Incidental Mutation 'R1463:Nav2'
| ID |
159225 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nav2
|
| Ensembl Gene |
ENSMUSG00000052512 |
| Gene Name |
neuron navigator 2 |
| Synonyms |
Rainb1, Unc53H2, 5330421F07Rik, POMFIL2, HELAD1, RAINB2 |
| MMRRC Submission |
039517-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.550)
|
| Stock # |
R1463 (G1)
|
| Quality Score |
216 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
48608796-49259838 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 49185710 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Serine
at position 951
(I951S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000139045
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000064395]
[ENSMUST00000183659]
[ENSMUST00000184945]
|
| AlphaFold |
E9Q842 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000064395
AA Change: I951S
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000067448
Gene: ENSMUSG00000052512
AA Change: I951S
| Domain | Start | End | E-Value | Type |
|---|
|
CH
|
84 |
187 |
1.58e-13 |
SMART |
|
low complexity region
|
202 |
210 |
N/A |
INTRINSIC |
|
low complexity region
|
297 |
310 |
N/A |
INTRINSIC |
|
low complexity region
|
337 |
348 |
N/A |
INTRINSIC |
|
low complexity region
|
412 |
424 |
N/A |
INTRINSIC |
|
coiled coil region
|
486 |
516 |
N/A |
INTRINSIC |
|
low complexity region
|
580 |
591 |
N/A |
INTRINSIC |
|
low complexity region
|
613 |
625 |
N/A |
INTRINSIC |
|
low complexity region
|
640 |
662 |
N/A |
INTRINSIC |
|
low complexity region
|
846 |
857 |
N/A |
INTRINSIC |
|
low complexity region
|
920 |
944 |
N/A |
INTRINSIC |
|
low complexity region
|
947 |
967 |
N/A |
INTRINSIC |
|
low complexity region
|
990 |
1004 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1074 |
N/A |
INTRINSIC |
|
low complexity region
|
1343 |
1360 |
N/A |
INTRINSIC |
|
low complexity region
|
1368 |
1385 |
N/A |
INTRINSIC |
|
low complexity region
|
1417 |
1432 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1466 |
N/A |
INTRINSIC |
|
low complexity region
|
1526 |
1540 |
N/A |
INTRINSIC |
|
low complexity region
|
1614 |
1628 |
N/A |
INTRINSIC |
|
coiled coil region
|
1630 |
1717 |
N/A |
INTRINSIC |
|
low complexity region
|
1789 |
1800 |
N/A |
INTRINSIC |
|
coiled coil region
|
1841 |
1909 |
N/A |
INTRINSIC |
|
AAA
|
2093 |
2247 |
1.69e-5 |
SMART |
|
low complexity region
|
2404 |
2430 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000183659
AA Change: I890S
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000139309
Gene: ENSMUSG00000052512
AA Change: I890S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
11 |
N/A |
INTRINSIC |
|
CH
|
23 |
126 |
6.19e-16 |
SMART |
|
low complexity region
|
141 |
149 |
N/A |
INTRINSIC |
|
low complexity region
|
236 |
249 |
N/A |
INTRINSIC |
|
low complexity region
|
276 |
287 |
N/A |
INTRINSIC |
|
low complexity region
|
351 |
363 |
N/A |
INTRINSIC |
|
coiled coil region
|
425 |
455 |
N/A |
INTRINSIC |
|
low complexity region
|
519 |
530 |
N/A |
INTRINSIC |
|
low complexity region
|
552 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
579 |
601 |
N/A |
INTRINSIC |
|
low complexity region
|
785 |
796 |
N/A |
INTRINSIC |
|
low complexity region
|
859 |
883 |
N/A |
INTRINSIC |
|
low complexity region
|
886 |
906 |
N/A |
INTRINSIC |
|
low complexity region
|
929 |
943 |
N/A |
INTRINSIC |
|
low complexity region
|
1001 |
1013 |
N/A |
INTRINSIC |
|
low complexity region
|
1282 |
1299 |
N/A |
INTRINSIC |
|
low complexity region
|
1307 |
1324 |
N/A |
INTRINSIC |
|
low complexity region
|
1356 |
1371 |
N/A |
INTRINSIC |
|
low complexity region
|
1393 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1465 |
1479 |
N/A |
INTRINSIC |
|
low complexity region
|
1553 |
1567 |
N/A |
INTRINSIC |
|
coiled coil region
|
1569 |
1656 |
N/A |
INTRINSIC |
|
low complexity region
|
1728 |
1739 |
N/A |
INTRINSIC |
|
coiled coil region
|
1780 |
1848 |
N/A |
INTRINSIC |
|
AAA
|
2032 |
2186 |
1.69e-5 |
SMART |
|
low complexity region
|
2343 |
2369 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000184945
AA Change: I951S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000139045
Gene: ENSMUSG00000052512
AA Change: I951S
| Domain | Start | End | E-Value | Type |
|---|
|
CH
|
84 |
187 |
1.58e-13 |
SMART |
|
low complexity region
|
202 |
210 |
N/A |
INTRINSIC |
|
low complexity region
|
297 |
310 |
N/A |
INTRINSIC |
|
low complexity region
|
337 |
348 |
N/A |
INTRINSIC |
|
low complexity region
|
412 |
424 |
N/A |
INTRINSIC |
|
coiled coil region
|
486 |
516 |
N/A |
INTRINSIC |
|
low complexity region
|
580 |
591 |
N/A |
INTRINSIC |
|
low complexity region
|
613 |
625 |
N/A |
INTRINSIC |
|
low complexity region
|
640 |
662 |
N/A |
INTRINSIC |
|
low complexity region
|
846 |
857 |
N/A |
INTRINSIC |
|
low complexity region
|
920 |
944 |
N/A |
INTRINSIC |
|
low complexity region
|
947 |
967 |
N/A |
INTRINSIC |
|
low complexity region
|
990 |
1004 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1074 |
N/A |
INTRINSIC |
|
low complexity region
|
1343 |
1360 |
N/A |
INTRINSIC |
|
low complexity region
|
1368 |
1385 |
N/A |
INTRINSIC |
|
low complexity region
|
1417 |
1432 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1466 |
N/A |
INTRINSIC |
|
low complexity region
|
1526 |
1540 |
N/A |
INTRINSIC |
|
low complexity region
|
1614 |
1628 |
N/A |
INTRINSIC |
|
coiled coil region
|
1630 |
1717 |
N/A |
INTRINSIC |
|
low complexity region
|
1789 |
1800 |
N/A |
INTRINSIC |
|
coiled coil region
|
1841 |
1909 |
N/A |
INTRINSIC |
|
AAA
|
2093 |
2247 |
1.69e-5 |
SMART |
|
low complexity region
|
2404 |
2430 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.4730 |
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.2%
- 10x: 96.0%
- 20x: 91.6%
|
| Validation Efficiency |
97% (97/100) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Homozygous null mice display impaired olfaction and hearing, increased latency in a hot plate test, degeneration of the optic nerve, decreased exploration in new environments, and weight loss. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca5 |
A |
T |
11: 110,205,384 (GRCm39) |
I299N |
probably damaging |
Het |
| Abcc8 |
T |
C |
7: 45,803,936 (GRCm39) |
T413A |
probably benign |
Het |
| Actc1 |
G |
A |
2: 113,880,010 (GRCm39) |
S201F |
probably damaging |
Het |
| Adam30 |
G |
A |
3: 98,069,841 (GRCm39) |
C558Y |
probably damaging |
Het |
| Adcy4 |
T |
A |
14: 56,016,396 (GRCm39) |
I352F |
probably damaging |
Het |
| Adgrl4 |
A |
T |
3: 151,216,233 (GRCm39) |
D472V |
probably damaging |
Het |
| Afap1l2 |
T |
A |
19: 56,918,583 (GRCm39) |
M117L |
probably benign |
Het |
| AI597479 |
T |
C |
1: 43,152,389 (GRCm39) |
V229A |
probably damaging |
Het |
| Ascc1 |
T |
C |
10: 59,898,338 (GRCm39) |
V267A |
probably benign |
Het |
| Asxl3 |
A |
G |
18: 22,649,810 (GRCm39) |
S600G |
possibly damaging |
Het |
| Atg14 |
T |
C |
14: 47,786,451 (GRCm39) |
I268V |
probably benign |
Het |
| Bcas1 |
C |
T |
2: 170,260,584 (GRCm39) |
V32I |
probably benign |
Het |
| Cacna1c |
G |
T |
6: 118,570,955 (GRCm39) |
D2106E |
probably benign |
Het |
| Cacna1i |
A |
G |
15: 80,263,255 (GRCm39) |
H1440R |
possibly damaging |
Het |
| Catsper2 |
G |
A |
2: 121,236,927 (GRCm39) |
T240M |
probably damaging |
Het |
| Ccn4 |
T |
A |
15: 66,791,120 (GRCm39) |
N307K |
possibly damaging |
Het |
| Cd163 |
A |
G |
6: 124,288,406 (GRCm39) |
E279G |
probably damaging |
Het |
| Cdx2 |
C |
T |
5: 147,243,470 (GRCm39) |
S108N |
probably benign |
Het |
| Cenpf |
A |
T |
1: 189,386,936 (GRCm39) |
N1781K |
probably damaging |
Het |
| Cgref1 |
T |
A |
5: 31,093,338 (GRCm39) |
|
probably benign |
Het |
| Clcn4 |
C |
T |
7: 7,299,763 (GRCm39) |
W22* |
probably null |
Het |
| Cntn2 |
A |
G |
1: 132,448,875 (GRCm39) |
|
probably null |
Het |
| Cntn5 |
C |
T |
9: 9,673,801 (GRCm39) |
|
probably null |
Het |
| Cpeb3 |
A |
G |
19: 37,116,500 (GRCm39) |
M377T |
probably benign |
Het |
| Cryge |
T |
A |
1: 65,087,997 (GRCm39) |
R135* |
probably null |
Het |
| Ctdsp2 |
C |
A |
10: 126,829,790 (GRCm39) |
|
probably benign |
Het |
| Ctsll3 |
G |
A |
13: 60,949,089 (GRCm39) |
|
probably benign |
Het |
| Cuzd1 |
C |
A |
7: 130,918,371 (GRCm39) |
G189C |
probably damaging |
Het |
| Dmbt1 |
T |
A |
7: 130,711,366 (GRCm39) |
|
probably null |
Het |
| Dnai4 |
T |
A |
4: 102,944,615 (GRCm39) |
L245F |
possibly damaging |
Het |
| Dnajc13 |
A |
T |
9: 104,056,139 (GRCm39) |
S1587R |
probably damaging |
Het |
| Dock4 |
GCTCAGTGTATC |
GC |
12: 40,866,324 (GRCm39) |
|
probably null |
Het |
| Dock6 |
T |
C |
9: 21,743,202 (GRCm39) |
H701R |
probably damaging |
Het |
| Edem3 |
A |
G |
1: 151,683,261 (GRCm39) |
T646A |
possibly damaging |
Het |
| Esrra |
A |
C |
19: 6,889,823 (GRCm39) |
D160E |
probably benign |
Het |
| Fbn2 |
T |
C |
18: 58,143,452 (GRCm39) |
T2868A |
probably benign |
Het |
| Galnt7 |
T |
A |
8: 58,105,892 (GRCm39) |
M41L |
probably benign |
Het |
| Gbf1 |
T |
C |
19: 46,259,984 (GRCm39) |
|
probably benign |
Het |
| Glyat |
A |
G |
19: 12,625,467 (GRCm39) |
N63S |
probably damaging |
Het |
| Gm9376 |
A |
T |
14: 118,504,894 (GRCm39) |
M109L |
probably benign |
Het |
| H2-M10.3 |
A |
G |
17: 36,677,612 (GRCm39) |
V222A |
probably damaging |
Het |
| Ifna12 |
T |
G |
4: 88,521,193 (GRCm39) |
D118A |
possibly damaging |
Het |
| Inpp5j |
T |
C |
11: 3,451,147 (GRCm39) |
M501V |
probably benign |
Het |
| Itpr3 |
C |
T |
17: 27,336,128 (GRCm39) |
|
probably benign |
Het |
| Ivns1abp |
A |
G |
1: 151,237,291 (GRCm39) |
N527S |
probably benign |
Het |
| Kif13a |
T |
C |
13: 47,083,088 (GRCm39) |
T4A |
possibly damaging |
Het |
| Kif3b |
T |
C |
2: 153,172,073 (GRCm39) |
*748Q |
probably null |
Het |
| Klf8 |
C |
T |
X: 152,167,677 (GRCm39) |
Q241* |
probably null |
Het |
| Kras |
A |
T |
6: 145,170,787 (GRCm39) |
|
probably benign |
Het |
| Lamc3 |
C |
A |
2: 31,777,423 (GRCm39) |
T23K |
probably benign |
Het |
| Lrrc74b |
T |
A |
16: 17,377,737 (GRCm39) |
H47L |
probably benign |
Het |
| Ly75 |
A |
G |
2: 60,199,101 (GRCm39) |
|
probably null |
Het |
| Map3k21 |
G |
A |
8: 126,668,876 (GRCm39) |
G821S |
probably benign |
Het |
| Mettl14 |
A |
G |
3: 123,167,722 (GRCm39) |
|
probably benign |
Het |
| Mettl5 |
T |
C |
2: 69,715,590 (GRCm39) |
|
probably benign |
Het |
| Mier3 |
A |
G |
13: 111,848,289 (GRCm39) |
D301G |
probably damaging |
Het |
| Mipep |
T |
C |
14: 61,025,595 (GRCm39) |
|
probably benign |
Het |
| Mmp21 |
T |
C |
7: 133,277,588 (GRCm39) |
|
probably null |
Het |
| Msh4 |
A |
G |
3: 153,563,207 (GRCm39) |
L723P |
probably damaging |
Het |
| Muc5b |
T |
C |
7: 141,412,817 (GRCm39) |
V1921A |
unknown |
Het |
| Myo1e |
G |
A |
9: 70,246,038 (GRCm39) |
E410K |
possibly damaging |
Het |
| Npc1 |
G |
A |
18: 12,324,887 (GRCm39) |
T1202I |
probably damaging |
Het |
| Or10j3 |
A |
G |
1: 173,030,934 (GRCm39) |
K4E |
probably benign |
Het |
| Or2ab1 |
A |
G |
11: 58,488,947 (GRCm39) |
R242G |
probably damaging |
Het |
| Or5a3 |
C |
T |
19: 12,400,252 (GRCm39) |
T193I |
probably benign |
Het |
| Pacc1 |
T |
C |
1: 191,060,486 (GRCm39) |
|
probably benign |
Het |
| Patl2 |
C |
T |
2: 121,954,216 (GRCm39) |
V452M |
probably benign |
Het |
| Pcdh18 |
A |
G |
3: 49,709,854 (GRCm39) |
V487A |
probably damaging |
Het |
| Pdzph1 |
C |
T |
17: 59,239,440 (GRCm39) |
A963T |
probably damaging |
Het |
| Pkd1l1 |
C |
T |
11: 8,866,302 (GRCm39) |
V518M |
probably damaging |
Het |
| Plcd3 |
A |
G |
11: 102,969,199 (GRCm39) |
F256S |
probably damaging |
Het |
| Proc |
T |
C |
18: 32,266,491 (GRCm39) |
D112G |
possibly damaging |
Het |
| Ptges2 |
T |
A |
2: 32,290,874 (GRCm39) |
|
probably null |
Het |
| Pth2r |
A |
T |
1: 65,402,436 (GRCm39) |
R312W |
probably damaging |
Het |
| Pttg1ip2 |
C |
A |
5: 5,502,073 (GRCm39) |
|
probably benign |
Het |
| Rbbp6 |
C |
T |
7: 122,591,676 (GRCm39) |
H546Y |
possibly damaging |
Het |
| Retreg2 |
A |
G |
1: 75,123,164 (GRCm39) |
E364G |
probably damaging |
Het |
| Rxrb |
G |
A |
17: 34,253,134 (GRCm39) |
C185Y |
probably damaging |
Het |
| Septin2 |
T |
A |
1: 93,427,037 (GRCm39) |
N133K |
possibly damaging |
Het |
| Serpina3b |
T |
A |
12: 104,104,969 (GRCm39) |
S382T |
probably benign |
Het |
| Serpinb9e |
T |
C |
13: 33,439,099 (GRCm39) |
F175S |
probably benign |
Het |
| Slc19a2 |
C |
T |
1: 164,084,766 (GRCm39) |
H219Y |
probably damaging |
Het |
| Slfn9 |
A |
T |
11: 82,872,524 (GRCm39) |
D737E |
possibly damaging |
Het |
| Snx31 |
T |
C |
15: 36,539,444 (GRCm39) |
E144G |
probably null |
Het |
| Sp2 |
A |
G |
11: 96,854,282 (GRCm39) |
|
probably benign |
Het |
| Spag9 |
C |
T |
11: 94,007,663 (GRCm39) |
L1117F |
probably damaging |
Het |
| Spata31e2 |
G |
T |
1: 26,721,222 (GRCm39) |
Y1319* |
probably null |
Het |
| Syndig1l |
A |
T |
12: 84,727,137 (GRCm39) |
|
probably benign |
Het |
| Sypl1 |
A |
T |
12: 33,024,332 (GRCm39) |
|
probably benign |
Het |
| Tmem169 |
T |
C |
1: 72,339,855 (GRCm39) |
M95T |
probably benign |
Het |
| Tnfrsf17 |
A |
G |
16: 11,133,066 (GRCm39) |
Y48C |
possibly damaging |
Het |
| Ttn |
A |
T |
2: 76,657,859 (GRCm39) |
|
probably benign |
Het |
| Uap1 |
G |
C |
1: 169,977,952 (GRCm39) |
H366Q |
probably benign |
Het |
| Ulbp1 |
A |
G |
10: 7,396,557 (GRCm39) |
|
probably benign |
Het |
| Urb2 |
T |
C |
8: 124,757,647 (GRCm39) |
V1118A |
probably benign |
Het |
| Usp54 |
T |
C |
14: 20,600,258 (GRCm39) |
N1493S |
probably benign |
Het |
| Vmn1r129 |
C |
A |
7: 21,094,655 (GRCm39) |
V188F |
probably benign |
Het |
| Vmn1r226 |
A |
T |
17: 20,907,994 (GRCm39) |
L75F |
probably benign |
Het |
| Yes1 |
T |
A |
5: 32,809,046 (GRCm39) |
S137R |
probably benign |
Het |
| Zfp804b |
A |
G |
5: 7,229,372 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Nav2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01097:Nav2
|
APN |
7 |
49,220,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01150:Nav2
|
APN |
7 |
49,102,269 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL01649:Nav2
|
APN |
7 |
49,225,477 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01662:Nav2
|
APN |
7 |
49,220,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02297:Nav2
|
APN |
7 |
49,243,977 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02313:Nav2
|
APN |
7 |
49,208,521 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02441:Nav2
|
APN |
7 |
49,102,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02472:Nav2
|
APN |
7 |
49,195,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02477:Nav2
|
APN |
7 |
49,232,623 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02725:Nav2
|
APN |
7 |
49,214,843 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02944:Nav2
|
APN |
7 |
49,070,004 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02953:Nav2
|
APN |
7 |
49,198,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03105:Nav2
|
APN |
7 |
49,114,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03234:Nav2
|
APN |
7 |
49,111,756 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03274:Nav2
|
APN |
7 |
49,011,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03294:Nav2
|
APN |
7 |
49,141,205 (GRCm39) |
nonsense |
probably null |
|
|
R0006:Nav2
|
UTSW |
7 |
49,102,978 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R0070:Nav2
|
UTSW |
7 |
49,220,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0113:Nav2
|
UTSW |
7 |
49,185,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0306:Nav2
|
UTSW |
7 |
49,195,651 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0346:Nav2
|
UTSW |
7 |
49,254,333 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0539:Nav2
|
UTSW |
7 |
49,111,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0669:Nav2
|
UTSW |
7 |
49,058,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0785:Nav2
|
UTSW |
7 |
49,070,081 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0970:Nav2
|
UTSW |
7 |
49,233,901 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1162:Nav2
|
UTSW |
7 |
49,185,788 (GRCm39) |
splice site |
probably benign |
|
|
R1274:Nav2
|
UTSW |
7 |
49,254,178 (GRCm39) |
nonsense |
probably null |
|
|
R1464:Nav2
|
UTSW |
7 |
49,011,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1464:Nav2
|
UTSW |
7 |
49,011,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1536:Nav2
|
UTSW |
7 |
49,195,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1612:Nav2
|
UTSW |
7 |
49,220,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1638:Nav2
|
UTSW |
7 |
49,102,213 (GRCm39) |
missense |
probably benign |
|
|
R1731:Nav2
|
UTSW |
7 |
49,197,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1734:Nav2
|
UTSW |
7 |
49,225,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1865:Nav2
|
UTSW |
7 |
49,197,943 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1945:Nav2
|
UTSW |
7 |
49,114,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1997:Nav2
|
UTSW |
7 |
49,198,219 (GRCm39) |
missense |
probably benign |
0.16 |
|
R2061:Nav2
|
UTSW |
7 |
49,248,645 (GRCm39) |
splice site |
probably benign |
|
|
R2117:Nav2
|
UTSW |
7 |
49,114,328 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2174:Nav2
|
UTSW |
7 |
49,102,411 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2182:Nav2
|
UTSW |
7 |
49,247,002 (GRCm39) |
missense |
probably benign |
0.38 |
|
R2251:Nav2
|
UTSW |
7 |
49,103,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2283:Nav2
|
UTSW |
7 |
49,141,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2343:Nav2
|
UTSW |
7 |
49,248,565 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R2472:Nav2
|
UTSW |
7 |
49,058,632 (GRCm39) |
missense |
probably benign |
|
|
R2568:Nav2
|
UTSW |
7 |
49,247,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2656:Nav2
|
UTSW |
7 |
49,195,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2964:Nav2
|
UTSW |
7 |
49,206,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2966:Nav2
|
UTSW |
7 |
49,206,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3817:Nav2
|
UTSW |
7 |
49,114,310 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3834:Nav2
|
UTSW |
7 |
49,195,606 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4207:Nav2
|
UTSW |
7 |
49,246,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4207:Nav2
|
UTSW |
7 |
49,222,046 (GRCm39) |
splice site |
probably null |
|
|
R4411:Nav2
|
UTSW |
7 |
49,047,857 (GRCm39) |
missense |
probably benign |
0.37 |
|
R4413:Nav2
|
UTSW |
7 |
49,047,857 (GRCm39) |
missense |
probably benign |
0.37 |
|
R4440:Nav2
|
UTSW |
7 |
49,225,011 (GRCm39) |
splice site |
probably benign |
|
|
R4440:Nav2
|
UTSW |
7 |
49,201,785 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4454:Nav2
|
UTSW |
7 |
49,198,292 (GRCm39) |
splice site |
probably null |
|
|
R4729:Nav2
|
UTSW |
7 |
49,102,567 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4801:Nav2
|
UTSW |
7 |
49,195,600 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4802:Nav2
|
UTSW |
7 |
49,195,600 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4824:Nav2
|
UTSW |
7 |
49,058,749 (GRCm39) |
intron |
probably benign |
|
|
R4887:Nav2
|
UTSW |
7 |
49,198,182 (GRCm39) |
nonsense |
probably null |
|
|
R4908:Nav2
|
UTSW |
7 |
49,254,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4952:Nav2
|
UTSW |
7 |
48,954,288 (GRCm39) |
intron |
probably benign |
|
|
R4965:Nav2
|
UTSW |
7 |
49,202,625 (GRCm39) |
nonsense |
probably null |
|
|
R5169:Nav2
|
UTSW |
7 |
49,198,231 (GRCm39) |
nonsense |
probably null |
|
|
R5224:Nav2
|
UTSW |
7 |
49,201,473 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5249:Nav2
|
UTSW |
7 |
49,185,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5285:Nav2
|
UTSW |
7 |
49,197,982 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5314:Nav2
|
UTSW |
7 |
49,058,440 (GRCm39) |
small deletion |
probably benign |
|
|
R5320:Nav2
|
UTSW |
7 |
49,141,121 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5377:Nav2
|
UTSW |
7 |
49,238,908 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5471:Nav2
|
UTSW |
7 |
49,197,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5754:Nav2
|
UTSW |
7 |
49,206,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5832:Nav2
|
UTSW |
7 |
49,197,817 (GRCm39) |
splice site |
probably null |
|
|
R5884:Nav2
|
UTSW |
7 |
49,246,917 (GRCm39) |
nonsense |
probably null |
|
|
R5921:Nav2
|
UTSW |
7 |
48,954,324 (GRCm39) |
intron |
probably benign |
|
|
R6180:Nav2
|
UTSW |
7 |
49,107,915 (GRCm39) |
missense |
probably benign |
0.39 |
|
R6208:Nav2
|
UTSW |
7 |
49,213,851 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6373:Nav2
|
UTSW |
7 |
49,102,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6450:Nav2
|
UTSW |
7 |
49,244,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6522:Nav2
|
UTSW |
7 |
49,247,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6626:Nav2
|
UTSW |
7 |
49,244,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6695:Nav2
|
UTSW |
7 |
49,114,652 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6705:Nav2
|
UTSW |
7 |
49,201,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6842:Nav2
|
UTSW |
7 |
49,107,917 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6847:Nav2
|
UTSW |
7 |
49,141,204 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7287:Nav2
|
UTSW |
7 |
49,070,076 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7312:Nav2
|
UTSW |
7 |
49,111,672 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R7315:Nav2
|
UTSW |
7 |
49,198,037 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R7337:Nav2
|
UTSW |
7 |
49,201,521 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7366:Nav2
|
UTSW |
7 |
49,203,951 (GRCm39) |
splice site |
probably null |
|
|
R7451:Nav2
|
UTSW |
7 |
49,202,577 (GRCm39) |
splice site |
probably null |
|
|
R7545:Nav2
|
UTSW |
7 |
49,232,605 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7706:Nav2
|
UTSW |
7 |
49,244,067 (GRCm39) |
missense |
probably benign |
0.35 |
|
R7730:Nav2
|
UTSW |
7 |
49,222,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7812:Nav2
|
UTSW |
7 |
49,246,921 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8097:Nav2
|
UTSW |
7 |
49,237,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8110:Nav2
|
UTSW |
7 |
49,201,698 (GRCm39) |
nonsense |
probably null |
|
|
R8119:Nav2
|
UTSW |
7 |
49,103,232 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8298:Nav2
|
UTSW |
7 |
49,204,009 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8306:Nav2
|
UTSW |
7 |
49,195,765 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8331:Nav2
|
UTSW |
7 |
49,102,371 (GRCm39) |
missense |
probably benign |
|
|
R8402:Nav2
|
UTSW |
7 |
49,103,185 (GRCm39) |
missense |
probably benign |
0.43 |
|
R8421:Nav2
|
UTSW |
7 |
49,102,269 (GRCm39) |
missense |
probably benign |
|
|
R8478:Nav2
|
UTSW |
7 |
49,111,733 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8724:Nav2
|
UTSW |
7 |
49,141,184 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8753:Nav2
|
UTSW |
7 |
49,102,320 (GRCm39) |
missense |
probably benign |
|
|
R8835:Nav2
|
UTSW |
7 |
49,248,551 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8933:Nav2
|
UTSW |
7 |
49,111,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8957:Nav2
|
UTSW |
7 |
49,220,964 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9069:Nav2
|
UTSW |
7 |
49,208,561 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9095:Nav2
|
UTSW |
7 |
49,254,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9223:Nav2
|
UTSW |
7 |
49,202,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9261:Nav2
|
UTSW |
7 |
49,246,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0023:Nav2
|
UTSW |
7 |
49,197,647 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
Z1177:Nav2
|
UTSW |
7 |
49,243,971 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Nav2
|
UTSW |
7 |
49,102,509 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTAGCCTCTGCTCATGAATCCACC -3'
(R):5'- ATGGTCTCTTCACACCAAACCAGTG -3'
Sequencing Primer
(F):5'- TCTGGAAGACATTCGGTCAC -3'
(R):5'- CAGTGAGAGTATAAGTTCCTTTGCC -3'
|
| Posted On |
2014-03-14 |
Incidental Mutation