Incidental Mutation 'R1437:Vsig10'
ID 161287
Institutional Source Beutler Lab
Gene Symbol Vsig10
Ensembl Gene ENSMUSG00000066894
Gene Name V-set and immunoglobulin domain containing 10
Synonyms
MMRRC Submission 039492-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R1437 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 117457331-117493071 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 117489635 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Arginine at position 467 (Q467R)
Ref Sequence ENSEMBL: ENSMUSP00000107598 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086464] [ENSMUST00000111967]
AlphaFold D3YX43
Predicted Effect probably damaging
Transcript: ENSMUST00000086464
AA Change: Q440R

PolyPhen 2 Score 0.957 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000083655
Gene: ENSMUSG00000066894
AA Change: Q440R

DomainStartEndE-ValueType
low complexity region 2 16 N/A INTRINSIC
IG 23 114 4.03e-8 SMART
IG 132 214 9.49e-5 SMART
Pfam:Ig_2 215 300 2.6e-2 PFAM
Pfam:Ig_3 216 284 3.5e-4 PFAM
IGc2 313 384 1.12e-6 SMART
transmembrane domain 403 425 N/A INTRINSIC
coiled coil region 446 481 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000111967
AA Change: Q467R

PolyPhen 2 Score 0.957 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000107598
Gene: ENSMUSG00000066894
AA Change: Q467R

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
IG 50 141 4.03e-8 SMART
IG 159 241 9.49e-5 SMART
Blast:IG_like 248 327 2e-33 BLAST
IGc2 340 411 1.12e-6 SMART
transmembrane domain 430 452 N/A INTRINSIC
coiled coil region 473 508 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122416
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139026
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147182
SMART Domains Protein: ENSMUSP00000125808
Gene: ENSMUSG00000066894

DomainStartEndE-ValueType
Blast:IG_like 1 41 3e-14 BLAST
IGc2 54 125 1.12e-6 SMART
transmembrane domain 144 166 N/A INTRINSIC
coiled coil region 187 222 N/A INTRINSIC
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 94.7%
  • 20x: 87.3%
Validation Efficiency
Allele List at MGI

All alleles(11) : Gene trapped(11)

Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1b T A 5: 8,871,436 (GRCm39) V330E possibly damaging Het
Abcb5 A G 12: 118,838,497 (GRCm39) S1022P probably damaging Het
Abcc8 A G 7: 45,829,237 (GRCm39) I46T probably damaging Het
Add3 A G 19: 53,222,109 (GRCm39) R275G probably damaging Het
Akap1 C A 11: 88,735,577 (GRCm39) G362* probably null Het
Arhgef4 A G 1: 34,763,026 (GRCm39) T761A unknown Het
Asap1 A T 15: 63,991,956 (GRCm39) L751Q probably damaging Het
Atg2a C A 19: 6,300,646 (GRCm39) P741H probably damaging Het
Atxn10 T C 15: 85,243,675 (GRCm39) I46T possibly damaging Het
BC049715 C A 6: 136,817,090 (GRCm39) A110E probably damaging Het
Bltp1 C A 3: 36,996,578 (GRCm39) H1097N possibly damaging Het
Btbd7 T A 12: 102,754,349 (GRCm39) T806S possibly damaging Het
Cdk4 C A 10: 126,900,558 (GRCm39) P108H probably damaging Het
Cep290 A G 10: 100,407,963 (GRCm39) T2391A probably benign Het
Col6a3 G T 1: 90,729,098 (GRCm39) A1281E probably damaging Het
Cpa5 A T 6: 30,624,654 (GRCm39) I165F probably damaging Het
Ctdp1 G T 18: 80,493,428 (GRCm39) Q356K probably benign Het
Ddx21 A G 10: 62,434,369 (GRCm39) M130T unknown Het
Epha5 T G 5: 84,381,555 (GRCm39) D432A probably damaging Het
Esr1 ACGCCGCCGCCGCCGCCGCCGCCGCCGCC ACGCCGCCGCCGCCGCCGCCGCCGCC 10: 4,662,571 (GRCm39) probably benign Het
Fads2 A T 19: 10,069,193 (GRCm39) L77Q probably benign Het
Fbn2 A T 18: 58,186,731 (GRCm39) H1723Q possibly damaging Het
Fbxo42 C T 4: 140,895,165 (GRCm39) H43Y probably benign Het
Fry A G 5: 150,233,890 (GRCm39) T121A possibly damaging Het
Gpr156 T G 16: 37,808,904 (GRCm39) S209A probably damaging Het
Hey2 T C 10: 30,709,845 (GRCm39) T303A probably benign Het
Hivep1 T A 13: 42,310,616 (GRCm39) M952K probably benign Het
Hydin C T 8: 111,308,617 (GRCm39) Q3968* probably null Het
Jup T C 11: 100,274,402 (GRCm39) E96G probably benign Het
Kcnn1 A G 8: 71,297,195 (GRCm39) I504T probably benign Het
Klk1b9 T C 7: 43,629,114 (GRCm39) V174A probably damaging Het
Lama3 G C 18: 12,682,284 (GRCm39) M1083I possibly damaging Het
Lcmt2 A G 2: 120,969,377 (GRCm39) S569P probably benign Het
Lrfn2 T C 17: 49,378,253 (GRCm39) S445P probably damaging Het
Lrp3 C A 7: 34,912,595 (GRCm39) G31W probably damaging Het
Lrrc8b T C 5: 105,629,568 (GRCm39) L638P probably damaging Het
Mief2 C T 11: 60,621,769 (GRCm39) T113M probably benign Het
Mrps2 T C 2: 28,358,899 (GRCm39) F76S probably damaging Het
Naca A G 10: 127,878,048 (GRCm39) probably benign Het
Ndst4 C A 3: 125,355,099 (GRCm39) R336S probably damaging Het
Nr1i3 CACTCAACACTAC CAC 1: 171,044,710 (GRCm39) probably null Het
Nr5a1 T A 2: 38,600,685 (GRCm39) T29S probably benign Het
Or5ak23 T C 2: 85,245,218 (GRCm39) I2V probably benign Het
Or5as1 C T 2: 86,980,115 (GRCm39) V297M possibly damaging Het
Pald1 A G 10: 61,177,064 (GRCm39) F662S possibly damaging Het
Pdcd4 G T 19: 53,897,674 (GRCm39) A59S probably damaging Het
Pde4a T C 9: 21,103,888 (GRCm39) probably null Het
Pkd1 T A 17: 24,814,106 (GRCm39) S4159T probably damaging Het
Plaat1 C A 16: 29,046,922 (GRCm39) A147E possibly damaging Het
Plch1 C A 3: 63,604,954 (GRCm39) R1641L probably benign Het
Plec G T 15: 76,073,481 (GRCm39) P308Q probably damaging Het
Pnkp A G 7: 44,509,826 (GRCm39) S262G possibly damaging Het
Pou2f1 A G 1: 165,719,399 (GRCm39) V504A probably damaging Het
Prepl G A 17: 85,395,785 (GRCm39) R66W probably damaging Het
Rasgrf2 T C 13: 92,167,396 (GRCm39) K226E probably damaging Het
Ror1 T A 4: 100,269,306 (GRCm39) F381L probably benign Het
Sbsn C T 7: 30,452,478 (GRCm39) Q498* probably null Het
Scgb2b19 T C 7: 32,977,980 (GRCm39) I106V probably benign Het
Sf3a2 G A 10: 80,640,040 (GRCm39) probably benign Het
Sis T C 3: 72,841,475 (GRCm39) H780R probably damaging Het
Slc28a3 G T 13: 58,706,389 (GRCm39) C617* probably null Het
Slc44a1 T A 4: 53,561,006 (GRCm39) V574D probably damaging Het
Slc8a3 T A 12: 81,362,760 (GRCm39) T20S probably damaging Het
Stt3b T A 9: 115,083,995 (GRCm39) I394F probably damaging Het
Ubap1l T A 9: 65,279,337 (GRCm39) V212D possibly damaging Het
Ugt2b35 T C 5: 87,148,890 (GRCm39) V47A probably benign Het
Vmn2r114 A G 17: 23,510,185 (GRCm39) F765S probably damaging Het
Vps50 C T 6: 3,517,852 (GRCm39) Q97* probably null Het
Wdsub1 T G 2: 59,708,477 (GRCm39) Y11S probably damaging Het
Zbtb11 T G 16: 55,811,983 (GRCm39) probably null Het
Other mutations in Vsig10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00163:Vsig10 APN 5 117,476,479 (GRCm39) missense probably benign 0.00
IGL00340:Vsig10 APN 5 117,489,652 (GRCm39) missense probably benign 0.03
IGL01082:Vsig10 APN 5 117,472,970 (GRCm39) missense probably benign 0.33
IGL01285:Vsig10 APN 5 117,462,954 (GRCm39) missense probably benign 0.43
IGL01790:Vsig10 APN 5 117,476,379 (GRCm39) missense probably damaging 1.00
IGL03004:Vsig10 APN 5 117,463,140 (GRCm39) missense probably damaging 1.00
D3080:Vsig10 UTSW 5 117,481,884 (GRCm39) missense probably damaging 1.00
R0101:Vsig10 UTSW 5 117,473,134 (GRCm39) critical splice donor site probably null
R0403:Vsig10 UTSW 5 117,476,526 (GRCm39) missense probably benign 0.05
R0674:Vsig10 UTSW 5 117,481,911 (GRCm39) missense probably damaging 1.00
R1689:Vsig10 UTSW 5 117,490,825 (GRCm39) missense probably benign 0.00
R1710:Vsig10 UTSW 5 117,489,719 (GRCm39) missense probably benign
R1765:Vsig10 UTSW 5 117,456,880 (GRCm39) unclassified probably benign
R4422:Vsig10 UTSW 5 117,462,986 (GRCm39) missense probably benign 0.00
R4541:Vsig10 UTSW 5 117,490,881 (GRCm39) utr 3 prime probably benign
R4909:Vsig10 UTSW 5 117,476,308 (GRCm39) missense probably benign 0.31
R4999:Vsig10 UTSW 5 117,482,040 (GRCm39) missense probably damaging 1.00
R5855:Vsig10 UTSW 5 117,476,335 (GRCm39) missense probably damaging 1.00
R5866:Vsig10 UTSW 5 117,490,814 (GRCm39) critical splice acceptor site probably null
R6214:Vsig10 UTSW 5 117,481,989 (GRCm39) missense probably damaging 1.00
R6418:Vsig10 UTSW 5 117,486,361 (GRCm39) missense probably benign 0.03
R6505:Vsig10 UTSW 5 117,489,824 (GRCm39) missense possibly damaging 0.95
R6854:Vsig10 UTSW 5 117,476,472 (GRCm39) missense probably benign 0.36
R7121:Vsig10 UTSW 5 117,481,967 (GRCm39) missense probably damaging 1.00
R7596:Vsig10 UTSW 5 117,472,848 (GRCm39) missense possibly damaging 0.46
R8066:Vsig10 UTSW 5 117,489,849 (GRCm39) missense probably benign 0.00
R8335:Vsig10 UTSW 5 117,486,435 (GRCm39) missense probably damaging 1.00
R8787:Vsig10 UTSW 5 117,472,981 (GRCm39) missense probably benign 0.18
R9026:Vsig10 UTSW 5 117,476,323 (GRCm39) missense probably benign 0.00
R9257:Vsig10 UTSW 5 117,463,131 (GRCm39) missense probably benign 0.29
R9386:Vsig10 UTSW 5 117,463,140 (GRCm39) missense probably damaging 1.00
R9474:Vsig10 UTSW 5 117,463,104 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGTGCCAGATGCCTGAGACAAC -3'
(R):5'- AGCAGTCACCCTGTGAATGTGTCC -3'

Sequencing Primer
(F):5'- TGCCTGAGACAACACAGTAG -3'
(R):5'- GAATGTGTCCATGCTTGCTTATC -3'
Posted On 2014-03-14