Incidental Mutation 'R1452:Arl15'
ID 161098
Institutional Source Beutler Lab
Gene Symbol Arl15
Ensembl Gene ENSMUSG00000042348
Gene Name ADP-ribosylation factor-like 15
Synonyms C230032K13Rik, Arfrp2
MMRRC Submission 039507-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1452 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 113931041-114293997 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 114104319 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 132 (V132A)
Ref Sequence ENSEMBL: ENSMUSP00000153127 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091201] [ENSMUST00000224068] [ENSMUST00000224858]
AlphaFold Q8BGR6
Predicted Effect probably benign
Transcript: ENSMUST00000091201
AA Change: V152A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000088740
Gene: ENSMUSG00000042348
AA Change: V152A

DomainStartEndE-ValueType
Pfam:Arf 27 194 7.7e-37 PFAM
Pfam:SRPRB 31 192 7.7e-10 PFAM
Pfam:Roc 34 146 6.5e-10 PFAM
Pfam:Ras 34 196 5.4e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000224068
AA Change: V132A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Predicted Effect probably benign
Transcript: ENSMUST00000224858
Meta Mutation Damage Score 0.0837 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.8%
  • 10x: 94.8%
  • 20x: 87.5%
Validation Efficiency 99% (70/71)
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m A G 6: 121,655,015 (GRCm39) I1446M probably benign Het
Acaca T A 11: 84,185,885 (GRCm39) probably benign Het
Adgre4 A T 17: 56,091,996 (GRCm39) E85D probably benign Het
Akt3 A T 1: 176,958,633 (GRCm39) Y26N possibly damaging Het
Atp6v1h A G 1: 5,168,360 (GRCm39) probably benign Het
Atrip T A 9: 108,901,727 (GRCm39) D110V probably damaging Het
Bahcc1 T G 11: 120,173,065 (GRCm39) probably benign Het
Cd53 C T 3: 106,676,275 (GRCm39) G31S probably damaging Het
Cdk14 T C 5: 4,938,927 (GRCm39) S404G possibly damaging Het
Cers3 A T 7: 66,433,152 (GRCm39) K156N probably damaging Het
Colgalt2 C A 1: 152,379,904 (GRCm39) L448M probably damaging Het
Cox15 G T 19: 43,735,344 (GRCm39) T141K probably damaging Het
Csnk2a2 C T 8: 96,184,003 (GRCm39) probably benign Het
Cyp2b10 A T 7: 25,624,813 (GRCm39) probably benign Het
Cyp2c55 A G 19: 38,999,534 (GRCm39) Y80C probably damaging Het
Depdc1a A G 3: 159,232,328 (GRCm39) Y693C possibly damaging Het
Des T C 1: 75,340,121 (GRCm39) S343P probably damaging Het
Dync1i2 T C 2: 71,080,207 (GRCm39) probably benign Het
Eif3m T A 2: 104,837,122 (GRCm39) Q199L probably damaging Het
Emsy G T 7: 98,249,881 (GRCm39) T802K probably damaging Het
Endov A G 11: 119,382,651 (GRCm39) T33A probably damaging Het
Epb41l5 G A 1: 119,476,896 (GRCm39) T728I probably damaging Het
Fbxo39 A G 11: 72,209,228 (GRCm39) I363V probably benign Het
Gm8674 C T 13: 50,054,553 (GRCm39) noncoding transcript Het
Il6st T A 13: 112,617,998 (GRCm39) N137K possibly damaging Het
Inf2 A G 12: 112,567,778 (GRCm39) N136S probably damaging Het
Iqub A T 6: 24,491,558 (GRCm39) I376N probably benign Het
Kansl3 A G 1: 36,393,874 (GRCm39) probably benign Het
Kbtbd2 A T 6: 56,758,909 (GRCm39) H71Q probably damaging Het
Lgals8 G T 13: 12,468,208 (GRCm39) Y140* probably null Het
Mab21l4 T C 1: 93,080,661 (GRCm39) Y415C probably damaging Het
Macf1 T A 4: 123,387,791 (GRCm39) I924L probably benign Het
Mcoln2 A T 3: 145,887,569 (GRCm39) T329S possibly damaging Het
Mex3d A T 10: 80,217,354 (GRCm39) L621Q probably damaging Het
Mmut A G 17: 41,248,359 (GRCm39) probably benign Het
Ncor1 T C 11: 62,225,457 (GRCm39) H1038R probably damaging Het
Neb A G 2: 52,161,309 (GRCm39) probably null Het
Ngrn A G 7: 79,914,520 (GRCm39) T224A probably benign Het
Nin G A 12: 70,064,424 (GRCm39) R2019* probably null Het
Nphp4 C G 4: 152,631,475 (GRCm39) Q792E probably damaging Het
Or13e8 C T 4: 43,696,823 (GRCm39) V117M probably benign Het
Or2z9 C T 8: 72,854,020 (GRCm39) Q139* probably null Het
Or4c3d C T 2: 89,882,015 (GRCm39) V218I possibly damaging Het
Or5d38 C T 2: 87,954,655 (GRCm39) V225I probably benign Het
Or8k3 T A 2: 86,058,799 (GRCm39) N172I probably damaging Het
Pde4dip C A 3: 97,631,418 (GRCm39) V1164L probably damaging Het
Plppr1 A G 4: 49,301,067 (GRCm39) probably benign Het
Pole2 G A 12: 69,254,703 (GRCm39) L381F probably benign Het
Ppp2r5e A G 12: 75,516,310 (GRCm39) probably benign Het
Prim2 T A 1: 33,669,485 (GRCm39) E163D probably benign Het
Prrc2b A T 2: 32,084,997 (GRCm39) D296V probably damaging Het
Pter A G 2: 12,983,432 (GRCm39) probably benign Het
Resf1 A T 6: 149,228,130 (GRCm39) K392I probably damaging Het
Robo2 C A 16: 73,758,798 (GRCm39) V662L probably damaging Het
Sirpd G T 3: 15,397,212 (GRCm39) T24K unknown Het
Slco1b2 A T 6: 141,617,926 (GRCm39) I424F probably benign Het
Snx29 A T 16: 11,449,335 (GRCm39) H260L probably damaging Het
Stil A G 4: 114,896,392 (GRCm39) N959S probably benign Het
Taar8c A T 10: 23,977,508 (GRCm39) D101E probably benign Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Trpc6 G A 9: 8,653,148 (GRCm39) M573I probably damaging Het
Tsr1 A T 11: 74,790,425 (GRCm39) D171V probably benign Het
Ube4b T C 4: 149,455,626 (GRCm39) T348A probably damaging Het
Vmn1r85 A T 7: 12,818,808 (GRCm39) I112N probably damaging Het
Vps36 A G 8: 22,708,226 (GRCm39) probably null Het
Wdfy3 G A 5: 102,085,604 (GRCm39) A630V possibly damaging Het
Wdsub1 A T 2: 59,707,144 (GRCm39) D14E probably null Het
Ylpm1 T C 12: 85,077,157 (GRCm39) I1294T possibly damaging Het
Zdhhc17 A G 10: 110,790,936 (GRCm39) F378L probably benign Het
Other mutations in Arl15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00336:Arl15 APN 13 114,291,288 (GRCm39) missense probably benign 0.00
IGL01986:Arl15 APN 13 114,058,902 (GRCm39) missense possibly damaging 0.90
IGL02061:Arl15 APN 13 113,931,193 (GRCm39) missense probably benign 0.01
IGL02871:Arl15 APN 13 114,291,374 (GRCm39) missense probably benign 0.00
R2114:Arl15 UTSW 13 114,104,196 (GRCm39) missense probably damaging 1.00
R2115:Arl15 UTSW 13 114,104,196 (GRCm39) missense probably damaging 1.00
R2117:Arl15 UTSW 13 114,104,196 (GRCm39) missense probably damaging 1.00
R3500:Arl15 UTSW 13 114,104,228 (GRCm39) missense probably damaging 1.00
R4701:Arl15 UTSW 13 114,104,261 (GRCm39) missense probably benign 0.26
R5977:Arl15 UTSW 13 114,070,645 (GRCm39) missense probably damaging 0.99
R6057:Arl15 UTSW 13 114,104,151 (GRCm39) missense probably damaging 1.00
R7649:Arl15 UTSW 13 114,104,208 (GRCm39) missense possibly damaging 0.72
R8471:Arl15 UTSW 13 114,037,632 (GRCm39) intron probably benign
Predicted Primers PCR Primer
(F):5'- AGCCGCTACTACCAAGGATCTCAAG -3'
(R):5'- TGGCTACCAAAGCCACAGTGTAAC -3'

Sequencing Primer
(F):5'- CCAAGGATCTCAAGGGGTCATATTC -3'
(R):5'- TAACCTTCTGAAAGCTAGTGGCG -3'
Posted On 2014-03-14