Incidental Mutation 'R1439:Vmn2r15'
ID |
160839 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r15
|
Ensembl Gene |
ENSMUSG00000091375 |
Gene Name |
vomeronasal 2, receptor 15 |
Synonyms |
EG211223 |
MMRRC Submission |
039494-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.090)
|
Stock # |
R1439 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
5 |
Chromosomal Location |
109434135-109445422 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to T
at 109441953 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Proline to Glutamine
at position 160
(P160Q)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000128333
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167133]
|
AlphaFold |
L7N2A0 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000167133
AA Change: P160Q
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000128333 Gene: ENSMUSG00000091375 AA Change: P160Q
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
75 |
472 |
1e-29 |
PFAM |
Pfam:NCD3G
|
514 |
568 |
5.8e-18 |
PFAM |
Pfam:7tm_3
|
601 |
836 |
9.1e-55 |
PFAM |
|
Meta Mutation Damage Score |
0.6467 |
Coding Region Coverage |
- 1x: 98.8%
- 3x: 97.8%
- 10x: 94.4%
- 20x: 86.3%
|
Validation Efficiency |
100% (72/72) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 70 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Agap1 |
A |
G |
1: 89,770,908 (GRCm39) |
N499S |
probably damaging |
Het |
AI661453 |
C |
A |
17: 47,777,587 (GRCm39) |
|
probably benign |
Het |
Akap1 |
C |
A |
11: 88,735,577 (GRCm39) |
G362* |
probably null |
Het |
Alkbh1 |
A |
G |
12: 87,475,915 (GRCm39) |
V289A |
probably damaging |
Het |
Bnc2 |
C |
T |
4: 84,194,305 (GRCm39) |
E1035K |
probably benign |
Het |
C1s2 |
T |
A |
6: 124,607,126 (GRCm39) |
|
probably benign |
Het |
Cabin1 |
A |
G |
10: 75,492,640 (GRCm39) |
I1885T |
probably damaging |
Het |
Col22a1 |
A |
G |
15: 71,824,226 (GRCm39) |
|
probably benign |
Het |
Cpne4 |
A |
T |
9: 104,866,831 (GRCm39) |
T248S |
probably damaging |
Het |
Cracd |
T |
C |
5: 76,988,757 (GRCm39) |
V36A |
probably damaging |
Het |
Cubn |
T |
C |
2: 13,292,379 (GRCm39) |
N3268S |
probably damaging |
Het |
Ddx10 |
T |
A |
9: 53,151,787 (GRCm39) |
K79N |
probably damaging |
Het |
Dennd1a |
A |
C |
2: 37,933,412 (GRCm39) |
L131R |
probably damaging |
Het |
Dnah9 |
T |
C |
11: 65,764,958 (GRCm39) |
Y3862C |
probably benign |
Het |
Eif3e |
A |
G |
15: 43,141,824 (GRCm39) |
|
probably benign |
Het |
Emsy |
T |
C |
7: 98,250,048 (GRCm39) |
|
probably benign |
Het |
Ep400 |
A |
T |
5: 110,833,344 (GRCm39) |
D1959E |
unknown |
Het |
Fpr-rs7 |
A |
G |
17: 20,333,869 (GRCm39) |
I207T |
probably benign |
Het |
Fubp3 |
C |
A |
2: 31,488,563 (GRCm39) |
L140I |
probably damaging |
Het |
Gas2l2 |
T |
C |
11: 83,318,298 (GRCm39) |
D137G |
probably damaging |
Het |
Git1 |
G |
T |
11: 77,397,244 (GRCm39) |
R699L |
possibly damaging |
Het |
Gnao1 |
T |
A |
8: 94,690,065 (GRCm39) |
F27L |
probably benign |
Het |
Hlx |
G |
T |
1: 184,464,184 (GRCm39) |
A52D |
probably damaging |
Het |
Itga6 |
T |
G |
2: 71,664,378 (GRCm39) |
Y505D |
probably damaging |
Het |
Itgad |
A |
T |
7: 127,782,178 (GRCm39) |
T205S |
probably benign |
Het |
Jakmip3 |
A |
T |
7: 138,631,375 (GRCm39) |
Y574F |
probably benign |
Het |
Laptm5 |
G |
T |
4: 130,653,520 (GRCm39) |
|
probably benign |
Het |
Mlana |
A |
T |
19: 29,684,252 (GRCm39) |
R71S |
probably benign |
Het |
Mroh2a |
G |
C |
1: 88,185,524 (GRCm39) |
E1510D |
probably damaging |
Het |
Mus81 |
G |
C |
19: 5,535,145 (GRCm39) |
R295G |
probably benign |
Het |
Ncapd3 |
T |
A |
9: 26,998,862 (GRCm39) |
|
probably null |
Het |
Nectin1 |
A |
G |
9: 43,703,396 (GRCm39) |
E218G |
possibly damaging |
Het |
Nectin3 |
A |
T |
16: 46,268,757 (GRCm39) |
Y548* |
probably null |
Het |
Nif3l1 |
T |
C |
1: 58,487,102 (GRCm39) |
F96S |
probably damaging |
Het |
Ntrk1 |
A |
G |
3: 87,696,918 (GRCm39) |
|
probably null |
Het |
Obsl1 |
C |
A |
1: 75,463,428 (GRCm39) |
E1755* |
probably null |
Het |
Or4p23 |
T |
C |
2: 88,577,178 (GRCm39) |
E18G |
possibly damaging |
Het |
Osbpl9 |
T |
C |
4: 108,958,353 (GRCm39) |
D74G |
probably damaging |
Het |
Osgin1 |
T |
A |
8: 120,169,852 (GRCm39) |
|
probably null |
Het |
Otogl |
A |
G |
10: 107,615,113 (GRCm39) |
Y1931H |
probably benign |
Het |
Pmepa1 |
A |
G |
2: 173,069,874 (GRCm39) |
I227T |
probably benign |
Het |
Pprc1 |
T |
A |
19: 46,052,175 (GRCm39) |
N564K |
possibly damaging |
Het |
Prkaa1 |
T |
C |
15: 5,194,225 (GRCm39) |
F92S |
probably damaging |
Het |
Ptprd |
A |
G |
4: 75,984,437 (GRCm39) |
F811L |
probably damaging |
Het |
Rad54b |
A |
G |
4: 11,606,152 (GRCm39) |
K520R |
possibly damaging |
Het |
Rbfox1 |
A |
G |
16: 7,148,297 (GRCm39) |
T269A |
possibly damaging |
Het |
Rfwd3 |
T |
C |
8: 112,004,920 (GRCm39) |
Y554C |
probably damaging |
Het |
Rfx2 |
A |
T |
17: 57,094,720 (GRCm39) |
V208E |
probably damaging |
Het |
Rgs22 |
G |
T |
15: 36,025,939 (GRCm39) |
|
probably benign |
Het |
Rrbp1 |
A |
G |
2: 143,797,032 (GRCm39) |
|
probably null |
Het |
Ryr2 |
C |
T |
13: 11,729,389 (GRCm39) |
|
probably benign |
Het |
Sbno1 |
A |
G |
5: 124,522,523 (GRCm39) |
|
probably benign |
Het |
Secisbp2 |
T |
C |
13: 51,833,759 (GRCm39) |
|
probably benign |
Het |
Sgsm2 |
C |
A |
11: 74,759,964 (GRCm39) |
R58L |
probably benign |
Het |
Slc25a36 |
A |
C |
9: 96,975,126 (GRCm39) |
|
probably benign |
Het |
Spink4 |
A |
G |
4: 40,929,121 (GRCm39) |
T49A |
possibly damaging |
Het |
Steap3 |
A |
T |
1: 120,155,550 (GRCm39) |
F470I |
probably damaging |
Het |
Stk10 |
A |
G |
11: 32,567,919 (GRCm39) |
Q907R |
probably damaging |
Het |
Tdrd5 |
A |
G |
1: 156,105,057 (GRCm39) |
V446A |
probably damaging |
Het |
Tmem117 |
G |
A |
15: 94,992,478 (GRCm39) |
M379I |
probably benign |
Het |
Trappc12 |
A |
G |
12: 28,797,160 (GRCm39) |
L124P |
possibly damaging |
Het |
Trim9 |
G |
A |
12: 70,297,867 (GRCm39) |
H613Y |
probably damaging |
Het |
Trio |
A |
G |
15: 27,898,000 (GRCm39) |
W371R |
probably damaging |
Het |
Ulk4 |
G |
C |
9: 121,095,324 (GRCm39) |
H110D |
possibly damaging |
Het |
Upb1 |
T |
C |
10: 75,275,776 (GRCm39) |
V387A |
probably benign |
Het |
Utrn |
A |
T |
10: 12,619,793 (GRCm39) |
I284N |
possibly damaging |
Het |
Vmn2r111 |
C |
A |
17: 22,790,097 (GRCm39) |
W303L |
probably benign |
Het |
Wdtc1 |
A |
G |
4: 133,029,118 (GRCm39) |
S323P |
probably benign |
Het |
Zfp846 |
T |
A |
9: 20,505,393 (GRCm39) |
C418S |
possibly damaging |
Het |
Zfyve26 |
G |
T |
12: 79,298,937 (GRCm39) |
P441Q |
probably benign |
Het |
|
Other mutations in Vmn2r15 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01335:Vmn2r15
|
APN |
5 |
109,434,602 (GRCm39) |
missense |
possibly damaging |
0.70 |
IGL01367:Vmn2r15
|
APN |
5 |
109,441,075 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01844:Vmn2r15
|
APN |
5 |
109,434,135 (GRCm39) |
makesense |
probably null |
|
IGL02190:Vmn2r15
|
APN |
5 |
109,441,240 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02754:Vmn2r15
|
APN |
5 |
109,441,134 (GRCm39) |
nonsense |
probably null |
|
IGL02797:Vmn2r15
|
APN |
5 |
109,445,250 (GRCm39) |
missense |
probably benign |
0.18 |
IGL03301:Vmn2r15
|
APN |
5 |
109,445,221 (GRCm39) |
critical splice donor site |
probably null |
|
IGL03407:Vmn2r15
|
APN |
5 |
109,434,185 (GRCm39) |
nonsense |
probably null |
|
BB001:Vmn2r15
|
UTSW |
5 |
109,434,254 (GRCm39) |
missense |
probably damaging |
1.00 |
BB011:Vmn2r15
|
UTSW |
5 |
109,434,254 (GRCm39) |
missense |
probably damaging |
1.00 |
PIT4445001:Vmn2r15
|
UTSW |
5 |
109,435,008 (GRCm39) |
missense |
probably damaging |
0.99 |
PIT4520001:Vmn2r15
|
UTSW |
5 |
109,434,871 (GRCm39) |
missense |
probably damaging |
1.00 |
R0038:Vmn2r15
|
UTSW |
5 |
109,441,010 (GRCm39) |
missense |
possibly damaging |
0.46 |
R0111:Vmn2r15
|
UTSW |
5 |
109,435,022 (GRCm39) |
missense |
possibly damaging |
0.56 |
R0379:Vmn2r15
|
UTSW |
5 |
109,434,344 (GRCm39) |
missense |
probably damaging |
1.00 |
R0427:Vmn2r15
|
UTSW |
5 |
109,434,953 (GRCm39) |
missense |
probably damaging |
1.00 |
R0639:Vmn2r15
|
UTSW |
5 |
109,440,881 (GRCm39) |
missense |
probably benign |
0.22 |
R0964:Vmn2r15
|
UTSW |
5 |
109,445,401 (GRCm39) |
missense |
probably benign |
0.34 |
R1147:Vmn2r15
|
UTSW |
5 |
109,441,072 (GRCm39) |
missense |
probably damaging |
1.00 |
R1147:Vmn2r15
|
UTSW |
5 |
109,441,072 (GRCm39) |
missense |
probably damaging |
1.00 |
R1232:Vmn2r15
|
UTSW |
5 |
109,441,168 (GRCm39) |
missense |
probably benign |
0.39 |
R1241:Vmn2r15
|
UTSW |
5 |
109,440,770 (GRCm39) |
missense |
probably damaging |
1.00 |
R1244:Vmn2r15
|
UTSW |
5 |
109,441,092 (GRCm39) |
nonsense |
probably null |
|
R1394:Vmn2r15
|
UTSW |
5 |
109,442,014 (GRCm39) |
missense |
probably benign |
0.44 |
R1395:Vmn2r15
|
UTSW |
5 |
109,442,014 (GRCm39) |
missense |
probably benign |
0.44 |
R1423:Vmn2r15
|
UTSW |
5 |
109,441,093 (GRCm39) |
missense |
probably damaging |
1.00 |
R1513:Vmn2r15
|
UTSW |
5 |
109,441,195 (GRCm39) |
missense |
probably damaging |
1.00 |
R1777:Vmn2r15
|
UTSW |
5 |
109,442,136 (GRCm39) |
missense |
possibly damaging |
0.79 |
R1844:Vmn2r15
|
UTSW |
5 |
109,434,860 (GRCm39) |
nonsense |
probably null |
|
R2072:Vmn2r15
|
UTSW |
5 |
109,434,619 (GRCm39) |
missense |
possibly damaging |
0.65 |
R2074:Vmn2r15
|
UTSW |
5 |
109,434,619 (GRCm39) |
missense |
possibly damaging |
0.65 |
R2122:Vmn2r15
|
UTSW |
5 |
109,434,322 (GRCm39) |
missense |
probably damaging |
1.00 |
R2208:Vmn2r15
|
UTSW |
5 |
109,445,309 (GRCm39) |
missense |
possibly damaging |
0.64 |
R2268:Vmn2r15
|
UTSW |
5 |
109,441,073 (GRCm39) |
missense |
probably benign |
0.31 |
R2831:Vmn2r15
|
UTSW |
5 |
109,434,458 (GRCm39) |
missense |
probably damaging |
1.00 |
R3848:Vmn2r15
|
UTSW |
5 |
109,445,312 (GRCm39) |
missense |
probably benign |
0.00 |
R4058:Vmn2r15
|
UTSW |
5 |
109,441,312 (GRCm39) |
missense |
probably damaging |
0.99 |
R4615:Vmn2r15
|
UTSW |
5 |
109,441,348 (GRCm39) |
missense |
possibly damaging |
0.91 |
R4663:Vmn2r15
|
UTSW |
5 |
109,441,940 (GRCm39) |
missense |
probably benign |
|
R4681:Vmn2r15
|
UTSW |
5 |
109,434,488 (GRCm39) |
missense |
probably damaging |
0.97 |
R4751:Vmn2r15
|
UTSW |
5 |
109,434,620 (GRCm39) |
missense |
probably benign |
0.01 |
R5095:Vmn2r15
|
UTSW |
5 |
109,436,317 (GRCm39) |
critical splice acceptor site |
probably null |
|
R5300:Vmn2r15
|
UTSW |
5 |
109,441,974 (GRCm39) |
missense |
probably damaging |
0.99 |
R5309:Vmn2r15
|
UTSW |
5 |
109,440,956 (GRCm39) |
missense |
probably damaging |
0.99 |
R5335:Vmn2r15
|
UTSW |
5 |
109,434,673 (GRCm39) |
missense |
probably damaging |
0.99 |
R5421:Vmn2r15
|
UTSW |
5 |
109,434,401 (GRCm39) |
missense |
probably damaging |
1.00 |
R5805:Vmn2r15
|
UTSW |
5 |
109,434,806 (GRCm39) |
missense |
possibly damaging |
0.88 |
R6280:Vmn2r15
|
UTSW |
5 |
109,441,291 (GRCm39) |
missense |
possibly damaging |
0.65 |
R6324:Vmn2r15
|
UTSW |
5 |
109,434,137 (GRCm39) |
makesense |
probably null |
|
R6383:Vmn2r15
|
UTSW |
5 |
109,441,092 (GRCm39) |
nonsense |
probably null |
|
R6772:Vmn2r15
|
UTSW |
5 |
109,434,238 (GRCm39) |
missense |
probably damaging |
0.99 |
R6991:Vmn2r15
|
UTSW |
5 |
109,441,180 (GRCm39) |
missense |
probably damaging |
1.00 |
R7194:Vmn2r15
|
UTSW |
5 |
109,440,649 (GRCm39) |
missense |
probably damaging |
1.00 |
R7365:Vmn2r15
|
UTSW |
5 |
109,445,388 (GRCm39) |
missense |
probably benign |
0.15 |
R7365:Vmn2r15
|
UTSW |
5 |
109,441,105 (GRCm39) |
missense |
probably benign |
0.19 |
R7423:Vmn2r15
|
UTSW |
5 |
109,445,394 (GRCm39) |
missense |
probably benign |
0.00 |
R7552:Vmn2r15
|
UTSW |
5 |
109,440,774 (GRCm39) |
nonsense |
probably null |
|
R7619:Vmn2r15
|
UTSW |
5 |
109,436,190 (GRCm39) |
critical splice donor site |
probably null |
|
R7892:Vmn2r15
|
UTSW |
5 |
109,434,217 (GRCm39) |
missense |
probably damaging |
1.00 |
R7924:Vmn2r15
|
UTSW |
5 |
109,434,254 (GRCm39) |
missense |
probably damaging |
1.00 |
R8058:Vmn2r15
|
UTSW |
5 |
109,440,956 (GRCm39) |
missense |
probably damaging |
0.99 |
R8099:Vmn2r15
|
UTSW |
5 |
109,441,185 (GRCm39) |
missense |
possibly damaging |
0.58 |
R8189:Vmn2r15
|
UTSW |
5 |
109,434,713 (GRCm39) |
missense |
probably benign |
0.02 |
R8275:Vmn2r15
|
UTSW |
5 |
109,434,150 (GRCm39) |
missense |
probably benign |
0.08 |
R8277:Vmn2r15
|
UTSW |
5 |
109,441,310 (GRCm39) |
missense |
probably damaging |
1.00 |
R8277:Vmn2r15
|
UTSW |
5 |
109,440,970 (GRCm39) |
missense |
probably benign |
0.00 |
R8465:Vmn2r15
|
UTSW |
5 |
109,445,302 (GRCm39) |
missense |
probably damaging |
1.00 |
R8679:Vmn2r15
|
UTSW |
5 |
109,434,779 (GRCm39) |
missense |
probably benign |
0.31 |
R8682:Vmn2r15
|
UTSW |
5 |
109,441,938 (GRCm39) |
missense |
probably damaging |
0.98 |
R8809:Vmn2r15
|
UTSW |
5 |
109,434,874 (GRCm39) |
missense |
probably benign |
0.22 |
R9016:Vmn2r15
|
UTSW |
5 |
109,442,109 (GRCm39) |
missense |
probably benign |
0.01 |
R9372:Vmn2r15
|
UTSW |
5 |
109,441,953 (GRCm39) |
missense |
possibly damaging |
0.60 |
R9596:Vmn2r15
|
UTSW |
5 |
109,440,791 (GRCm39) |
missense |
probably benign |
0.01 |
R9619:Vmn2r15
|
UTSW |
5 |
109,440,622 (GRCm39) |
missense |
possibly damaging |
0.58 |
R9685:Vmn2r15
|
UTSW |
5 |
109,440,598 (GRCm39) |
missense |
probably benign |
0.05 |
R9716:Vmn2r15
|
UTSW |
5 |
109,445,224 (GRCm39) |
missense |
possibly damaging |
0.88 |
R9772:Vmn2r15
|
UTSW |
5 |
109,434,923 (GRCm39) |
missense |
probably damaging |
1.00 |
X0065:Vmn2r15
|
UTSW |
5 |
109,441,174 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1187:Vmn2r15
|
UTSW |
5 |
109,434,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- GCATACTCTCCAAGTTTTCATGTAGGCA -3'
(R):5'- GCAGCACACTGACTCTCTACGGTATAAG -3'
Sequencing Primer
(F):5'- tggttaagagcactgcctg -3'
(R):5'- AACATGTCTTTGATATCCCCCG -3'
|
Posted On |
2014-03-14 |