Incidental Mutation 'R1420:Tex19.1'
ID 160066
Institutional Source Beutler Lab
Gene Symbol Tex19.1
Ensembl Gene ENSMUSG00000039329
Gene Name testis expressed gene 19.1
Synonyms Tex19.1, Tex19, 2410081M02Rik
MMRRC Submission 039476-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.205) question?
Stock # R1420 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 121036969-121039140 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 121037872 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 77 (S77P)
Ref Sequence ENSEMBL: ENSMUSP00000048592 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039088] [ENSMUST00000155694]
AlphaFold Q99MV2
Predicted Effect probably damaging
Transcript: ENSMUST00000039088
AA Change: S77P

PolyPhen 2 Score 0.966 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000048592
Gene: ENSMUSG00000039329
AA Change: S77P

DomainStartEndE-ValueType
Pfam:TEX19 1 164 2.3e-73 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000155694
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.6%
  • 20x: 90.6%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased fertility, which in males is due to impaired spermatogenesis and increased male germ cell apoptosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh1l2 A G 10: 83,331,799 (GRCm39) Y669H probably damaging Het
Amotl2 A T 9: 102,601,982 (GRCm39) M409L possibly damaging Het
Ankrd35 A G 3: 96,592,054 (GRCm39) E780G probably benign Het
Brwd1 T C 16: 95,837,234 (GRCm39) Y866C probably damaging Het
Cul4b G C X: 37,653,918 (GRCm39) probably null Het
Daw1 A T 1: 83,137,548 (GRCm39) Y10F possibly damaging Het
Dgki A T 6: 37,027,204 (GRCm39) probably null Het
Dnah3 A T 7: 119,551,202 (GRCm39) V3039E probably damaging Het
Ercc4 C T 16: 12,948,073 (GRCm39) T340I probably benign Het
Fam83b T C 9: 76,399,894 (GRCm39) N403S possibly damaging Het
Fbh1 A G 2: 11,772,493 (GRCm39) F63L probably benign Het
Foxm1 G A 6: 128,349,884 (GRCm39) R395H possibly damaging Het
Gtpbp4 C T 13: 9,023,298 (GRCm39) A589T probably benign Het
Ifna7 C A 4: 88,734,906 (GRCm39) H148N probably damaging Het
Il23r T C 6: 67,463,181 (GRCm39) Y104C probably damaging Het
Il31ra A T 13: 112,668,286 (GRCm39) W347R probably damaging Het
Ints7 T G 1: 191,345,169 (GRCm39) F620V possibly damaging Het
Iqcd T C 5: 120,738,860 (GRCm39) L226P probably damaging Het
Jak3 G T 8: 72,134,182 (GRCm39) R428L possibly damaging Het
Kif28 C A 1: 179,529,962 (GRCm39) C733F probably damaging Het
Klkb1 C A 8: 45,729,183 (GRCm39) C347F probably damaging Het
Ksr2 A G 5: 117,552,904 (GRCm39) E4G probably benign Het
Lama1 T C 17: 68,097,942 (GRCm39) L1774P probably damaging Het
Lrriq3 A G 3: 154,893,349 (GRCm39) E350G probably benign Het
Nav3 G A 10: 109,659,115 (GRCm39) A834V probably benign Het
Ncoa6 G A 2: 155,263,073 (GRCm39) Q454* probably null Het
Nfatc2 C A 2: 168,346,585 (GRCm39) M836I probably benign Het
Nphp3 G T 9: 103,913,092 (GRCm39) probably null Het
Olfml2b C T 1: 170,496,596 (GRCm39) T409M probably benign Het
Oprk1 A G 1: 5,672,544 (GRCm39) K227R probably damaging Het
Or8g35 A T 9: 39,381,289 (GRCm39) H244Q probably damaging Het
Pate1 A T 9: 35,596,505 (GRCm39) W87R probably damaging Het
Pcnx4 T C 12: 72,602,760 (GRCm39) Y341H probably benign Het
Pde4c T A 8: 71,201,066 (GRCm39) H421Q probably damaging Het
Pglyrp4 T C 3: 90,636,021 (GRCm39) V82A probably damaging Het
Pnmt G T 11: 98,278,502 (GRCm39) R156L probably benign Het
Prdm9 C A 17: 15,764,638 (GRCm39) C714F probably damaging Het
Pwp1 T C 10: 85,712,402 (GRCm39) V80A probably damaging Het
Pxdn T C 12: 30,052,067 (GRCm39) L568P probably damaging Het
Rasgrp4 C A 7: 28,839,770 (GRCm39) Q161K probably damaging Het
Rnf138 A G 18: 21,159,159 (GRCm39) E193G probably damaging Het
Slc16a6 A G 11: 109,345,772 (GRCm39) V413A probably damaging Het
Slc7a15 T C 12: 8,584,442 (GRCm39) T363A probably benign Het
Sufu T C 19: 46,385,623 (GRCm39) S28P probably benign Het
Tmc7 A T 7: 118,165,440 (GRCm39) Y91* probably null Het
Ttbk2 C G 2: 120,576,393 (GRCm39) R792S probably benign Het
Tyw1 T C 5: 130,303,586 (GRCm39) probably null Het
U2surp A G 9: 95,344,856 (GRCm39) S907P probably benign Het
Vmn2r115 ATCTTCT ATCT 17: 23,578,962 (GRCm39) probably benign Het
Vps50 T A 6: 3,588,007 (GRCm39) L660* probably null Het
Wdr55 A G 18: 36,893,392 (GRCm39) E18G probably benign Het
Wipi1 A G 11: 109,469,198 (GRCm39) V331A probably benign Het
Other mutations in Tex19.1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01351:Tex19.1 APN 11 121,038,072 (GRCm39) missense probably damaging 0.98
R1593:Tex19.1 UTSW 11 121,038,079 (GRCm39) missense probably damaging 0.99
R5113:Tex19.1 UTSW 11 121,038,625 (GRCm39) missense probably benign 0.41
R6906:Tex19.1 UTSW 11 121,037,948 (GRCm39) missense probably benign 0.42
R7389:Tex19.1 UTSW 11 121,037,986 (GRCm39) missense possibly damaging 0.92
R7943:Tex19.1 UTSW 11 121,037,986 (GRCm39) missense possibly damaging 0.92
R8049:Tex19.1 UTSW 11 121,038,148 (GRCm39) missense probably benign
R9445:Tex19.1 UTSW 11 121,038,283 (GRCm39) missense probably benign 0.00
X0026:Tex19.1 UTSW 11 121,037,872 (GRCm39) missense possibly damaging 0.84
Z1176:Tex19.1 UTSW 11 121,038,389 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- AGCAAGTCTGAATCTGTGTGTCCG -3'
(R):5'- AAGCCCATCAAGTCTCCAGGGAAG -3'

Sequencing Primer
(F):5'- TGCAGACAGACTTCTTGACC -3'
(R):5'- AGATCCAGGGGTACAGCTTCC -3'
Posted On 2014-03-14