Incidental Mutation 'R1437:Zbtb11'
ID 161332
Institutional Source Beutler Lab
Gene Symbol Zbtb11
Ensembl Gene ENSMUSG00000022601
Gene Name zinc finger and BTB domain containing 11
Synonyms 9230110G02Rik, ZNF-U69274
MMRRC Submission 039492-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.972) question?
Stock # R1437 (G1)
Quality Score 225
Status Not validated
Chromosome 16
Chromosomal Location 55794246-55829276 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to G at 55811983 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000056923 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050248]
AlphaFold G5E8B9
Predicted Effect probably null
Transcript: ENSMUST00000050248
SMART Domains Protein: ENSMUSP00000056923
Gene: ENSMUSG00000022601

DomainStartEndE-ValueType
low complexity region 136 158 N/A INTRINSIC
low complexity region 161 177 N/A INTRINSIC
BTB 214 312 4.77e-13 SMART
low complexity region 371 399 N/A INTRINSIC
ZnF_C2H2 566 588 1.1e-2 SMART
ZnF_C2H2 594 616 2.09e-3 SMART
low complexity region 623 640 N/A INTRINSIC
ZnF_C2H2 648 670 4.47e-3 SMART
ZnF_C2H2 676 698 8.22e-2 SMART
ZnF_C2H2 704 726 2.27e-4 SMART
ZnF_C2H2 732 754 1.28e-3 SMART
ZnF_C2H2 763 785 2.95e-3 SMART
ZnF_C2H2 791 813 7.67e-2 SMART
ZnF_C2H2 819 843 2.95e-3 SMART
ZnF_C2H2 855 877 1.67e-2 SMART
ZnF_C2H2 883 905 3.02e0 SMART
ZnF_C2H2 911 934 9.58e-3 SMART
low complexity region 979 994 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183440
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 94.7%
  • 20x: 87.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1b T A 5: 8,871,436 (GRCm39) V330E possibly damaging Het
Abcb5 A G 12: 118,838,497 (GRCm39) S1022P probably damaging Het
Abcc8 A G 7: 45,829,237 (GRCm39) I46T probably damaging Het
Add3 A G 19: 53,222,109 (GRCm39) R275G probably damaging Het
Akap1 C A 11: 88,735,577 (GRCm39) G362* probably null Het
Arhgef4 A G 1: 34,763,026 (GRCm39) T761A unknown Het
Asap1 A T 15: 63,991,956 (GRCm39) L751Q probably damaging Het
Atg2a C A 19: 6,300,646 (GRCm39) P741H probably damaging Het
Atxn10 T C 15: 85,243,675 (GRCm39) I46T possibly damaging Het
BC049715 C A 6: 136,817,090 (GRCm39) A110E probably damaging Het
Bltp1 C A 3: 36,996,578 (GRCm39) H1097N possibly damaging Het
Btbd7 T A 12: 102,754,349 (GRCm39) T806S possibly damaging Het
Cdk4 C A 10: 126,900,558 (GRCm39) P108H probably damaging Het
Cep290 A G 10: 100,407,963 (GRCm39) T2391A probably benign Het
Col6a3 G T 1: 90,729,098 (GRCm39) A1281E probably damaging Het
Cpa5 A T 6: 30,624,654 (GRCm39) I165F probably damaging Het
Ctdp1 G T 18: 80,493,428 (GRCm39) Q356K probably benign Het
Ddx21 A G 10: 62,434,369 (GRCm39) M130T unknown Het
Epha5 T G 5: 84,381,555 (GRCm39) D432A probably damaging Het
Esr1 ACGCCGCCGCCGCCGCCGCCGCCGCCGCC ACGCCGCCGCCGCCGCCGCCGCCGCC 10: 4,662,571 (GRCm39) probably benign Het
Fads2 A T 19: 10,069,193 (GRCm39) L77Q probably benign Het
Fbn2 A T 18: 58,186,731 (GRCm39) H1723Q possibly damaging Het
Fbxo42 C T 4: 140,895,165 (GRCm39) H43Y probably benign Het
Fry A G 5: 150,233,890 (GRCm39) T121A possibly damaging Het
Gpr156 T G 16: 37,808,904 (GRCm39) S209A probably damaging Het
Hey2 T C 10: 30,709,845 (GRCm39) T303A probably benign Het
Hivep1 T A 13: 42,310,616 (GRCm39) M952K probably benign Het
Hydin C T 8: 111,308,617 (GRCm39) Q3968* probably null Het
Jup T C 11: 100,274,402 (GRCm39) E96G probably benign Het
Kcnn1 A G 8: 71,297,195 (GRCm39) I504T probably benign Het
Klk1b9 T C 7: 43,629,114 (GRCm39) V174A probably damaging Het
Lama3 G C 18: 12,682,284 (GRCm39) M1083I possibly damaging Het
Lcmt2 A G 2: 120,969,377 (GRCm39) S569P probably benign Het
Lrfn2 T C 17: 49,378,253 (GRCm39) S445P probably damaging Het
Lrp3 C A 7: 34,912,595 (GRCm39) G31W probably damaging Het
Lrrc8b T C 5: 105,629,568 (GRCm39) L638P probably damaging Het
Mief2 C T 11: 60,621,769 (GRCm39) T113M probably benign Het
Mrps2 T C 2: 28,358,899 (GRCm39) F76S probably damaging Het
Naca A G 10: 127,878,048 (GRCm39) probably benign Het
Ndst4 C A 3: 125,355,099 (GRCm39) R336S probably damaging Het
Nr1i3 CACTCAACACTAC CAC 1: 171,044,710 (GRCm39) probably null Het
Nr5a1 T A 2: 38,600,685 (GRCm39) T29S probably benign Het
Or5ak23 T C 2: 85,245,218 (GRCm39) I2V probably benign Het
Or5as1 C T 2: 86,980,115 (GRCm39) V297M possibly damaging Het
Pald1 A G 10: 61,177,064 (GRCm39) F662S possibly damaging Het
Pdcd4 G T 19: 53,897,674 (GRCm39) A59S probably damaging Het
Pde4a T C 9: 21,103,888 (GRCm39) probably null Het
Pkd1 T A 17: 24,814,106 (GRCm39) S4159T probably damaging Het
Plaat1 C A 16: 29,046,922 (GRCm39) A147E possibly damaging Het
Plch1 C A 3: 63,604,954 (GRCm39) R1641L probably benign Het
Plec G T 15: 76,073,481 (GRCm39) P308Q probably damaging Het
Pnkp A G 7: 44,509,826 (GRCm39) S262G possibly damaging Het
Pou2f1 A G 1: 165,719,399 (GRCm39) V504A probably damaging Het
Prepl G A 17: 85,395,785 (GRCm39) R66W probably damaging Het
Rasgrf2 T C 13: 92,167,396 (GRCm39) K226E probably damaging Het
Ror1 T A 4: 100,269,306 (GRCm39) F381L probably benign Het
Sbsn C T 7: 30,452,478 (GRCm39) Q498* probably null Het
Scgb2b19 T C 7: 32,977,980 (GRCm39) I106V probably benign Het
Sf3a2 G A 10: 80,640,040 (GRCm39) probably benign Het
Sis T C 3: 72,841,475 (GRCm39) H780R probably damaging Het
Slc28a3 G T 13: 58,706,389 (GRCm39) C617* probably null Het
Slc44a1 T A 4: 53,561,006 (GRCm39) V574D probably damaging Het
Slc8a3 T A 12: 81,362,760 (GRCm39) T20S probably damaging Het
Stt3b T A 9: 115,083,995 (GRCm39) I394F probably damaging Het
Ubap1l T A 9: 65,279,337 (GRCm39) V212D possibly damaging Het
Ugt2b35 T C 5: 87,148,890 (GRCm39) V47A probably benign Het
Vmn2r114 A G 17: 23,510,185 (GRCm39) F765S probably damaging Het
Vps50 C T 6: 3,517,852 (GRCm39) Q97* probably null Het
Vsig10 A G 5: 117,489,635 (GRCm39) Q467R probably damaging Het
Wdsub1 T G 2: 59,708,477 (GRCm39) Y11S probably damaging Het
Other mutations in Zbtb11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00839:Zbtb11 APN 16 55,820,965 (GRCm39) nonsense probably null
IGL01107:Zbtb11 APN 16 55,826,370 (GRCm39) missense probably damaging 1.00
IGL01341:Zbtb11 APN 16 55,811,294 (GRCm39) missense possibly damaging 0.68
IGL01510:Zbtb11 APN 16 55,810,706 (GRCm39) missense probably damaging 0.99
IGL01611:Zbtb11 APN 16 55,800,973 (GRCm39) missense probably damaging 1.00
IGL01736:Zbtb11 APN 16 55,818,523 (GRCm39) missense probably damaging 1.00
IGL01834:Zbtb11 APN 16 55,811,371 (GRCm39) missense probably benign 0.35
IGL02427:Zbtb11 APN 16 55,802,713 (GRCm39) missense possibly damaging 0.95
IGL02441:Zbtb11 APN 16 55,794,552 (GRCm39) missense possibly damaging 0.94
IGL02455:Zbtb11 APN 16 55,821,038 (GRCm39) missense probably damaging 1.00
PIT4544001:Zbtb11 UTSW 16 55,818,556 (GRCm39) nonsense probably null
R0987:Zbtb11 UTSW 16 55,811,071 (GRCm39) missense probably benign 0.00
R1414:Zbtb11 UTSW 16 55,810,923 (GRCm39) nonsense probably null
R1570:Zbtb11 UTSW 16 55,811,178 (GRCm39) missense probably benign
R1658:Zbtb11 UTSW 16 55,794,588 (GRCm39) missense possibly damaging 0.71
R1735:Zbtb11 UTSW 16 55,811,045 (GRCm39) missense probably benign
R2048:Zbtb11 UTSW 16 55,818,372 (GRCm39) missense probably damaging 1.00
R2925:Zbtb11 UTSW 16 55,794,447 (GRCm39) missense probably benign 0.00
R4072:Zbtb11 UTSW 16 55,818,427 (GRCm39) missense possibly damaging 0.89
R4075:Zbtb11 UTSW 16 55,818,427 (GRCm39) missense possibly damaging 0.89
R4076:Zbtb11 UTSW 16 55,818,427 (GRCm39) missense possibly damaging 0.89
R5023:Zbtb11 UTSW 16 55,826,428 (GRCm39) missense probably damaging 1.00
R5755:Zbtb11 UTSW 16 55,821,076 (GRCm39) missense probably benign 0.02
R5757:Zbtb11 UTSW 16 55,827,392 (GRCm39) missense probably damaging 1.00
R6218:Zbtb11 UTSW 16 55,818,436 (GRCm39) missense probably benign 0.00
R6313:Zbtb11 UTSW 16 55,810,854 (GRCm39) missense probably benign 0.03
R6461:Zbtb11 UTSW 16 55,827,234 (GRCm39) missense probably damaging 0.99
R6666:Zbtb11 UTSW 16 55,826,615 (GRCm39) missense probably damaging 1.00
R6807:Zbtb11 UTSW 16 55,810,865 (GRCm39) missense probably benign 0.03
R7194:Zbtb11 UTSW 16 55,827,551 (GRCm39) missense probably damaging 1.00
R7424:Zbtb11 UTSW 16 55,810,850 (GRCm39) missense probably benign 0.01
R8022:Zbtb11 UTSW 16 55,826,383 (GRCm39) missense probably damaging 0.99
R8436:Zbtb11 UTSW 16 55,821,022 (GRCm39) nonsense probably null
R8532:Zbtb11 UTSW 16 55,811,252 (GRCm39) missense probably benign 0.03
R8806:Zbtb11 UTSW 16 55,802,637 (GRCm39) missense probably damaging 1.00
R9033:Zbtb11 UTSW 16 55,818,492 (GRCm39) missense probably benign
R9673:Zbtb11 UTSW 16 55,827,336 (GRCm39) missense probably damaging 1.00
RF014:Zbtb11 UTSW 16 55,800,960 (GRCm39) missense probably damaging 0.97
Z1176:Zbtb11 UTSW 16 55,811,865 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AATGATACTGAAGCTGGATGTGGTGATG -3'
(R):5'- TTTTCACTGTCCTCTTTCTGAGGAAGC -3'

Sequencing Primer
(F):5'- gctacatagcaaaaccatgcc -3'
(R):5'- ggaagcctgaattaggaggataac -3'
Posted On 2014-03-14