Incidental Mutation 'R1416:Or5an11'
ID 159614
Institutional Source Beutler Lab
Gene Symbol Or5an11
Ensembl Gene ENSMUSG00000060049
Gene Name olfactory receptor family 5 subfamily AN member 11
Synonyms Olfr245, GA_x6K02T2LL2P-1028-792, Olfr232, GA_x6K02T03CT6-1-477, GA_x6K02T057QT-4025-4642, MOR214-3, Olfr235, MOR214-3
MMRRC Submission 039472-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R1416 (G1)
Quality Score 81
Status Not validated
Chromosome 19
Chromosomal Location 12245596-12246534 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 12246258 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 221 (F221L)
Ref Sequence ENSEMBL: ENSMUSP00000150313 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073507] [ENSMUST00000207969] [ENSMUST00000214551] [ENSMUST00000214613] [ENSMUST00000214638] [ENSMUST00000215407]
AlphaFold E9Q9Z6
Predicted Effect probably benign
Transcript: ENSMUST00000073507
AA Change: F221L

PolyPhen 2 Score 0.094 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000073203
Gene: ENSMUSG00000060049
AA Change: F221L

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 3.8e-56 PFAM
Pfam:7tm_1 42 309 1.2e-17 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207842
AA Change: F221L
Predicted Effect probably benign
Transcript: ENSMUST00000207969
AA Change: F221L

PolyPhen 2 Score 0.094 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect probably benign
Transcript: ENSMUST00000214551
AA Change: F221L

PolyPhen 2 Score 0.094 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect probably benign
Transcript: ENSMUST00000214613
AA Change: F221L

PolyPhen 2 Score 0.094 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect probably benign
Transcript: ENSMUST00000214638
AA Change: F221L

PolyPhen 2 Score 0.094 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect probably benign
Transcript: ENSMUST00000215407
AA Change: F221L

PolyPhen 2 Score 0.094 (Sensitivity: 0.93; Specificity: 0.85)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 92.1%
Validation Efficiency 94% (63/67)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad11 T C 9: 103,950,822 (GRCm39) S49P probably damaging Het
Afm T C 5: 90,674,238 (GRCm39) I250T possibly damaging Het
Alox5 G A 6: 116,400,106 (GRCm39) Q278* probably null Het
Anxa7 G A 14: 20,512,775 (GRCm39) R253C probably damaging Het
Arfgef1 T A 1: 10,243,164 (GRCm39) T1059S probably damaging Het
Arpp21 T C 9: 112,008,197 (GRCm39) E101G probably damaging Het
Bcr A T 10: 74,897,338 (GRCm39) I161F possibly damaging Het
Ccdc141 T C 2: 76,845,140 (GRCm39) E1309G probably damaging Het
Ccdc39 T C 3: 33,880,629 (GRCm39) K446R probably damaging Het
Cep41 C T 6: 30,657,356 (GRCm39) S233N probably damaging Het
Col5a1 T G 2: 27,812,076 (GRCm39) S53A unknown Het
Cplane1 C T 15: 8,276,422 (GRCm39) Q2689* probably null Het
Efnb2 A G 8: 8,672,329 (GRCm39) probably null Het
Epb41l5 T C 1: 119,477,606 (GRCm39) probably benign Het
Eri2 A G 7: 119,390,397 (GRCm39) F77S probably damaging Het
Ern1 C T 11: 106,312,806 (GRCm39) probably benign Het
Eya3 T C 4: 132,434,440 (GRCm39) probably benign Het
Icos T C 1: 61,033,802 (GRCm39) L144P probably damaging Het
Ipo8 A G 6: 148,690,591 (GRCm39) V717A probably benign Het
Lrp12 T C 15: 39,742,019 (GRCm39) E232G probably damaging Het
Lrp1b A G 2: 40,888,228 (GRCm39) I2344T probably damaging Het
Mettl5 A T 2: 69,701,633 (GRCm39) F207I possibly damaging Het
Mtor G T 4: 148,575,871 (GRCm39) E1342* probably null Het
Nrap A G 19: 56,315,725 (GRCm39) Y1360H possibly damaging Het
Nsun7 T C 5: 66,418,423 (GRCm39) V51A probably damaging Het
Or5p5 T C 7: 107,414,469 (GRCm39) L228P probably damaging Het
Or8g18 G C 9: 39,149,547 (GRCm39) P58A probably benign Het
Or8k27 T C 2: 86,275,664 (GRCm39) I221V probably benign Het
Or9m1b T A 2: 87,836,915 (GRCm39) Y60F probably damaging Het
Otud6b A C 4: 14,818,473 (GRCm39) L143V probably damaging Het
Pabir2 T C X: 52,335,023 (GRCm39) *256W probably null Het
Pp2d1 T C 17: 53,822,835 (GRCm39) N77S probably benign Het
Ppp4r3c2 A T X: 88,797,283 (GRCm39) M372L probably benign Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Pwwp4a G T X: 72,171,261 (GRCm39) G218C probably damaging Het
Raly G T 2: 154,699,273 (GRCm39) G26* probably null Het
Rarb T C 14: 16,435,177 (GRCm38) M290V possibly damaging Het
Rusc2 A G 4: 43,421,617 (GRCm39) E679G possibly damaging Het
Scap T C 9: 110,213,841 (GRCm39) V1268A probably damaging Het
Setd1b C T 5: 123,298,748 (GRCm39) probably benign Het
Shisa3 C G 5: 67,768,777 (GRCm39) P226A probably benign Het
Smox C T 2: 131,364,051 (GRCm39) S481F probably damaging Het
Stard9 T C 2: 120,531,453 (GRCm39) V2570A probably benign Het
Sucla2 C T 14: 73,798,074 (GRCm39) probably benign Het
Sult4a1 C T 15: 83,970,847 (GRCm39) R186Q probably benign Het
Taf2 G T 15: 54,901,806 (GRCm39) A796E possibly damaging Het
Taf4b T C 18: 14,954,484 (GRCm39) probably benign Het
Thbs4 G T 13: 92,898,041 (GRCm39) Q593K probably benign Het
Tigd3 T C 19: 5,941,753 (GRCm39) D459G probably benign Het
Tmem168 A T 6: 13,591,400 (GRCm39) L472Q probably damaging Het
Tmem169 G T 1: 72,339,875 (GRCm39) V102F probably damaging Het
Tmem241 T C 18: 12,126,631 (GRCm39) T274A probably benign Het
Trip10 A G 17: 57,557,800 (GRCm39) Y28C probably damaging Het
Ubp1 T C 9: 113,799,239 (GRCm39) V398A probably benign Het
Ubr3 A G 2: 69,775,415 (GRCm39) Y567C probably damaging Het
Uckl1 A T 2: 181,211,362 (GRCm39) M489K possibly damaging Het
Ush2a C T 1: 188,169,080 (GRCm39) P1074S probably damaging Het
Vmn1r62 T C 7: 5,678,904 (GRCm39) V195A probably damaging Het
Vmn2r63 T A 7: 42,577,339 (GRCm39) I400L probably benign Het
Vmn2r67 T A 7: 84,800,824 (GRCm39) I371F probably benign Het
Wdr64 A G 1: 175,633,568 (GRCm39) T940A probably benign Het
Zfp105 A T 9: 122,759,742 (GRCm39) Y471F probably damaging Het
Zfp287 A T 11: 62,605,166 (GRCm39) H580Q probably damaging Het
Other mutations in Or5an11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02116:Or5an11 APN 19 12,246,374 (GRCm39) missense probably damaging 1.00
IGL03397:Or5an11 APN 19 12,245,866 (GRCm39) missense probably benign 0.03
R1239:Or5an11 UTSW 19 12,246,340 (GRCm39) missense probably damaging 1.00
R1441:Or5an11 UTSW 19 12,245,750 (GRCm39) nonsense probably null
R1694:Or5an11 UTSW 19 12,246,281 (GRCm39) missense probably damaging 1.00
R1727:Or5an11 UTSW 19 12,246,365 (GRCm39) missense possibly damaging 0.70
R2422:Or5an11 UTSW 19 12,246,283 (GRCm39) missense probably damaging 0.99
R3439:Or5an11 UTSW 19 12,245,759 (GRCm39) missense possibly damaging 0.56
R4545:Or5an11 UTSW 19 12,246,188 (GRCm39) missense possibly damaging 0.91
R4605:Or5an11 UTSW 19 12,246,532 (GRCm39) makesense probably null
R5147:Or5an11 UTSW 19 12,246,268 (GRCm39) missense probably damaging 1.00
R5382:Or5an11 UTSW 19 12,245,773 (GRCm39) missense possibly damaging 0.62
R5717:Or5an11 UTSW 19 12,246,520 (GRCm39) missense probably benign 0.13
R6455:Or5an11 UTSW 19 12,246,070 (GRCm39) missense probably damaging 0.97
R6880:Or5an11 UTSW 19 12,245,974 (GRCm39) missense probably benign 0.22
R7311:Or5an11 UTSW 19 12,246,068 (GRCm39) missense probably benign 0.29
R7384:Or5an11 UTSW 19 12,246,440 (GRCm39) missense possibly damaging 0.80
R8138:Or5an11 UTSW 19 12,246,436 (GRCm39) missense possibly damaging 0.61
R9005:Or5an11 UTSW 19 12,245,704 (GRCm39) missense probably benign
R9118:Or5an11 UTSW 19 12,246,263 (GRCm39) missense probably benign 0.02
R9484:Or5an11 UTSW 19 12,245,735 (GRCm39) missense possibly damaging 0.58
R9549:Or5an11 UTSW 19 12,246,408 (GRCm39) missense probably benign 0.02
R9691:Or5an11 UTSW 19 12,246,379 (GRCm39) nonsense probably null
R9738:Or5an11 UTSW 19 12,245,869 (GRCm39) missense probably benign 0.09
Predicted Primers PCR Primer
(F):5'- GTCACCCACACTATGTGCTCAGATG -3'
(R):5'- CTGTCAAAACTAGAGGAGCCACCAG -3'

Sequencing Primer
(F):5'- GGACTCACAGGCTCTGTATC -3'
(R):5'- CCAGAGCTGGATCGCAAATAG -3'
Posted On 2014-03-14