Mutagenetix > Incidental Mutation

Incidental Mutation 'R1421:Tex36'

159814

Institutional Source

Beutler Lab

Gene Symbol

Tex36

Ensembl Gene

ENSMUSG00000030976

Gene Name

testis expressed 36

Synonyms

4930404H21Rik

MMRRC Submission

039477-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.048) question?

Stock #

R1421 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

133188753-133203844 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 133197078 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000033275 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000033275] [ENSMUST00000033275] [ENSMUST00000033275]

AlphaFold

Q9D5N9

Predicted Effect

probably null
Transcript: ENSMUST00000033275

SMART Domains

Protein: ENSMUSP00000033275
Gene: ENSMUSG00000030976

Domain	Start	End	E-Value	Type
Pfam:HDNR	1	177	1.2e-66	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000033275

SMART Domains

Protein: ENSMUSP00000033275
Gene: ENSMUSG00000030976

Domain	Start	End	E-Value	Type
Pfam:HDNR	1	177	1.2e-66	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000033275

SMART Domains

Protein: ENSMUSP00000033275
Gene: ENSMUSG00000030976

Domain	Start	End	E-Value	Type
Pfam:HDNR	1	177	1.2e-66	PFAM

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.2%
20x: 92.7%

Validation Efficiency

96% (54/56)

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2ml1	T	C	6: 128,520,923 (GRCm39)	T1344A	probably benign	Het
Abcf1	G	A	17: 36,271,801 (GRCm39)	A375V	probably damaging	Het
Adam20	T	A	8: 41,249,784 (GRCm39)	H631Q	possibly damaging	Het
Adcy10	T	C	1: 165,391,516 (GRCm39)	S1258P	probably damaging	Het
Agtpbp1	A	G	13: 59,643,389 (GRCm39)	I717T	possibly damaging	Het
Ahnak	T	A	19: 8,992,995 (GRCm39)	F4760I	possibly damaging	Het
Ano6	A	G	15: 95,811,266 (GRCm39)	K122R	probably benign	Het
Arhgap5	T	C	12: 52,563,631 (GRCm39)	C201R	probably damaging	Het
Atg16l1	T	C	1: 87,714,080 (GRCm39)		probably benign	Het
Cdhr3	A	T	12: 33,110,291 (GRCm39)	I331K	probably damaging	Het
Coq8a	A	G	1: 179,998,006 (GRCm39)		probably benign	Het
Crebbp	A	G	16: 3,942,511 (GRCm39)	V662A	probably damaging	Het
Cspg4	T	A	9: 56,803,910 (GRCm39)	M1667K	probably benign	Het
Dnah7a	A	G	1: 53,580,032 (GRCm39)		probably benign	Het
Dnajc6	A	T	4: 101,468,513 (GRCm39)	Y251F	probably damaging	Het
Dpy19l4	A	T	4: 11,304,011 (GRCm39)	M133K	probably benign	Het
Emb	T	C	13: 117,408,624 (GRCm39)	Y322H	probably benign	Het
Gcm1	A	T	9: 77,966,982 (GRCm39)	H67L	probably damaging	Het
Gls2	A	T	10: 128,037,217 (GRCm39)	K253*	probably null	Het
Gm28042	T	A	2: 119,866,944 (GRCm39)	S196T	probably benign	Het
Gm43302	T	C	5: 105,365,215 (GRCm39)	T598A	probably benign	Het
Gramd1a	T	A	7: 30,842,291 (GRCm39)	Q90L	probably damaging	Het
Grhl2	A	G	15: 37,309,960 (GRCm39)	Y352C	probably damaging	Het
Ifi203-ps	T	C	1: 173,625,563 (GRCm39)		noncoding transcript	Het
Ifitm2	T	C	7: 140,534,972 (GRCm39)	I121V	probably benign	Het
Insyn2a	A	T	7: 134,500,960 (GRCm39)		probably benign	Het
Kptn	T	G	7: 15,856,949 (GRCm39)		probably benign	Het
L2hgdh	C	T	12: 69,748,092 (GRCm39)	D345N	probably benign	Het
Lgals12	T	C	19: 7,584,079 (GRCm39)	H6R	probably benign	Het
Lrrc4b	A	G	7: 44,110,475 (GRCm39)	I116V	probably benign	Het
Misp	A	G	10: 79,662,681 (GRCm39)	D366G	probably damaging	Het
Nav1	T	C	1: 135,512,748 (GRCm39)	E104G	probably damaging	Het
Nup155	A	T	15: 8,187,244 (GRCm39)	H1391L	probably damaging	Het
Parp1	T	C	1: 180,427,653 (GRCm39)		probably benign	Het
Pikfyve	G	A	1: 65,310,470 (GRCm39)	G1919D	probably damaging	Het
Pomt1	A	G	2: 32,126,765 (GRCm39)		probably benign	Het
Prrc2b	C	T	2: 32,090,990 (GRCm39)	S454F	possibly damaging	Het
Selenbp1	T	C	3: 94,851,183 (GRCm39)	S360P	probably benign	Het
Slc6a12	T	A	6: 121,336,085 (GRCm39)	I352N	probably damaging	Het
Snx9	G	A	17: 5,952,759 (GRCm39)	G197D	probably benign	Het
Ston1	T	C	17: 88,943,221 (GRCm39)	V209A	probably benign	Het
Taf7l2	A	G	10: 115,949,343 (GRCm39)	V61A	probably damaging	Het
Tnnt3	A	G	7: 142,065,103 (GRCm39)	E108G	probably damaging	Het
Vmn2r98	T	A	17: 19,285,440 (GRCm39)	F87I	probably damaging	Het
Vwa8	C	T	14: 79,145,670 (GRCm39)	R116C	probably damaging	Het
Wdr64	T	C	1: 175,594,716 (GRCm39)	I479T	possibly damaging	Het
Xrcc5	A	G	1: 72,349,636 (GRCm39)	N22D	probably benign	Het
Zfp407	C	T	18: 84,577,898 (GRCm39)	A1072T	probably benign	Het
Zfp735	C	A	11: 73,601,523 (GRCm39)	L156I	probably benign	Het
Zfp820	A	T	17: 22,038,861 (GRCm39)	Y156N	possibly damaging	Het

Other mutations in Tex36

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02412:Tex36	APN	7	133,189,137 (GRCm39)	missense	probably benign	0.27
R2061:Tex36	UTSW	7	133,196,952 (GRCm39)	missense	probably damaging	1.00
R4580:Tex36	UTSW	7	133,189,111 (GRCm39)	missense	possibly damaging	0.47
R4905:Tex36	UTSW	7	133,189,182 (GRCm39)	missense	probably damaging	1.00
R5023:Tex36	UTSW	7	133,197,019 (GRCm39)	missense	probably benign	0.00
R5532:Tex36	UTSW	7	133,203,712 (GRCm39)	missense	probably benign	0.02
R6306:Tex36	UTSW	7	133,197,054 (GRCm39)	missense	probably benign
R6658:Tex36	UTSW	7	133,196,140 (GRCm39)	missense	probably damaging	1.00
R6862:Tex36	UTSW	7	133,189,002 (GRCm39)	missense	probably benign
R7215:Tex36	UTSW	7	133,189,147 (GRCm39)	nonsense	probably null
R7291:Tex36	UTSW	7	133,188,952 (GRCm39)	missense	probably benign
R7428:Tex36	UTSW	7	133,196,866 (GRCm39)	splice site	probably null
R8110:Tex36	UTSW	7	133,197,012 (GRCm39)	missense	possibly damaging	0.91
R8481:Tex36	UTSW	7	133,189,189 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GACGAGGAGAATCCCAGCTCATTG -3'
(R):5'- GCTCCATAAGACCTTGAAGAAGCCC -3'

Sequencing Primer
(F):5'- AGAGCCCTGAGATGCTATATCTG -3'
(R):5'- ACCTTGAAGAAGCCCTTGTG -3'

Posted On

2014-03-14