Incidental Mutation 'R1432:Mgam'
| ID |
162294 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mgam
|
| Ensembl Gene |
ENSMUSG00000068587 |
| Gene Name |
maltase-glucoamylase |
| Synonyms |
6030407P20Rik |
| MMRRC Submission |
039487-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.237)
|
| Stock # |
R1432 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
40605765-40746057 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 40733301 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 692
(M692K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000144680
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000071535]
[ENSMUST00000201148]
[ENSMUST00000202779]
[ENSMUST00000202966]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000071535
AA Change: M1438K
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000071466
Gene: ENSMUSG00000068587
AA Change: M1438K
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
12 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
47 |
59 |
N/A |
INTRINSIC |
|
PD
|
63 |
111 |
1.81e-8 |
SMART |
|
Pfam:NtCtMGAM_N
|
124 |
233 |
6.2e-36 |
PFAM |
|
Pfam:Glyco_hydro_31
|
323 |
795 |
3.4e-145 |
PFAM |
|
PD
|
924 |
977 |
4.52e-9 |
SMART |
|
Pfam:NtCtMGAM_N
|
988 |
1101 |
1.5e-30 |
PFAM |
|
Blast:ANK
|
1141 |
1171 |
1e-7 |
BLAST |
|
Pfam:Glyco_hydro_31
|
1189 |
1691 |
2e-139 |
PFAM |
|
low complexity region
|
1776 |
1791 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000201148
AA Change: M1438K
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000143946
Gene: ENSMUSG00000068587
AA Change: M1438K
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
12 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
47 |
59 |
N/A |
INTRINSIC |
|
PD
|
63 |
111 |
1.81e-8 |
SMART |
|
Pfam:NtCtMGAM_N
|
124 |
233 |
6.2e-36 |
PFAM |
|
Pfam:Glyco_hydro_31
|
323 |
795 |
3.4e-145 |
PFAM |
|
PD
|
924 |
977 |
4.52e-9 |
SMART |
|
Pfam:NtCtMGAM_N
|
988 |
1101 |
1.5e-30 |
PFAM |
|
Blast:ANK
|
1141 |
1171 |
1e-7 |
BLAST |
|
Pfam:Glyco_hydro_31
|
1189 |
1691 |
2e-139 |
PFAM |
|
low complexity region
|
1776 |
1791 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000202775
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000202779
AA Change: M811K
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000144627
Gene: ENSMUSG00000068587
AA Change: M811K
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Glyco_hydro_31
|
2 |
170 |
1.4e-53 |
PFAM |
|
PD
|
297 |
350 |
1.4e-14 |
SMART |
|
Pfam:NtCtMGAM_N
|
361 |
474 |
1.5e-26 |
PFAM |
|
Blast:ANK
|
514 |
544 |
7e-8 |
BLAST |
|
Pfam:Glyco_hydro_31
|
562 |
1064 |
2.2e-137 |
PFAM |
|
low complexity region
|
1149 |
1164 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000202966
AA Change: M692K
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000144680
Gene: ENSMUSG00000068587
AA Change: M692K
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
2 |
88 |
2.6e-19 |
PROSPERO |
|
PD
|
178 |
231 |
1.4e-14 |
SMART |
|
Pfam:NtCtMGAM_N
|
242 |
355 |
1.1e-26 |
PFAM |
|
Blast:ANK
|
395 |
425 |
6e-8 |
BLAST |
|
Pfam:Glyco_hydro_31
|
443 |
945 |
1.3e-137 |
PFAM |
|
| Meta Mutation Damage Score |
0.3989 |
| Coding Region Coverage |
- 1x: 98.9%
- 3x: 97.8%
- 10x: 94.4%
- 20x: 86.1%
|
| Validation Efficiency |
98% (90/92) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes maltase-glucoamylase, which is a brush border membrane enzyme that plays a role in the final steps of digestion of starch. The protein has two catalytic sites identical to those of sucrase-isomaltase, but the proteins are only 59% homologous. Both are members of glycosyl hydrolase family 31, which has a variety of substrate specificities. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele display abnormalities in starch digestion and prandial glucose homeostasis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700049A03Rik |
A |
G |
12: 71,217,361 (GRCm39) |
|
probably null |
Het |
| 9130401M01Rik |
A |
T |
15: 57,892,256 (GRCm39) |
L117Q |
probably damaging |
Het |
| Abcb1b |
A |
G |
5: 8,887,771 (GRCm39) |
K886E |
possibly damaging |
Het |
| Acaa2 |
A |
T |
18: 74,920,198 (GRCm39) |
I9F |
probably damaging |
Het |
| Acap2 |
A |
T |
16: 30,929,901 (GRCm39) |
S386T |
probably damaging |
Het |
| Acsm2 |
A |
T |
7: 119,172,798 (GRCm39) |
I138F |
possibly damaging |
Het |
| Agl |
T |
C |
3: 116,540,342 (GRCm39) |
Y1424C |
probably damaging |
Het |
| Aoc1l1 |
T |
A |
6: 48,952,588 (GRCm39) |
F171Y |
probably damaging |
Het |
| Apc2 |
T |
C |
10: 80,148,183 (GRCm39) |
V1079A |
probably benign |
Het |
| Arhgef6 |
T |
C |
X: 56,383,922 (GRCm39) |
M5V |
probably benign |
Het |
| Armc8 |
C |
T |
9: 99,405,185 (GRCm39) |
|
probably benign |
Het |
| Catsperb |
A |
G |
12: 101,588,476 (GRCm39) |
Y953C |
probably damaging |
Het |
| Cdk13 |
G |
A |
13: 17,893,001 (GRCm39) |
A720V |
probably damaging |
Het |
| Chka |
T |
C |
19: 3,924,809 (GRCm39) |
|
probably benign |
Het |
| Clcc1 |
T |
C |
3: 108,575,418 (GRCm39) |
I165T |
probably benign |
Het |
| Cndp1 |
G |
A |
18: 84,652,777 (GRCm39) |
|
probably benign |
Het |
| Dip2c |
C |
A |
13: 9,603,340 (GRCm39) |
P297Q |
probably damaging |
Het |
| Dnah17 |
A |
T |
11: 117,914,153 (GRCm39) |
W4429R |
probably damaging |
Het |
| Dram2 |
T |
C |
3: 106,478,082 (GRCm39) |
V138A |
possibly damaging |
Het |
| Dus4l |
T |
C |
12: 31,698,770 (GRCm39) |
N78S |
probably benign |
Het |
| Dync1h1 |
G |
A |
12: 110,602,943 (GRCm39) |
E2195K |
probably benign |
Het |
| Ebf1 |
T |
C |
11: 44,895,533 (GRCm39) |
|
probably benign |
Het |
| Epm2a |
T |
A |
10: 11,266,587 (GRCm39) |
Y111N |
probably damaging |
Het |
| Gm773 |
T |
C |
X: 55,247,377 (GRCm39) |
T52A |
probably benign |
Het |
| Gpam |
C |
A |
19: 55,067,693 (GRCm39) |
M483I |
probably damaging |
Het |
| Gpr12 |
T |
C |
5: 146,520,235 (GRCm39) |
H229R |
probably damaging |
Het |
| Gpr149 |
T |
C |
3: 62,438,439 (GRCm39) |
T573A |
probably damaging |
Het |
| Gtf3c3 |
C |
T |
1: 54,456,937 (GRCm39) |
A488T |
probably damaging |
Het |
| Hells |
T |
A |
19: 38,945,628 (GRCm39) |
|
probably null |
Het |
| Herc1 |
T |
A |
9: 66,372,751 (GRCm39) |
N3102K |
probably benign |
Het |
| Herc3 |
A |
T |
6: 58,893,827 (GRCm39) |
T968S |
possibly damaging |
Het |
| Ift88 |
A |
G |
14: 57,674,736 (GRCm39) |
Y69C |
probably benign |
Het |
| Incenp |
G |
A |
19: 9,862,890 (GRCm39) |
T388M |
unknown |
Het |
| Jrkl |
A |
G |
9: 13,245,337 (GRCm39) |
F108S |
probably benign |
Het |
| Khdc1a |
A |
G |
1: 21,420,542 (GRCm39) |
E54G |
possibly damaging |
Het |
| Kif6 |
T |
A |
17: 49,927,728 (GRCm39) |
F58L |
probably damaging |
Het |
| Klk14 |
T |
C |
7: 43,344,342 (GRCm39) |
S218P |
probably damaging |
Het |
| Kmt2e |
T |
C |
5: 23,655,319 (GRCm39) |
M19T |
probably benign |
Het |
| Llgl1 |
G |
T |
11: 60,599,380 (GRCm39) |
G454C |
probably damaging |
Het |
| Lyrm4 |
A |
G |
13: 36,276,898 (GRCm39) |
V33A |
probably benign |
Het |
| Mcam |
C |
T |
9: 44,052,588 (GRCm39) |
R606C |
probably damaging |
Het |
| Mmp28 |
C |
T |
11: 83,333,765 (GRCm39) |
R392H |
probably damaging |
Het |
| Mpdz |
G |
A |
4: 81,210,788 (GRCm39) |
T1699M |
probably damaging |
Het |
| Mrps11 |
T |
C |
7: 78,433,310 (GRCm39) |
|
probably benign |
Het |
| Mrtfb |
A |
G |
16: 13,218,866 (GRCm39) |
N504S |
probably benign |
Het |
| Msmo1 |
A |
G |
8: 65,180,650 (GRCm39) |
|
probably benign |
Het |
| Mst1 |
A |
G |
9: 107,961,403 (GRCm39) |
E571G |
probably benign |
Het |
| Myh14 |
T |
C |
7: 44,265,723 (GRCm39) |
E1585G |
probably damaging |
Het |
| Myrfl |
A |
G |
10: 116,613,332 (GRCm39) |
C824R |
probably damaging |
Het |
| Ncapd3 |
C |
T |
9: 26,981,168 (GRCm39) |
|
probably benign |
Het |
| Nlrp4a |
G |
GGTTCTTC |
7: 26,163,622 (GRCm39) |
|
probably null |
Het |
| Nos1 |
C |
T |
5: 118,087,684 (GRCm39) |
|
probably benign |
Het |
| Notch3 |
T |
C |
17: 32,383,198 (GRCm39) |
S47G |
probably benign |
Het |
| Npsr1 |
A |
G |
9: 24,221,371 (GRCm39) |
Y122C |
probably damaging |
Het |
| Or10ak12 |
T |
C |
4: 118,666,435 (GRCm39) |
M209V |
probably benign |
Het |
| Or1j11 |
C |
T |
2: 36,311,655 (GRCm39) |
L82F |
probably damaging |
Het |
| Or5a1 |
G |
T |
19: 12,097,603 (GRCm39) |
R158S |
possibly damaging |
Het |
| Or6c1b |
C |
T |
10: 129,272,807 (GRCm39) |
T42I |
probably damaging |
Het |
| Or6k2 |
T |
A |
1: 173,986,483 (GRCm39) |
V48E |
possibly damaging |
Het |
| Or8b9 |
T |
A |
9: 37,766,548 (GRCm39) |
L145M |
possibly damaging |
Het |
| Otog |
G |
T |
7: 45,950,007 (GRCm39) |
V2490F |
probably damaging |
Het |
| Pibf1 |
T |
C |
14: 99,350,425 (GRCm39) |
V191A |
probably benign |
Het |
| Pip |
A |
G |
6: 41,826,852 (GRCm39) |
M66V |
probably benign |
Het |
| Plxna2 |
C |
T |
1: 194,449,771 (GRCm39) |
R830C |
probably benign |
Het |
| Prkca |
A |
T |
11: 107,830,346 (GRCm39) |
V248E |
probably benign |
Het |
| Prmt7 |
T |
A |
8: 106,963,916 (GRCm39) |
L253* |
probably null |
Het |
| Prrc2a |
G |
T |
17: 35,372,888 (GRCm39) |
|
probably benign |
Het |
| Rasgrf1 |
A |
G |
9: 89,894,853 (GRCm39) |
D1091G |
probably benign |
Het |
| Rbm7 |
C |
A |
9: 48,401,245 (GRCm39) |
G161V |
probably benign |
Het |
| Scn1a |
A |
T |
2: 66,152,773 (GRCm39) |
I736N |
probably damaging |
Het |
| Skint6 |
A |
G |
4: 112,726,721 (GRCm39) |
|
probably benign |
Het |
| Slc22a2 |
C |
T |
17: 12,803,195 (GRCm39) |
H10Y |
possibly damaging |
Het |
| Sned1 |
G |
A |
1: 93,209,376 (GRCm39) |
V830M |
possibly damaging |
Het |
| Stam2 |
A |
G |
2: 52,604,821 (GRCm39) |
|
probably benign |
Het |
| Stk40 |
T |
C |
4: 126,030,626 (GRCm39) |
L282P |
probably damaging |
Het |
| Tas2r110 |
A |
G |
6: 132,845,331 (GRCm39) |
N121D |
probably damaging |
Het |
| Tbc1d32 |
A |
G |
10: 55,893,758 (GRCm39) |
Y1272H |
probably damaging |
Het |
| Thoc2l |
T |
C |
5: 104,665,970 (GRCm39) |
F164S |
probably damaging |
Het |
| Tmem131l |
T |
C |
3: 83,836,021 (GRCm39) |
D696G |
probably damaging |
Het |
| Trdmt1 |
T |
C |
2: 13,524,657 (GRCm39) |
Y266C |
probably damaging |
Het |
| Trim5 |
G |
T |
7: 103,928,726 (GRCm39) |
H72N |
probably benign |
Het |
| Trim5 |
A |
C |
7: 103,928,728 (GRCm39) |
L71R |
probably benign |
Het |
| Twf2 |
T |
A |
9: 106,092,012 (GRCm39) |
|
probably benign |
Het |
| Ubap2l |
T |
C |
3: 89,926,635 (GRCm39) |
T580A |
probably benign |
Het |
| Ugt1a10 |
C |
T |
1: 88,143,982 (GRCm39) |
R201C |
probably damaging |
Het |
| Unc5a |
A |
G |
13: 55,152,285 (GRCm39) |
|
probably benign |
Het |
| Vmn2r85 |
T |
C |
10: 130,261,155 (GRCm39) |
N394S |
possibly damaging |
Het |
| Wrn |
A |
T |
8: 33,809,169 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Mgam |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01024:Mgam
|
APN |
6 |
40,619,944 (GRCm39) |
missense |
probably benign |
|
|
IGL01065:Mgam
|
APN |
6 |
40,639,644 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01402:Mgam
|
APN |
6 |
40,621,879 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01404:Mgam
|
APN |
6 |
40,621,879 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01413:Mgam
|
APN |
6 |
40,638,211 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01546:Mgam
|
APN |
6 |
40,631,627 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01596:Mgam
|
APN |
6 |
40,635,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02133:Mgam
|
APN |
6 |
40,620,010 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02734:Mgam
|
APN |
6 |
40,639,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB002:Mgam
|
UTSW |
6 |
40,735,985 (GRCm39) |
missense |
probably damaging |
0.99 |
|
BB012:Mgam
|
UTSW |
6 |
40,735,985 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0012:Mgam
|
UTSW |
6 |
40,742,190 (GRCm39) |
splice site |
probably null |
|
|
R0116:Mgam
|
UTSW |
6 |
40,635,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0310:Mgam
|
UTSW |
6 |
40,737,969 (GRCm39) |
splice site |
probably benign |
|
|
R0452:Mgam
|
UTSW |
6 |
40,736,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0497:Mgam
|
UTSW |
6 |
40,641,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0699:Mgam
|
UTSW |
6 |
40,619,953 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R0738:Mgam
|
UTSW |
6 |
40,731,869 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1033:Mgam
|
UTSW |
6 |
40,657,558 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1403:Mgam
|
UTSW |
6 |
40,643,815 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1403:Mgam
|
UTSW |
6 |
40,643,815 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1430:Mgam
|
UTSW |
6 |
40,733,305 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1443:Mgam
|
UTSW |
6 |
40,736,714 (GRCm39) |
nonsense |
probably null |
|
|
R1470:Mgam
|
UTSW |
6 |
40,736,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1470:Mgam
|
UTSW |
6 |
40,736,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1519:Mgam
|
UTSW |
6 |
40,638,617 (GRCm39) |
missense |
probably benign |
0.45 |
|
R1654:Mgam
|
UTSW |
6 |
40,734,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1667:Mgam
|
UTSW |
6 |
40,653,978 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R1730:Mgam
|
UTSW |
6 |
40,641,794 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1781:Mgam
|
UTSW |
6 |
40,646,797 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1783:Mgam
|
UTSW |
6 |
40,641,794 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1829:Mgam
|
UTSW |
6 |
40,643,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1833:Mgam
|
UTSW |
6 |
40,631,652 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1872:Mgam
|
UTSW |
6 |
40,638,234 (GRCm39) |
nonsense |
probably null |
|
|
R1912:Mgam
|
UTSW |
6 |
40,741,119 (GRCm39) |
nonsense |
probably null |
|
|
R1977:Mgam
|
UTSW |
6 |
40,641,814 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2048:Mgam
|
UTSW |
6 |
40,633,363 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R2086:Mgam
|
UTSW |
6 |
40,737,962 (GRCm39) |
splice site |
probably null |
|
|
R2138:Mgam
|
UTSW |
6 |
40,733,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2224:Mgam
|
UTSW |
6 |
40,741,208 (GRCm39) |
splice site |
probably null |
|
|
R2408:Mgam
|
UTSW |
6 |
40,663,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2508:Mgam
|
UTSW |
6 |
40,736,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2842:Mgam
|
UTSW |
6 |
40,638,279 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2847:Mgam
|
UTSW |
6 |
40,629,649 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R2848:Mgam
|
UTSW |
6 |
40,629,649 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R2965:Mgam
|
UTSW |
6 |
40,745,154 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R2966:Mgam
|
UTSW |
6 |
40,745,154 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R3035:Mgam
|
UTSW |
6 |
40,640,464 (GRCm39) |
missense |
probably benign |
|
|
R3895:Mgam
|
UTSW |
6 |
40,736,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4027:Mgam
|
UTSW |
6 |
40,731,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4030:Mgam
|
UTSW |
6 |
40,731,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4302:Mgam
|
UTSW |
6 |
40,740,019 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4707:Mgam
|
UTSW |
6 |
40,691,566 (GRCm39) |
splice site |
probably null |
|
|
R4826:Mgam
|
UTSW |
6 |
40,657,582 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R4898:Mgam
|
UTSW |
6 |
40,619,988 (GRCm39) |
missense |
probably benign |
|
|
R5438:Mgam
|
UTSW |
6 |
40,661,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5492:Mgam
|
UTSW |
6 |
40,733,297 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5770:Mgam
|
UTSW |
6 |
40,646,738 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5839:Mgam
|
UTSW |
6 |
40,716,998 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5845:Mgam
|
UTSW |
6 |
40,652,257 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R5847:Mgam
|
UTSW |
6 |
40,660,989 (GRCm39) |
missense |
probably benign |
0.42 |
|
R5891:Mgam
|
UTSW |
6 |
40,721,282 (GRCm39) |
missense |
probably benign |
|
|
R6158:Mgam
|
UTSW |
6 |
40,734,648 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6193:Mgam
|
UTSW |
6 |
40,724,854 (GRCm39) |
nonsense |
probably null |
|
|
R6423:Mgam
|
UTSW |
6 |
40,653,979 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6706:Mgam
|
UTSW |
6 |
40,721,720 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6813:Mgam
|
UTSW |
6 |
40,727,099 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6863:Mgam
|
UTSW |
6 |
40,705,943 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6906:Mgam
|
UTSW |
6 |
40,724,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7091:Mgam
|
UTSW |
6 |
40,745,210 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7099:Mgam
|
UTSW |
6 |
40,638,650 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7282:Mgam
|
UTSW |
6 |
40,740,045 (GRCm39) |
missense |
probably benign |
|
|
R7282:Mgam
|
UTSW |
6 |
40,633,446 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7354:Mgam
|
UTSW |
6 |
40,721,732 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7374:Mgam
|
UTSW |
6 |
40,734,373 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7399:Mgam
|
UTSW |
6 |
40,643,788 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7406:Mgam
|
UTSW |
6 |
40,640,459 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7446:Mgam
|
UTSW |
6 |
40,723,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7466:Mgam
|
UTSW |
6 |
40,721,723 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7525:Mgam
|
UTSW |
6 |
40,742,954 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7530:Mgam
|
UTSW |
6 |
40,686,152 (GRCm39) |
splice site |
probably null |
|
|
R7570:Mgam
|
UTSW |
6 |
40,723,367 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7669:Mgam
|
UTSW |
6 |
40,635,944 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7679:Mgam
|
UTSW |
6 |
40,619,980 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7746:Mgam
|
UTSW |
6 |
40,645,127 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7859:Mgam
|
UTSW |
6 |
40,717,113 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7925:Mgam
|
UTSW |
6 |
40,735,985 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8206:Mgam
|
UTSW |
6 |
40,657,169 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8244:Mgam
|
UTSW |
6 |
40,727,520 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8309:Mgam
|
UTSW |
6 |
40,722,111 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8472:Mgam
|
UTSW |
6 |
40,671,460 (GRCm39) |
splice site |
probably null |
|
|
R8758:Mgam
|
UTSW |
6 |
40,705,977 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8777:Mgam
|
UTSW |
6 |
40,632,185 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8777-TAIL:Mgam
|
UTSW |
6 |
40,632,185 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8783:Mgam
|
UTSW |
6 |
40,633,423 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8939:Mgam
|
UTSW |
6 |
40,740,137 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8968:Mgam
|
UTSW |
6 |
40,734,745 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8987:Mgam
|
UTSW |
6 |
40,706,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9055:Mgam
|
UTSW |
6 |
40,691,663 (GRCm39) |
intron |
probably benign |
|
|
R9171:Mgam
|
UTSW |
6 |
40,745,146 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R9252:Mgam
|
UTSW |
6 |
40,706,577 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9258:Mgam
|
UTSW |
6 |
40,657,121 (GRCm39) |
missense |
probably benign |
|
|
R9262:Mgam
|
UTSW |
6 |
40,723,422 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9287:Mgam
|
UTSW |
6 |
40,705,905 (GRCm39) |
intron |
probably benign |
|
|
R9521:Mgam
|
UTSW |
6 |
40,722,118 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9589:Mgam
|
UTSW |
6 |
40,727,519 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9658:Mgam
|
UTSW |
6 |
40,721,311 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9784:Mgam
|
UTSW |
6 |
40,736,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF011:Mgam
|
UTSW |
6 |
40,734,370 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF020:Mgam
|
UTSW |
6 |
40,662,243 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF023:Mgam
|
UTSW |
6 |
40,657,642 (GRCm39) |
missense |
probably benign |
|
|
X0021:Mgam
|
UTSW |
6 |
40,635,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Mgam
|
UTSW |
6 |
40,619,994 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1176:Mgam
|
UTSW |
6 |
40,706,000 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Mgam
|
UTSW |
6 |
40,654,578 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Mgam
|
UTSW |
6 |
40,717,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTTCCAGAGCATGTGGTAACTTGC -3'
(R):5'- TTACACCAGTGACTGGACATCCCC -3'
Sequencing Primer
(F):5'- CCACAGGAATGTTGCAGTTC -3'
(R):5'- CCCACTAATAATGCCAAGTGTTGTG -3'
|
| Posted On |
2014-03-14 |
Incidental Mutation