Incidental Mutation 'R1430:Or2y1b'
ID 161491
Institutional Source Beutler Lab
Gene Symbol Or2y1b
Ensembl Gene ENSMUSG00000100923
Gene Name olfactory receptor family 2 subfamily Y member 1B
Synonyms L45, MOR256-55, Olfr10, GA_x6K02T2QP88-6117098-6116163
MMRRC Submission 039486-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R1430 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 49208375-49209310 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 49208928 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000150635 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000187570] [ENSMUST00000215671] [ENSMUST00000217290]
AlphaFold Q60883
Predicted Effect possibly damaging
Transcript: ENSMUST00000074358
AA Change: K185R

PolyPhen 2 Score 0.810 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000073963
Gene: ENSMUSG00000057168
AA Change: K185R

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 9.5e-49 PFAM
Pfam:7TM_GPCR_Srsx 35 222 4.7e-7 PFAM
Pfam:7tm_1 41 289 6.9e-24 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000187570
AA Change: K185R

PolyPhen 2 Score 0.810 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000139744
Gene: ENSMUSG00000100923
AA Change: K185R

DomainStartEndE-ValueType
low complexity region 23 34 N/A INTRINSIC
Pfam:7TM_GPCR_Srsx 35 222 4.7e-7 PFAM
Pfam:7tm_1 41 289 1.3e-33 PFAM
Pfam:7tm_4 139 282 4.6e-43 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000215671
Predicted Effect possibly damaging
Transcript: ENSMUST00000217290
AA Change: K185R

PolyPhen 2 Score 0.810 (Sensitivity: 0.84; Specificity: 0.93)
Meta Mutation Damage Score 0.3635 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.5%
  • 20x: 89.9%
Validation Efficiency 100% (55/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam3 T A 8: 25,204,287 (GRCm39) probably benign Het
Aoc2 A G 11: 101,217,321 (GRCm39) Y468C probably damaging Het
Cdyl2 A G 8: 117,306,056 (GRCm39) probably benign Het
Cfh A G 1: 140,030,436 (GRCm39) probably benign Het
Cyp2j9 G T 4: 96,472,201 (GRCm39) probably benign Het
Dapk1 T G 13: 60,901,957 (GRCm39) F929V probably benign Het
Dhx9 A T 1: 153,359,493 (GRCm39) M35K probably benign Het
Dnah5 G A 15: 28,346,003 (GRCm39) E2448K probably benign Het
Doc2b A T 11: 75,670,981 (GRCm39) C217S possibly damaging Het
Dock11 A G X: 35,333,565 (GRCm39) I2010V probably benign Het
Dram1 T C 10: 88,160,641 (GRCm39) T227A possibly damaging Het
Eppin G A 2: 164,431,323 (GRCm39) T101M probably damaging Het
F13a1 T C 13: 37,082,105 (GRCm39) D533G probably damaging Het
Fmo1 C A 1: 162,667,293 (GRCm39) R174L probably damaging Het
Fsip2 C A 2: 82,828,407 (GRCm39) L6735I possibly damaging Het
Gab1 G T 8: 81,515,241 (GRCm39) T359K probably benign Het
Ggta1 T C 2: 35,298,029 (GRCm39) D118G possibly damaging Het
Gramd1a A G 7: 30,832,211 (GRCm39) S609P probably damaging Het
Gtf3c3 C T 1: 54,456,937 (GRCm39) A488T probably damaging Het
Hsh2d G A 8: 72,954,304 (GRCm39) D229N probably benign Het
Lama1 A G 17: 68,089,150 (GRCm39) Y1607C possibly damaging Het
Lrrc24 G T 15: 76,607,992 (GRCm39) probably null Het
Mak C A 13: 41,223,760 (GRCm39) probably benign Het
Megf8 G A 7: 25,063,768 (GRCm39) R2708Q possibly damaging Het
Mettl24 T C 10: 40,613,791 (GRCm39) C177R probably damaging Het
Mgam G C 6: 40,733,305 (GRCm39) E812D probably benign Het
Mroh8 T C 2: 157,111,445 (GRCm39) R170G possibly damaging Het
Msn G A X: 95,196,325 (GRCm39) V130I probably benign Het
Ncoa4 G A 14: 31,898,679 (GRCm39) V500I probably benign Het
Or2aj5 A G 16: 19,424,752 (GRCm39) L222P probably damaging Het
Or5an6 C T 19: 12,371,801 (GRCm39) T58I probably benign Het
Or8k3b T C 2: 86,520,866 (GRCm39) Y151C possibly damaging Het
Ppm1h T C 10: 122,693,004 (GRCm39) S302P probably damaging Het
Prkce T A 17: 86,866,565 (GRCm39) probably benign Het
Psenen T C 7: 30,261,815 (GRCm39) I34V probably benign Het
Rbl1 T C 2: 157,011,826 (GRCm39) T710A probably benign Het
Sdk2 C T 11: 113,729,472 (GRCm39) silent Het
Slc1a5 A G 7: 16,516,328 (GRCm39) D168G probably benign Het
Slc35e1 T C 8: 73,246,415 (GRCm39) probably benign Het
Sned1 G A 1: 93,209,376 (GRCm39) V830M possibly damaging Het
Syce1 A T 7: 140,359,351 (GRCm39) probably benign Het
Tbc1d23 G T 16: 57,034,573 (GRCm39) D75E probably damaging Het
Tbk1 A G 10: 121,395,839 (GRCm39) V418A probably benign Het
Tmem132e T C 11: 82,329,122 (GRCm39) V467A probably damaging Het
Tmem241 T C 18: 12,126,651 (GRCm39) D144G probably benign Het
Tsc2 A G 17: 24,817,997 (GRCm39) probably null Het
Ubxn4 T A 1: 128,202,617 (GRCm39) F420I probably benign Het
Usp34 A G 11: 23,409,151 (GRCm39) T2645A probably damaging Het
Utp14b A G 1: 78,644,111 (GRCm39) K670E probably benign Het
Zfp407 C T 18: 84,227,580 (GRCm39) V2010M probably benign Het
Zfp879 A G 11: 50,724,784 (GRCm39) F91L probably benign Het
Zfyve26 A G 12: 79,329,591 (GRCm39) S532P probably benign Het
Other mutations in Or2y1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01349:Or2y1b APN 11 49,209,127 (GRCm39) nonsense probably null 0.00
IGL02283:Or2y1b APN 11 49,209,162 (GRCm39) missense probably benign
IGL03010:Or2y1b APN 11 49,208,973 (GRCm39) missense probably damaging 0.99
R0575:Or2y1b UTSW 11 49,208,880 (GRCm39) missense probably damaging 1.00
R1891:Or2y1b UTSW 11 49,208,684 (GRCm39) missense probably benign 0.00
R2509:Or2y1b UTSW 11 49,209,048 (GRCm39) missense probably damaging 0.97
R2511:Or2y1b UTSW 11 49,209,048 (GRCm39) missense probably damaging 0.97
R4942:Or2y1b UTSW 11 49,208,375 (GRCm39) start codon destroyed probably null 0.99
R5080:Or2y1b UTSW 11 49,208,914 (GRCm39) missense probably benign 0.03
R5413:Or2y1b UTSW 11 49,209,240 (GRCm39) missense probably damaging 1.00
R5843:Or2y1b UTSW 11 49,209,076 (GRCm39) missense probably benign 0.34
R6354:Or2y1b UTSW 11 49,208,465 (GRCm39) missense probably damaging 0.98
R6605:Or2y1b UTSW 11 49,208,541 (GRCm39) missense probably damaging 0.97
R8005:Or2y1b UTSW 11 49,208,968 (GRCm39) missense probably benign 0.12
R8284:Or2y1b UTSW 11 49,209,002 (GRCm39) missense probably benign
R8902:Or2y1b UTSW 11 49,209,206 (GRCm39) missense probably benign 0.03
R9003:Or2y1b UTSW 11 49,209,155 (GRCm39) missense possibly damaging 0.66
R9431:Or2y1b UTSW 11 49,208,459 (GRCm39) missense probably benign
R9696:Or2y1b UTSW 11 49,208,390 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GCTTTTGACCGCTATGCTGCTG -3'
(R):5'- AAGGGCCACAAACTTCCCCTTG -3'

Sequencing Primer
(F):5'- TGTGTGTCGTCCACTGC -3'
(R):5'- AAACTTCCCCTTGCTCTCAGAATAG -3'
Posted On 2014-03-14