Incidental Mutation 'R1460:Itgb4'
ID 162088
Institutional Source Beutler Lab
Gene Symbol Itgb4
Ensembl Gene ENSMUSG00000020758
Gene Name integrin beta 4
Synonyms CD104
MMRRC Submission 039515-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1460 (G1)
Quality Score 147
Status Validated
Chromosome 11
Chromosomal Location 115865556-115899238 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 115874990 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 449 (D449G)
Ref Sequence ENSEMBL: ENSMUSP00000127604 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021107] [ENSMUST00000068981] [ENSMUST00000106458] [ENSMUST00000106460] [ENSMUST00000106461] [ENSMUST00000169928]
AlphaFold A2A863
Predicted Effect probably damaging
Transcript: ENSMUST00000021107
AA Change: D449G

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000021107
Gene: ENSMUSG00000020758
AA Change: D449G

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
PSI 30 74 3.89e-1 SMART
INB 38 457 4.23e-213 SMART
VWA 130 361 8.29e-1 SMART
EGF_like 544 576 3.23e1 SMART
Integrin_B_tail 628 712 1.32e-28 SMART
low complexity region 715 732 N/A INTRINSIC
transmembrane domain 737 756 N/A INTRINSIC
Calx_beta 980 1085 3.13e-35 SMART
FN3 1125 1203 3.15e-8 SMART
FN3 1218 1305 6.29e-8 SMART
low complexity region 1324 1332 N/A INTRINSIC
FN3 1508 1589 1.79e-12 SMART
FN3 1621 1705 1.7e-13 SMART
low complexity region 1738 1751 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000068981
AA Change: D449G

PolyPhen 2 Score 0.306 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000070811
Gene: ENSMUSG00000020758
AA Change: D449G

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
PSI 30 74 3.89e-1 SMART
INB 38 457 4.23e-213 SMART
VWA 130 361 8.29e-1 SMART
EGF_like 544 576 3.23e1 SMART
Integrin_B_tail 628 713 7.06e-29 SMART
low complexity region 716 733 N/A INTRINSIC
transmembrane domain 738 757 N/A INTRINSIC
Calx_beta 981 1086 3.13e-35 SMART
FN3 1129 1207 3.15e-8 SMART
FN3 1222 1309 6.29e-8 SMART
low complexity region 1328 1336 N/A INTRINSIC
FN3 1459 1540 1.79e-12 SMART
FN3 1572 1656 1.7e-13 SMART
low complexity region 1689 1702 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000106458
AA Change: D449G

PolyPhen 2 Score 0.306 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000102066
Gene: ENSMUSG00000020758
AA Change: D449G

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
PSI 30 74 3.89e-1 SMART
INB 38 457 4.23e-213 SMART
VWA 130 361 8.29e-1 SMART
EGF_like 544 576 3.23e1 SMART
Integrin_B_tail 628 713 7.06e-29 SMART
low complexity region 716 733 N/A INTRINSIC
transmembrane domain 738 757 N/A INTRINSIC
Calx_beta 981 1086 3.13e-35 SMART
FN3 1129 1207 3.15e-8 SMART
FN3 1222 1309 6.29e-8 SMART
low complexity region 1328 1336 N/A INTRINSIC
low complexity region 1413 1425 N/A INTRINSIC
FN3 1524 1605 1.79e-12 SMART
FN3 1637 1721 1.7e-13 SMART
low complexity region 1754 1767 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000106460
AA Change: D449G

PolyPhen 2 Score 0.306 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000102068
Gene: ENSMUSG00000020758
AA Change: D449G

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
PSI 30 74 3.89e-1 SMART
INB 38 457 4.23e-213 SMART
VWA 130 361 8.29e-1 SMART
EGF_like 544 576 3.23e1 SMART
Integrin_B_tail 628 713 7.06e-29 SMART
low complexity region 716 733 N/A INTRINSIC
transmembrane domain 738 757 N/A INTRINSIC
Calx_beta 981 1086 3.13e-35 SMART
FN3 1129 1207 3.15e-8 SMART
FN3 1222 1309 6.29e-8 SMART
low complexity region 1328 1336 N/A INTRINSIC
FN3 1512 1593 1.79e-12 SMART
FN3 1625 1709 1.7e-13 SMART
low complexity region 1742 1755 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000106461
AA Change: D449G

PolyPhen 2 Score 0.306 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000102069
Gene: ENSMUSG00000020758
AA Change: D449G

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
PSI 30 74 3.89e-1 SMART
INB 38 457 4.23e-213 SMART
VWA 130 361 8.29e-1 SMART
EGF_like 544 576 3.23e1 SMART
Integrin_B_tail 628 713 7.06e-29 SMART
low complexity region 716 733 N/A INTRINSIC
transmembrane domain 738 757 N/A INTRINSIC
Calx_beta 981 1086 3.13e-35 SMART
FN3 1129 1207 3.15e-8 SMART
FN3 1222 1309 6.29e-8 SMART
low complexity region 1328 1336 N/A INTRINSIC
low complexity region 1413 1425 N/A INTRINSIC
FN3 1524 1605 1.79e-12 SMART
FN3 1637 1721 1.7e-13 SMART
low complexity region 1754 1767 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151691
Predicted Effect probably damaging
Transcript: ENSMUST00000169928
AA Change: D449G

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000127604
Gene: ENSMUSG00000020758
AA Change: D449G

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
PSI 30 74 3.89e-1 SMART
INB 38 457 4.23e-213 SMART
VWA 130 361 8.29e-1 SMART
EGF_like 544 576 3.23e1 SMART
Integrin_B_tail 628 712 1.32e-28 SMART
low complexity region 715 732 N/A INTRINSIC
transmembrane domain 737 756 N/A INTRINSIC
Calx_beta 980 1085 3.13e-35 SMART
FN3 1125 1203 3.15e-8 SMART
FN3 1218 1305 6.29e-8 SMART
low complexity region 1324 1332 N/A INTRINSIC
FN3 1508 1589 1.79e-12 SMART
FN3 1621 1705 1.7e-13 SMART
low complexity region 1738 1751 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180782
Meta Mutation Damage Score 0.3595 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.2%
  • 20x: 89.1%
Validation Efficiency 94% (93/99)
MGI Phenotype FUNCTION: Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for targeted null mutations die shortly after birth with extensive detachment of the epidermis and other squamus epithelia. Stratified tissues lack hemidesmosomes and simple epithelia are also defective in adherence. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 96 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930522H14Rik A T 4: 109,388,407 (GRCm39) probably null Het
Abcb11 A G 2: 69,087,718 (GRCm39) probably benign Het
Abi3bp T C 16: 56,382,780 (GRCm39) V130A probably damaging Het
Adamts4 A G 1: 171,084,009 (GRCm39) probably benign Het
Adgrd1 A G 5: 129,199,627 (GRCm39) T155A possibly damaging Het
Ano3 A T 2: 110,513,103 (GRCm39) S631T probably damaging Het
Ass1 G A 2: 31,404,753 (GRCm39) V345I probably benign Het
Atg7 G A 6: 114,680,325 (GRCm39) A384T probably damaging Het
Atp6v0a1 T A 11: 100,924,824 (GRCm39) I303N probably damaging Het
B3gntl1 T G 11: 121,530,624 (GRCm39) Y149S probably damaging Het
Btnl2 A G 17: 34,585,424 (GRCm39) D475G probably benign Het
Cdcp1 A T 9: 123,009,092 (GRCm39) S529T possibly damaging Het
Cenpt A G 8: 106,575,520 (GRCm39) L194P probably damaging Het
Cfhr4 T A 1: 139,625,934 (GRCm39) I788F probably damaging Het
Chmp4b A G 2: 154,534,515 (GRCm39) D177G possibly damaging Het
Chmp7 C T 14: 69,956,899 (GRCm39) M336I probably benign Het
Cish G T 9: 107,177,596 (GRCm39) E91* probably null Het
Col22a1 T C 15: 71,693,780 (GRCm39) D740G unknown Het
Cplane2 T C 4: 140,945,523 (GRCm39) F125L probably damaging Het
Crocc G A 4: 140,756,551 (GRCm39) Q1025* probably null Het
Ctrc C A 4: 141,566,120 (GRCm39) probably benign Het
Cyb5r2 T A 7: 107,356,450 (GRCm39) D7V probably benign Het
Dhx29 T C 13: 113,101,744 (GRCm39) probably benign Het
Dhx9 A C 1: 153,341,426 (GRCm39) D607E probably benign Het
Dnajb7 C T 15: 81,291,888 (GRCm39) G150R probably benign Het
Dnase1l3 T A 14: 7,974,050 (GRCm38) T214S probably benign Het
Dpm1 A T 2: 168,052,549 (GRCm39) I229N probably damaging Het
Dstn T C 2: 143,780,408 (GRCm39) V36A possibly damaging Het
Entpd1 T C 19: 40,714,632 (GRCm39) V247A probably damaging Het
Ephb3 C A 16: 21,037,672 (GRCm39) H277Q probably benign Het
Etl4 A T 2: 20,793,288 (GRCm39) N671I probably damaging Het
Fabp3 C T 4: 130,206,180 (GRCm39) T57I probably benign Het
Fancd2os G A 6: 113,574,973 (GRCm39) T11I probably damaging Het
Fcrlb G T 1: 170,739,853 (GRCm39) probably benign Het
Fhip1a T C 3: 85,638,183 (GRCm39) I39V probably damaging Het
Gm9991 T C 1: 90,606,780 (GRCm39) noncoding transcript Het
Gstk1 C T 6: 42,223,529 (GRCm39) R40W probably damaging Het
Gstt1 C T 10: 75,620,004 (GRCm39) V190M probably damaging Het
Hectd2 G A 19: 36,592,908 (GRCm39) W691* probably null Het
Hecw2 T C 1: 53,852,404 (GRCm39) T1572A probably damaging Het
Hoxa5 T C 6: 52,180,928 (GRCm39) T135A probably benign Het
Igfl3 T A 7: 17,913,880 (GRCm39) C77S possibly damaging Het
Larp1b T C 3: 40,916,653 (GRCm39) V11A probably benign Het
Lhx9 A G 1: 138,766,447 (GRCm39) probably benign Het
Lig3 G T 11: 82,686,624 (GRCm39) probably benign Het
Lipo4 A C 19: 33,476,718 (GRCm39) F343L probably benign Het
Lyn T A 4: 3,789,908 (GRCm39) Y480* probably null Het
Mib2 C T 4: 155,743,917 (GRCm39) G42S probably damaging Het
Mill1 C A 7: 17,996,595 (GRCm39) A137D probably damaging Het
Mmut T C 17: 41,248,266 (GRCm39) Y98H probably damaging Het
Morc2a A T 11: 3,633,794 (GRCm39) R635S probably benign Het
Mpped2 A G 2: 106,575,237 (GRCm39) probably benign Het
Mug2 T C 6: 122,017,492 (GRCm39) probably benign Het
Mynn C A 3: 30,657,853 (GRCm39) S57Y probably damaging Het
Myo3b G A 2: 70,062,798 (GRCm39) E333K probably benign Het
Myt1 A T 2: 181,444,725 (GRCm39) I514F probably damaging Het
Nlrp4f A G 13: 65,338,082 (GRCm39) C708R probably benign Het
Nod2 A G 8: 89,390,440 (GRCm39) E249G probably damaging Het
Npy2r T C 3: 82,448,251 (GRCm39) I175V probably benign Het
Obscn A T 11: 58,946,792 (GRCm39) V4114D probably damaging Het
Or1l8 A T 2: 36,817,820 (GRCm39) M102K probably damaging Het
Or2y12 T A 11: 49,426,504 (GRCm39) M164K possibly damaging Het
Or4a76 A G 2: 89,460,282 (GRCm39) probably null Het
Or52e7 T A 7: 104,684,915 (GRCm39) I170N possibly damaging Het
Or8g33 A G 9: 39,337,503 (GRCm39) M288T probably benign Het
Pbxip1 T A 3: 89,352,921 (GRCm39) I196N probably damaging Het
Piezo1 G A 8: 123,228,890 (GRCm39) T209M possibly damaging Het
Polr1a T C 6: 71,918,368 (GRCm39) M642T probably damaging Het
Prdm4 T C 10: 85,743,686 (GRCm39) M190V probably benign Het
Psmd7 G A 8: 108,307,691 (GRCm39) S264L possibly damaging Het
Qrich1 T G 9: 108,410,846 (GRCm39) probably benign Het
Rapgef4 G T 2: 71,861,520 (GRCm39) probably null Het
Rfx5 T C 3: 94,863,636 (GRCm39) I95T probably damaging Het
Rgr G A 14: 36,767,683 (GRCm39) R113C probably damaging Het
Rnf20 T C 4: 49,645,873 (GRCm39) probably benign Het
Rps3a1 G A 3: 86,045,369 (GRCm39) A241V probably benign Het
Rttn A T 18: 89,127,481 (GRCm39) probably benign Het
Scn2a A G 2: 65,532,187 (GRCm39) T600A probably damaging Het
Scyl2 T C 10: 89,493,751 (GRCm39) D339G possibly damaging Het
Sipa1 T A 19: 5,701,475 (GRCm39) H1029L probably benign Het
Slc49a4 T C 16: 35,539,736 (GRCm39) T362A probably benign Het
Snrnp48 A G 13: 38,395,081 (GRCm39) T124A probably benign Het
Sptbn1 A T 11: 30,088,637 (GRCm39) M875K possibly damaging Het
Supt6 A G 11: 78,113,024 (GRCm39) V973A possibly damaging Het
Supv3l1 T C 10: 62,279,162 (GRCm39) probably benign Het
Svep1 G T 4: 58,068,740 (GRCm39) N3015K possibly damaging Het
Tgfb3 A G 12: 86,105,841 (GRCm39) probably benign Het
Trerf1 A G 17: 47,628,771 (GRCm39) noncoding transcript Het
Trim24 T A 6: 37,941,761 (GRCm39) F904I probably damaging Het
Trim30d T A 7: 104,121,311 (GRCm39) Y328F probably benign Het
Ttn T C 2: 76,698,717 (GRCm39) E6G probably damaging Het
Ube2m T C 7: 12,769,762 (GRCm39) probably benign Het
Vmn2r-ps158 A T 7: 42,672,639 (GRCm39) R91S probably benign Het
Wdr90 A T 17: 26,079,422 (GRCm39) S237R possibly damaging Het
Zfp735 A T 11: 73,603,159 (GRCm39) H701L possibly damaging Het
Zp1 T C 19: 10,896,242 (GRCm39) D161G probably benign Het
Other mutations in Itgb4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01360:Itgb4 APN 11 115,881,766 (GRCm39) missense probably damaging 1.00
IGL01391:Itgb4 APN 11 115,881,746 (GRCm39) missense probably damaging 1.00
IGL01431:Itgb4 APN 11 115,897,283 (GRCm39) splice site probably benign
IGL01750:Itgb4 APN 11 115,879,752 (GRCm39) missense probably damaging 0.99
IGL01752:Itgb4 APN 11 115,879,752 (GRCm39) missense probably damaging 0.99
IGL01756:Itgb4 APN 11 115,879,752 (GRCm39) missense probably damaging 0.99
IGL01766:Itgb4 APN 11 115,879,752 (GRCm39) missense probably damaging 0.99
IGL01769:Itgb4 APN 11 115,879,752 (GRCm39) missense probably damaging 0.99
IGL02188:Itgb4 APN 11 115,894,213 (GRCm39) missense probably benign 0.08
IGL02262:Itgb4 APN 11 115,879,752 (GRCm39) missense probably damaging 0.99
IGL02293:Itgb4 APN 11 115,879,752 (GRCm39) missense probably damaging 0.99
IGL02318:Itgb4 APN 11 115,879,752 (GRCm39) missense probably damaging 0.99
IGL02319:Itgb4 APN 11 115,879,752 (GRCm39) missense probably damaging 0.99
IGL02338:Itgb4 APN 11 115,898,795 (GRCm39) missense probably damaging 1.00
IGL02734:Itgb4 APN 11 115,896,792 (GRCm39) missense probably benign
IGL02879:Itgb4 APN 11 115,885,178 (GRCm39) missense probably benign 0.05
IGL02889:Itgb4 APN 11 115,879,731 (GRCm39) missense probably damaging 1.00
IGL03183:Itgb4 APN 11 115,879,550 (GRCm39) missense probably damaging 1.00
IGL03054:Itgb4 UTSW 11 115,891,166 (GRCm39) nonsense probably null
R0021:Itgb4 UTSW 11 115,870,453 (GRCm39) missense possibly damaging 0.95
R0092:Itgb4 UTSW 11 115,869,950 (GRCm39) missense probably damaging 1.00
R0305:Itgb4 UTSW 11 115,870,238 (GRCm39) missense probably damaging 1.00
R0408:Itgb4 UTSW 11 115,898,428 (GRCm39) missense probably damaging 0.99
R0465:Itgb4 UTSW 11 115,870,582 (GRCm39) missense probably damaging 1.00
R0499:Itgb4 UTSW 11 115,870,521 (GRCm39) missense probably benign 0.00
R0535:Itgb4 UTSW 11 115,881,835 (GRCm39) missense possibly damaging 0.86
R0571:Itgb4 UTSW 11 115,870,594 (GRCm39) missense possibly damaging 0.94
R0613:Itgb4 UTSW 11 115,884,168 (GRCm39) missense probably damaging 0.98
R0838:Itgb4 UTSW 11 115,888,988 (GRCm39) intron probably benign
R1381:Itgb4 UTSW 11 115,885,163 (GRCm39) missense probably benign 0.00
R1451:Itgb4 UTSW 11 115,881,710 (GRCm39) missense probably damaging 1.00
R1459:Itgb4 UTSW 11 115,869,937 (GRCm39) missense probably benign 0.42
R1473:Itgb4 UTSW 11 115,874,873 (GRCm39) missense probably benign 0.01
R1484:Itgb4 UTSW 11 115,890,625 (GRCm39) missense probably benign 0.01
R1593:Itgb4 UTSW 11 115,871,817 (GRCm39) missense probably damaging 1.00
R1623:Itgb4 UTSW 11 115,882,142 (GRCm39) nonsense probably null
R1633:Itgb4 UTSW 11 115,898,586 (GRCm39) missense probably damaging 1.00
R1642:Itgb4 UTSW 11 115,898,183 (GRCm39) missense probably damaging 1.00
R1669:Itgb4 UTSW 11 115,882,156 (GRCm39) missense probably benign 0.07
R1713:Itgb4 UTSW 11 115,894,315 (GRCm39) missense probably damaging 1.00
R1732:Itgb4 UTSW 11 115,879,744 (GRCm39) missense probably damaging 1.00
R1791:Itgb4 UTSW 11 115,879,346 (GRCm39) missense probably damaging 1.00
R1847:Itgb4 UTSW 11 115,874,590 (GRCm39) missense probably benign 0.31
R1902:Itgb4 UTSW 11 115,871,564 (GRCm39) missense probably damaging 0.98
R1945:Itgb4 UTSW 11 115,884,279 (GRCm39) nonsense probably null
R2102:Itgb4 UTSW 11 115,896,561 (GRCm39) missense probably benign 0.23
R2184:Itgb4 UTSW 11 115,870,450 (GRCm39) missense probably damaging 0.96
R2334:Itgb4 UTSW 11 115,884,261 (GRCm39) missense probably damaging 1.00
R2401:Itgb4 UTSW 11 115,897,389 (GRCm39) missense possibly damaging 0.67
R3743:Itgb4 UTSW 11 115,894,496 (GRCm39) missense probably damaging 1.00
R3938:Itgb4 UTSW 11 115,896,752 (GRCm39) missense possibly damaging 0.92
R4134:Itgb4 UTSW 11 115,897,296 (GRCm39) missense probably benign 0.03
R4280:Itgb4 UTSW 11 115,881,761 (GRCm39) missense probably damaging 1.00
R4342:Itgb4 UTSW 11 115,879,555 (GRCm39) missense probably benign 0.01
R4434:Itgb4 UTSW 11 115,890,640 (GRCm39) missense probably benign 0.10
R4505:Itgb4 UTSW 11 115,874,087 (GRCm39) splice site silent
R4585:Itgb4 UTSW 11 115,884,151 (GRCm39) missense probably damaging 1.00
R4586:Itgb4 UTSW 11 115,884,151 (GRCm39) missense probably damaging 1.00
R4601:Itgb4 UTSW 11 115,896,548 (GRCm39) missense probably damaging 1.00
R4921:Itgb4 UTSW 11 115,897,431 (GRCm39) missense probably benign 0.12
R4962:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5027:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5029:Itgb4 UTSW 11 115,879,417 (GRCm39) intron probably benign
R5084:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5085:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5124:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5125:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5150:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5175:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5176:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5179:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5207:Itgb4 UTSW 11 115,897,365 (GRCm39) missense probably damaging 1.00
R5263:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5264:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5334:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5337:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5344:Itgb4 UTSW 11 115,880,575 (GRCm39) missense probably null 0.92
R5391:Itgb4 UTSW 11 115,875,894 (GRCm39) missense probably benign 0.05
R5437:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5440:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5653:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5654:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5655:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5772:Itgb4 UTSW 11 115,879,258 (GRCm39) intron probably benign
R5812:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5813:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5814:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5863:Itgb4 UTSW 11 115,881,748 (GRCm39) missense probably damaging 1.00
R5864:Itgb4 UTSW 11 115,881,748 (GRCm39) missense probably damaging 1.00
R5865:Itgb4 UTSW 11 115,881,748 (GRCm39) missense probably damaging 1.00
R5951:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5954:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5982:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R6043:Itgb4 UTSW 11 115,870,212 (GRCm39) missense probably benign 0.30
R6133:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R6134:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R6135:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R6169:Itgb4 UTSW 11 115,885,102 (GRCm39) missense probably damaging 0.98
R6172:Itgb4 UTSW 11 115,891,237 (GRCm39) missense probably benign 0.23
R6255:Itgb4 UTSW 11 115,888,963 (GRCm39) missense possibly damaging 0.83
R6258:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R6259:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R6260:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R6612:Itgb4 UTSW 11 115,874,897 (GRCm39) missense probably benign 0.00
R7037:Itgb4 UTSW 11 115,896,391 (GRCm39) nonsense probably null
R7371:Itgb4 UTSW 11 115,888,906 (GRCm39) missense probably benign 0.29
R7605:Itgb4 UTSW 11 115,897,302 (GRCm39) missense probably benign 0.01
R7659:Itgb4 UTSW 11 115,870,557 (GRCm39) missense probably damaging 1.00
R7759:Itgb4 UTSW 11 115,894,536 (GRCm39) missense possibly damaging 0.92
R7804:Itgb4 UTSW 11 115,894,510 (GRCm39) missense probably damaging 1.00
R7832:Itgb4 UTSW 11 115,891,087 (GRCm39) missense probably damaging 1.00
R7842:Itgb4 UTSW 11 115,873,531 (GRCm39) missense probably benign 0.18
R7923:Itgb4 UTSW 11 115,873,525 (GRCm39) critical splice acceptor site probably null
R8004:Itgb4 UTSW 11 115,873,531 (GRCm39) missense probably benign 0.00
R8143:Itgb4 UTSW 11 115,884,255 (GRCm39) missense probably damaging 1.00
R8427:Itgb4 UTSW 11 115,882,544 (GRCm39) critical splice donor site probably null
R8857:Itgb4 UTSW 11 115,871,853 (GRCm39) missense probably benign 0.04
R8863:Itgb4 UTSW 11 115,875,898 (GRCm39) nonsense probably null
R8932:Itgb4 UTSW 11 115,879,295 (GRCm39) missense probably benign 0.01
R9153:Itgb4 UTSW 11 115,874,879 (GRCm39) missense probably benign 0.00
R9207:Itgb4 UTSW 11 115,897,923 (GRCm39) missense probably damaging 1.00
R9239:Itgb4 UTSW 11 115,898,130 (GRCm39) missense probably damaging 1.00
R9267:Itgb4 UTSW 11 115,870,465 (GRCm39) missense probably benign
R9289:Itgb4 UTSW 11 115,885,187 (GRCm39) missense probably benign 0.01
R9328:Itgb4 UTSW 11 115,880,625 (GRCm39) missense probably benign 0.00
R9435:Itgb4 UTSW 11 115,895,855 (GRCm39) missense probably benign 0.01
R9450:Itgb4 UTSW 11 115,874,097 (GRCm39) missense probably damaging 1.00
R9649:Itgb4 UTSW 11 115,885,171 (GRCm39) missense possibly damaging 0.78
R9779:Itgb4 UTSW 11 115,882,485 (GRCm39) missense probably damaging 1.00
X0062:Itgb4 UTSW 11 115,884,278 (GRCm39) missense probably damaging 1.00
Z1176:Itgb4 UTSW 11 115,897,346 (GRCm39) missense probably damaging 1.00
Z1177:Itgb4 UTSW 11 115,888,884 (GRCm39) missense probably benign 0.00
Z1177:Itgb4 UTSW 11 115,877,637 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GCTTACCAAGTCCCTGTCCATACAC -3'
(R):5'- TTATGCCTGGCTTTGCCACTGG -3'

Sequencing Primer
(F):5'- TCCCTGTCCATACACTGGGAG -3'
(R):5'- GCCACTGGACACTTCTGC -3'
Posted On 2014-03-14