pfam:OSR1_C 500 537 1.5e-22 PFAM
coiled coil region 563 597 N/A INTRINSIC
low complexity region 734 746 N/A INTRINSIC
low complexity region 793 809 N/A INTRINSIC
internal_repeat_1 887 929 5.8e-6 PROSPERO
low complexity region 1040 1056 N/A INTRINSIC
low complexity region 1096 1108 N/A INTRINSIC
low complexity region 1130 1147 N/A INTRINSIC
low complexity region 1149 1179 N/A INTRINSIC
low complexity region 1180 1205 N/A INTRINSIC
low complexity region 1247 1266 N/A INTRINSIC
low complexity region 1293 1307 N/A INTRINSIC
low complexity region 1337 1360 N/A INTRINSIC
low complexity region 1421 1442 N/A INTRINSIC
low complexity region 1449 1463 N/A INTRINSIC
low complexity region 1489 1515 N/A INTRINSIC
low complexity region 1633 1651 N/A INTRINSIC
coiled coil region 1816 1843 N/A INTRINSIC
low complexity region 1854 1865 N/A INTRINSIC
low complexity region 1867 1891 N/A INTRINSIC
low complexity region 1959 1983 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161185
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160769
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204207
Predicted Effect probably benign
Transcript: ENSMUST00000162368
SMART Domains Protein: ENSMUSP00000125383
Gene: ENSMUSG00000045962

DomainStartEndE-ValueType
low complexity region 83 95 N/A INTRINSIC
low complexity region 142 158 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000161802
SMART Domains Protein: ENSMUSP00000124724
Gene: ENSMUSG00000045962

DomainStartEndE-ValueType
low complexity region 24 50 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000161048
SMART Domains Protein: ENSMUSP00000125345
Gene: ENSMUSG00000045962

DomainStartEndE-ValueType
Blast:S_TKc 2 68 3e-34 BLAST
SCOP:d1phk__ 3 70 2e-7 SMART
Pfam:OSR1_C 89 126 9.5e-21 PFAM
coiled coil region 151 185 N/A INTRINSIC
low complexity region 323 335 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000177761
SMART Domains Protein: ENSMUSP00000136777
Gene: ENSMUSG00000045962

DomainStartEndE-ValueType
low complexity region 101 115 N/A INTRINSIC
low complexity region 127 141 N/A INTRINSIC
low complexity region 171 193 N/A INTRINSIC
Pfam:Pkinase_Tyr 221 477 1.7e-44 PFAM
Pfam:Pkinase 221 479 5.1e-58 PFAM
Pfam:OSR1_C 500 537 2.2e-22 PFAM
coiled coil region 563 597 N/A INTRINSIC
low complexity region 710 722 N/A INTRINSIC
low complexity region 828 839 N/A INTRINSIC
low complexity region 1005 1021 N/A INTRINSIC
low complexity region 1136 1149 N/A INTRINSIC
low complexity region 1153 1162 N/A INTRINSIC
low complexity region 1232 1244 N/A INTRINSIC
low complexity region 1291 1307 N/A INTRINSIC
internal_repeat_1 1385 1427 1.91e-5 PROSPERO
low complexity region 1538 1554 N/A INTRINSIC
low complexity region 1594 1606 N/A INTRINSIC
low complexity region 1628 1645 N/A INTRINSIC
low complexity region 1647 1677 N/A INTRINSIC
low complexity region 1678 1703 N/A INTRINSIC
low complexity region 1745 1764 N/A INTRINSIC
low complexity region 1791 1805 N/A INTRINSIC
low complexity region 1835 1858 N/A INTRINSIC
low complexity region 1919 1940 N/A INTRINSIC
low complexity region 1947 1961 N/A INTRINSIC
low complexity region 1987 2013 N/A INTRINSIC
low complexity region 2131 2149 N/A INTRINSIC
coiled coil region 2314 2341 N/A INTRINSIC
low complexity region 2352 2363 N/A INTRINSIC
low complexity region 2365 2389 N/A INTRINSIC
low complexity region 2457 2481 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000162541
SMART Domains Protein: ENSMUSP00000125193
Gene: ENSMUSG00000045962

DomainStartEndE-ValueType
low complexity region 63 84 N/A INTRINSIC
low complexity region 91 105 N/A INTRINSIC
low complexity region 131 157 N/A INTRINSIC
low complexity region 247 265 N/A INTRINSIC
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.9%
  • 10x: 94.7%
  • 20x: 87.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]
PHENOTYPE: Homozygous mutant mice die before birth, whereas heterozygotes survive and exhibit decreased blood pressure. Mice homozygous for an allele that does not produce the kidney isoform exhibit a slight increase in systemic arterial diastolic blood pressure and reduced sensitivity to amiloride. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700013G24Rik A G 4: 137,182,666 (GRCm39) N274D possibly damaging Het
6430571L13Rik T A 9: 107,219,689 (GRCm39) N47K probably damaging Het
Aasdh C T 5: 77,034,136 (GRCm39) A472T probably benign Het
Abca13 A G 11: 9,248,580 (GRCm39) T2776A probably damaging Het
Adamts10 T A 17: 33,764,613 (GRCm39) V711D probably damaging Het
Adrb3 G A 8: 27,717,415 (GRCm39) R345C probably damaging Het
Ak7 T C 12: 105,708,520 (GRCm39) V325A possibly damaging Het
Armc6 G A 8: 70,677,943 (GRCm39) L129F probably benign Het
Bend6 T C 1: 33,917,424 (GRCm39) N10S probably benign Het
Bmpr1b T C 3: 141,577,134 (GRCm39) E59G possibly damaging Het
Brd3 A G 2: 27,340,263 (GRCm39) probably null Het
Brd3 A G 2: 27,347,028 (GRCm39) Y369H probably damaging Het
Cacna1e C T 1: 154,361,408 (GRCm39) probably null Het
Camk4 A G 18: 33,072,528 (GRCm39) D27G probably damaging Het
Camkk1 T G 11: 72,924,710 (GRCm39) S308A probably damaging Het
Catsperb A G 12: 101,554,456 (GRCm39) T717A probably benign Het
Cdh23 A T 10: 60,212,730 (GRCm39) S1563R probably damaging Het
Cep44 A T 8: 56,993,985 (GRCm39) S197R probably benign Het
Col3a1 T A 1: 45,360,771 (GRCm39) I67N unknown Het
Dcaf12l1 T C X: 43,878,304 (GRCm39) T165A probably benign Het
Dicer1 T C 12: 104,695,502 (GRCm39) Y143C possibly damaging Het
Dlg5 A G 14: 24,185,711 (GRCm39) I1898T possibly damaging Het
Dnah1 T C 14: 30,985,908 (GRCm39) N3762D probably damaging Het
Dscaml1 A T 9: 45,653,521 (GRCm39) T1382S possibly damaging Het
Entpd3 A T 9: 120,395,555 (GRCm39) R513W probably damaging Het
Foxred1 A G 9: 35,120,738 (GRCm39) S132P probably damaging Het
Ftsj3 T C 11: 106,143,826 (GRCm39) I273V probably benign Het
Hsd17b7 C T 1: 169,787,251 (GRCm39) probably null Het
Iars1 T A 13: 49,887,186 (GRCm39) V1253D probably damaging Het
Iqsec1 T A 6: 90,667,790 (GRCm39) K216* probably null Het
Itga7 A G 10: 128,789,370 (GRCm39) D971G probably benign Het
Kcnk2 G A 1: 189,072,223 (GRCm39) S35L probably benign Het
Kif13a T C 13: 46,966,212 (GRCm39) Y402C probably damaging Het
Lamc1 A G 1: 153,126,241 (GRCm39) S484P probably benign Het
Lap3 T C 5: 45,666,861 (GRCm39) probably null Het
Lhx8 G T 3: 154,033,742 (GRCm39) S46* probably null Het
Lin7a T C 10: 107,159,813 (GRCm39) S42P probably damaging Het
Lrba G A 3: 86,261,585 (GRCm39) R1513Q probably damaging Het
Maml2 C A 9: 13,531,980 (GRCm39) P398Q possibly damaging Het
Mast2 T C 4: 116,166,210 (GRCm39) I1201V probably damaging Het
Mmp20 A T 9: 7,642,769 (GRCm39) D201V probably damaging Het
Morn5 T A 2: 35,947,092 (GRCm39) C123* probably null Het
Mrpl4 A G 9: 20,918,807 (GRCm39) K175E possibly damaging Het
Nav3 A T 10: 109,689,372 (GRCm39) S302T probably benign Het
Ndrg2 T C 14: 52,145,591 (GRCm39) Y217C probably damaging Het
Nfx1 A G 4: 40,976,803 (GRCm39) D159G probably damaging Het
Nlrp9b A T 7: 19,757,089 (GRCm39) T109S possibly damaging Het
Npepps A G 11: 97,097,980 (GRCm39) Y909H probably benign Het
Or10g1 A G 14: 52,648,024 (GRCm39) C102R probably damaging Het
Or11g7 A G 14: 50,691,378 (GRCm39) N290D probably damaging Het
Or51a25 A T 7: 102,373,397 (GRCm39) F100Y probably damaging Het
Or6c211 T A 10: 129,506,238 (GRCm39) D50V probably damaging Het
Or6c69b A C 10: 129,626,723 (GRCm39) V245G probably damaging Het
Pcdh1 T C 18: 38,322,929 (GRCm39) H968R probably damaging Het
Pde1b T A 15: 103,433,470 (GRCm39) I296N probably damaging Het
Phldb1 T A 9: 44,627,930 (GRCm39) T172S probably benign Het
Plxdc2 T C 2: 16,665,592 (GRCm39) V215A possibly damaging Het
Poln A G 5: 34,171,682 (GRCm39) I695T probably damaging Het
Pou6f2 G T 13: 18,347,000 (GRCm39) Q31K probably damaging Het
Psd T A 19: 46,313,250 (GRCm39) Y40F probably damaging Het
Rnf126 T C 10: 79,597,448 (GRCm39) N155D probably benign Het
Rpl36-ps3 C A 12: 12,962,032 (GRCm39) noncoding transcript Het
Rrp15 C A 1: 186,468,465 (GRCm39) V184F possibly damaging Het
Rslcan18 G T 13: 67,250,164 (GRCm39) L24M possibly damaging Het
Sall1 A G 8: 89,759,111 (GRCm39) I331T probably benign Het
Slamf7 A T 1: 171,468,606 (GRCm39) N95K possibly damaging Het
Slc1a6 T C 10: 78,635,951 (GRCm39) Y339H probably damaging Het
Slc39a8 A G 3: 135,532,446 (GRCm39) N72D probably benign Het
Slf1 A G 13: 77,231,568 (GRCm39) S604P probably damaging Het
Slfn4 C T 11: 83,079,819 (GRCm39) T110M probably benign Het
Tnpo1 T C 13: 99,015,220 (GRCm39) T116A probably damaging Het
Tor1b T C 2: 30,845,893 (GRCm39) I190T probably damaging Het
Ttn C A 2: 76,800,138 (GRCm39) E357* probably null Het
Tubg2 G T 11: 101,047,699 (GRCm39) E95* probably null Het
Ubap2 A G 4: 41,209,351 (GRCm39) probably null Het
Ube2i T C 17: 25,487,538 (GRCm39) D67G possibly damaging Het
Ubxn11 A G 4: 133,852,203 (GRCm39) E50G probably damaging Het
Zcchc7 A G 4: 44,929,124 (GRCm39) T38A possibly damaging Het
Zfp236 A G 18: 82,664,130 (GRCm39) S552P probably damaging Het
Other mutations in Wnk1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00901:Wnk1 APN 6 119,937,669 (GRCm39) missense probably damaging 1.00
IGL01364:Wnk1 APN 6 119,914,372 (GRCm39) missense probably damaging 1.00
IGL01715:Wnk1 APN 6 119,925,358 (GRCm39) missense probably damaging 1.00
IGL01951:Wnk1 APN 6 119,940,446 (GRCm39) missense probably damaging 0.99
IGL02043:Wnk1 APN 6 119,926,039 (GRCm39) unclassified probably benign
IGL02268:Wnk1 APN 6 119,914,334 (GRCm39) nonsense probably null
IGL02348:Wnk1 APN 6 119,940,289 (GRCm39) missense probably damaging 0.98
IGL02425:Wnk1 APN 6 119,940,415 (GRCm39) missense probably damaging 1.00
IGL02850:Wnk1 APN 6 119,914,823 (GRCm39) missense probably benign 0.26
IGL03160:Wnk1 APN 6 119,903,594 (GRCm39) missense probably damaging 1.00
IGL03387:Wnk1 APN 6 119,931,148 (GRCm39) missense possibly damaging 0.76
IGL03405:Wnk1 APN 6 119,930,856 (GRCm39) missense probably benign 0.41
Actor UTSW 6 119,947,939 (GRCm39) missense probably damaging 1.00
Bad UTSW 6 119,942,639 (GRCm39) intron probably benign
Blink UTSW 6 119,979,234 (GRCm39) nonsense probably null
Knock UTSW 6 119,920,839 (GRCm39) splice site probably null
Narrow UTSW 6 119,969,369 (GRCm39) missense probably damaging 1.00
nictitate UTSW 6 119,979,241 (GRCm39) missense possibly damaging 0.88
opportunity UTSW 6 119,928,029 (GRCm39) missense probably damaging 1.00
path UTSW 6 120,014,110 (GRCm39) missense probably damaging 0.99
Stormy UTSW 6 119,969,408 (GRCm39) missense probably damaging 1.00
tear UTSW 6 119,940,431 (GRCm39) missense probably damaging 0.98
Tic UTSW 6 119,927,044 (GRCm39) missense probably damaging 1.00
Unforgiving UTSW 6 119,925,243 (GRCm39) missense probably damaging 1.00
Window UTSW 6 119,969,414 (GRCm39) missense probably damaging 1.00
Woke UTSW 6 119,939,916 (GRCm39) missense probably benign 0.12
IGL03052:Wnk1 UTSW 6 119,921,760 (GRCm39) splice site probably benign
PIT4480001:Wnk1 UTSW 6 119,940,328 (GRCm39) nonsense probably null
R0044:Wnk1 UTSW 6 120,014,110 (GRCm39) missense probably damaging 0.99
R0207:Wnk1 UTSW 6 119,929,694 (GRCm39) missense probably damaging 1.00
R0333:Wnk1 UTSW 6 119,905,124 (GRCm39) intron probably benign
R0453:Wnk1 UTSW 6 119,940,112 (GRCm39) missense probably damaging 0.99
R0457:Wnk1 UTSW 6 119,946,293 (GRCm39) missense probably damaging 1.00
R0501:Wnk1 UTSW 6 119,939,764 (GRCm39) missense probably damaging 1.00
R0525:Wnk1 UTSW 6 119,903,525 (GRCm39) missense probably damaging 1.00
R0526:Wnk1 UTSW 6 119,928,953 (GRCm39) missense probably damaging 0.99
R0606:Wnk1 UTSW 6 119,903,644 (GRCm39) missense probably damaging 1.00
R0658:Wnk1 UTSW 6 119,925,466 (GRCm39) missense probably damaging 0.98
R1148:Wnk1 UTSW 6 119,928,967 (GRCm39) splice site probably benign
R1188:Wnk1 UTSW 6 119,925,670 (GRCm39) nonsense probably null
R1245:Wnk1 UTSW 6 119,925,418 (GRCm39) missense probably benign 0.26
R1469:Wnk1 UTSW 6 119,927,645 (GRCm39) splice site probably benign
R1869:Wnk1 UTSW 6 119,928,050 (GRCm39) missense probably damaging 1.00
R1871:Wnk1 UTSW 6 119,928,050 (GRCm39) missense probably damaging 1.00
R1928:Wnk1 UTSW 6 119,929,884 (GRCm39) missense probably damaging 1.00
R1959:Wnk1 UTSW 6 119,946,208 (GRCm39) missense probably damaging 0.98
R1961:Wnk1 UTSW 6 119,946,208 (GRCm39) missense probably damaging 0.98
R1964:Wnk1 UTSW 6 119,911,343 (GRCm39) missense possibly damaging 0.86
R1983:Wnk1 UTSW 6 119,914,539 (GRCm39) missense probably damaging 1.00
R2062:Wnk1 UTSW 6 119,905,118 (GRCm39) splice site probably null
R2144:Wnk1 UTSW 6 119,925,949 (GRCm39) unclassified probably benign
R2186:Wnk1 UTSW 6 119,925,528 (GRCm39) missense probably benign 0.26
R2281:Wnk1 UTSW 6 119,940,601 (GRCm39) splice site probably null
R2338:Wnk1 UTSW 6 119,946,495 (GRCm39) missense probably benign 0.42
R2420:Wnk1 UTSW 6 119,913,328 (GRCm39) critical splice donor site probably null
R3727:Wnk1 UTSW 6 119,969,414 (GRCm39) missense probably damaging 1.00
R3773:Wnk1 UTSW 6 119,979,241 (GRCm39) missense possibly damaging 0.88
R3836:Wnk1 UTSW 6 119,927,004 (GRCm39) missense probably damaging 1.00
R3837:Wnk1 UTSW 6 119,927,004 (GRCm39) missense probably damaging 1.00
R3847:Wnk1 UTSW 6 119,946,315 (GRCm39) missense possibly damaging 0.70
R3903:Wnk1 UTSW 6 119,926,012 (GRCm39) missense probably damaging 1.00
R4031:Wnk1 UTSW 6 119,928,029 (GRCm39) missense probably damaging 1.00
R4095:Wnk1 UTSW 6 119,925,087 (GRCm39) missense probably damaging 1.00
R4232:Wnk1 UTSW 6 119,926,222 (GRCm39) missense possibly damaging 0.90
R4422:Wnk1 UTSW 6 119,930,856 (GRCm39) missense probably benign 0.41
R4423:Wnk1 UTSW 6 119,903,387 (GRCm39) missense probably damaging 1.00
R4572:Wnk1 UTSW 6 119,928,872 (GRCm39) missense possibly damaging 0.49
R4704:Wnk1 UTSW 6 119,942,705 (GRCm39) missense possibly damaging 0.83
R4755:Wnk1 UTSW 6 119,940,431 (GRCm39) missense probably damaging 0.98
R4812:Wnk1 UTSW 6 119,929,732 (GRCm39) missense probably benign 0.16
R4822:Wnk1 UTSW 6 119,939,399 (GRCm39) missense probably benign 0.02
R4879:Wnk1 UTSW 6 119,926,338 (GRCm39) missense probably damaging 1.00
R4970:Wnk1 UTSW 6 119,942,696 (GRCm39) intron probably benign
R5002:Wnk1 UTSW 6 119,914,924 (GRCm39) missense probably benign 0.13
R5037:Wnk1 UTSW 6 119,942,696 (GRCm39) intron probably benign
R5152:Wnk1 UTSW 6 119,979,241 (GRCm39) missense possibly damaging 0.88
R5257:Wnk1 UTSW 6 120,014,149 (GRCm39) missense probably benign 0.00
R5354:Wnk1 UTSW 6 119,945,484 (GRCm39) missense probably benign 0.01
R5421:Wnk1 UTSW 6 119,929,779 (GRCm39) missense probably damaging 1.00
R5564:Wnk1 UTSW 6 119,925,852 (GRCm39) unclassified probably benign
R5600:Wnk1 UTSW 6 119,926,319 (GRCm39) missense probably damaging 1.00
R5847:Wnk1 UTSW 6 119,969,369 (GRCm39) missense probably damaging 1.00
R6083:Wnk1 UTSW 6 120,014,562 (GRCm39) missense probably damaging 0.99
R6110:Wnk1 UTSW 6 119,949,958 (GRCm39) intron probably benign
R6128:Wnk1 UTSW 6 119,940,747 (GRCm39) splice site probably null
R6237:Wnk1 UTSW 6 119,929,728 (GRCm39) missense probably damaging 1.00
R6341:Wnk1 UTSW 6 119,925,546 (GRCm39) missense probably damaging 1.00
R6467:Wnk1 UTSW 6 119,939,916 (GRCm39) missense probably benign 0.12
R6696:Wnk1 UTSW 6 119,925,243 (GRCm39) missense probably damaging 1.00
R6888:Wnk1 UTSW 6 119,925,742 (GRCm39) missense probably benign 0.26
R6923:Wnk1 UTSW 6 119,942,639 (GRCm39) intron probably benign
R7024:Wnk1 UTSW 6 119,942,687 (GRCm39) intron probably benign
R7072:Wnk1 UTSW 6 119,914,822 (GRCm39) missense unknown
R7087:Wnk1 UTSW 6 120,014,491 (GRCm39) missense possibly damaging 0.94
R7102:Wnk1 UTSW 6 119,925,268 (GRCm39) missense unknown
R7134:Wnk1 UTSW 6 119,903,389 (GRCm39) missense unknown
R7137:Wnk1 UTSW 6 120,015,173 (GRCm39) unclassified probably benign
R7142:Wnk1 UTSW 6 119,926,240 (GRCm39) missense probably benign 0.09
R7174:Wnk1 UTSW 6 119,947,939 (GRCm39) missense probably damaging 1.00
R7205:Wnk1 UTSW 6 119,920,839 (GRCm39) splice site probably null
R7218:Wnk1 UTSW 6 119,979,234 (GRCm39) nonsense probably null
R7498:Wnk1 UTSW 6 119,904,157 (GRCm39) missense unknown
R7599:Wnk1 UTSW 6 119,906,789 (GRCm39) missense possibly damaging 0.83
R7615:Wnk1 UTSW 6 119,909,699 (GRCm39) missense probably benign 0.27
R7799:Wnk1 UTSW 6 119,926,137 (GRCm39) missense probably benign 0.04
R7979:Wnk1 UTSW 6 120,014,409 (GRCm39) missense probably damaging 1.00
R8075:Wnk1 UTSW 6 119,909,675 (GRCm39) missense probably damaging 0.99
R8331:Wnk1 UTSW 6 119,930,794 (GRCm39) missense probably benign 0.09
R8343:Wnk1 UTSW 6 119,940,454 (GRCm39) missense probably damaging 0.99
R8348:Wnk1 UTSW 6 119,906,960 (GRCm39) splice site probably null
R8359:Wnk1 UTSW 6 119,969,408 (GRCm39) missense probably damaging 1.00
R8424:Wnk1 UTSW 6 119,911,388 (GRCm39) missense unknown
R8519:Wnk1 UTSW 6 119,927,044 (GRCm39) missense probably damaging 1.00
R8930:Wnk1 UTSW 6 119,940,226 (GRCm39) missense probably damaging 0.99
R8932:Wnk1 UTSW 6 119,940,226 (GRCm39) missense probably damaging 0.99
R8933:Wnk1 UTSW 6 120,013,959 (GRCm39) missense probably damaging 1.00
R9005:Wnk1 UTSW 6 119,939,393 (GRCm39) missense probably damaging 1.00
R9147:Wnk1 UTSW 6 119,925,631 (GRCm39) missense unknown
R9148:Wnk1 UTSW 6 119,925,631 (GRCm39) missense unknown
R9354:Wnk1 UTSW 6 119,942,660 (GRCm39) missense unknown
R9379:Wnk1 UTSW 6 119,928,678 (GRCm39) missense probably damaging 1.00
X0064:Wnk1 UTSW 6 120,013,993 (GRCm39) missense possibly damaging 0.93
Z1177:Wnk1 UTSW 6 119,925,166 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TTCCCAACAGAACAGCCAGTGG -3'
(R):5'- AGAAAGTGGGACACTGTCCTTTGC -3'

Sequencing Primer
(F):5'- GGCATTTCATTCTGCTGTAAGAC -3'
(R):5'- AATTTGATGTCTCAACCTGCAC -3'
Posted On 2014-03-14