Incidental Mutation 'R1425:Tas2r115'
| ID |
161257 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tas2r115
|
| Ensembl Gene |
ENSMUSG00000071149 |
| Gene Name |
taste receptor, type 2, member 115 |
| Synonyms |
T2R15, mt2r49, Tas2r15, mGR15 |
| MMRRC Submission |
039481-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.055)
|
| Stock # |
R1425 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
132714017-132714949 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 132714442 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Arginine
at position 170
(S170R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000093043
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000095394]
|
| AlphaFold |
Q7M719 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000095394
AA Change: S170R
PolyPhen 2
Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000093043
Gene: ENSMUSG00000071149
AA Change: S170R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
299 |
2.2e-84 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.0%
- 10x: 95.4%
- 20x: 89.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 9 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Atp6ap1l |
T |
C |
13: 91,047,638 (GRCm39) |
N58S |
possibly damaging |
Het |
| Gdpd4 |
A |
T |
7: 97,623,219 (GRCm39) |
T277S |
probably benign |
Het |
| Itgb2 |
G |
A |
10: 77,383,130 (GRCm39) |
G167S |
probably null |
Het |
| Kcnt2 |
A |
G |
1: 140,310,766 (GRCm39) |
T191A |
probably damaging |
Het |
| Or52b1 |
A |
T |
7: 104,978,922 (GRCm39) |
F159Y |
probably damaging |
Het |
| Ppm1k |
C |
T |
6: 57,501,774 (GRCm39) |
G130R |
probably damaging |
Het |
| Rfc1 |
A |
C |
5: 65,476,861 (GRCm39) |
F6V |
probably damaging |
Het |
| Sec14l3 |
A |
G |
11: 4,016,487 (GRCm39) |
E53G |
probably damaging |
Het |
| Zfp738 |
T |
C |
13: 67,818,894 (GRCm39) |
T366A |
possibly damaging |
Het |
|
| Other mutations in Tas2r115 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00565:Tas2r115
|
APN |
6 |
132,714,741 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL01285:Tas2r115
|
APN |
6 |
132,714,641 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01516:Tas2r115
|
APN |
6 |
132,714,576 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01637:Tas2r115
|
APN |
6 |
132,714,592 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02041:Tas2r115
|
APN |
6 |
132,714,430 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02178:Tas2r115
|
APN |
6 |
132,714,271 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0467:Tas2r115
|
UTSW |
6 |
132,714,682 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0553:Tas2r115
|
UTSW |
6 |
132,714,922 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1770:Tas2r115
|
UTSW |
6 |
132,714,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2120:Tas2r115
|
UTSW |
6 |
132,714,470 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R2136:Tas2r115
|
UTSW |
6 |
132,714,309 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2141:Tas2r115
|
UTSW |
6 |
132,714,321 (GRCm39) |
missense |
probably benign |
0.43 |
|
R2142:Tas2r115
|
UTSW |
6 |
132,714,321 (GRCm39) |
missense |
probably benign |
0.43 |
|
R4479:Tas2r115
|
UTSW |
6 |
132,714,495 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4687:Tas2r115
|
UTSW |
6 |
132,714,247 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4948:Tas2r115
|
UTSW |
6 |
132,714,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5097:Tas2r115
|
UTSW |
6 |
132,714,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5856:Tas2r115
|
UTSW |
6 |
132,714,501 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6927:Tas2r115
|
UTSW |
6 |
132,714,895 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7473:Tas2r115
|
UTSW |
6 |
132,714,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7688:Tas2r115
|
UTSW |
6 |
132,714,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8415:Tas2r115
|
UTSW |
6 |
132,714,798 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8495:Tas2r115
|
UTSW |
6 |
132,714,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9032:Tas2r115
|
UTSW |
6 |
132,714,327 (GRCm39) |
missense |
probably benign |
0.37 |
|
R9085:Tas2r115
|
UTSW |
6 |
132,714,327 (GRCm39) |
missense |
probably benign |
0.37 |
|
R9318:Tas2r115
|
UTSW |
6 |
132,714,472 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9665:Tas2r115
|
UTSW |
6 |
132,714,390 (GRCm39) |
missense |
probably benign |
0.31 |
|
R9751:Tas2r115
|
UTSW |
6 |
132,714,918 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
Z1088:Tas2r115
|
UTSW |
6 |
132,714,044 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Tas2r115
|
UTSW |
6 |
132,714,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CGCTTGCACCAATACTGTAGCCAC -3'
(R):5'- TGGTTTGCTACCAGCCTCAGCATC -3'
Sequencing Primer
(F):5'- GTACTGAAAGCAAGTCCTGTCTC -3'
(R):5'- GCATCTTTTATCTCTTCAAGATAGCC -3'
|
| Posted On |
2014-03-14 |
Incidental Mutation