Incidental Mutation 'R1420:Il31ra'
ID 160071
Institutional Source Beutler Lab
Gene Symbol Il31ra
Ensembl Gene ENSMUSG00000050377
Gene Name interleukin 31 receptor A
Synonyms GLM-R, GPL
MMRRC Submission 039476-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1420 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 112649439-112717266 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 112668286 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Arginine at position 347 (W347R)
Ref Sequence ENSEMBL: ENSMUSP00000153382 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051756] [ENSMUST00000223752] [ENSMUST00000223819] [ENSMUST00000224510] [ENSMUST00000224576]
AlphaFold Q8K5B1
Predicted Effect probably damaging
Transcript: ENSMUST00000051756
AA Change: W428R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000058045
Gene: ENSMUSG00000050377
AA Change: W428R

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
FN3 115 198 7.75e0 SMART
Blast:FN3 216 297 1e-40 BLAST
FN3 325 394 1.15e1 SMART
FN3 408 490 7.18e-3 SMART
low complexity region 508 522 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223577
Predicted Effect probably benign
Transcript: ENSMUST00000223752
Predicted Effect probably damaging
Transcript: ENSMUST00000223819
AA Change: W455R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224070
Predicted Effect probably damaging
Transcript: ENSMUST00000224510
AA Change: W347R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably benign
Transcript: ENSMUST00000224576
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.6%
  • 20x: 90.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
PHENOTYPE: Homozygous null mice display no apparent abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh1l2 A G 10: 83,331,799 (GRCm39) Y669H probably damaging Het
Amotl2 A T 9: 102,601,982 (GRCm39) M409L possibly damaging Het
Ankrd35 A G 3: 96,592,054 (GRCm39) E780G probably benign Het
Brwd1 T C 16: 95,837,234 (GRCm39) Y866C probably damaging Het
Cul4b G C X: 37,653,918 (GRCm39) probably null Het
Daw1 A T 1: 83,137,548 (GRCm39) Y10F possibly damaging Het
Dgki A T 6: 37,027,204 (GRCm39) probably null Het
Dnah3 A T 7: 119,551,202 (GRCm39) V3039E probably damaging Het
Ercc4 C T 16: 12,948,073 (GRCm39) T340I probably benign Het
Fam83b T C 9: 76,399,894 (GRCm39) N403S possibly damaging Het
Fbh1 A G 2: 11,772,493 (GRCm39) F63L probably benign Het
Foxm1 G A 6: 128,349,884 (GRCm39) R395H possibly damaging Het
Gtpbp4 C T 13: 9,023,298 (GRCm39) A589T probably benign Het
Ifna7 C A 4: 88,734,906 (GRCm39) H148N probably damaging Het
Il23r T C 6: 67,463,181 (GRCm39) Y104C probably damaging Het
Ints7 T G 1: 191,345,169 (GRCm39) F620V possibly damaging Het
Iqcd T C 5: 120,738,860 (GRCm39) L226P probably damaging Het
Jak3 G T 8: 72,134,182 (GRCm39) R428L possibly damaging Het
Kif28 C A 1: 179,529,962 (GRCm39) C733F probably damaging Het
Klkb1 C A 8: 45,729,183 (GRCm39) C347F probably damaging Het
Ksr2 A G 5: 117,552,904 (GRCm39) E4G probably benign Het
Lama1 T C 17: 68,097,942 (GRCm39) L1774P probably damaging Het
Lrriq3 A G 3: 154,893,349 (GRCm39) E350G probably benign Het
Nav3 G A 10: 109,659,115 (GRCm39) A834V probably benign Het
Ncoa6 G A 2: 155,263,073 (GRCm39) Q454* probably null Het
Nfatc2 C A 2: 168,346,585 (GRCm39) M836I probably benign Het
Nphp3 G T 9: 103,913,092 (GRCm39) probably null Het
Olfml2b C T 1: 170,496,596 (GRCm39) T409M probably benign Het
Oprk1 A G 1: 5,672,544 (GRCm39) K227R probably damaging Het
Or8g35 A T 9: 39,381,289 (GRCm39) H244Q probably damaging Het
Pate1 A T 9: 35,596,505 (GRCm39) W87R probably damaging Het
Pcnx4 T C 12: 72,602,760 (GRCm39) Y341H probably benign Het
Pde4c T A 8: 71,201,066 (GRCm39) H421Q probably damaging Het
Pglyrp4 T C 3: 90,636,021 (GRCm39) V82A probably damaging Het
Pnmt G T 11: 98,278,502 (GRCm39) R156L probably benign Het
Prdm9 C A 17: 15,764,638 (GRCm39) C714F probably damaging Het
Pwp1 T C 10: 85,712,402 (GRCm39) V80A probably damaging Het
Pxdn T C 12: 30,052,067 (GRCm39) L568P probably damaging Het
Rasgrp4 C A 7: 28,839,770 (GRCm39) Q161K probably damaging Het
Rnf138 A G 18: 21,159,159 (GRCm39) E193G probably damaging Het
Slc16a6 A G 11: 109,345,772 (GRCm39) V413A probably damaging Het
Slc7a15 T C 12: 8,584,442 (GRCm39) T363A probably benign Het
Sufu T C 19: 46,385,623 (GRCm39) S28P probably benign Het
Tex19.1 T C 11: 121,037,872 (GRCm39) S77P probably damaging Het
Tmc7 A T 7: 118,165,440 (GRCm39) Y91* probably null Het
Ttbk2 C G 2: 120,576,393 (GRCm39) R792S probably benign Het
Tyw1 T C 5: 130,303,586 (GRCm39) probably null Het
U2surp A G 9: 95,344,856 (GRCm39) S907P probably benign Het
Vmn2r115 ATCTTCT ATCT 17: 23,578,962 (GRCm39) probably benign Het
Vps50 T A 6: 3,588,007 (GRCm39) L660* probably null Het
Wdr55 A G 18: 36,893,392 (GRCm39) E18G probably benign Het
Wipi1 A G 11: 109,469,198 (GRCm39) V331A probably benign Het
Other mutations in Il31ra
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00095:Il31ra APN 13 112,684,012 (GRCm39) missense possibly damaging 0.94
IGL00639:Il31ra APN 13 112,686,093 (GRCm39) nonsense probably null
IGL01640:Il31ra APN 13 112,668,292 (GRCm39) missense possibly damaging 0.58
IGL02009:Il31ra APN 13 112,670,401 (GRCm39) missense probably damaging 0.98
IGL02431:Il31ra APN 13 112,666,830 (GRCm39) missense probably damaging 1.00
IGL02675:Il31ra APN 13 112,660,886 (GRCm39) missense probably benign 0.00
IGL02718:Il31ra APN 13 112,666,903 (GRCm39) nonsense probably null
IGL03388:Il31ra APN 13 112,682,746 (GRCm39) missense probably damaging 1.00
IGL03408:Il31ra APN 13 112,662,422 (GRCm39) missense probably benign 0.21
R0482:Il31ra UTSW 13 112,664,015 (GRCm39) missense possibly damaging 0.89
R0639:Il31ra UTSW 13 112,662,377 (GRCm39) missense possibly damaging 0.95
R0905:Il31ra UTSW 13 112,668,207 (GRCm39) missense probably damaging 1.00
R0948:Il31ra UTSW 13 112,666,912 (GRCm39) missense possibly damaging 0.81
R1538:Il31ra UTSW 13 112,684,000 (GRCm39) missense possibly damaging 0.91
R1776:Il31ra UTSW 13 112,677,773 (GRCm39) missense probably damaging 0.97
R1931:Il31ra UTSW 13 112,677,756 (GRCm39) missense probably damaging 1.00
R2006:Il31ra UTSW 13 112,666,890 (GRCm39) missense probably damaging 1.00
R2134:Il31ra UTSW 13 112,680,422 (GRCm39) missense possibly damaging 0.94
R3103:Il31ra UTSW 13 112,666,885 (GRCm39) missense probably damaging 1.00
R4089:Il31ra UTSW 13 112,688,453 (GRCm39) nonsense probably null
R4742:Il31ra UTSW 13 112,660,501 (GRCm39) nonsense probably null
R4787:Il31ra UTSW 13 112,664,079 (GRCm39) missense possibly damaging 0.82
R5154:Il31ra UTSW 13 112,660,531 (GRCm39) missense possibly damaging 0.87
R5193:Il31ra UTSW 13 112,660,864 (GRCm39) missense probably benign 0.34
R5402:Il31ra UTSW 13 112,660,669 (GRCm39) missense probably benign 0.01
R5743:Il31ra UTSW 13 112,664,021 (GRCm39) missense possibly damaging 0.89
R5917:Il31ra UTSW 13 112,682,846 (GRCm39) missense probably benign
R6126:Il31ra UTSW 13 112,666,908 (GRCm39) missense probably damaging 1.00
R6414:Il31ra UTSW 13 112,660,441 (GRCm39) missense possibly damaging 0.90
R6580:Il31ra UTSW 13 112,688,476 (GRCm39) missense possibly damaging 0.90
R6727:Il31ra UTSW 13 112,683,902 (GRCm39) missense probably damaging 1.00
R6783:Il31ra UTSW 13 112,688,522 (GRCm39) critical splice acceptor site probably null
R6912:Il31ra UTSW 13 112,685,998 (GRCm39) missense probably damaging 0.99
R6925:Il31ra UTSW 13 112,664,063 (GRCm39) missense possibly damaging 0.56
R7187:Il31ra UTSW 13 112,682,845 (GRCm39) missense probably benign 0.04
R7210:Il31ra UTSW 13 112,686,034 (GRCm39) missense possibly damaging 0.95
R7236:Il31ra UTSW 13 112,660,439 (GRCm39) makesense probably null
R7323:Il31ra UTSW 13 112,688,497 (GRCm39) missense probably damaging 1.00
R7618:Il31ra UTSW 13 112,688,514 (GRCm39) missense possibly damaging 0.66
R7783:Il31ra UTSW 13 112,677,785 (GRCm39) missense probably benign
R8353:Il31ra UTSW 13 112,660,717 (GRCm39) missense probably damaging 1.00
R8453:Il31ra UTSW 13 112,660,717 (GRCm39) missense probably damaging 1.00
R8679:Il31ra UTSW 13 112,662,372 (GRCm39) missense possibly damaging 0.81
R8890:Il31ra UTSW 13 112,660,861 (GRCm39) missense possibly damaging 0.95
R9032:Il31ra UTSW 13 112,660,628 (GRCm39) missense
R9077:Il31ra UTSW 13 112,670,361 (GRCm39) missense probably benign 0.00
R9085:Il31ra UTSW 13 112,660,628 (GRCm39) missense
R9147:Il31ra UTSW 13 112,670,276 (GRCm39) missense probably benign 0.01
R9148:Il31ra UTSW 13 112,670,276 (GRCm39) missense probably benign 0.01
R9158:Il31ra UTSW 13 112,670,394 (GRCm39) nonsense probably null
R9178:Il31ra UTSW 13 112,677,780 (GRCm39) missense probably damaging 1.00
R9250:Il31ra UTSW 13 112,669,508 (GRCm39) missense probably damaging 1.00
R9260:Il31ra UTSW 13 112,668,202 (GRCm39) missense probably damaging 0.98
R9312:Il31ra UTSW 13 112,686,023 (GRCm39) missense probably benign 0.01
R9381:Il31ra UTSW 13 112,668,253 (GRCm39) missense possibly damaging 0.81
Predicted Primers PCR Primer
(F):5'- ACTGAGCAGGAGAGGTCCTATCAAC -3'
(R):5'- TTTTGCCTGAAACAATGGTAGCAGC -3'

Sequencing Primer
(F):5'- ACACGTTTGTAACTCCTGAGG -3'
(R):5'- GGATGTGATTCAGCCTTGGT -3'
Posted On 2014-03-14