Incidental Mutation 'R1458:Adgrb2'
| ID |
161861 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adgrb2
|
| Ensembl Gene |
ENSMUSG00000028782 |
| Gene Name |
adhesion G protein-coupled receptor B2 |
| Synonyms |
Bai2 |
| MMRRC Submission |
039513-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1458 (G1)
|
| Quality Score |
178 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
129878663-129916426 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 129908384 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 1042
(M1042K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112524
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030571]
[ENSMUST00000097868]
[ENSMUST00000106015]
[ENSMUST00000106017]
[ENSMUST00000106018]
[ENSMUST00000120204]
[ENSMUST00000121049]
|
| AlphaFold |
Q8CGM1 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000030571
AA Change: M1097K
PolyPhen 2
Score 0.478 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000030571
Gene: ENSMUSG00000028782
AA Change: M1097K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:GAIN
|
600 |
842 |
1.6e-41 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1192 |
1.7e-67 |
PFAM |
|
low complexity region
|
1357 |
1371 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000097868
AA Change: M1097K
PolyPhen 2
Score 0.478 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000095480
Gene: ENSMUSG00000028782
AA Change: M1097K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
597 |
859 |
1.2e-54 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1159 |
2.6e-69 |
PFAM |
|
low complexity region
|
1324 |
1338 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000106012
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000106015
AA Change: M1097K
PolyPhen 2
Score 0.478 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000101636
Gene: ENSMUSG00000028782
AA Change: M1097K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
597 |
859 |
6.4e-55 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1192 |
4.1e-68 |
PFAM |
|
low complexity region
|
1357 |
1371 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000106017
AA Change: M1097K
PolyPhen 2
Score 0.478 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000101638
Gene: ENSMUSG00000028782
AA Change: M1097K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
597 |
859 |
6.3e-55 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1180 |
4.6e-68 |
PFAM |
|
low complexity region
|
1345 |
1359 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000106018
AA Change: M1042K
PolyPhen 2
Score 0.478 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000101639
Gene: ENSMUSG00000028782
AA Change: M1042K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
1.86e-13 |
SMART |
|
TSP1
|
358 |
408 |
9.89e-9 |
SMART |
|
TSP1
|
414 |
464 |
3.09e-10 |
SMART |
|
HormR
|
466 |
532 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
542 |
804 |
1.1e-54 |
PFAM |
|
GPS
|
809 |
862 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
868 |
1104 |
2.4e-69 |
PFAM |
|
low complexity region
|
1269 |
1283 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000120204
AA Change: M1042K
PolyPhen 2
Score 0.478 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000112524
Gene: ENSMUSG00000028782
AA Change: M1042K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
9.89e-9 |
SMART |
|
TSP1
|
414 |
464 |
3.09e-10 |
SMART |
|
HormR
|
466 |
532 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
542 |
804 |
8.2e-55 |
PFAM |
|
GPS
|
809 |
862 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
868 |
1104 |
9.6e-70 |
PFAM |
|
low complexity region
|
1269 |
1283 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000121049
AA Change: M1042K
PolyPhen 2
Score 0.422 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000112869
Gene: ENSMUSG00000028782
AA Change: M1042K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
1.86e-13 |
SMART |
|
TSP1
|
358 |
408 |
9.89e-9 |
SMART |
|
TSP1
|
414 |
464 |
3.09e-10 |
SMART |
|
HormR
|
466 |
532 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
542 |
804 |
6.1e-55 |
PFAM |
|
GPS
|
809 |
862 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
868 |
1137 |
3.8e-68 |
PFAM |
|
low complexity region
|
1302 |
1316 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136416
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000166118
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000149282
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000163625
|
| Meta Mutation Damage Score |
0.8402 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.3%
- 20x: 92.8%
|
| Validation Efficiency |
98% (95/97) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
PHENOTYPE: Mice homozygous for disruptions in this gene show a lessening of depression like behavior. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 94 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700036A12Rik |
A |
G |
9: 60,677,043 (GRCm39) |
|
noncoding transcript |
Het |
| A430110L20Rik |
T |
A |
1: 181,055,423 (GRCm39) |
|
noncoding transcript |
Het |
| Abce1 |
T |
C |
8: 80,433,864 (GRCm39) |
K63R |
possibly damaging |
Het |
| Acp6 |
A |
G |
3: 97,081,104 (GRCm39) |
|
probably benign |
Het |
| Adamts13 |
T |
A |
2: 26,878,366 (GRCm39) |
L579Q |
probably damaging |
Het |
| Adamtsl3 |
T |
A |
7: 82,172,528 (GRCm39) |
M497K |
probably damaging |
Het |
| Akap12 |
A |
T |
10: 4,303,693 (GRCm39) |
S168C |
probably damaging |
Het |
| Akap3 |
A |
T |
6: 126,842,517 (GRCm39) |
M379L |
probably damaging |
Het |
| Aldh6a1 |
C |
T |
12: 84,486,437 (GRCm39) |
M135I |
probably null |
Het |
| Arhgef12 |
A |
G |
9: 42,900,294 (GRCm39) |
S860P |
probably damaging |
Het |
| Atp11b |
A |
C |
3: 35,843,707 (GRCm39) |
T185P |
probably damaging |
Het |
| Bcas1 |
T |
C |
2: 170,229,871 (GRCm39) |
D243G |
probably damaging |
Het |
| Cdhr2 |
T |
A |
13: 54,865,685 (GRCm39) |
S228T |
probably damaging |
Het |
| Cic |
T |
C |
7: 24,979,162 (GRCm39) |
|
probably benign |
Het |
| Cimap1d |
A |
T |
10: 79,481,392 (GRCm39) |
|
probably benign |
Het |
| Cmya5 |
T |
A |
13: 93,201,835 (GRCm39) |
I3376L |
probably benign |
Het |
| Ctrc |
C |
A |
4: 141,573,535 (GRCm39) |
|
probably null |
Het |
| Dchs1 |
G |
T |
7: 105,404,451 (GRCm39) |
P2697Q |
probably damaging |
Het |
| Dmbt1 |
A |
G |
7: 130,646,217 (GRCm39) |
|
probably benign |
Het |
| Drd2 |
G |
A |
9: 49,313,512 (GRCm39) |
R227H |
probably damaging |
Het |
| Dscc1 |
C |
A |
15: 54,950,160 (GRCm39) |
C195F |
probably damaging |
Het |
| Dzip1 |
T |
A |
14: 119,160,125 (GRCm39) |
M28L |
probably benign |
Het |
| Edar |
A |
T |
10: 58,443,188 (GRCm39) |
S313T |
probably benign |
Het |
| Eef1e1 |
C |
A |
13: 38,840,099 (GRCm39) |
A69S |
probably damaging |
Het |
| Fbn1 |
A |
G |
2: 125,143,849 (GRCm39) |
V2760A |
probably benign |
Het |
| Fez1 |
GACAAACA |
GACA |
9: 36,781,845 (GRCm39) |
|
probably null |
Het |
| Fgl1 |
C |
G |
8: 41,663,496 (GRCm39) |
A11P |
possibly damaging |
Het |
| Fras1 |
T |
C |
5: 96,748,592 (GRCm39) |
V689A |
probably benign |
Het |
| Fry |
T |
A |
5: 150,304,324 (GRCm39) |
D571E |
probably damaging |
Het |
| Gm11232 |
T |
A |
4: 71,675,450 (GRCm39) |
R104* |
probably null |
Het |
| Gm1527 |
A |
G |
3: 28,972,199 (GRCm39) |
I439V |
possibly damaging |
Het |
| Gm4922 |
C |
A |
10: 18,659,640 (GRCm39) |
G361* |
probably null |
Het |
| Gm7052 |
T |
A |
17: 22,259,447 (GRCm39) |
|
probably benign |
Het |
| Gpatch8 |
A |
T |
11: 102,372,055 (GRCm39) |
S494R |
unknown |
Het |
| Gria2 |
A |
T |
3: 80,639,352 (GRCm39) |
V220E |
possibly damaging |
Het |
| Grik4 |
G |
A |
9: 42,432,418 (GRCm39) |
H860Y |
probably benign |
Het |
| Gtpbp1 |
A |
C |
15: 79,591,930 (GRCm39) |
S93R |
probably damaging |
Het |
| Gucy2g |
C |
A |
19: 55,203,468 (GRCm39) |
|
probably benign |
Het |
| H2ac8 |
C |
A |
13: 23,755,221 (GRCm39) |
|
probably benign |
Het |
| Hmcn1 |
G |
A |
1: 150,485,451 (GRCm39) |
R4384C |
probably damaging |
Het |
| Hspa12b |
G |
C |
2: 130,987,112 (GRCm39) |
A678P |
probably damaging |
Het |
| Igsf21 |
T |
A |
4: 139,755,435 (GRCm39) |
N407Y |
probably damaging |
Het |
| Insig2 |
A |
G |
1: 121,234,885 (GRCm39) |
Y174H |
probably benign |
Het |
| Itpr3 |
T |
A |
17: 27,337,346 (GRCm39) |
M2413K |
probably benign |
Het |
| Kalrn |
A |
T |
16: 33,994,857 (GRCm39) |
I1322N |
probably damaging |
Het |
| Klk1b24 |
T |
A |
7: 43,840,890 (GRCm39) |
M106K |
possibly damaging |
Het |
| Krt81 |
G |
T |
15: 101,358,198 (GRCm39) |
Q352K |
probably benign |
Het |
| Lca5l |
A |
T |
16: 95,961,059 (GRCm39) |
S468T |
possibly damaging |
Het |
| Lvrn |
T |
C |
18: 47,015,452 (GRCm39) |
|
probably benign |
Het |
| Mcpt1 |
T |
A |
14: 56,256,621 (GRCm39) |
|
probably benign |
Het |
| Med13l |
T |
C |
5: 118,876,524 (GRCm39) |
M900T |
probably benign |
Het |
| Med16 |
A |
G |
10: 79,743,312 (GRCm39) |
|
probably benign |
Het |
| Megf6 |
G |
T |
4: 154,261,578 (GRCm39) |
V68L |
probably benign |
Het |
| Mep1a |
T |
C |
17: 43,802,563 (GRCm39) |
H154R |
probably damaging |
Het |
| Mrc2 |
A |
T |
11: 105,228,598 (GRCm39) |
D659V |
probably benign |
Het |
| Mroh8 |
T |
A |
2: 157,063,224 (GRCm39) |
E799V |
probably damaging |
Het |
| Mrpl21 |
A |
G |
19: 3,334,808 (GRCm39) |
Y50C |
possibly damaging |
Het |
| Msl1 |
A |
G |
11: 98,694,808 (GRCm39) |
|
probably benign |
Het |
| Myo1a |
C |
A |
10: 127,555,806 (GRCm39) |
Q932K |
probably benign |
Het |
| Nav3 |
A |
C |
10: 109,555,905 (GRCm39) |
S1675R |
probably damaging |
Het |
| Neurl2 |
A |
G |
2: 164,674,666 (GRCm39) |
V232A |
possibly damaging |
Het |
| Nfatc1 |
T |
A |
18: 80,708,482 (GRCm39) |
|
probably benign |
Het |
| Or2w4 |
C |
T |
13: 21,795,992 (GRCm39) |
C49Y |
probably benign |
Het |
| Or5k8 |
T |
A |
16: 58,645,039 (GRCm39) |
E11V |
probably null |
Het |
| P4hb |
A |
G |
11: 120,453,381 (GRCm39) |
|
probably benign |
Het |
| Papss1 |
T |
G |
3: 131,311,615 (GRCm39) |
I281S |
probably damaging |
Het |
| Pde10a |
A |
T |
17: 9,183,540 (GRCm39) |
D832V |
probably damaging |
Het |
| Pfkfb2 |
A |
T |
1: 130,635,927 (GRCm39) |
Y35N |
possibly damaging |
Het |
| Phaf1 |
T |
C |
8: 105,973,188 (GRCm39) |
|
probably null |
Het |
| Phf20l1 |
T |
A |
15: 66,476,662 (GRCm39) |
F253Y |
probably damaging |
Het |
| Pkhd1l1 |
G |
A |
15: 44,379,511 (GRCm39) |
V1046I |
probably benign |
Het |
| Plin3 |
C |
T |
17: 56,591,337 (GRCm39) |
A148T |
probably benign |
Het |
| Ppp1r8 |
T |
C |
4: 132,567,942 (GRCm39) |
|
probably benign |
Het |
| Ppp2r3d |
A |
G |
9: 101,088,511 (GRCm39) |
L604P |
probably damaging |
Het |
| Prdm5 |
T |
C |
6: 65,860,585 (GRCm39) |
V239A |
probably damaging |
Het |
| Prickle1 |
A |
G |
15: 93,398,519 (GRCm39) |
S770P |
probably damaging |
Het |
| Prl2c5 |
T |
A |
13: 13,365,310 (GRCm39) |
I155N |
probably benign |
Het |
| Prom1 |
T |
C |
5: 44,190,274 (GRCm39) |
|
probably benign |
Het |
| Psg25 |
C |
T |
7: 18,263,512 (GRCm39) |
G104R |
probably damaging |
Het |
| Rbm19 |
T |
C |
5: 120,282,094 (GRCm39) |
V817A |
probably benign |
Het |
| Ryr2 |
T |
A |
13: 11,741,908 (GRCm39) |
Y2091F |
probably damaging |
Het |
| Slc16a4 |
A |
G |
3: 107,208,248 (GRCm39) |
T253A |
probably benign |
Het |
| Smg7 |
A |
T |
1: 152,731,594 (GRCm39) |
|
probably null |
Het |
| Spink5 |
C |
A |
18: 44,140,786 (GRCm39) |
H662N |
probably benign |
Het |
| Taf2 |
A |
T |
15: 54,923,311 (GRCm39) |
M322K |
probably damaging |
Het |
| Tmc2 |
T |
C |
2: 130,090,682 (GRCm39) |
F676S |
probably damaging |
Het |
| Tmem177 |
A |
G |
1: 119,837,915 (GRCm39) |
S255P |
possibly damaging |
Het |
| Trim46 |
A |
T |
3: 89,142,375 (GRCm39) |
|
probably null |
Het |
| Tubb1 |
T |
A |
2: 174,292,596 (GRCm39) |
|
probably null |
Het |
| Upf1 |
T |
C |
8: 70,796,904 (GRCm39) |
T110A |
probably benign |
Het |
| Vmn2r9 |
T |
A |
5: 108,996,850 (GRCm39) |
I140L |
probably benign |
Het |
| Zfp638 |
T |
A |
6: 83,921,638 (GRCm39) |
H588Q |
probably damaging |
Het |
| Zfp780b |
T |
A |
7: 27,664,252 (GRCm39) |
N101I |
probably damaging |
Het |
| Zpld2 |
T |
C |
4: 133,924,144 (GRCm39) |
D467G |
probably benign |
Het |
|
| Other mutations in Adgrb2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00309:Adgrb2
|
APN |
4 |
129,912,598 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00425:Adgrb2
|
APN |
4 |
129,912,865 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL00490:Adgrb2
|
APN |
4 |
129,905,665 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL00928:Adgrb2
|
APN |
4 |
129,886,096 (GRCm39) |
missense |
probably benign |
|
|
IGL01353:Adgrb2
|
APN |
4 |
129,906,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01521:Adgrb2
|
APN |
4 |
129,886,085 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01590:Adgrb2
|
APN |
4 |
129,907,606 (GRCm39) |
splice site |
probably benign |
|
|
IGL01813:Adgrb2
|
APN |
4 |
129,906,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01831:Adgrb2
|
APN |
4 |
129,903,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01939:Adgrb2
|
APN |
4 |
129,885,925 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01960:Adgrb2
|
APN |
4 |
129,906,177 (GRCm39) |
splice site |
probably benign |
|
|
IGL01993:Adgrb2
|
APN |
4 |
129,912,635 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02646:Adgrb2
|
APN |
4 |
129,913,075 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02655:Adgrb2
|
APN |
4 |
129,885,972 (GRCm39) |
nonsense |
probably null |
|
|
IGL02695:Adgrb2
|
APN |
4 |
129,912,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02998:Adgrb2
|
APN |
4 |
129,912,862 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL03372:Adgrb2
|
APN |
4 |
129,911,362 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0098:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0206:Adgrb2
|
UTSW |
4 |
129,886,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0311:Adgrb2
|
UTSW |
4 |
129,910,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0380:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0382:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0492:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0544:Adgrb2
|
UTSW |
4 |
129,911,335 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0965:Adgrb2
|
UTSW |
4 |
129,886,209 (GRCm39) |
small deletion |
probably benign |
|
|
R1601:Adgrb2
|
UTSW |
4 |
129,886,630 (GRCm39) |
missense |
probably benign |
0.43 |
|
R1711:Adgrb2
|
UTSW |
4 |
129,886,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1758:Adgrb2
|
UTSW |
4 |
129,905,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1783:Adgrb2
|
UTSW |
4 |
129,903,098 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R1827:Adgrb2
|
UTSW |
4 |
129,906,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1838:Adgrb2
|
UTSW |
4 |
129,904,024 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1881:Adgrb2
|
UTSW |
4 |
129,904,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1888:Adgrb2
|
UTSW |
4 |
129,907,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1888:Adgrb2
|
UTSW |
4 |
129,907,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1894:Adgrb2
|
UTSW |
4 |
129,907,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2275:Adgrb2
|
UTSW |
4 |
129,900,647 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2926:Adgrb2
|
UTSW |
4 |
129,902,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4472:Adgrb2
|
UTSW |
4 |
129,902,146 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4490:Adgrb2
|
UTSW |
4 |
129,906,121 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4499:Adgrb2
|
UTSW |
4 |
129,886,454 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4758:Adgrb2
|
UTSW |
4 |
129,903,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4900:Adgrb2
|
UTSW |
4 |
129,907,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4904:Adgrb2
|
UTSW |
4 |
129,906,332 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R4922:Adgrb2
|
UTSW |
4 |
129,901,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5330:Adgrb2
|
UTSW |
4 |
129,915,995 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5331:Adgrb2
|
UTSW |
4 |
129,915,995 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5550:Adgrb2
|
UTSW |
4 |
129,908,727 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5995:Adgrb2
|
UTSW |
4 |
129,910,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6047:Adgrb2
|
UTSW |
4 |
129,912,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6534:Adgrb2
|
UTSW |
4 |
129,916,012 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6565:Adgrb2
|
UTSW |
4 |
129,913,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6813:Adgrb2
|
UTSW |
4 |
129,903,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6963:Adgrb2
|
UTSW |
4 |
129,908,155 (GRCm39) |
frame shift |
probably null |
|
|
R6966:Adgrb2
|
UTSW |
4 |
129,908,155 (GRCm39) |
frame shift |
probably null |
|
|
R7197:Adgrb2
|
UTSW |
4 |
129,903,315 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7409:Adgrb2
|
UTSW |
4 |
129,912,862 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7451:Adgrb2
|
UTSW |
4 |
129,908,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7453:Adgrb2
|
UTSW |
4 |
129,908,430 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7461:Adgrb2
|
UTSW |
4 |
129,915,006 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
R7511:Adgrb2
|
UTSW |
4 |
129,915,904 (GRCm39) |
missense |
probably benign |
|
|
R7613:Adgrb2
|
UTSW |
4 |
129,915,006 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
R7729:Adgrb2
|
UTSW |
4 |
129,885,917 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7818:Adgrb2
|
UTSW |
4 |
129,908,762 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7818:Adgrb2
|
UTSW |
4 |
129,908,353 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8033:Adgrb2
|
UTSW |
4 |
129,912,805 (GRCm39) |
missense |
probably benign |
|
|
R8039:Adgrb2
|
UTSW |
4 |
129,916,061 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8097:Adgrb2
|
UTSW |
4 |
129,901,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8256:Adgrb2
|
UTSW |
4 |
129,901,921 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8425:Adgrb2
|
UTSW |
4 |
129,898,850 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R8804:Adgrb2
|
UTSW |
4 |
129,899,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9011:Adgrb2
|
UTSW |
4 |
129,916,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9018:Adgrb2
|
UTSW |
4 |
129,907,659 (GRCm39) |
missense |
probably benign |
0.34 |
|
R9102:Adgrb2
|
UTSW |
4 |
129,912,802 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9113:Adgrb2
|
UTSW |
4 |
129,910,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9120:Adgrb2
|
UTSW |
4 |
129,906,302 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R9211:Adgrb2
|
UTSW |
4 |
129,886,199 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9267:Adgrb2
|
UTSW |
4 |
129,885,901 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9328:Adgrb2
|
UTSW |
4 |
129,915,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9470:Adgrb2
|
UTSW |
4 |
129,903,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9608:Adgrb2
|
UTSW |
4 |
129,907,352 (GRCm39) |
missense |
probably damaging |
0.98 |
|
RF020:Adgrb2
|
UTSW |
4 |
129,903,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Adgrb2
|
UTSW |
4 |
129,911,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Adgrb2
|
UTSW |
4 |
129,912,912 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1177:Adgrb2
|
UTSW |
4 |
129,905,619 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCAGCAGTCATTGTCCTGGTATGTG -3'
(R):5'- TAACATGGCATTCCTGGCCGAG -3'
Sequencing Primer
(F):5'- TTTCAGCATCCAGGGAGGG -3'
(R):5'- CTCCACACGCTGAGCAG -3'
|
| Posted On |
2014-03-14 |
Incidental Mutation