Mutagenetix > Incidental Mutation

Incidental Mutation 'R1458:Nav3'

161897

Institutional Source

Beutler Lab

Gene Symbol

Nav3

Ensembl Gene

ENSMUSG00000020181

Gene Name

neuron navigator 3

Synonyms

Pomfil1p, 9630020C08Rik, POMFIL1, steerin 3, 4732483H20Rik, unc53H3

MMRRC Submission

039513-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1458 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

109517120-110292065 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 109555905 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Arginine at position 1675 (S1675R)

Ref Sequence

ENSEMBL: ENSMUSP00000032719 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032719]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000032719
AA Change: S1675R

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000032719
Gene: ENSMUSG00000020181
AA Change: S1675R

Domain	Start	End	E-Value	Type
CH	79	182	4.41e-12	SMART
low complexity region	184	194	N/A	INTRINSIC
low complexity region	318	329	N/A	INTRINSIC
low complexity region	353	363	N/A	INTRINSIC
low complexity region	427	439	N/A	INTRINSIC
low complexity region	522	536	N/A	INTRINSIC
low complexity region	713	724	N/A	INTRINSIC
low complexity region	807	818	N/A	INTRINSIC
low complexity region	873	896	N/A	INTRINSIC
low complexity region	904	916	N/A	INTRINSIC
low complexity region	1077	1095	N/A	INTRINSIC
low complexity region	1160	1173	N/A	INTRINSIC
low complexity region	1207	1229	N/A	INTRINSIC
low complexity region	1256	1266	N/A	INTRINSIC
low complexity region	1274	1285	N/A	INTRINSIC
low complexity region	1293	1312	N/A	INTRINSIC
low complexity region	1327	1341	N/A	INTRINSIC
low complexity region	1383	1397	N/A	INTRINSIC
low complexity region	1462	1474	N/A	INTRINSIC
low complexity region	1550	1563	N/A	INTRINSIC
coiled coil region	1565	1656	N/A	INTRINSIC
low complexity region	1675	1692	N/A	INTRINSIC
low complexity region	1722	1733	N/A	INTRINSIC
low complexity region	1756	1781	N/A	INTRINSIC
low complexity region	1782	1795	N/A	INTRINSIC
coiled coil region	1801	1842	N/A	INTRINSIC
low complexity region	1848	1871	N/A	INTRINSIC
AAA	2029	2184	4.94e-7	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000161223

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000161582

SMART Domains

Protein: ENSMUSP00000124591
Gene: ENSMUSG00000020181

Domain	Start	End	E-Value	Type
low complexity region	84	95	N/A	INTRINSIC
low complexity region	150	173	N/A	INTRINSIC
low complexity region	181	193	N/A	INTRINSIC
low complexity region	354	372	N/A	INTRINSIC
low complexity region	437	450	N/A	INTRINSIC
low complexity region	484	506	N/A	INTRINSIC
low complexity region	533	543	N/A	INTRINSIC
low complexity region	551	562	N/A	INTRINSIC
low complexity region	570	589	N/A	INTRINSIC
low complexity region	604	618	N/A	INTRINSIC
low complexity region	660	674	N/A	INTRINSIC
low complexity region	739	751	N/A	INTRINSIC
low complexity region	827	840	N/A	INTRINSIC
coiled coil region	842	933	N/A	INTRINSIC
low complexity region	952	969	N/A	INTRINSIC
low complexity region	992	1003	N/A	INTRINSIC
low complexity region	1026	1051	N/A	INTRINSIC
low complexity region	1052	1065	N/A	INTRINSIC
coiled coil region	1071	1112	N/A	INTRINSIC
low complexity region	1118	1141	N/A	INTRINSIC
AAA	1299	1454	4.94e-7	SMART

Meta Mutation Damage Score

0.3449

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.3%
20x: 92.8%

Validation Efficiency

98% (95/97)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. Multiple alternatively spliced transcript variants for this gene have been described but only one has had its full-length nature determined. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 94 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700036A12Rik	A	G	9: 60,677,043 (GRCm39)		noncoding transcript	Het
A430110L20Rik	T	A	1: 181,055,423 (GRCm39)		noncoding transcript	Het
Abce1	T	C	8: 80,433,864 (GRCm39)	K63R	possibly damaging	Het
Acp6	A	G	3: 97,081,104 (GRCm39)		probably benign	Het
Adamts13	T	A	2: 26,878,366 (GRCm39)	L579Q	probably damaging	Het
Adamtsl3	T	A	7: 82,172,528 (GRCm39)	M497K	probably damaging	Het
Adgrb2	T	A	4: 129,908,384 (GRCm39)	M1042K	possibly damaging	Het
Akap12	A	T	10: 4,303,693 (GRCm39)	S168C	probably damaging	Het
Akap3	A	T	6: 126,842,517 (GRCm39)	M379L	probably damaging	Het
Aldh6a1	C	T	12: 84,486,437 (GRCm39)	M135I	probably null	Het
Arhgef12	A	G	9: 42,900,294 (GRCm39)	S860P	probably damaging	Het
Atp11b	A	C	3: 35,843,707 (GRCm39)	T185P	probably damaging	Het
Bcas1	T	C	2: 170,229,871 (GRCm39)	D243G	probably damaging	Het
Cdhr2	T	A	13: 54,865,685 (GRCm39)	S228T	probably damaging	Het
Cic	T	C	7: 24,979,162 (GRCm39)		probably benign	Het
Cimap1d	A	T	10: 79,481,392 (GRCm39)		probably benign	Het
Cmya5	T	A	13: 93,201,835 (GRCm39)	I3376L	probably benign	Het
Ctrc	C	A	4: 141,573,535 (GRCm39)		probably null	Het
Dchs1	G	T	7: 105,404,451 (GRCm39)	P2697Q	probably damaging	Het
Dmbt1	A	G	7: 130,646,217 (GRCm39)		probably benign	Het
Drd2	G	A	9: 49,313,512 (GRCm39)	R227H	probably damaging	Het
Dscc1	C	A	15: 54,950,160 (GRCm39)	C195F	probably damaging	Het
Dzip1	T	A	14: 119,160,125 (GRCm39)	M28L	probably benign	Het
Edar	A	T	10: 58,443,188 (GRCm39)	S313T	probably benign	Het
Eef1e1	C	A	13: 38,840,099 (GRCm39)	A69S	probably damaging	Het
Fbn1	A	G	2: 125,143,849 (GRCm39)	V2760A	probably benign	Het
Fez1	GACAAACA	GACA	9: 36,781,845 (GRCm39)		probably null	Het
Fgl1	C	G	8: 41,663,496 (GRCm39)	A11P	possibly damaging	Het
Fras1	T	C	5: 96,748,592 (GRCm39)	V689A	probably benign	Het
Fry	T	A	5: 150,304,324 (GRCm39)	D571E	probably damaging	Het
Gm11232	T	A	4: 71,675,450 (GRCm39)	R104*	probably null	Het
Gm1527	A	G	3: 28,972,199 (GRCm39)	I439V	possibly damaging	Het
Gm4922	C	A	10: 18,659,640 (GRCm39)	G361*	probably null	Het
Gm7052	T	A	17: 22,259,447 (GRCm39)		probably benign	Het
Gpatch8	A	T	11: 102,372,055 (GRCm39)	S494R	unknown	Het
Gria2	A	T	3: 80,639,352 (GRCm39)	V220E	possibly damaging	Het
Grik4	G	A	9: 42,432,418 (GRCm39)	H860Y	probably benign	Het
Gtpbp1	A	C	15: 79,591,930 (GRCm39)	S93R	probably damaging	Het
Gucy2g	C	A	19: 55,203,468 (GRCm39)		probably benign	Het
H2ac8	C	A	13: 23,755,221 (GRCm39)		probably benign	Het
Hmcn1	G	A	1: 150,485,451 (GRCm39)	R4384C	probably damaging	Het
Hspa12b	G	C	2: 130,987,112 (GRCm39)	A678P	probably damaging	Het
Igsf21	T	A	4: 139,755,435 (GRCm39)	N407Y	probably damaging	Het
Insig2	A	G	1: 121,234,885 (GRCm39)	Y174H	probably benign	Het
Itpr3	T	A	17: 27,337,346 (GRCm39)	M2413K	probably benign	Het
Kalrn	A	T	16: 33,994,857 (GRCm39)	I1322N	probably damaging	Het
Klk1b24	T	A	7: 43,840,890 (GRCm39)	M106K	possibly damaging	Het
Krt81	G	T	15: 101,358,198 (GRCm39)	Q352K	probably benign	Het
Lca5l	A	T	16: 95,961,059 (GRCm39)	S468T	possibly damaging	Het
Lvrn	T	C	18: 47,015,452 (GRCm39)		probably benign	Het
Mcpt1	T	A	14: 56,256,621 (GRCm39)		probably benign	Het
Med13l	T	C	5: 118,876,524 (GRCm39)	M900T	probably benign	Het
Med16	A	G	10: 79,743,312 (GRCm39)		probably benign	Het
Megf6	G	T	4: 154,261,578 (GRCm39)	V68L	probably benign	Het
Mep1a	T	C	17: 43,802,563 (GRCm39)	H154R	probably damaging	Het
Mrc2	A	T	11: 105,228,598 (GRCm39)	D659V	probably benign	Het
Mroh8	T	A	2: 157,063,224 (GRCm39)	E799V	probably damaging	Het
Mrpl21	A	G	19: 3,334,808 (GRCm39)	Y50C	possibly damaging	Het
Msl1	A	G	11: 98,694,808 (GRCm39)		probably benign	Het
Myo1a	C	A	10: 127,555,806 (GRCm39)	Q932K	probably benign	Het
Neurl2	A	G	2: 164,674,666 (GRCm39)	V232A	possibly damaging	Het
Nfatc1	T	A	18: 80,708,482 (GRCm39)		probably benign	Het
Or2w4	C	T	13: 21,795,992 (GRCm39)	C49Y	probably benign	Het
Or5k8	T	A	16: 58,645,039 (GRCm39)	E11V	probably null	Het
P4hb	A	G	11: 120,453,381 (GRCm39)		probably benign	Het
Papss1	T	G	3: 131,311,615 (GRCm39)	I281S	probably damaging	Het
Pde10a	A	T	17: 9,183,540 (GRCm39)	D832V	probably damaging	Het
Pfkfb2	A	T	1: 130,635,927 (GRCm39)	Y35N	possibly damaging	Het
Phaf1	T	C	8: 105,973,188 (GRCm39)		probably null	Het
Phf20l1	T	A	15: 66,476,662 (GRCm39)	F253Y	probably damaging	Het
Pkhd1l1	G	A	15: 44,379,511 (GRCm39)	V1046I	probably benign	Het
Plin3	C	T	17: 56,591,337 (GRCm39)	A148T	probably benign	Het
Ppp1r8	T	C	4: 132,567,942 (GRCm39)		probably benign	Het
Ppp2r3d	A	G	9: 101,088,511 (GRCm39)	L604P	probably damaging	Het
Prdm5	T	C	6: 65,860,585 (GRCm39)	V239A	probably damaging	Het
Prickle1	A	G	15: 93,398,519 (GRCm39)	S770P	probably damaging	Het
Prl2c5	T	A	13: 13,365,310 (GRCm39)	I155N	probably benign	Het
Prom1	T	C	5: 44,190,274 (GRCm39)		probably benign	Het
Psg25	C	T	7: 18,263,512 (GRCm39)	G104R	probably damaging	Het
Rbm19	T	C	5: 120,282,094 (GRCm39)	V817A	probably benign	Het
Ryr2	T	A	13: 11,741,908 (GRCm39)	Y2091F	probably damaging	Het
Slc16a4	A	G	3: 107,208,248 (GRCm39)	T253A	probably benign	Het
Smg7	A	T	1: 152,731,594 (GRCm39)		probably null	Het
Spink5	C	A	18: 44,140,786 (GRCm39)	H662N	probably benign	Het
Taf2	A	T	15: 54,923,311 (GRCm39)	M322K	probably damaging	Het
Tmc2	T	C	2: 130,090,682 (GRCm39)	F676S	probably damaging	Het
Tmem177	A	G	1: 119,837,915 (GRCm39)	S255P	possibly damaging	Het
Trim46	A	T	3: 89,142,375 (GRCm39)		probably null	Het
Tubb1	T	A	2: 174,292,596 (GRCm39)		probably null	Het
Upf1	T	C	8: 70,796,904 (GRCm39)	T110A	probably benign	Het
Vmn2r9	T	A	5: 108,996,850 (GRCm39)	I140L	probably benign	Het
Zfp638	T	A	6: 83,921,638 (GRCm39)	H588Q	probably damaging	Het
Zfp780b	T	A	7: 27,664,252 (GRCm39)	N101I	probably damaging	Het
Zpld2	T	C	4: 133,924,144 (GRCm39)	D467G	probably benign	Het

Other mutations in Nav3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00095:Nav3	APN	10	109,677,594 (GRCm39)	missense	probably damaging	0.99
IGL00425:Nav3	APN	10	109,539,368 (GRCm39)	missense	probably benign	0.13
IGL00465:Nav3	APN	10	109,688,607 (GRCm39)	missense	probably damaging	0.99
IGL00531:Nav3	APN	10	109,539,171 (GRCm39)	missense	probably null	0.99
IGL00575:Nav3	APN	10	109,600,626 (GRCm39)	missense	probably damaging	0.98
IGL00770:Nav3	APN	10	109,652,124 (GRCm39)	missense	probably damaging	1.00
IGL00774:Nav3	APN	10	109,652,124 (GRCm39)	missense	probably damaging	1.00
IGL00858:Nav3	APN	10	109,578,493 (GRCm39)	missense	probably damaging	0.98
IGL00935:Nav3	APN	10	109,541,527 (GRCm39)	missense	probably benign
IGL01638:Nav3	APN	10	109,688,724 (GRCm39)	missense	probably damaging	1.00
IGL01662:Nav3	APN	10	109,605,119 (GRCm39)	missense	possibly damaging	0.56
IGL01670:Nav3	APN	10	109,550,102 (GRCm39)	missense	possibly damaging	0.92
IGL01885:Nav3	APN	10	109,578,521 (GRCm39)	nonsense	probably null
IGL01979:Nav3	APN	10	109,540,790 (GRCm39)	missense	probably benign	0.01
IGL02121:Nav3	APN	10	109,594,897 (GRCm39)	missense	probably damaging	0.99
IGL02210:Nav3	APN	10	109,602,851 (GRCm39)	missense	probably benign
IGL02523:Nav3	APN	10	109,605,157 (GRCm39)	missense	probably damaging	1.00
IGL02573:Nav3	APN	10	109,702,835 (GRCm39)	missense	probably benign	0.23
IGL02633:Nav3	APN	10	109,527,997 (GRCm39)	missense	probably benign	0.09
IGL02810:Nav3	APN	10	109,652,135 (GRCm39)	missense	probably damaging	1.00
IGL02964:Nav3	APN	10	109,572,814 (GRCm39)	missense	probably damaging	0.99
IGL03015:Nav3	APN	10	109,554,158 (GRCm39)	missense	probably damaging	0.98
IGL03288:Nav3	APN	10	109,594,878 (GRCm39)	missense	probably damaging	1.00
IGL03310:Nav3	APN	10	109,660,433 (GRCm39)	critical splice donor site	probably null
PIT4377001:Nav3	UTSW	10	109,552,466 (GRCm39)	missense	probably damaging	0.99
R0010:Nav3	UTSW	10	109,659,087 (GRCm39)	splice site	probably benign
R0043:Nav3	UTSW	10	109,603,379 (GRCm39)	missense	possibly damaging	0.95
R0053:Nav3	UTSW	10	109,602,778 (GRCm39)	splice site	probably benign
R0053:Nav3	UTSW	10	109,602,778 (GRCm39)	splice site	probably benign
R0077:Nav3	UTSW	10	109,552,503 (GRCm39)	missense	possibly damaging	0.87
R0219:Nav3	UTSW	10	109,702,791 (GRCm39)	critical splice donor site	probably null
R0310:Nav3	UTSW	10	109,602,989 (GRCm39)	missense	possibly damaging	0.82
R0380:Nav3	UTSW	10	109,594,740 (GRCm39)	splice site	probably benign
R0403:Nav3	UTSW	10	109,602,964 (GRCm39)	missense	probably damaging	0.98
R0480:Nav3	UTSW	10	109,689,161 (GRCm39)	missense	probably damaging	1.00
R0626:Nav3	UTSW	10	109,659,325 (GRCm39)	missense	probably damaging	1.00
R0637:Nav3	UTSW	10	109,606,058 (GRCm39)	missense	probably benign	0.25
R0847:Nav3	UTSW	10	109,739,718 (GRCm39)	missense	possibly damaging	0.94
R0988:Nav3	UTSW	10	109,552,389 (GRCm39)	missense	probably damaging	1.00
R1272:Nav3	UTSW	10	109,572,860 (GRCm39)	missense	probably damaging	0.98
R1295:Nav3	UTSW	10	109,527,963 (GRCm39)	missense	probably damaging	1.00
R1405:Nav3	UTSW	10	109,606,194 (GRCm39)	splice site	probably benign
R1406:Nav3	UTSW	10	109,719,495 (GRCm39)	missense	possibly damaging	0.64
R1406:Nav3	UTSW	10	109,719,495 (GRCm39)	missense	possibly damaging	0.64
R1420:Nav3	UTSW	10	109,659,115 (GRCm39)	missense	probably benign	0.02
R1449:Nav3	UTSW	10	109,689,372 (GRCm39)	missense	probably benign	0.13
R1469:Nav3	UTSW	10	109,596,369 (GRCm39)	missense	probably damaging	1.00
R1469:Nav3	UTSW	10	109,596,369 (GRCm39)	missense	probably damaging	1.00
R1472:Nav3	UTSW	10	109,563,802 (GRCm39)	missense	probably damaging	0.99
R1537:Nav3	UTSW	10	109,702,846 (GRCm39)	missense	probably damaging	1.00
R1539:Nav3	UTSW	10	109,603,031 (GRCm39)	missense	probably damaging	0.99
R1581:Nav3	UTSW	10	109,659,289 (GRCm39)	missense	probably damaging	1.00
R1586:Nav3	UTSW	10	109,689,115 (GRCm39)	missense	probably damaging	1.00
R1654:Nav3	UTSW	10	109,688,984 (GRCm39)	missense	possibly damaging	0.85
R1725:Nav3	UTSW	10	109,659,451 (GRCm39)	missense	probably damaging	1.00
R1742:Nav3	UTSW	10	109,605,074 (GRCm39)	missense	probably benign
R1793:Nav3	UTSW	10	109,539,233 (GRCm39)	missense	probably benign	0.00
R1830:Nav3	UTSW	10	109,659,184 (GRCm39)	missense	probably damaging	1.00
R1834:Nav3	UTSW	10	109,555,883 (GRCm39)	missense	probably damaging	0.99
R1881:Nav3	UTSW	10	109,688,420 (GRCm39)	missense	probably damaging	0.96
R1922:Nav3	UTSW	10	109,541,467 (GRCm39)	missense	probably benign	0.43
R1944:Nav3	UTSW	10	109,552,391 (GRCm39)	missense	probably damaging	0.99
R1981:Nav3	UTSW	10	109,554,951 (GRCm39)	splice site	probably benign
R1985:Nav3	UTSW	10	109,606,045 (GRCm39)	splice site	probably benign
R1996:Nav3	UTSW	10	109,689,262 (GRCm39)	missense	probably damaging	1.00
R2051:Nav3	UTSW	10	109,660,536 (GRCm39)	missense	probably damaging	0.99
R2062:Nav3	UTSW	10	109,555,882 (GRCm39)	missense	probably damaging	1.00
R2139:Nav3	UTSW	10	109,688,996 (GRCm39)	missense	probably benign	0.22
R2248:Nav3	UTSW	10	109,532,088 (GRCm39)	missense	probably damaging	1.00
R2420:Nav3	UTSW	10	109,699,674 (GRCm39)	missense	probably damaging	0.98
R2444:Nav3	UTSW	10	109,600,776 (GRCm39)	missense	probably benign	0.09
R3026:Nav3	UTSW	10	109,660,465 (GRCm39)	missense	probably damaging	0.99
R3052:Nav3	UTSW	10	109,739,613 (GRCm39)	missense	probably damaging	0.99
R3441:Nav3	UTSW	10	109,540,789 (GRCm39)	missense	probably benign	0.01
R3845:Nav3	UTSW	10	109,689,237 (GRCm39)	missense	possibly damaging	0.82
R3929:Nav3	UTSW	10	109,520,064 (GRCm39)	missense	probably damaging	1.00
R3932:Nav3	UTSW	10	109,529,896 (GRCm39)	missense	probably damaging	0.99
R4056:Nav3	UTSW	10	109,716,394 (GRCm39)	critical splice donor site	probably null
R4057:Nav3	UTSW	10	109,716,394 (GRCm39)	critical splice donor site	probably null
R4120:Nav3	UTSW	10	109,739,605 (GRCm39)	critical splice donor site	probably null
R4244:Nav3	UTSW	10	109,605,157 (GRCm39)	missense	probably damaging	1.00
R4361:Nav3	UTSW	10	109,688,847 (GRCm39)	missense	probably damaging	1.00
R4512:Nav3	UTSW	10	109,529,943 (GRCm39)	missense	possibly damaging	0.89
R4514:Nav3	UTSW	10	109,529,943 (GRCm39)	missense	possibly damaging	0.89
R4700:Nav3	UTSW	10	109,600,796 (GRCm39)	missense	probably benign	0.10
R4815:Nav3	UTSW	10	109,659,413 (GRCm39)	missense	probably benign
R4981:Nav3	UTSW	10	109,716,553 (GRCm39)	missense	probably benign
R5042:Nav3	UTSW	10	109,605,129 (GRCm39)	missense	probably benign	0.27
R5251:Nav3	UTSW	10	109,689,114 (GRCm39)	missense	probably damaging	0.99
R5252:Nav3	UTSW	10	109,550,152 (GRCm39)	small deletion	probably benign
R5273:Nav3	UTSW	10	109,528,899 (GRCm39)	critical splice donor site	probably null
R5288:Nav3	UTSW	10	109,688,966 (GRCm39)	missense	probably benign	0.10
R5407:Nav3	UTSW	10	109,702,796 (GRCm39)	missense	probably benign	0.28
R5533:Nav3	UTSW	10	109,719,539 (GRCm39)	missense	possibly damaging	0.61
R5561:Nav3	UTSW	10	109,552,413 (GRCm39)	missense	probably damaging	1.00
R5577:Nav3	UTSW	10	109,605,264 (GRCm39)	missense	probably damaging	1.00
R5656:Nav3	UTSW	10	109,600,494 (GRCm39)	missense	probably damaging	0.96
R5872:Nav3	UTSW	10	109,600,648 (GRCm39)	missense	probably damaging	1.00
R6023:Nav3	UTSW	10	109,659,376 (GRCm39)	missense	possibly damaging	0.95
R6061:Nav3	UTSW	10	109,702,845 (GRCm39)	nonsense	probably null
R6189:Nav3	UTSW	10	109,555,880 (GRCm39)	missense	probably damaging	0.98
R6214:Nav3	UTSW	10	109,688,426 (GRCm39)	missense	probably damaging	1.00
R6215:Nav3	UTSW	10	109,688,426 (GRCm39)	missense	probably damaging	1.00
R6264:Nav3	UTSW	10	109,524,694 (GRCm39)	missense	probably damaging	0.97
R6500:Nav3	UTSW	10	109,600,617 (GRCm39)	missense	probably damaging	1.00
R6524:Nav3	UTSW	10	109,555,891 (GRCm39)	missense	probably damaging	0.99
R6868:Nav3	UTSW	10	109,529,027 (GRCm39)	missense	possibly damaging	0.49
R7079:Nav3	UTSW	10	109,603,153 (GRCm39)	missense	probably benign	0.16
R7099:Nav3	UTSW	10	109,539,195 (GRCm39)	missense	probably benign	0.11
R7139:Nav3	UTSW	10	109,689,338 (GRCm39)	missense	probably benign	0.44
R7238:Nav3	UTSW	10	109,689,185 (GRCm39)	missense	possibly damaging	0.75
R7338:Nav3	UTSW	10	109,605,073 (GRCm39)	missense	probably benign	0.04
R7343:Nav3	UTSW	10	109,739,619 (GRCm39)	missense	probably damaging	0.98
R7383:Nav3	UTSW	10	109,552,532 (GRCm39)	missense	probably damaging	0.98
R7391:Nav3	UTSW	10	109,539,317 (GRCm39)	missense	probably benign	0.07
R7399:Nav3	UTSW	10	109,688,795 (GRCm39)	missense	possibly damaging	0.74
R7457:Nav3	UTSW	10	109,532,189 (GRCm39)	nonsense	probably null
R7462:Nav3	UTSW	10	109,659,439 (GRCm39)	missense	probably damaging	1.00
R7542:Nav3	UTSW	10	109,659,394 (GRCm39)	missense	possibly damaging	0.89
R7659:Nav3	UTSW	10	109,602,851 (GRCm39)	missense	probably benign	0.09
R7749:Nav3	UTSW	10	109,539,213 (GRCm39)	missense	probably damaging	0.99
R7794:Nav3	UTSW	10	109,524,717 (GRCm39)	missense	probably benign	0.08
R7876:Nav3	UTSW	10	109,689,359 (GRCm39)	missense	probably benign	0.26
R8048:Nav3	UTSW	10	109,600,779 (GRCm39)	missense	probably benign	0.13
R8104:Nav3	UTSW	10	109,594,828 (GRCm39)	missense	probably damaging	0.99
R8125:Nav3	UTSW	10	109,688,520 (GRCm39)	missense	probably damaging	0.99
R8275:Nav3	UTSW	10	109,527,984 (GRCm39)	missense	noncoding transcript
R8325:Nav3	UTSW	10	109,541,464 (GRCm39)	missense	probably benign	0.24
R8336:Nav3	UTSW	10	109,603,430 (GRCm39)	missense	probably damaging	0.99
R8523:Nav3	UTSW	10	109,659,138 (GRCm39)	missense	probably damaging	1.00
R8529:Nav3	UTSW	10	109,689,192 (GRCm39)	missense	probably benign	0.09
R8745:Nav3	UTSW	10	109,659,311 (GRCm39)	missense	probably benign	0.08
R8752:Nav3	UTSW	10	109,596,165 (GRCm39)	intron	probably benign
R8794:Nav3	UTSW	10	109,605,032 (GRCm39)	nonsense	probably null
R8816:Nav3	UTSW	10	109,699,721 (GRCm39)	missense	possibly damaging	0.69
R9029:Nav3	UTSW	10	109,699,613 (GRCm39)	missense	possibly damaging	0.68
R9117:Nav3	UTSW	10	109,520,100 (GRCm39)	missense	probably benign	0.41
R9126:Nav3	UTSW	10	109,541,524 (GRCm39)	missense	probably benign
R9258:Nav3	UTSW	10	109,550,243 (GRCm39)	missense	probably damaging	0.99
R9347:Nav3	UTSW	10	109,738,955 (GRCm39)	missense	probably damaging	0.98
R9353:Nav3	UTSW	10	109,554,065 (GRCm39)	missense	probably damaging	0.99
R9366:Nav3	UTSW	10	109,659,364 (GRCm39)	missense	probably damaging	0.99
R9384:Nav3	UTSW	10	109,554,158 (GRCm39)	missense	probably damaging	0.98
R9428:Nav3	UTSW	10	109,605,176 (GRCm39)	missense	probably benign
R9454:Nav3	UTSW	10	109,835,864 (GRCm39)	missense	probably benign	0.01
R9516:Nav3	UTSW	10	109,520,015 (GRCm39)	missense	probably damaging	1.00
R9521:Nav3	UTSW	10	109,835,845 (GRCm39)	missense	possibly damaging	0.95
R9622:Nav3	UTSW	10	109,603,103 (GRCm39)	missense	probably benign
R9689:Nav3	UTSW	10	109,605,034 (GRCm39)	missense	probably damaging	1.00
R9796:Nav3	UTSW	10	109,527,969 (GRCm39)	missense	probably damaging	0.99
X0012:Nav3	UTSW	10	109,527,958 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GAAAGCTAAGTCCCTGACCCTTCAC -3'
(R):5'- AAAGCATCTTTGACGTGCTTGTTCC -3'

Sequencing Primer
(F):5'- GACCCTTCACAGGTTCTGAATG -3'
(R):5'- GGACAGAACTCATTCTTGGCATC -3'

Posted On

2014-03-14