Incidental Mutation 'R1426:Zkscan7'
ID 162249
Institutional Source Beutler Lab
Gene Symbol Zkscan7
Ensembl Gene ENSMUSG00000063488
Gene Name zinc finger with KRAB and SCAN domains 7
Synonyms Zfp167
MMRRC Submission 039482-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1426 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 122715883-122727684 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 122724228 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 399 (I399T)
Ref Sequence ENSEMBL: ENSMUSP00000071695 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063980] [ENSMUST00000215872]
AlphaFold E9PVW1
Predicted Effect probably benign
Transcript: ENSMUST00000063980
AA Change: I399T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000071695
Gene: ENSMUSG00000063488
AA Change: I399T

DomainStartEndE-ValueType
SCAN 45 156 1.18e-65 SMART
ZnF_C2H2 350 372 5.59e-4 SMART
ZnF_C2H2 378 400 3.69e-4 SMART
ZnF_C2H2 434 456 8.4e1 SMART
ZnF_C2H2 487 509 4.24e-4 SMART
ZnF_C2H2 515 537 8.34e-3 SMART
ZnF_C2H2 543 565 7.37e-4 SMART
ZnF_C2H2 571 593 1.92e-2 SMART
ZnF_C2H2 599 621 1.13e-4 SMART
ZnF_C2H2 627 649 2.24e-3 SMART
ZnF_C2H2 655 677 4.17e-3 SMART
ZnF_C2H2 683 705 1.04e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180486
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180877
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214426
Predicted Effect probably benign
Transcript: ENSMUST00000215872
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216429
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216924
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.7%
  • 10x: 94.3%
  • 20x: 86.1%
Validation Efficiency 100% (40/40)
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc10 A T 17: 46,635,361 (GRCm39) V214E probably damaging Het
Adh1 A G 3: 137,992,556 (GRCm39) D224G probably damaging Het
Arhgap28 C A 17: 68,164,459 (GRCm39) Q554H probably damaging Het
Atp8a2 T C 14: 60,097,719 (GRCm39) K770E probably benign Het
Brat1 G A 5: 140,703,768 (GRCm39) V674I probably benign Het
Brd2 ATCTTCTTC ATCTTC 17: 34,332,981 (GRCm39) probably benign Het
Ccdc162 T C 10: 41,429,178 (GRCm39) D438G possibly damaging Het
Cyp4x1 T A 4: 114,969,988 (GRCm39) probably benign Het
Dip2a T C 10: 76,115,654 (GRCm39) probably benign Het
Eif2s1 A G 12: 78,927,942 (GRCm39) D206G probably benign Het
Elovl7 T A 13: 108,419,028 (GRCm39) I220N possibly damaging Het
Gsto1 A G 19: 47,846,381 (GRCm39) E76G probably damaging Het
Hspa14 A T 2: 3,509,858 (GRCm39) W12R probably damaging Het
L3mbtl2 T A 15: 81,560,518 (GRCm39) C260S possibly damaging Het
Lama3 G T 18: 12,614,155 (GRCm39) probably null Het
Lrrc34 T A 3: 30,697,728 (GRCm39) probably benign Het
Lrrc45 A T 11: 120,610,839 (GRCm39) Q525L probably benign Het
Lss T C 10: 76,372,137 (GRCm39) I164T probably damaging Het
Myh11 T A 16: 14,023,795 (GRCm39) K1527* probably null Het
Naip2 T C 13: 100,298,362 (GRCm39) E558G probably benign Het
Naip2 C T 13: 100,298,368 (GRCm39) G556D probably benign Het
Ncoa1 T A 12: 4,320,737 (GRCm39) probably benign Het
Or5an1c G T 19: 12,218,546 (GRCm39) Q160K possibly damaging Het
Or6c38 A T 10: 128,929,559 (GRCm39) C95S probably damaging Het
Pafah1b3 T C 7: 24,996,560 (GRCm39) E41G possibly damaging Het
Pnma8a C T 7: 16,694,909 (GRCm39) P255S possibly damaging Het
Prkar2b A T 12: 32,012,987 (GRCm39) probably benign Het
Rbck1 A T 2: 152,169,161 (GRCm39) probably benign Het
Rcor2 A G 19: 7,248,395 (GRCm39) S137G possibly damaging Het
Slc25a48 T A 13: 56,596,804 (GRCm39) probably benign Het
Slc7a4 A G 16: 17,391,808 (GRCm39) probably null Het
Tert T C 13: 73,790,472 (GRCm39) probably benign Het
Traf7 A T 17: 24,730,655 (GRCm39) I344N probably damaging Het
Vmn1r194 T A 13: 22,429,236 (GRCm39) F284L probably damaging Het
Xpc A G 6: 91,470,220 (GRCm39) M699T probably damaging Het
Zbtb5 T C 4: 44,993,968 (GRCm39) H472R possibly damaging Het
Zfp786 A G 6: 47,802,013 (GRCm39) V88A probably benign Het
Zyg11b G A 4: 108,108,009 (GRCm39) R466C probably damaging Het
Other mutations in Zkscan7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00594:Zkscan7 APN 9 122,724,659 (GRCm39) missense possibly damaging 0.95
IGL01650:Zkscan7 APN 9 122,723,892 (GRCm39) missense probably benign
IGL01905:Zkscan7 APN 9 122,719,826 (GRCm39) missense possibly damaging 0.93
IGL02466:Zkscan7 APN 9 122,717,950 (GRCm39) missense probably damaging 0.98
R0310:Zkscan7 UTSW 9 122,717,958 (GRCm39) nonsense probably null
R0355:Zkscan7 UTSW 9 122,717,872 (GRCm39) missense probably damaging 1.00
R0477:Zkscan7 UTSW 9 122,719,874 (GRCm39) splice site probably null
R1276:Zkscan7 UTSW 9 122,719,788 (GRCm39) missense probably damaging 0.98
R2055:Zkscan7 UTSW 9 122,718,002 (GRCm39) missense probably damaging 1.00
R2195:Zkscan7 UTSW 9 122,724,686 (GRCm39) missense possibly damaging 0.73
R2354:Zkscan7 UTSW 9 122,723,892 (GRCm39) missense probably benign
R4878:Zkscan7 UTSW 9 122,719,865 (GRCm39) nonsense probably null
R5106:Zkscan7 UTSW 9 122,725,198 (GRCm39) unclassified probably benign
R6266:Zkscan7 UTSW 9 122,724,299 (GRCm39) nonsense probably null
R6299:Zkscan7 UTSW 9 122,717,782 (GRCm39) missense probably damaging 1.00
R6513:Zkscan7 UTSW 9 122,725,170 (GRCm39) missense probably benign 0.00
R6881:Zkscan7 UTSW 9 122,717,766 (GRCm39) missense possibly damaging 0.96
R7640:Zkscan7 UTSW 9 122,725,121 (GRCm39) missense possibly damaging 0.71
R7920:Zkscan7 UTSW 9 122,724,974 (GRCm39) missense probably benign 0.19
Predicted Primers PCR Primer
(F):5'- AAATGCCCTCCAGTCCTGTTGAGC -3'
(R):5'- GCCTCGCCAGATTCATCAGGTTTC -3'

Sequencing Primer
(F):5'- CCAGTCCTGTTGAGCATCAG -3'
(R):5'- AGATTCATCAGGTTTCTCTCCAGTG -3'
Posted On 2014-03-14