Incidental Mutation 'R1438:Vmn2r50'
ID 160765
Institutional Source Beutler Lab
Gene Symbol Vmn2r50
Ensembl Gene ENSMUSG00000094606
Gene Name vomeronasal 2, receptor 50
Synonyms EG434117
MMRRC Submission 039493-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.117) question?
Stock # R1438 (G1)
Quality Score 83
Status Not validated
Chromosome 7
Chromosomal Location 9771162-9787105 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 9784062 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 137 (C137*)
Ref Sequence ENSEMBL: ENSMUSP00000083478 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074943] [ENSMUST00000086298]
AlphaFold E9PW61
Predicted Effect probably null
Transcript: ENSMUST00000074943
AA Change: C137*
SMART Domains Protein: ENSMUSP00000074476
Gene: ENSMUSG00000094606
AA Change: C137*

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 469 1.4e-32 PFAM
Pfam:NCD3G 512 565 2.9e-20 PFAM
Pfam:7tm_3 597 833 1.3e-55 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000086298
AA Change: C137*
SMART Domains Protein: ENSMUSP00000083478
Gene: ENSMUSG00000094606
AA Change: C137*

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 452 7e-31 PFAM
Pfam:NCD3G 496 549 5.3e-19 PFAM
Pfam:7tm_3 579 818 3.9e-78 PFAM
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 94.7%
  • 20x: 87.3%
Validation Efficiency 99% (80/81)
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl6b A T 5: 137,552,871 (GRCm39) I67F probably damaging Het
Adam24 A T 8: 41,134,431 (GRCm39) N633I probably benign Het
Adgrg6 T C 10: 14,344,585 (GRCm39) S123G possibly damaging Het
Afdn T A 17: 14,075,652 (GRCm39) F940L probably damaging Het
Ahrr A T 13: 74,372,987 (GRCm39) Y26* probably null Het
Akap1 C A 11: 88,735,577 (GRCm39) G362* probably null Het
Aox3 A T 1: 58,192,337 (GRCm39) T536S probably benign Het
Boc A T 16: 44,309,109 (GRCm39) probably null Het
Cchcr1 T C 17: 35,841,457 (GRCm39) probably null Het
Cct2 A T 10: 116,890,897 (GRCm39) probably benign Het
Cd84 A T 1: 171,679,685 (GRCm39) Y121F probably damaging Het
Cecr2 T A 6: 120,738,433 (GRCm39) C275* probably null Het
Chchd3 C A 6: 32,985,503 (GRCm39) probably benign Het
Ckmt2 A T 13: 92,007,971 (GRCm39) probably benign Het
Col5a3 T C 9: 20,691,253 (GRCm39) K1131E probably damaging Het
Dek A T 13: 47,241,647 (GRCm39) S306T probably benign Het
Dhx32 T C 7: 133,339,069 (GRCm39) E322G possibly damaging Het
Dlg5 T A 14: 24,204,673 (GRCm39) D941V possibly damaging Het
Dnah10 A G 5: 124,876,009 (GRCm39) N2559S probably benign Het
Dnajc3 A G 14: 119,205,518 (GRCm39) T171A probably benign Het
Eftud2 G T 11: 102,750,868 (GRCm39) F308L probably damaging Het
Elp6 T C 9: 110,143,123 (GRCm39) F95S probably damaging Het
Emsy C T 7: 98,270,613 (GRCm39) V450I possibly damaging Het
Exoc3 A T 13: 74,338,298 (GRCm39) M362K probably damaging Het
Fat2 A T 11: 55,178,637 (GRCm39) D1474E probably damaging Het
Fcgbp T A 7: 27,803,158 (GRCm39) C1587* probably null Het
Fosl2 T A 5: 32,304,329 (GRCm39) L88Q probably damaging Het
Fsd2 T C 7: 81,198,621 (GRCm39) D381G probably benign Het
Golim4 A C 3: 75,863,440 (GRCm39) S56A probably damaging Het
Gpr39 T C 1: 125,800,093 (GRCm39) probably benign Het
Gucy1b2 T C 14: 62,651,770 (GRCm39) I409V probably damaging Het
Hivep1 A G 13: 42,311,596 (GRCm39) T1279A probably benign Het
Ifit1bl2 T A 19: 34,596,569 (GRCm39) Q349L possibly damaging Het
Kcnc1 A T 7: 46,077,691 (GRCm39) I498F possibly damaging Het
Kctd21 T A 7: 96,996,704 (GRCm39) I59N probably damaging Het
Lama5 T A 2: 179,824,593 (GRCm39) T2577S probably benign Het
Mief2 G T 11: 60,621,140 (GRCm39) R9M possibly damaging Het
Mmp3 T C 9: 7,453,705 (GRCm39) V442A probably benign Het
Nkapd1 C A 9: 50,518,972 (GRCm39) K213N possibly damaging Het
Nrxn3 C T 12: 90,298,909 (GRCm39) R477W probably damaging Het
Or12e7 A G 2: 87,288,336 (GRCm39) T276A probably benign Het
Or7a41 T A 10: 78,871,122 (GRCm39) V164E possibly damaging Het
Parp1 A G 1: 180,418,807 (GRCm39) T656A probably benign Het
Pcdhb19 A G 18: 37,631,015 (GRCm39) D270G probably damaging Het
Phlpp1 A G 1: 106,101,142 (GRCm39) D470G possibly damaging Het
Prdm1 T C 10: 44,318,124 (GRCm39) E248G probably benign Het
Prtg C T 9: 72,818,032 (GRCm39) probably benign Het
Ptpn1 T C 2: 167,818,529 (GRCm39) Y424H probably damaging Het
Ptprr T C 10: 116,092,109 (GRCm39) V369A probably damaging Het
Rai1 T G 11: 60,076,221 (GRCm39) V95G probably benign Het
Rasal3 T A 17: 32,612,509 (GRCm39) probably null Het
Rbm19 A G 5: 120,260,961 (GRCm39) E195G probably benign Het
Rhbdd3 T A 11: 5,053,332 (GRCm39) L44Q probably damaging Het
Ripply2 T C 9: 86,901,713 (GRCm39) W80R probably damaging Het
Rnf183 A G 4: 62,346,760 (GRCm39) C13R probably damaging Het
Rorb A G 19: 18,932,417 (GRCm39) L367P probably damaging Het
Rpl7a-ps5 C T 17: 58,146,135 (GRCm39) probably benign Het
Rreb1 A G 13: 38,114,581 (GRCm39) N647D probably benign Het
Rtn1 A T 12: 72,351,187 (GRCm39) S341T probably damaging Het
Ryr3 T C 2: 112,588,046 (GRCm39) S2632G probably benign Het
Scube1 A G 15: 83,499,227 (GRCm39) C633R possibly damaging Het
Sdk1 A T 5: 142,024,078 (GRCm39) I723F probably damaging Het
Sec23a A T 12: 59,048,796 (GRCm39) C109S probably damaging Het
Septin11 T C 5: 93,296,287 (GRCm39) F60L probably damaging Het
Sgf29 G A 7: 126,271,063 (GRCm39) probably null Het
Skint5 A G 4: 113,413,308 (GRCm39) probably benign Het
Smo G A 6: 29,755,482 (GRCm39) V385I possibly damaging Het
Tada2a G A 11: 84,000,837 (GRCm39) T76I probably damaging Het
Tas2r118 T A 6: 23,969,422 (GRCm39) H213L possibly damaging Het
Thoc5 A T 11: 4,861,427 (GRCm39) probably benign Het
Tmem33 T A 5: 67,424,634 (GRCm39) probably null Het
Top1mt A G 15: 75,546,247 (GRCm39) L78P probably damaging Het
Uvssa T A 5: 33,571,228 (GRCm39) probably benign Het
Vmn2r81 A G 10: 79,129,691 (GRCm39) T861A probably benign Het
Wnt3 A T 11: 103,699,077 (GRCm39) N61I probably damaging Het
Zswim9 A G 7: 13,011,144 (GRCm39) I68T possibly damaging Het
Zzef1 T C 11: 72,803,771 (GRCm39) I2535T probably damaging Het
Other mutations in Vmn2r50
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01536:Vmn2r50 APN 7 9,771,610 (GRCm39) missense probably damaging 1.00
IGL01739:Vmn2r50 APN 7 9,771,364 (GRCm39) missense probably damaging 1.00
IGL02351:Vmn2r50 APN 7 9,787,002 (GRCm39) missense probably benign 0.01
IGL02358:Vmn2r50 APN 7 9,787,002 (GRCm39) missense probably benign 0.01
IGL02871:Vmn2r50 APN 7 9,781,714 (GRCm39) missense possibly damaging 0.91
IGL02962:Vmn2r50 APN 7 9,784,252 (GRCm39) missense probably damaging 1.00
IGL03187:Vmn2r50 APN 7 9,771,368 (GRCm39) missense probably damaging 1.00
IGL03346:Vmn2r50 APN 7 9,779,929 (GRCm39) missense probably damaging 0.99
PIT4651001:Vmn2r50 UTSW 7 9,771,659 (GRCm39) missense probably benign 0.30
R0530:Vmn2r50 UTSW 7 9,781,644 (GRCm39) missense possibly damaging 0.82
R1291:Vmn2r50 UTSW 7 9,771,404 (GRCm39) missense probably damaging 0.98
R1713:Vmn2r50 UTSW 7 9,771,731 (GRCm39) missense probably damaging 1.00
R1747:Vmn2r50 UTSW 7 9,781,605 (GRCm39) missense probably benign 0.20
R1750:Vmn2r50 UTSW 7 9,786,915 (GRCm39) missense possibly damaging 0.69
R1918:Vmn2r50 UTSW 7 9,781,610 (GRCm39) missense probably benign 0.03
R2435:Vmn2r50 UTSW 7 9,787,026 (GRCm39) missense probably benign 0.27
R2511:Vmn2r50 UTSW 7 9,781,640 (GRCm39) missense possibly damaging 0.81
R3795:Vmn2r50 UTSW 7 9,771,851 (GRCm39) missense probably benign 0.18
R4156:Vmn2r50 UTSW 7 9,774,309 (GRCm39) missense probably benign 0.12
R4332:Vmn2r50 UTSW 7 9,786,922 (GRCm39) missense probably benign 0.32
R4399:Vmn2r50 UTSW 7 9,781,834 (GRCm39) missense possibly damaging 0.81
R4411:Vmn2r50 UTSW 7 9,784,235 (GRCm39) missense probably damaging 0.99
R4412:Vmn2r50 UTSW 7 9,784,235 (GRCm39) missense probably damaging 0.99
R4413:Vmn2r50 UTSW 7 9,784,235 (GRCm39) missense probably damaging 0.99
R4645:Vmn2r50 UTSW 7 9,771,162 (GRCm39) makesense probably null
R5151:Vmn2r50 UTSW 7 9,786,970 (GRCm39) missense probably benign 0.00
R5175:Vmn2r50 UTSW 7 9,771,644 (GRCm39) missense probably damaging 1.00
R5291:Vmn2r50 UTSW 7 9,781,752 (GRCm39) missense probably damaging 1.00
R5457:Vmn2r50 UTSW 7 9,781,873 (GRCm39) missense probably damaging 0.98
R5559:Vmn2r50 UTSW 7 9,771,253 (GRCm39) missense probably damaging 1.00
R5579:Vmn2r50 UTSW 7 9,784,016 (GRCm39) missense probably benign 0.00
R5711:Vmn2r50 UTSW 7 9,774,299 (GRCm39) missense possibly damaging 0.81
R5759:Vmn2r50 UTSW 7 9,781,905 (GRCm39) missense probably damaging 1.00
R6004:Vmn2r50 UTSW 7 9,783,986 (GRCm39) missense probably benign 0.00
R6394:Vmn2r50 UTSW 7 9,774,253 (GRCm39) missense probably damaging 1.00
R6488:Vmn2r50 UTSW 7 9,771,644 (GRCm39) missense probably damaging 1.00
R6762:Vmn2r50 UTSW 7 9,787,010 (GRCm39) missense probably benign 0.04
R6995:Vmn2r50 UTSW 7 9,779,964 (GRCm39) nonsense probably null
R6998:Vmn2r50 UTSW 7 9,771,684 (GRCm39) missense probably benign 0.03
R7019:Vmn2r50 UTSW 7 9,784,172 (GRCm39) missense probably benign 0.01
R7027:Vmn2r50 UTSW 7 9,781,539 (GRCm39) missense probably damaging 1.00
R7231:Vmn2r50 UTSW 7 9,787,010 (GRCm39) missense probably benign 0.04
R7343:Vmn2r50 UTSW 7 9,784,277 (GRCm39) critical splice acceptor site probably null
R7554:Vmn2r50 UTSW 7 9,784,066 (GRCm39) missense probably null 0.00
R7704:Vmn2r50 UTSW 7 9,781,665 (GRCm39) missense probably benign 0.05
R7768:Vmn2r50 UTSW 7 9,771,298 (GRCm39) missense probably damaging 0.99
R7773:Vmn2r50 UTSW 7 9,771,562 (GRCm39) missense possibly damaging 0.70
R7975:Vmn2r50 UTSW 7 9,771,272 (GRCm39) missense probably benign 0.39
R7987:Vmn2r50 UTSW 7 9,772,016 (GRCm39) missense probably benign 0.14
R7996:Vmn2r50 UTSW 7 9,781,795 (GRCm39) missense probably damaging 0.99
R8062:Vmn2r50 UTSW 7 9,774,240 (GRCm39) critical splice donor site probably null
R8396:Vmn2r50 UTSW 7 9,781,639 (GRCm39) nonsense probably null
R8466:Vmn2r50 UTSW 7 9,783,997 (GRCm39) missense probably damaging 0.97
R8985:Vmn2r50 UTSW 7 9,779,974 (GRCm39) missense probably damaging 1.00
R9068:Vmn2r50 UTSW 7 9,772,061 (GRCm39) missense possibly damaging 0.46
R9155:Vmn2r50 UTSW 7 9,781,571 (GRCm39) missense probably damaging 1.00
R9238:Vmn2r50 UTSW 7 9,781,503 (GRCm39) missense probably benign 0.01
R9576:Vmn2r50 UTSW 7 9,771,190 (GRCm39) missense probably benign
R9626:Vmn2r50 UTSW 7 9,771,960 (GRCm39) nonsense probably null
R9631:Vmn2r50 UTSW 7 9,786,990 (GRCm39) nonsense probably null
X0067:Vmn2r50 UTSW 7 9,786,954 (GRCm39) missense probably damaging 0.99
Z1088:Vmn2r50 UTSW 7 9,780,086 (GRCm39) missense probably benign 0.01
Z1088:Vmn2r50 UTSW 7 9,771,427 (GRCm39) missense possibly damaging 0.91
Predicted Primers PCR Primer
(F):5'- GAACAGCACGAACAAATCTCTGCTTG -3'
(R):5'- AACCACAAATATGCTTTGGCATTGGTC -3'

Sequencing Primer
(F):5'- CGAACAAATCTCTGCTTGCTGAG -3'
(R):5'- GGTCTTTTCAATGGATGAAATCAAC -3'
Posted On 2014-03-14