Incidental Mutation 'R1436:Areg'
ID 160631
Institutional Source Beutler Lab
Gene Symbol Areg
Ensembl Gene ENSMUSG00000029378
Gene Name amphiregulin
Synonyms Mcub, Sdgf, AR
MMRRC Submission 039491-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1436 (G1)
Quality Score 88
Status Validated
Chromosome 5
Chromosomal Location 91287458-91296291 bp(+) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) G to T at 91287664 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000031325 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031325]
AlphaFold P31955
Predicted Effect probably benign
Transcript: ENSMUST00000031325
SMART Domains Protein: ENSMUSP00000031325
Gene: ENSMUSG00000029378

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
EGF 138 175 7.41e0 SMART
transmembrane domain 193 215 N/A INTRINSIC
low complexity region 222 240 N/A INTRINSIC
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.8%
  • 10x: 94.6%
  • 20x: 86.8%
Validation Efficiency 94% (65/69)
MGI Phenotype FUNCTION: This gene encodes a member of the epidermal growth factor (EGF) family and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and has been shown to play a role in immunity, inflammation, tissue repair, and lung and mammary gland development. Homozygous knockout mice for this gene exhibit impaired immune system regulation in the skin and gene expression changes characteristic of chronic liver damage. [provided by RefSeq, Aug 2015]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit impaired development of mammary gland ducts in pubescent females. Mutant ducts show retarded elongation with few terminal end buds. [provided by MGI curators]
Allele List at MGI

All alleles(4) : Targeted(4)

Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m T C 6: 121,621,172 (GRCm39) F292S probably benign Het
Aadacl2fm3 A T 3: 59,772,760 (GRCm39) D88V probably damaging Het
Abca13 T C 11: 9,242,646 (GRCm39) V1503A probably damaging Het
AI661453 C T 17: 47,777,627 (GRCm39) probably benign Het
Ano2 T C 6: 125,844,134 (GRCm39) probably null Het
Atg16l2 A G 7: 100,940,757 (GRCm39) V453A probably damaging Het
BC034090 A G 1: 155,101,662 (GRCm39) S563P probably benign Het
Bhmt-ps1 A G 4: 26,369,591 (GRCm39) noncoding transcript Het
Birc6 C A 17: 74,959,700 (GRCm39) P3855Q probably damaging Het
Cd151 A T 7: 141,049,197 (GRCm39) K8M probably damaging Het
Cd163 T C 6: 124,304,890 (GRCm39) V1089A possibly damaging Het
Chd3 A T 11: 69,248,400 (GRCm39) probably null Het
Cnot6l T A 5: 96,281,971 (GRCm39) E9V probably damaging Het
Col22a1 A G 15: 71,794,806 (GRCm39) probably benign Het
Cyp2c68 A G 19: 39,729,484 (GRCm39) M1T probably null Het
Dbp T C 7: 45,357,879 (GRCm39) V149A probably damaging Het
Dnah10 T C 5: 124,839,285 (GRCm39) V1241A probably benign Het
Galnt10 T C 11: 57,662,295 (GRCm39) S314P probably damaging Het
Glce C T 9: 61,977,292 (GRCm39) probably null Het
Gm5093 C G 17: 46,750,680 (GRCm39) D116H probably damaging Het
Golim4 A G 3: 75,785,951 (GRCm39) probably null Het
Helz2 A T 2: 180,877,317 (GRCm39) I1107N probably damaging Het
Hoxc9 T C 15: 102,890,304 (GRCm39) S74P probably benign Het
Ikbkb T A 8: 23,163,419 (GRCm39) N297I probably benign Het
Il20ra T A 10: 19,625,000 (GRCm39) I93N probably damaging Het
Itch C A 2: 155,034,065 (GRCm39) N412K probably damaging Het
Kcna5 T A 6: 126,511,724 (GRCm39) T135S probably damaging Het
Lncpint G A 6: 31,157,974 (GRCm39) noncoding transcript Het
Lrrc39 A T 3: 116,373,293 (GRCm39) probably null Het
Mad2l1 T A 6: 66,516,797 (GRCm39) V163E possibly damaging Het
Moxd1 C T 10: 24,120,256 (GRCm39) T128M probably damaging Het
Mpeg1 C T 19: 12,439,823 (GRCm39) S427F probably damaging Het
Nckap5 T C 1: 125,953,798 (GRCm39) Y854C possibly damaging Het
Ncln C T 10: 81,325,727 (GRCm39) E373K probably damaging Het
Neurod4 T C 10: 130,106,540 (GRCm39) T245A possibly damaging Het
Nsun5 T C 5: 135,399,067 (GRCm39) L39P probably damaging Het
Or2ad1 G T 13: 21,327,162 (GRCm39) Q22K probably benign Het
Or4c105 A T 2: 88,648,336 (GRCm39) T274S possibly damaging Het
Or4f7 A G 2: 111,644,906 (GRCm39) L55S probably damaging Het
Pde8b T C 13: 95,162,678 (GRCm39) T815A probably benign Het
Pofut2 C T 10: 77,104,398 (GRCm39) R392W probably damaging Het
Ppip5k2 G A 1: 97,639,507 (GRCm39) T1186I probably benign Het
Rhot2 A C 17: 26,060,374 (GRCm39) S277R probably benign Het
Satb1 T G 17: 52,111,391 (GRCm39) probably null Het
Sec31b T C 19: 44,524,634 (GRCm39) I88V probably damaging Het
Selenon T A 4: 134,267,997 (GRCm39) E483V probably damaging Het
Serpinc1 A G 1: 160,820,981 (GRCm39) T22A possibly damaging Het
Sf3a2 G A 10: 80,640,040 (GRCm39) probably benign Het
Sf3b1 A G 1: 55,040,580 (GRCm39) Y561H possibly damaging Het
Smarcc1 T A 9: 109,947,708 (GRCm39) probably benign Het
Stard3nl C T 13: 19,556,819 (GRCm39) R107Q probably damaging Het
Syce1 C T 7: 140,357,593 (GRCm39) R324H possibly damaging Het
Tnk1 G T 11: 69,743,119 (GRCm39) probably benign Het
Trim46 A G 3: 89,150,968 (GRCm39) F198L probably damaging Het
Trip4 A T 9: 65,788,233 (GRCm39) W71R probably damaging Het
Ubox5 A C 2: 130,439,213 (GRCm39) probably benign Het
Ust G A 10: 8,183,202 (GRCm39) T167M probably damaging Het
Zbtb2 T C 10: 4,318,697 (GRCm39) Q443R probably benign Het
Zfp407 A G 18: 84,361,196 (GRCm39) probably benign Het
Other mutations in Areg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01391:Areg APN 5 91,288,954 (GRCm39) missense probably damaging 0.99
IGL01929:Areg APN 5 91,292,312 (GRCm39) missense probably benign
IGL01971:Areg APN 5 91,288,870 (GRCm39) missense probably benign 0.03
IGL02250:Areg APN 5 91,288,967 (GRCm39) missense possibly damaging 0.83
R1674:Areg UTSW 5 91,291,485 (GRCm39) missense probably damaging 0.96
R1699:Areg UTSW 5 91,291,357 (GRCm39) missense probably damaging 1.00
R4239:Areg UTSW 5 91,291,375 (GRCm39) missense probably damaging 1.00
R4240:Areg UTSW 5 91,291,375 (GRCm39) missense probably damaging 1.00
R4613:Areg UTSW 5 91,291,363 (GRCm39) missense probably benign 0.34
R4738:Areg UTSW 5 91,294,583 (GRCm39) missense possibly damaging 0.91
R5040:Areg UTSW 5 91,292,198 (GRCm39) missense possibly damaging 0.94
R5305:Areg UTSW 5 91,292,308 (GRCm39) missense probably damaging 1.00
R5987:Areg UTSW 5 91,294,577 (GRCm39) missense possibly damaging 0.83
R6075:Areg UTSW 5 91,291,456 (GRCm39) missense probably damaging 0.99
R7210:Areg UTSW 5 91,288,764 (GRCm39) nonsense probably null
R8165:Areg UTSW 5 91,291,492 (GRCm39) missense probably damaging 0.97
R9054:Areg UTSW 5 91,292,217 (GRCm39) missense probably damaging 1.00
R9498:Areg UTSW 5 91,294,553 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCAGCGGGTCTATAAAAGCAGCAG -3'
(R):5'- CCCTCCTAGCATGAGCAATTTCAGG -3'

Sequencing Primer
(F):5'- TCTATAAAAGCAGCAGGTGCTC -3'
(R):5'- CATGAGCAATTTCAGGGGTATG -3'
Posted On 2014-03-14