Incidental Mutation 'IGL00095:Radil'
ID 1605
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Radil
Ensembl Gene ENSMUSG00000029576
Gene Name Ras association and DIL domains
Synonyms D930005D10Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL00095
Quality Score
Status
Chromosome 5
Chromosomal Location 142470594-142536853 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 142483677 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 510 (S510P)
Ref Sequence ENSEMBL: ENSMUSP00000106412 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063635] [ENSMUST00000085758] [ENSMUST00000110784] [ENSMUST00000110785]
AlphaFold Q69Z89
Predicted Effect probably damaging
Transcript: ENSMUST00000063635
AA Change: S510P

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000064539
Gene: ENSMUSG00000029576
AA Change: S510P

DomainStartEndE-ValueType
RA 61 164 1.68e-15 SMART
Blast:FHA 265 332 2e-25 BLAST
low complexity region 344 354 N/A INTRINSIC
low complexity region 550 560 N/A INTRINSIC
DIL 634 743 6.19e-34 SMART
low complexity region 950 964 N/A INTRINSIC
PDZ 979 1056 3.86e-16 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000085758
AA Change: S539P

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000082910
Gene: ENSMUSG00000029576
AA Change: S539P

DomainStartEndE-ValueType
RA 90 193 1.68e-15 SMART
Blast:FHA 294 361 2e-25 BLAST
low complexity region 373 383 N/A INTRINSIC
low complexity region 579 589 N/A INTRINSIC
DIL 663 772 6.19e-34 SMART
low complexity region 979 993 N/A INTRINSIC
PDZ 1008 1085 3.86e-16 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000110784
AA Change: S270P

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000106411
Gene: ENSMUSG00000029576
AA Change: S270P

DomainStartEndE-ValueType
Blast:FHA 25 92 3e-25 BLAST
low complexity region 104 114 N/A INTRINSIC
low complexity region 310 320 N/A INTRINSIC
DIL 394 503 6.19e-34 SMART
low complexity region 710 724 N/A INTRINSIC
PDZ 739 816 3.86e-16 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000110785
AA Change: S510P

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000106412
Gene: ENSMUSG00000029576
AA Change: S510P

DomainStartEndE-ValueType
RA 61 164 1.68e-15 SMART
Blast:FHA 265 332 2e-25 BLAST
low complexity region 344 354 N/A INTRINSIC
low complexity region 550 560 N/A INTRINSIC
DIL 634 743 6.19e-34 SMART
low complexity region 973 987 N/A INTRINSIC
PDZ 1002 1079 3.86e-16 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139824
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cadm2 A T 16: 66,679,639 (GRCm39) Y65N probably damaging Het
Catsperg2 C A 7: 29,397,483 (GRCm39) C1042F possibly damaging Het
Cluh T C 11: 74,554,890 (GRCm39) V776A probably benign Het
Crxos T A 7: 15,632,543 (GRCm39) C116* probably null Het
Csmd1 A G 8: 16,059,297 (GRCm39) probably benign Het
Cubn C A 2: 13,496,631 (GRCm39) probably benign Het
Exoc2 A G 13: 31,004,609 (GRCm39) I858T probably benign Het
Frmpd1 C A 4: 45,279,456 (GRCm39) T727K possibly damaging Het
Hapln3 T C 7: 78,771,731 (GRCm39) T53A probably damaging Het
Hnrnpul1 T A 7: 25,425,579 (GRCm39) Q584L possibly damaging Het
Ikbkb A T 8: 23,196,127 (GRCm39) F26I probably damaging Het
Il31ra A T 13: 112,684,012 (GRCm39) I120N possibly damaging Het
Itih1 C T 14: 30,651,778 (GRCm39) V855M probably benign Het
Krtap4-16 A G 11: 99,742,032 (GRCm39) S123P possibly damaging Het
Large1 C T 8: 73,564,125 (GRCm39) R547Q probably damaging Het
Madd A G 2: 91,006,111 (GRCm39) probably benign Het
Mark1 A G 1: 184,630,800 (GRCm39) V770A probably damaging Het
Mpeg1 T C 19: 12,440,074 (GRCm39) F511L probably benign Het
Mrgpra9 A G 7: 46,884,839 (GRCm39) V276A possibly damaging Het
Nav3 T C 10: 109,677,594 (GRCm39) T666A probably damaging Het
Ndufa8 T C 2: 35,934,467 (GRCm39) D37G probably damaging Het
Nlrx1 A G 9: 44,164,576 (GRCm39) L956P probably damaging Het
Nr5a1 T C 2: 38,598,353 (GRCm39) E148G probably benign Het
Or10ab5 A T 7: 108,245,043 (GRCm39) F247I possibly damaging Het
Or14c46 T C 7: 85,918,877 (GRCm39) N40S probably damaging Het
Otulinl A G 15: 27,658,202 (GRCm39) S273P possibly damaging Het
Patj A C 4: 98,423,799 (GRCm39) Q1184P possibly damaging Het
Phf20l1 A G 15: 66,500,884 (GRCm39) T619A probably benign Het
Pla2g6 T C 15: 79,173,441 (GRCm39) T643A probably damaging Het
Pramel42 T C 5: 94,685,663 (GRCm39) L441P probably damaging Het
Spock1 A G 13: 57,735,552 (GRCm39) probably benign Het
Stag3 C T 5: 138,297,400 (GRCm39) T577M probably damaging Het
Tap2 C T 17: 34,434,352 (GRCm39) R613C probably benign Het
Tnn A G 1: 159,953,021 (GRCm39) V673A possibly damaging Het
Trrap T C 5: 144,716,784 (GRCm39) probably benign Het
Vmn2r28 T C 7: 5,491,068 (GRCm39) D393G probably benign Het
Zbtb48 T C 4: 152,105,851 (GRCm39) H418R probably damaging Het
Zc3h12d T C 10: 7,738,231 (GRCm39) V179A probably damaging Het
Other mutations in Radil
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01359:Radil APN 5 142,529,468 (GRCm39) missense probably damaging 0.98
IGL01714:Radil APN 5 142,529,152 (GRCm39) unclassified probably benign
IGL02086:Radil APN 5 142,529,576 (GRCm39) missense probably benign 0.28
IGL02250:Radil APN 5 142,529,529 (GRCm39) missense probably damaging 1.00
IGL02296:Radil APN 5 142,492,218 (GRCm39) missense probably benign 0.10
IGL02890:Radil APN 5 142,529,463 (GRCm39) missense probably damaging 1.00
IGL02978:Radil APN 5 142,480,674 (GRCm39) missense probably benign 0.00
IGL03131:Radil APN 5 142,481,097 (GRCm39) missense probably damaging 1.00
R0362:Radil UTSW 5 142,529,582 (GRCm39) missense probably benign 0.00
R0389:Radil UTSW 5 142,529,226 (GRCm39) missense probably damaging 0.98
R0426:Radil UTSW 5 142,483,628 (GRCm39) missense probably damaging 1.00
R1753:Radil UTSW 5 142,481,091 (GRCm39) missense probably damaging 1.00
R2168:Radil UTSW 5 142,492,718 (GRCm39) missense probably benign 0.00
R3055:Radil UTSW 5 142,481,161 (GRCm39) missense possibly damaging 0.77
R3177:Radil UTSW 5 142,492,611 (GRCm39) missense probably damaging 1.00
R3277:Radil UTSW 5 142,492,611 (GRCm39) missense probably damaging 1.00
R3851:Radil UTSW 5 142,492,752 (GRCm39) missense probably damaging 1.00
R4043:Radil UTSW 5 142,479,988 (GRCm39) missense probably benign 0.31
R4245:Radil UTSW 5 142,529,546 (GRCm39) missense probably damaging 1.00
R4367:Radil UTSW 5 142,480,560 (GRCm39) missense probably benign 0.06
R4697:Radil UTSW 5 142,472,556 (GRCm39) missense probably benign
R4798:Radil UTSW 5 142,470,918 (GRCm39) missense probably benign 0.39
R4948:Radil UTSW 5 142,470,994 (GRCm39) missense probably benign 0.02
R5407:Radil UTSW 5 142,493,970 (GRCm39) missense probably damaging 1.00
R5784:Radil UTSW 5 142,473,268 (GRCm39) missense possibly damaging 0.88
R5918:Radil UTSW 5 142,473,357 (GRCm39) missense probably benign 0.43
R5943:Radil UTSW 5 142,471,213 (GRCm39) missense probably damaging 1.00
R6112:Radil UTSW 5 142,529,399 (GRCm39) missense probably damaging 1.00
R6147:Radil UTSW 5 142,483,695 (GRCm39) missense probably benign 0.01
R6174:Radil UTSW 5 142,472,870 (GRCm39) missense probably benign
R6241:Radil UTSW 5 142,480,697 (GRCm39) missense probably damaging 1.00
R6874:Radil UTSW 5 142,492,557 (GRCm39) missense probably damaging 1.00
R6881:Radil UTSW 5 142,472,672 (GRCm39) missense probably benign 0.00
R7056:Radil UTSW 5 142,480,109 (GRCm39) nonsense probably null
R7134:Radil UTSW 5 142,471,304 (GRCm39) missense probably damaging 1.00
R7167:Radil UTSW 5 142,471,260 (GRCm39) splice site probably null
R7374:Radil UTSW 5 142,471,235 (GRCm39) missense probably damaging 1.00
R7482:Radil UTSW 5 142,472,518 (GRCm39) missense probably benign
R7607:Radil UTSW 5 142,492,368 (GRCm39) missense probably damaging 0.99
R7607:Radil UTSW 5 142,480,550 (GRCm39) missense probably damaging 0.98
R7777:Radil UTSW 5 142,529,303 (GRCm39) missense probably damaging 1.00
R7779:Radil UTSW 5 142,473,320 (GRCm39) missense probably benign 0.03
R8047:Radil UTSW 5 142,480,695 (GRCm39) missense probably damaging 1.00
R8123:Radil UTSW 5 142,473,375 (GRCm39) missense probably damaging 0.99
R8418:Radil UTSW 5 142,480,676 (GRCm39) missense probably benign 0.23
R8525:Radil UTSW 5 142,474,256 (GRCm39) missense probably damaging 1.00
R8708:Radil UTSW 5 142,471,204 (GRCm39) missense probably damaging 1.00
R8827:Radil UTSW 5 142,493,859 (GRCm39) missense probably damaging 1.00
R9181:Radil UTSW 5 142,480,722 (GRCm39) missense probably damaging 1.00
R9315:Radil UTSW 5 142,474,254 (GRCm39) missense probably damaging 0.98
R9462:Radil UTSW 5 142,471,220 (GRCm39) missense probably damaging 1.00
R9545:Radil UTSW 5 142,492,392 (GRCm39) missense probably benign
R9694:Radil UTSW 5 142,473,378 (GRCm39) missense probably damaging 1.00
X0058:Radil UTSW 5 142,473,269 (GRCm39) missense possibly damaging 0.68
Posted On 2011-07-12