Incidental Mutation 'R0046:Usp35'
ID 16038
Institutional Source Beutler Lab
Gene Symbol Usp35
Ensembl Gene ENSMUSG00000035713
Gene Name ubiquitin specific peptidase 35
Synonyms LOC244144, LOC381901
MMRRC Submission 038340-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # R0046 (G1)
Quality Score
Status Validated
Chromosome 7
Chromosomal Location 96958587-96981227 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 96962804 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000137927 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004622] [ENSMUST00000139582] [ENSMUST00000139582] [ENSMUST00000168435] [ENSMUST00000168435]
AlphaFold M0QWN7
Predicted Effect probably benign
Transcript: ENSMUST00000004622
SMART Domains Protein: ENSMUSP00000004622
Gene: ENSMUSG00000004508

DomainStartEndE-ValueType
PH 9 121 1.07e-22 SMART
Blast:PH 268 314 4e-11 BLAST
low complexity region 348 355 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000139582
SMART Domains Protein: ENSMUSP00000137726
Gene: ENSMUSG00000035713

DomainStartEndE-ValueType
low complexity region 86 102 N/A INTRINSIC
Pfam:UCH 440 915 5.2e-50 PFAM
Pfam:UCH_1 441 890 1.5e-29 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000139582
SMART Domains Protein: ENSMUSP00000137726
Gene: ENSMUSG00000035713

DomainStartEndE-ValueType
low complexity region 86 102 N/A INTRINSIC
Pfam:UCH 440 915 5.2e-50 PFAM
Pfam:UCH_1 441 890 1.5e-29 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000168435
SMART Domains Protein: ENSMUSP00000137927
Gene: ENSMUSG00000035713

DomainStartEndE-ValueType
low complexity region 86 102 N/A INTRINSIC
Pfam:UCH 440 915 7.1e-48 PFAM
Pfam:UCH_1 441 890 7.4e-26 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000168435
SMART Domains Protein: ENSMUSP00000137927
Gene: ENSMUSG00000035713

DomainStartEndE-ValueType
low complexity region 86 102 N/A INTRINSIC
Pfam:UCH 440 915 7.1e-48 PFAM
Pfam:UCH_1 441 890 7.4e-26 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180476
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181351
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181651
SMART Domains Protein: ENSMUSP00000137720
Gene: ENSMUSG00000035713

DomainStartEndE-ValueType
Pfam:UCH 8 223 1e-24 PFAM
Pfam:UCH_1 9 196 5.7e-22 PFAM
low complexity region 236 247 N/A INTRINSIC
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 89.2%
  • 3x: 86.2%
  • 10x: 78.3%
  • 20x: 64.0%
Validation Efficiency 98% (86/88)
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl7a A T 4: 56,743,877 (GRCm39) K135* probably null Het
Adamts16 A G 13: 70,911,579 (GRCm39) S871P probably benign Het
Adcy10 A T 1: 165,367,403 (GRCm39) I558F probably damaging Het
Adsl T G 15: 80,846,989 (GRCm39) probably null Het
Aldob T C 4: 49,543,842 (GRCm39) I47V possibly damaging Het
Alkbh8 A G 9: 3,343,247 (GRCm39) E46G probably damaging Het
Atp1a4 A T 1: 172,067,664 (GRCm39) L533Q probably benign Het
Auts2 T C 5: 131,799,624 (GRCm39) noncoding transcript Het
B3gnt3 T C 8: 72,145,567 (GRCm39) Y267C probably damaging Het
Ccdc39 A G 3: 33,898,301 (GRCm39) F15L possibly damaging Het
Cntnap5c T G 17: 58,666,295 (GRCm39) D1108E probably benign Het
Col14a1 G A 15: 55,272,359 (GRCm39) probably benign Het
Col9a3 G A 2: 180,251,280 (GRCm39) A317T possibly damaging Het
Cpt1c A T 7: 44,609,256 (GRCm39) probably benign Het
Cpt2 A G 4: 107,761,559 (GRCm39) probably null Het
Crebrf T A 17: 26,982,308 (GRCm39) L565M probably damaging Het
Dmxl1 T A 18: 50,011,149 (GRCm39) V1102E probably benign Het
Dock4 G A 12: 40,787,359 (GRCm39) probably benign Het
Dpp3 G T 19: 4,964,671 (GRCm39) N545K probably damaging Het
Elmo2 T A 2: 165,140,646 (GRCm39) N275I probably damaging Het
Farp1 A G 14: 121,492,925 (GRCm39) K509R probably benign Het
Flg T A 3: 93,185,028 (GRCm39) probably benign Het
Gas2l2 A T 11: 83,312,736 (GRCm39) W859R probably damaging Het
Gatm T C 2: 122,431,225 (GRCm39) D254G probably damaging Het
Gjd4 T A 18: 9,280,998 (GRCm39) I27F probably damaging Het
Gm19410 A G 8: 36,269,799 (GRCm39) E1148G probably benign Het
Haus5 C T 7: 30,353,605 (GRCm39) V591I probably benign Het
Kcnab3 G A 11: 69,221,053 (GRCm39) probably null Het
Limk1 T C 5: 134,701,615 (GRCm39) Y96C probably damaging Het
Lrp2bp T A 8: 46,466,192 (GRCm39) Y100* probably null Het
Ly75 A T 2: 60,169,801 (GRCm39) probably benign Het
Mamstr T G 7: 45,291,194 (GRCm39) probably benign Het
Man1a A G 10: 53,795,283 (GRCm39) Y657H probably damaging Het
Marf1 G A 16: 13,929,591 (GRCm39) P1672S possibly damaging Het
Mboat7 T C 7: 3,686,817 (GRCm39) Y341C probably damaging Het
Nhsl1 A T 10: 18,401,417 (GRCm39) N881I probably damaging Het
Nox3 T C 17: 3,733,236 (GRCm39) Y225C probably benign Het
Or4c109 C T 2: 88,817,693 (GRCm39) M284I probably benign Het
Or4c35 C T 2: 89,808,851 (GRCm39) T243I probably damaging Het
Pclo C T 5: 14,590,493 (GRCm39) T931M unknown Het
Pfas G T 11: 68,881,293 (GRCm39) R1025S probably benign Het
Prg4 T C 1: 150,331,837 (GRCm39) T279A possibly damaging Het
Psma1 A T 7: 113,866,440 (GRCm39) probably benign Het
Rab11fip1 A G 8: 27,643,149 (GRCm39) L550P probably damaging Het
Rgs12 T A 5: 35,122,664 (GRCm39) I149N probably damaging Het
Rmnd5a T C 6: 71,376,215 (GRCm39) H195R probably damaging Het
Rnf17 T C 14: 56,708,830 (GRCm39) L750P probably damaging Het
Rtcb T C 10: 85,793,520 (GRCm39) N18D probably benign Het
Seh1l T C 18: 67,925,086 (GRCm39) probably null Het
Sptbn2 T C 19: 4,795,405 (GRCm39) probably benign Het
Stag3 C T 5: 138,281,285 (GRCm39) probably benign Het
Taar2 G A 10: 23,817,393 (GRCm39) R311H probably benign Het
Taok3 C T 5: 117,410,294 (GRCm39) Q829* probably null Het
Tsbp1 T C 17: 34,679,095 (GRCm39) probably null Het
Ttn A G 2: 76,781,886 (GRCm39) probably benign Het
Unc79 A G 12: 103,091,940 (GRCm39) E1756G probably damaging Het
Zbtb40 A G 4: 136,714,589 (GRCm39) C1067R probably damaging Het
Other mutations in Usp35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03239:Usp35 APN 7 96,970,799 (GRCm39) missense possibly damaging 0.62
R0046:Usp35 UTSW 7 96,962,804 (GRCm39) splice site probably null
R0739:Usp35 UTSW 7 96,960,874 (GRCm39) nonsense probably null
R2655:Usp35 UTSW 7 96,961,354 (GRCm39) missense probably benign
R3623:Usp35 UTSW 7 96,961,827 (GRCm39) missense probably damaging 1.00
R4750:Usp35 UTSW 7 96,959,546 (GRCm39) missense possibly damaging 0.85
R4967:Usp35 UTSW 7 96,962,782 (GRCm39) missense probably damaging 1.00
R5317:Usp35 UTSW 7 96,960,846 (GRCm39) missense probably damaging 0.99
R5341:Usp35 UTSW 7 96,975,134 (GRCm39) missense probably damaging 1.00
R5761:Usp35 UTSW 7 96,961,558 (GRCm39) missense probably benign 0.00
R5894:Usp35 UTSW 7 96,962,284 (GRCm39) missense probably damaging 1.00
R6113:Usp35 UTSW 7 96,973,533 (GRCm39) missense probably damaging 1.00
R6282:Usp35 UTSW 7 96,975,155 (GRCm39) missense probably damaging 1.00
R6454:Usp35 UTSW 7 96,960,851 (GRCm39) nonsense probably null
R6454:Usp35 UTSW 7 96,960,767 (GRCm39) missense probably damaging 0.98
R7142:Usp35 UTSW 7 96,960,754 (GRCm39) missense probably damaging 0.97
R7158:Usp35 UTSW 7 96,975,171 (GRCm39) start codon destroyed probably null 0.89
R7260:Usp35 UTSW 7 96,969,286 (GRCm39) missense probably damaging 0.98
R8270:Usp35 UTSW 7 96,961,551 (GRCm39) missense probably benign
R8275:Usp35 UTSW 7 96,964,026 (GRCm39) missense probably damaging 1.00
R8795:Usp35 UTSW 7 96,961,270 (GRCm39) missense probably benign
R8795:Usp35 UTSW 7 96,961,167 (GRCm39) missense possibly damaging 0.92
R9198:Usp35 UTSW 7 96,962,276 (GRCm39) missense probably damaging 1.00
RF003:Usp35 UTSW 7 96,971,303 (GRCm39) missense possibly damaging 0.88
Posted On 2013-01-08